DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and nedd4a

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	NP_001029358.1	Gene:	nedd4a / 619412	ZFINID:	ZDB-GENE-051005-2	Length:	910	Species:	Danio rerio

Alignment Length:	971	Identity:	190/971 - (19%)
Similarity:	333/971 - (34%)	Gaps:	318/971 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1973 GFYDKQDTISGR---INNLSPMTESY-----DTDDELANLEEFNADVQMSASSMPSGSQGTRRHA 2029
            |:.::||.: ||   :|:.|..|:.:     |:..:....:|.:::.|.:..:....|:....|
Zfish   197 GWEERQDNL-GRTYYVNHESRTTQWHRPTIQDSQRDNEQRQETHSESQRAFLTRRQISEHEENH- 259

  Fly  2030 FFARSESTLSLGCSAPEGFELPLDMAMPLADKPHLLQPNSKRQELFANLPLLVTT---NANNSGA 2091
              .|.||        ||.:|:      ..||:..|....|:|.....:.|:.::|   ..|...|
Zfish   260 --ERRES--------PESWEI------ITADESTLYSSLSERSPPPPHSPMEISTFCEEFNRLQA 308

  Fly  2092 TNDGDGGSIFDYTPTRLGFSNSLKRNERVYETVPIDSSKTGDGNVTNKAEGSTDSNIYVQLKKKQ 2156
            |||                        |.....|         .||..||
Zfish   309 TND------------------------RRTSLTP---------QVTAAAE--------------- 325

  Fly  2157 GSDDFKSHKEADGNQSKYEKVV----LMETDDSLPS--------------TSKSTEALMATRP-- 2201
                     |.| ..|::..::    |:.|...||.              .:.::.....|||
Zfish   326 ---------EVD-RPSRWRSILFTHSLLPTSAGLPPGWEEKQDSKGRIYFVNHNSRTTTWTRPLI 380

  Fly  2202 EVIIAPNKASVSP-ATAARSVIVLAGGSCLKTIDSDINNYSASNLSTAEQAKCDTQYQKSTSDHL 2265
            ::|..|:::..|| |:.:.|:...|.|..|....|..:.::.::..|.|              |.
Zfish   381 QLIQPPSESPASPMASGSTSLSQNAAGYALPPDVSPQHTHTHTHTHTPE--------------HP 431

  Fly  2266 LLFPA--------RGSQFYQSNFSELPSWNFLLSRWKLTLDLFGRVFMD--DVGMEHGSVLPELR 2320
            .|.|.        .|..|:..:.::..:|:.  .|.|:.:.:..||.:|  |:|
Zfish   432 GLMPTGWEVRSAPSGRPFFIDHNTKTTTWDD--PRLKVPVQMRRRVSLDPTDLG----------- 483

  Fly  2321 GFPVKEMRFRRHMEKLRNGQQRDLVLCKLERNRESLIVQTFKELNTQFGNQSRRIQPPITFNRVK 2385
                          .|..|.:.:.::..    ..|.::.|.|..|.:  ....||||.:
Zfish   484 --------------PLPPGWESECIVMA----ESSTLITTQKPHNGK--THDYRIQPSL------ 522

  Fly  2386 VTFKDEPGEGSGVARSF---YTSIAEALLASAKIPNLESVQVGTNHSKYVVPFSSILRSRTVSGS 2447
                   |.....:|.:   |....:.|...|:|||...:              |:.|:..:..|
Zfish   523 -------GPAVPYSRDYKQKYEYFRKKLKKPAEIPNRFEL--------------SVRRNAVLEDS 566

  Fly  2448 SRDQSTLQRRGSNSKILWRSARERKALNLD--ARPYTPPNSSDNATPESLNDHLSVHLQQIGERL 2510
            .|...:::|.......||......|.|:..  ||.:                     ...|.:.:
Zfish   567 YRRILSVKRSELLKARLWVEFEGEKGLDYGGVAREW---------------------FFLISKEM 610

  Fly  2511 YPKIHSINQTHAPKITGMLLEIPTPQLLSVISSDETLRQKVNEAIEIITFKQKSETSAQSSQPKK 2575
            :...:.:.:..|..                           |..::|
Zfish   611 FNPYYGLFEYSATD---------------------------NYTLQI------------------ 630

  Fly  2576 SPSVVVVDPVDDDNEPLFYSPGKRGFYTPRQGFASFERINAFRNIGRLIGLCLLQNELLPLFLQR 2640
                                       .|..|..:.:.::.|:.|||:.|:.:...:||..|..|
Zfish   631 ---------------------------NPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDAFFIR 668

  Fly  2641 HVLKYILGRKIKFHDLAFFDPALYESFRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCG---N 2702
            ...|.:|.:.|...|:...|...:.|.|.|::|..|.        ::|.|.||   ||..|   .
Zfish   669 PFYKMMLQKPITLQDMESVDSEYFNSLRWILENDPTD--------LDLRFTID---EELFGQTHQ 722

  Fly  2703 RELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLL 2767
            .||.|||.|:.|..:|..||:....::|.:...::.:.|.|:|.::::|.:.:......:|.||:
Zfish   723 HELKPGGADIVVNDTNKKEYIHLVMQWRFVDRIQRQMTAFKEGFYELIPQDLIKIFDENELELLM 787

  Fly  2768 NGVGDINVSTLISYTTFNDESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEE 2832
            .|:||::|:.....|.:.:..:.....::    |||..|..|:..:|..|:.|.||:..:|.:
Zfish   788 CGLGDVDVNDWRENTKYKNGYNPNHPAII----WFWKTVLLMDAEKRIRLLQFVTGTSRVPMN-- 846

  Fly  2833 GFQPL-----PSV-TIRP-ADDSHLPTANTCISRLYIPLYSSKSILRSKMLMAIKSKNFGF 2886
            ||..|     |.: ||.. .....||.|:||.:||.:|...|...||.|:.|||::.. ||
Zfish   847 GFAELYGSNGPQLFTIEQWGTREKLPRAHTCFNRLDLPPXESFEELREKLHMAIENAQ-GF 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	4/62 (6%)
		HECTc	2589..2885	CDD:238033	83/305 (27%)
		HECTc	2589..2884	CDD:214523	83/304 (27%)
nedd4a	NP_001029358.1	C2_NEDD4_NEDD4L	22..153	CDD:175999
		WW	194..223	CDD:366073	8/26 (31%)
		WW	349..378	CDD:366073	3/28 (11%)
		WW	435..465	CDD:238122	4/31 (13%)
		HECTc	577..906	CDD:214523	93/439 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000