DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hyd and HECW2

DIOPT Version :9

Sequence 1:NP_001287262.1 Gene:hyd / 41181 FlyBaseID:FBgn0002431 Length:2887 Species:Drosophila melanogaster
Sequence 2:XP_006712709.1 Gene:HECW2 / 57520 HGNCID:29853 Length:1579 Species:Homo sapiens


Alignment Length:2032 Identity:387/2032 - (19%)
Similarity:668/2032 - (32%) Gaps:735/2032 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  1129 REHALTILQQMCVSPALRPYLC-HMLSTKDAQGQTPFMLSVSCRAYEAGIILLNTILMLSEQDPQ 1192
            |||.|.:.::   :|.:|..|. ..|.:..||...|..:::. ||..      :|.|:.||....
Human     6 REHLLFVRRR---NPQMRYTLSPENLQSLAAQSSMPENMTLQ-RANS------DTDLVTSESRSS 60

  Fly  1193 LKEAM----------------IFPNGSPADQSPLHVICYNDTCSFTWTGADHINQ----NIFECK 1237
            |..:|                |.....|:|                |.|..||::    |.::.|
Human    61 LTASMYEYTLGQAQNLIIFWDIKEEVDPSD----------------WIGLYHIDENSPANFWDSK 109

  Fly  1238 TCGLTGSLCCCTECA-----------------RVCHK---GHDCKLKRTAPTAYCDCWEKCKCKA 1282
            ..|:||     |:..                 ::|.|   |....|:.|.|              
Human   110 NRGVTG-----TQKGQIVWRIEPGPYFMEPEIKICFKYYHGISGALRATTP-------------- 155

  Fly  1283 LIAGNLTKRFALLCKLVSCTDLVTKFNSKGESILLFLIQTVGRQIVEQRQYRFSVRVRNVSTAAT 1347
                         |..|           |..::::      |.:.:|                 .
Human   156 -------------CITV-----------KNPAVMM------GAEGME-----------------G 173

  Fly  1348 GATGNNSVISNRKTSAAEIDNDMPDHDLEPPKFARKALERLLIDWNAVRSMIMSGAERGDVPNPA 1412
            ||:||                          ..:||.:...|.|..||      |.::|...|| 
Human   174 GASGN--------------------------LHSRKLVSFTLSDLRAV------GLKKGMFFNP- 205

  Fly  1413 GSASENSNSEGFNMFIQ----------TQHG----STLLDKFTHSLIVKCTSDHLDT----LLLT 1459
                    .....|.||          ..||    ||::...|:.:.      |.:.    .|||
Human   206 --------DPYLKMSIQPGKKSSFPTCAHHGQERRSTIISNTTNPIW------HREKYSFFALLT 256

  Fly  1460 LVRELQNASVSNRSKEAEEVVRRFVRS----VARVFVIFNLEKQP--------NPEKRKSHSSCN 1512
            .|.|::   :.::..::..:::||:..    |.|:     ||:|.        |..:|......:
Human   257 DVLEIE---IKDKFAKSRPIIKRFLGKLTIPVQRL-----LERQAIGDQMLSYNLGRRLPADHVS 313

  Fly  1513 KYVQSCVKVFQTLHKISIEELCEVSEALIAPVRLGVVRPTAPFTMSSSNLDVRN-SDDLFSVDPL 1576
            .|:|..|:|..::|:   |.|...|:|  :|..:|.:     ..::|.|.|:.: |||    :.:
Human   314 GYLQFKVEVTSSVHE---EMLFSHSDA--SPEAVGTI-----LGVNSVNGDLGSPSDD----EDM 364

  Fly  1577 APSNVESPSEQILVHDAGNDQSA-------NFNIQQNYDVVAMETIRDASESEEVINREANSHNQ 1634
            ..|:.:|   |:..:...::.||       :|......::...|....:|.:.....|:.:.::.
Human   365 PGSHHDS---QVCSNGPVSEDSAADGTPKHSFRTSSTLEIDTEELTSTSSRTSPPRGRQDSLNDY 426

  Fly  1635 DDELIENQRNEDGMQD-------------DESDNDFTFND-AETESDSDDNQSNQEVQRSVQAGA 1685
            .|.:..|..:..|...             .....|...|. ...:||.:|::..|          
Human   427 LDAIEHNGHSRPGTATCSERSMGASPKLRSSFPTDTRLNAMLHIDSDEEDHEFQQ---------- 481

  Fly  1686 TVGSENDIGV-LFLEDESGDSSAQEEDGSEDGESDDQSDEFNFNEQQLERRSTNSNARSDLAPQT 1749
                  |:|. ..||:|.|.........::||....|: :...|..:.|..||:..|..:..|:.
Human   482 ------DLGYPSSLEEEGGLIMFSRASRADDGSLTSQT-KLEDNPVENEEASTHEAASFEDKPEN 539

  Fly  1750 MQWAIRSRDTARSSVRV----PTGSNMVFIDPMALRRST-VPASTTVTTPSIEPHTMATTASNLA 1809
            :.      :.|.||:..    ..|.......|.|.:.|. :..|..|..|:....|..:.||..:
Human   540 LP------ELAESSLPAGPAPEEGEGGPEPQPSADQGSAELCGSQEVDQPTSGADTGTSDASGGS 598

  Fly  1810 RAFGITIRQISELISILSYNVLNDIETSLKIQNDEAIAVQAFVEKRLKATWDWMFTVMDGTEAQL 1874
            |      |.:||..|:                 |:                        |:|.  
Human   599 R------RAVSETESL-----------------DQ------------------------GSEP-- 614

  Fly  1875 KFGAYLTNYTDPNHPLHPLNLSAQASS---SQTPAPATSSSVNGVNIMGSNSRRDFFTYCLSLMR 1936
               :.:::.|:|:.|....::| :||:   .::......||.| .::....|..|  |.|.||..
Human   615 ---SQVSSETEPSDPARTESVS-EASTRPEGESDLECADSSCN-ESVTTQLSSVD--TRCSSLES 672

  Fly  1937 SH--------TSEHRD------------------------ALPVLDITALRHIAYVLDAFVYYMR 1969
            :.        :.|..|                        :|||:.:.:               .
Human   673 ARFPETPAFSSQEEEDGACAAEPTSSGPAEGSQESVCTAGSLPVVQVPS---------------G 722

  Fly  1970 NDSGFYDKQDTISGRINNLSPMTESYDTDD--ELANLEEFNADVQMSASSMPS-----GS----Q 2023
            .|.|                |..||....|  ||..:.:....::.:|::..|     ||    |
Human   723 EDEG----------------PGAESATVPDQEELGEVWQRRGSLEGAAAAAESPPQEEGSAGEAQ 771

  Fly  2024 GTRRHAFFARSESTLSLGCSAPEGFELPLDMAMPLADKPHLLQPNSKRQELFANLPLLVTTNANN 2088
            ||...|......:|   |.|...|.:       ||...|.:.|..|:.|.:...||       .|
Human   772 GTCEGATAQEEGAT---GGSQANGHQ-------PLRSLPSVRQDVSRYQRVDEALP-------PN 819

  Fly  2089 SGATNDGDGGSIF-DY--------------TPTRLGFSNSLKRNE---RVYETVPIDSSKTGDGN 2135
            ..|..|..|...: |:              .|..|..|||:::.|   |.|:::....:......
Human   820 WEARIDSHGRIFYVDHVNRTTTWQRPTAPPAPQVLQRSNSIQQMEQLNRRYQSIRRTMTNERPEE 884

  Fly  2136 VTNKAEGSTDSNIYVQLKKKQGSDDFKSHKEADGNQSKYEKVVLMETDDSLP-STSKSTEALMAT 2199
            .||..:|:.:                    |||.:|:..:    ...::.|| |||:|...|:..
Human   885 NTNAIDGAGE--------------------EADFHQASAD----FRRENILPHSTSRSRITLLLQ 925

  Fly  2200 RPEV--IIAPNKASV--SPATAARSVIVLAGGSCLKTIDSDINNYSASNLSTAEQAKCDTQYQKS 2260
            .|.|  :|:|...:|  |..:|.|   :....:|||.:.:.:..              ||.:   
Human   926 SPPVKFLISPEFFTVLHSNPSAYR---MFTNNTCLKHMITKVRR--------------DTHH--- 970

  Fly  2261 TSDHLLLFPARGSQFYQSNFSELPSWNFLLSR-------WKLTLDLFGRVFMDDVGMEHGS---- 2314
                        .:.||.|...:...|...::       |::..|..|:.|.    ::|.|    
Human   971 ------------FERYQHNRDLVGFLNMFANKQLELPRGWEMKHDHQGKAFF----VDHNSRTTT 1019

  Fly  2315 ----VLPELRGFPVKEMRFRRHMEKLRNGQQRDLVLCKLERNRESLIVQTFKELNTQFGNQSRRI 2375
                .||.....|...:..|:|:.:.|:....::                        |..||..
Human  1020 FIDPRLPLQSSRPTSALVHRQHLTRQRSHSAGEV------------------------GEDSRHA 1060

  Fly  2376 QPPI------TFNRVKVTFKDEPGEGSGVARSFYTSIA-----EALLASAKIPNLESV------Q 2423
            .||:      |||.              |:|..|..:.     :.::|..:.||:..:      .
Human  1061 GPPVLPRPSSTFNT--------------VSRPQYQDMVPVAYNDKIVAFLRQPNIFEILQERQPD 1111

  Fly  2424 VGTNHSKYVVPFSSILRSRTVSGSSRDQSTLQRRGSNSK-ILWRSARERKALNLDARPYTPPNS- 2486
            :..|||         ||.:.....:.....|.|..|::. ::..|..|.:.::     |.||:: 
Human  1112 LTRNHS---------LREKIQFIRTEGTPGLVRLSSDADLVMLLSLFEEEIMS-----YVPPHAL 1162

  Fly  2487 -------SDNATPESLNDHLSVHLQQIGERLYPKIHSINQTHAPKITGMLLEIPTPQLLSVISSD 2544
                   |...:|.|                       :..::|.........|.|         
Human  1163 LHPSYCQSPRGSPVS-----------------------SPQNSPGTQRANARAPAP--------- 1195

  Fly  2545 ETLRQKVNEAIEIITFKQKSETSAQSSQPKKSPSVVVVDPVDDD--------------------- 2588
                .|.:...::..|.:|.||......|.|...::..|.:.:|                     
Human  1196 ----YKRDFEAKLRNFYRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVT 1256

  Fly  2589 ---NEPLFYSPGKRGF--------YTPRQGFASFERINA------------------FRNIGRLI 2624
               .|.|.||...|.|        :.|..|...:...:.                  ||..||::
Human  1257 FVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRIL 1321

  Fly  2625 GLCLLQNELLPLFLQRHVLKYILGRKIKFHDLAFFDPALYESFRQIIQNAQTKEGEETINRMELC 2689
            ||.|:...||..|..|...|.:|.......||.:.|    |.|.|.:|..:..:..:.   ::|.
Human  1322 GLALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLD----EEFHQSLQWMKDNDIHDI---LDLT 1379

  Fly  2690 FVIDLMKEEGCG---NRELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLP 2751
            |.::   ||..|   .|||.|||.::.||..|..||:.|..::|:.:...:..|:|..|.::|:.
Human  1380 FTVN---EEVFGQITERELKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVD 1441

  Fly  2752 DNSMINLTAEDLRLLLNGVGDINVSTLISYTTFNDESSEGPDKLLKFKKWFWSIVEKMNIMERQD 2816
            ...:....|.:|.|::.|..:|::|...:.|.:.....:....:    :|||:.||:.|..:|..
Human  1442 ARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVI----RWFWAAVERFNNEQRLR 1502

  Fly  2817 LVYFWTGSPALPASEEGFQPLPSVTIRPADD------------SHLPTANTCISRLYIPLYSSKS 2869
            |:.|.||:.::|  .|||     .::|.::.            :.||.|:||.:||.:|.|.|.|
Human  1503 LLQFVTGTSSIP--YEGF-----ASLRGSNGPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFS 1560

  Fly  2870 ILRSKMLMAI-KSKNFG 2885
            :|..|:|.|: ::..||
Human  1561 MLYEKLLTAVEETSTFG 1577

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hydNP_001287262.1 E3_UbLigase_EDD 150..196 CDD:288409
ZnF_UBR1 1217..1284 CDD:197698 16/90 (18%)
ASF1_hist_chap 1535..1733 CDD:304562 38/220 (17%)
PolyA 2498..2561 CDD:197769 4/62 (6%)
HECTc 2589..2885 CDD:238033 88/337 (26%)
HECTc 2589..2884 CDD:214523 88/336 (26%)
HECW2XP_006712709.1 HECW_N 45..164 CDD:318711 30/183 (16%)
C2_NEDL1-like 185..321 CDD:176073 33/164 (20%)
NESP55 <471..638 CDD:115071 46/242 (19%)
PHA03169 591..>801 CDD:223003 52/306 (17%)
WW 816..845 CDD:306827 7/35 (20%)
WW 994..1023 CDD:306827 6/32 (19%)
HECTc 1223..1577 CDD:238033 90/374 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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