DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and SMURF2

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	NP_073576.1	Gene:	SMURF2 / 64750	HGNCID:	16809	Length:	748	Species:	Homo sapiens

Alignment Length:	703	Identity:	154/703 - (21%)
Similarity:	251/703 - (35%)	Gaps:	223/703 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  2339 GQQRDLVLCKLERN-----RESLIVQTFKELNTQFGNQSRRIQPPITFNRVKVTFKDEPGEGSGV 2398
            |.|| |.||||..|     |..::|..          |||                |..|.|..|
Human   111 GYQR-LDLCKLGPNDNDTVRGQIVVSL----------QSR----------------DRIGTGGQV 148

  Fly  2399 ---ARSFYTSI----AEALLASAKIPNLESV----------QVGTNHSKYVVPFSSILRSRT--- 2443
               :|.|...:    .|...||.:|..|..:          :..:.:|....|.|..:...|
Human   149 VDCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPIS 213

  Fly  2444 -VSGSSRDQSTLQRRGSNSKILWRSARERKALNLDARP--YTPPNS------------------- 2486
             .:|::..||      |:.::..|..|.::..|..:|.  :|||:.
Human   214 GTNGATCGQS------SDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHT 272

  Fly  2487 -------SDNATPESLNDHLSVHLQQIGE-------------RLYPKIHSINQTH--APKITGML 2529
                   .|...|..|:   :::.:::|.             |:|...|:...|.  .|:::..|
Human   273 QTGVSTWHDPRVPRDLS---NINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANL 334

  Fly  2530 -------LEIPTPQLLSVIS--SDETLRQKVNEAIEIITFKQ---------KSETSAQSSQ---- 2572
                   .::...|...|:|  .|:|      |.:.:..:|:         :.|.|.|..|
Human   335 HLVLNRQNQLKDQQQQQVVSLCPDDT------ECLTVPRYKRDLVQKLKILRQELSQQQPQAGHC 393

  Fly  2573 ----------PKKSPSVVVVDPVDDDNEPLFYSPGKRG-----------------FYTPRQGFAS 2610
                      .:....|:.:.|.|.....:....|:.|                 ...|..|...
Human   394 RIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQ 458

  Fly  2611 F------------------ERINAFRNIGRLIGLCLLQNE------LLPLFLQRHVLKYILGRKI 2651
            :                  |.::.|..:||::|:.:....      .||.:      |.:||:.|
Human   459 YSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFY------KQLLGKSI 517

  Fly  2652 KFHDLAFFDPALYESFRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCGNRELIPGGRDVAVTS 2716
            ...|:...||.|:.|...|::|..|...:.|       |.::..........||.|.|:.:.|..
Human   518 TLDDMELVDPDLHNSLVWILENDITGVLDHT-------FCVEHNAYGEIIQHELKPNGKSIPVNE 575

  Fly  2717 SNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVG--DIN---VS 2776
            .|..||||.|..:|.::..|....||:.|..:|:|.:.:.....::|.|::.|:|  |:|   |:
Human   576 ENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKVN 640

  Fly  2777 TLISYTTFNDESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPLPSV- 2840
            |.:.:.|        ||.  ...||||..||..:...|..|:.|.|||..:|.  :||:.|...
Human   641 TRLKHCT--------PDS--NIVKWFWKAVEFFDEERRARLLQFVTGSSRVPL--QGFKALQGAA 693

  Fly  2841 -----TIRPAD--DSHLPTANTCISRLYIPLYSSKSILRSKMLMAIKSKNFGF 2886
                 ||...|  .::||.|:||.:|:.||.|.|...|..|:|.||: :..||
Human   694 GPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIE-ETCGF 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	13/86 (15%)
		HECTc	2589..2885	CDD:238033	88/349 (25%)
		HECTc	2589..2884	CDD:214523	88/348 (25%)
SMURF2	NP_073576.1	C2_Smurf-like	13..137	CDD:176028	11/36 (31%)
SMURF2	NP_073576.1	HUL4	<159..745	CDD:227354	132/626 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900