DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and HACE1

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	NP_065822.2	Gene:	HACE1 / 57531	HGNCID:	21033	Length:	909	Species:	Homo sapiens

Alignment Length:	816	Identity:	188/816 - (23%)
Similarity:	312/816 - (38%)	Gaps:	249/816 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  2229 CLKTIDSDINNYSASNLSTAEQAKCDTQYQKSTSDHLLLFPARGSQFYQSNFSELPSWNFLLSRW 2293
            ||....:|||..:.|. :|.....| :..|:.|:..|||   ||:::       ||..|.:
Human   182 CLLDSGADINRPNVSG-ATPLYFAC-SHGQRDTAQILLL---RGAKY-------LPDKNGV---- 230

  Fly  2294 KLTLDL-----FG-----------RVFMDDVGMEHGSVLPELRGFPVKEMRFRRHMEKLRNGQQR 2342
             ..|||     :|           |:|...:.|.                            |..
Human   231 -TPLDLCVQGGYGETCEVLIQYHPRLFQTIIQMT----------------------------QNE 266

  Fly  2343 DLVLCKLERNRESLIVQTFKELNTQFGNQSRRIQPPITFNRVKVTFKDEPGEGSG----VARSFY 2403
            ||        ||:::.|..:.|:.|..:|..:|          :|...|....:|    ...|.|
Human   267 DL--------RENMLRQVLEHLSQQSESQYLKI----------LTSLAEVATTNGHKLLSLSSNY 313

  Fly  2404 TSIAEALLASAKI--------PNLES--VQVGTNHSKYVVPFSSILRSRTVSGSSRDQ------S 2452
            .:..::||...::        |:..|  :.:|.|.:|  .|.|.:.:...:...|.|:      :
Human   314 DAQMKSLLRIVRMFCHVFRIGPSSPSNGIDMGYNGNK--TPRSQVFKPLELLWHSLDEWLVLIAT 376

  Fly  2453 TLQRRGSNSKILWRSARERKALNLDAR---PYTP--PNSSDN---ATPESLNDHL------SVHL 2503
            .|.:...:|..:.....::|..:.||.   |:.|  |.|.:|   .|.||..|.|      |...
Human   377 ELMKNKRDSTEITSILLKQKGQDQDAASIPPFEPPGPGSYENLSTGTRESKPDALAGRQEASADC 441

  Fly  2504 QQIGERLYPKIHSINQTH--------APKITGMLLEIPTPQLLS-VISSDETLRQKVNEAIEII- 2558
            |.:......::.::.|..        .|.:|       :|:.:. |...||.|:..||...:||
Human   442 QDVISMTANRLSAVIQAFYMCCSCQMPPGMT-------SPRFIEFVCKHDEVLKCFVNRNPKIIF 499

  Fly  2559 -----------------------TFKQKSE---TSAQSSQPKKSPSVVVVDPVDDDN------EP 2591
                                   .||.:.|   ....|.||   .|.:|..||::::      :.
Human   500 DHFHFLLECPELMSRFMHIIKAQPFKDRCEWFYEHLHSGQP---DSDMVHRPVNENDILLVHRDS 561

  Fly  2592 LFYSP---------------------GKRG---------------------------------FY 2602
            :|.|.                     |:.|                                 |.
Human   562 IFRSSCEVVSKANCAKLKQGIAVRFHGEEGMGQGVVREWFDILSNEIVNPDYALFTQSADGTTFQ 626

  Fly  2603 TPRQGFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIKFHDLAFFDPALYESF 2667
            .....:.:.:.:|.||..|:::||.|...:|:.::..|...|:|||..:.:.|:|..||...::.
Human   627 PNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNL 691

  Fly  2668 RQIIQNAQTKEGEETINRMELCF-----VIDLMKEEGCGNRELIPGGRDVAVTSSNIFEYVRRYT 2727
            :.|:.|..:..|      :||.|     |...|:|.     .|.|||..:.||.:|..|||:..|
Human   692 QWILDNDISDLG------LELTFSVETDVFGAMEEV-----PLKPGGGSILVTQNNKAEYVQLVT 745

  Fly  2728 EYRLIKSQEKALEALKDGVFDVLPDNSMINLTAE-DLRLLLNGVGDINVSTLISYTTFNDESSEG 2791
            |.|:.::.:..:.|...|....:|. |:|.|..| :|.|||:|:.:|:||..|.    |.|.:.|
Human   746 ELRMTRAIQPQINAFLQGFHMFIPP-SLIQLFDEYELELLLSGMPEIDVSDWIK----NTEYTSG 805

  Fly  2792 PDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALP----ASEEGFQPLPSVTIR--PADDSHL 2850
            .::.....:|||.:||.:...||..|:.|.|||..:|    |:..|...|.:.||.  |...:.|
Human   806 YEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLL 870

  Fly  2851 PTANTCISRLYIPLYSSKSILRSKMLMAIKSKNFGF 2886
            ||::|||:.|.:|.|.||.||:.::|:|:...::|:
Human   871 PTSSTCINMLKLPEYPSKEILKDRLLVALHCGSYGY 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	15/101 (15%)
		HECTc	2589..2885	CDD:238033	97/367 (26%)
		HECTc	2589..2884	CDD:214523	97/366 (27%)
HACE1	NP_065822.2	Ank_2	<27..>283	CDD:330894	32/153 (21%)
		ANK 1	64..93
		ANK repeat	66..95	CDD:293786
		ANK	92..217	CDD:238125	10/36 (28%)
		ANK repeat	97..128	CDD:293786
		ANK 2	97..126
		ANK repeat	130..161	CDD:293786
		ANK 3	130..159
		ANK repeat	163..194	CDD:293786	5/11 (45%)
		ANK 4	163..192		4/9 (44%)
		ANK 5	196..226		11/41 (27%)
		ANK repeat	196..221	CDD:293786	9/29 (31%)
		ANK 6	228..257		6/33 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..433		12/34 (35%)
		HECTc	554..903	CDD:238033	97/364 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900