DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hyd and Smurf1

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	XP_006248944.1	Gene:	Smurf1 / 690516	RGDID:	1594738	Length:	757	Species:	Rattus norvegicus

Alignment Length:	487	Identity:	110/487 - (22%)
Similarity:	190/487 - (39%)	Gaps:	96/487 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  2469 RERKALNLDARPYTPPNSSDNATPES---LNDHLSVHLQQIGERLYPKIHSINQTHAPKITGMLL 2530
            |:..::|.|.....||.....:|...   ..||.:...|....||:   |.:|.....|.....|
  Rat   295 RDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLH---HIMNHQCQLKEPSQPL 356

  Fly  2531 EIPT-----PQLLSVISSDETLRQKVNEAIEIITFKQ------KSETSAQSSQPKKSPSVVVVDP 2584
            ::|:     .:.|.....:..|.||:......::.:|      :.|.|.:....:....::.:.|
  Rat   357 QLPSEGSVEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRP 421

  Fly  2585 VDDDNEPLFYSPGKRG-----------------FYTPRQGFASF------------------ERI 2614
            .|.....:....|:.|                 ...|..|...:                  :.:
  Rat   422 KDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSINPDHL 486

  Fly  2615 NAFRNIGRLIGLCLLQNELL------PLFLQRHVLKYILGRKIKFHDLAFFDPALYESFRQIIQN 2673
            :.|..:||::||.:.....:      |.:      |.:||:.|:..||...||.|::|...|::|
  Rat   487 SYFHFVGRIMGLAVFHGHYINGGFTVPFY------KQLLGKPIQLSDLESVDPELHKSLVWILEN 545

  Fly  2674 AQTKEGEETINRMELCFVIDLMKEEGCG---NRELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQ 2735
            ..|...:.|     .|     ::....|   ..||.|.||:|.||..|..||||.|..:|.::..
  Rat   546 DITPVLDHT-----FC-----VEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGI 600

  Fly  2736 EKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVSTLISYTTFNDESSEGPDKLLKFKK 2800
            |....||:.|..:::|.:.:.....::|.|::.|:..|:::...|.|......::.     ...:
  Rat   601 EAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADS-----NIVR 660

  Fly  2801 WFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPLPSVT-----------IRPADDSHLPTAN 2854
            |||..||..:...|..|:.|.|||..:|.  :||:.|...|           :..|:..:||.|:
  Rat   661 WFWQAVETFDEERRARLLQFVTGSTRVPL--QGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAH 723

  Fly  2855 TCISRLYIPLYSSKSILRSKMLMAIKSKNFGF 2886
            ||.:|:.||.|.|...|..|:|.|:: :..||
  Rat   724 TCFNRIDIPPYESYEKLYEKLLTAVE-ETCGF 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	13/67 (19%)
		HECTc	2589..2885	CDD:238033	83/350 (24%)
		HECTc	2589..2884	CDD:214523	83/349 (24%)
Smurf1	XP_006248944.1	C2_Smurf-like	14..138	CDD:176028
		WW	236..267	CDD:197736
		WW	307..339	CDD:197736	6/31 (19%)
		HECTc	399..754	CDD:238033	87/378 (23%)
		HECTc	423..754	CDD:214523	84/354 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900