DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and HECTD3

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	NP_078878.3	Gene:	HECTD3 / 79654	HGNCID:	26117	Length:	861	Species:	Homo sapiens

Alignment Length:	859	Identity:	179/859 - (20%)
Similarity:	294/859 - (34%)	Gaps:	280/859 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  2206 APNKASVSPATAARSVIVLAGGSCLKTIDSDI-NNYSASNLSTAEQAKCDTQYQKSTSDHL---- 2265
            ||...| .|..|||..|.|..|:|::|...:: |.:......|.||          .::||
Human    81 APGTGS-GPLRAARDSIELRRGACVRTTGEELCNGHGLWVKLTKEQ----------LAEHLGDCG 134

  Fly  2266 -----LLF--PARGSQFYQSNFSELPSWNFLLSRWKLTLDLFGRVFMDDVGMEHGSVLPELRGFP 2323
                 ||.  ||.|.    :....:.:.|.|..:.:|            .|:::   .|.||...
Human   135 LQEGWLLVCRPAEGG----ARLVPIDTPNHLQRQQQL------------FGVDY---RPVLRWEQ 180

  Fly  2324 VKEMRFRRHM-------EKLRNGQQR--------------DLV------LCKLERNR-------E 2354
            |.::.:...:       |......||              ||:      |.|.:.|.       |
Human   181 VVDLTYSHRLGSRPQPAEAYAEAVQRLLYVPPTWTYECDEDLIHFLYDHLGKEDENLGSVKQYVE 245

  Fly  2355 SLIVQTFKE-----------LNTQFGNQSRRIQPPITFNRVKVTFK---------------DE-- 2391
            |:.|.::.|           .:|.:.:...:.|     :.|::|.|               |:
Human   246 SIDVSSYTEEFNVSCLTDSNADTYWESDGSQCQ-----HWVRLTMKKGTIVKKLLLTVDTTDDNF 305

  Fly  2392 --------PGEGSGVARSFYTSIAEALLASAKIPNLESVQVGTNHSKYVVPFSSILRSRTVSGSS 2448
                    .|||..:.:....||.|.|:....:  ||.:.|   |    :|   |:..|.|  ..
Human   306 MPKRVVVYGGEGDNLKKLSDVSIDETLIGDVCV--LEDMTV---H----LP---IIEIRIV--EC 356

  Fly  2449 RDQS-TLQRRGSNSKILWRSARERKALNLDARPYTPPN-----SSDNATPESLNDHLSVHLQQIG 2507
            ||.. .::.||...|    |:|:|: |.|:|..:.|.:     ..:...||.|. ..:|.||:..
Human   357 RDDGIDVRLRGVKIK----SSRQRE-LGLNADLFQPTSLVRYPRLEGTDPEVLY-RRAVLLQRFI 415

  Fly  2508 ERLYPKIHSINQTHAP---KITGMLLEIPTPQLLSVISSDETLRQKVNEAIEIITFKQKSETSAQ 2569
            :.|...:|.:    .|   ...|...||...:...::|     ||:.....:.:   :.||:|..
Human   416 KILDSVLHHL----VPAWDHTLGTFSEIKQVKQFLLLS-----RQRPGLVAQCL---RDSESSKP 468

  Fly  2570 SSQPK--------------------------------KSPSVVVVDPVD---------------- 2586
            |..|:                                ..||.....|:|
Human   469 SFMPRLYINRRLAMEHRACPSRDPACKNAVFTQVYEGLKPSDKYEKPLDYRWPMRYDQWWECKFI 533

  Fly  2587 ----------------DDNE-------------PLFYSPGKRG--------FYTPR---QGFASF 2611
                            |.:|             |.|.....:|        .|.|.   :.||.:
Human   534 AEGIIDQGGGFRDSLADMSEELCPSSADTPVPLPFFVRTANQGNGTGEARDMYVPNPSCRDFAKY 598

  Fly  2612 ERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIKF-HDLAFFDPALYESFRQIIQNAQ 2675
            |.      ||:|:|..|...|.|.|.|...|.|.:.|.::.: .|....|..|.:...  :....
Human   599 EW------IGQLMGAALRGKEFLVLALPGFVWKQLSGEEVSWSKDFPAVDSVLVKLLE--VMEGM 655

  Fly  2676 TKEGEETINRMELCFVIDLMKEEGCGNRELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALE 2740
            .||..|.....||.|...|..::..   ||||||..:.|...:...:::...:.||.:|:|: :.
Human   656 DKETFEFKFGKELTFTTVLSDQQVV---ELIPGGAGIVVGYGDRSRFIQLVQKARLEESKEQ-VA 716

  Fly  2741 ALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVSTLISYTTFNDESSEGPDKLLKFKKWFWSI 2805
            |::.|:..|:|...:..||.::|...:.|..::.|..|...|.|.|  .|..|..:::   ||..
Human   717 AMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFED--FEPSDSRVQY---FWEA 776

  Fly  2806 VEKMNIMERQDLVYFWTGSPALPA------SEEGFQPLPSVTIRPADDSHLPTANTCISRLYIPL 2864
            :......:|...:.|.||...|||      .:.|::...:          ||.::||.|.|::|.
Human   777 LNNFTNEDRSRFLRFVTGRSRLPARIYIYPDKLGYETTDA----------LPESSTCSSTLFLPH 831

  Fly  2865 YSSKSILRSKMLMA 2878
            |:|..:...|:..|
Human   832 YASAKVCEEKLRYA 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	12/65 (18%)
		HECTc	2589..2885	CDD:238033	78/321 (24%)
		HECTc	2589..2884	CDD:214523	78/321 (24%)
HECTD3	NP_078878.3	APC10-HECTD3	238..371	CDD:176487	29/151 (19%)
HECTD3	NP_078878.3	HECT	579..845	CDD:366212	73/292 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900