DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hyd and Herc4

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	NP_084390.1	Gene:	Herc4 / 67345	MGIID:	1914595	Length:	1057	Species:	Mus musculus

Alignment Length:	393	Identity:	96/393 - (24%)
Similarity:	163/393 - (41%)	Gaps:	45/393 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly  2516 SINQTHAPKITGMLL---EIPTPQLLSVISSDETLRQKVNEAIEIITFKQKSETSAQSSQPKKSP 2577
            :|:|.|...::.:.|   |...|.|:.|:..:..    |.:|:|::       ...::...||..
Mouse   685 AIDQAHRQNVSSLFLPVIESVNPCLILVVRRENI----VGDAMEVL-------RKTKNIDYKKPL 738

  Fly  2578 SVVVV--DPVDDDN-EPLFYSPGKRGFYTPRQGF--------------ASFERINAFRNIGRLIG 2625
            .|:.|  |.||... ...|:....|....|:.|.              .:||..:.|..||.:.|
Mouse   739 KVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDLFHLIGVICG 803

  Fly  2626 LCLLQNELLPLFLQRHVLKYILGRKIKFHDLAFFDPALYESFRQIIQNAQTKEGEETINRMELCF 2690
            |.:....::.|.....:.|.:|.||....||....||:..|.:|::...: .:.|||..   |.|
Mouse   804 LAIYNFTIVDLHFPLALYKKLLKRKPSLDDLKELMPAVGRSMQQLLDYPE-DDIEETFC---LNF 864

  Fly  2691 VIDLMKEEGCGNRELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSM 2755
            .|.:........:||:..|.|.||...|..|:|..|.:|...||.....:|...|...|.....:
Mouse   865 TITVENFGATEVKELVLNGADTAVNRQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVL 929

  Fly  2756 INLTAEDLRLLLNGVGDINVSTLISYTTFNDES-SEGPDKLLKFKKWFWSIVEKMNIMERQDLVY 2819
            :.....:|:.::.|..:.:...|...|.:..|. ::.|.     .|.||.:..::.:.:::..:.
Mouse   930 LLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWADHPT-----IKIFWEVFHELPLEKKKQFLL 989

  Fly  2820 FWTGSPALPASEEGFQPLPSV-TIRPADDSHLPTANTCISRLYIPLYSSKSILRSKMLMAIKSKN 2883
            |.|||..:|..  |.:.|..| ......:|:||.::||.:.|.:|.|:.|..||.|::.|| ..|
Mouse   990 FLTGSDRIPIL--GMKSLKLVIQSTGGGESYLPVSHTCFNLLDLPKYTEKETLRCKLIQAI-DHN 1051

  Fly  2884 FGF 2886
            .||
Mouse  1052 EGF 1054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	11/47 (23%)
		HECTc	2589..2885	CDD:238033	76/312 (24%)
		HECTc	2589..2884	CDD:214523	75/311 (24%)
Herc4	NP_084390.1	RCC1 1	1..51
		RCC1	3..49	CDD:278826
		RCC1 2	52..101
		RCC1	52..99	CDD:278826
		RCC1 3	102..154
		RCC1	102..152	CDD:278826
		RCC1 4	156..207
		RCC1	157..205	CDD:278826
		RCC1 5	208..259
		RCC1	208..257	CDD:278826
		RCC1	260..308	CDD:278826
		RCC1 6	261..311
		RCC1 7	313..366
		RCC1	313..>343	CDD:278826
		HECTc	709..1055	CDD:238033	90/369 (24%)
		HECTc	735..1054	CDD:214523	83/330 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900