DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and Herc3

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	NP_001348895.1	Gene:	Herc3 / 73998	MGIID:	1921248	Length:	1050	Species:	Mus musculus

Alignment Length:	873	Identity:	172/873 - (19%)
Similarity:	293/873 - (33%)	Gaps:	232/873 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  2181 ETDDSLPSTSKSTEALMATRPEVIIAPNKASVSPATAARSVIVLAGGSCLK----TIDSDINNYS 2241
            |.|...|...|    |:.|:..|.|:..:...:..|.:..|.....|||.:    :::.::|...
Mouse   227 EKDRESPCHVK----LLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSVNDEVNPRR 287

  Fly  2242 ASNLSTAE--QAKCDTQYQKSTSDHLLLFPARGSQFYQSNFSELPSWNFLLSRWKLTLDLFGRVF 2304
            ...|..:|  |..|..|:.      |.|.|:.|                       .:..||...
Mouse   288 VLELMGSEVTQIACGRQHT------LALVPSSG-----------------------LIYAFGCGA 323

  Fly  2305 MDDVGMEH-----------GSVLPELRGFPVKEMRFR-RHMEKLRNGQQRDLVLCKLERNRESLI 2357
            ...:|..|           |...........:..||: |.::::.:|..:..|||....|....:
Mouse   324 KGQLGTGHTCNVKCPSPVKGHWAAHSSQLSARADRFKYRVVKQIFSGGDQTFVLCSTYENSSPAV 388

  Fly  2358 VQTFKELN-TQFGNQSRRIQPPITFNRVKVTFKDEPGEGSGVAR----------SFY-TSIAEAL 2410
              .|:.:| |.:.|...  ...|...|.|:|..:.....:||.:          ||. ..|.|..
Mouse   389 --DFRTVNQTHYTNLIN--DETIAVWRQKLTEHNNANTVNGVVQILSSAACWNGSFLEKKIDEHF 449

  Fly  2411 LASAKIP--NLESVQV---GTNHSKYVVPFSSILRS------RTVSGSSRD-------------- 2450
            ..|.|||  :|.|.::   ...||::.:....||.|      ..:|.|..|
Mouse   450 KTSPKIPGIDLNSTRILFEKLMHSQHSMILEQILNSFESCLIPQLSSSPPDVEAMRIYLILPEFP 514

  Fly  2451 ----------------QSTLQRRGSNSKIL---WRSARERKALNL-----DARPYTPPNSSDNAT 2491
                            .:.|:...:.||:|   |..|..:..:.|     .|..|..........
Mouse   515 LLQDSKYYITLTIPLAMAILRLETNPSKVLDNWWSQACPKYFMKLVTLYKGAVLYLLRGRKTFLI 579

  Fly  2492 PESLNDHLSVHLQQIGERLYP---KIHSI--NQTHAPKITGMLLEIPTPQLL------------- 2538
            |...|::::..|:.: |:||.   |:..:  ::.:.|:|:. |::|....|:
Mouse   580 PVLFNNYMTATLKLL-EKLYKVNLKVKHVEYDKFYIPEISS-LVDIQEDYLMWFLHQSGMKARPS 642

  Fly  2539 ---------------------SVISSDETLRQKV-------NEAIEIITFK-------------- 2561
                                 .::.:|..|:.:|       .....::|.:
Mouse   643 IMQDAVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLVLHVR 707

  Fly  2562 -------QKSETSAQSSQPKKSPSVVVVD---PVDDDN--------------EPLFYSPGKRGFY 2602
                   ...|.|..|....|.|..|:.|   .||...              .|::      |.:
Mouse   708 RNHLVGDALRELSIHSDIDLKKPLKVIFDGEEGVDAGGVTKEFFLLLLKELLNPIY------GMF 766

  Fly  2603 TPRQG-----FAS--FERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIKFHDLAFFD 2660
            |..|.     |:.  |...|.|..||...||.:..:.::.|.....:.|.:|..|....||....
Mouse   767 TYYQDSNLLWFSDTCFVEHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPSLEDLKELS 831

  Fly  2661 PALYESFRQIIQNAQTKEGEETINRMELCFVIDLMKEE--GCGNRELIPGGRDVAVTSSNIFEYV 2723
            |....|.:::: :...::.|||     .|....:.:|.  ....::|||||..|||...|..|:|
Mouse   832 PTEGRSLQELL-DYPGEDIEET-----FCLNFTVCRESYGVIEQKKLIPGGDRVAVCKDNRQEFV 890

  Fly  2724 RRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVSTLISYTTF-NDE 2787
            ..|..|....|..:...|...|...|.....:......:||.::.|..:.:...|.....: .|.
Mouse   891 DAYVNYIFQISVHEWYTAFSSGFLKVCGGKVLELFQPAELRAMMVGNSNYDWEELEETAVYRGDY 955

  Fly  2788 SSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPLPSVTIRPA-DDSHLP 2851
            ||..|.     .|.||....:..:.:::..:.|.|||..:|.  .|...|..:....| .:.:||
Mouse   956 SSTHPT-----VKLFWETFHEFPLEKKKKFLLFLTGSDRIPI--YGMASLQIIIQSTATGEEYLP 1013

  Fly  2852 TANTCISRLYIPLYSSKSILRSKMLMAI 2879
            .|:||.:.|.:|.||||.|:::::..|:
Mouse  1014 VAHTCYNLLDLPKYSSKEIMKARLTQAL 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	14/108 (13%)
		HECTc	2589..2885	CDD:238033	74/316 (23%)
		HECTc	2589..2884	CDD:214523	74/316 (23%)
Herc3	NP_001348895.1	ATS1	2..331	CDD:227511	26/136 (19%)
		RCC1	313..377	CDD:366085	10/86 (12%)
		HECTc	702..1048	CDD:238033	83/359 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900