DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hyd and trip12

DIOPT Version :9

Sequence 1:NP_001287262.1 Gene:hyd / 41181 FlyBaseID:FBgn0002431 Length:2887 Species:Drosophila melanogaster
Sequence 2:XP_005159283.1 Gene:trip12 / 564866 ZFINID:ZDB-GENE-041111-262 Length:2096 Species:Danio rerio


Alignment Length:2614 Identity:488/2614 - (18%)
Similarity:822/2614 - (31%) Gaps:938/2614 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   560 RMKIININTNSGVDKSQAAGNNLNAHGITPDKDLP-KSTAMPSTGSSKN------GQSFSNSKES 617
            |.|::    :|....|.|:|.  :|..|:|:...| |:.|..||.|.|.      ..:.:.||:|
Zfish   131 RPKVV----SSHFSDSSASGP--SAPAISPEVTEPRKAPASVSTKSKKRRLAAEPAPARALSKKS 189

  Fly   618 TDRIDMPPPPSPASSTCSDTGSVTSHKRTKRATT----KEDSNAPQEGRKDEELWEVKDVVFVED 678
            :..    |.||.||||       .|.||.|...|    ...|:.|..                ..
Zfish   190 SSY----PGPSGASST-------PSQKRKKADATLLSSSSSSSLPSS----------------SS 227

  Fly   679 KVGPV---------GKVLKVDGDFVAVRFPAINAAAVAAAAAATSSTSNTASTSKEEGKEDDWQQ 734
            ..||:         .|..|:.....|......:....:::::|:||:|:::|:|...|......|
Zfish   228 AAGPLPPRSEASRAAKPTKLASKSAASAKAGCSTVTDSSSSSASSSSSSSSSSSAATGTNSCAPQ 292

  Fly   735 -CRLLRREDVQIFRTAMSTRGPDWLQKQPKKINVGGDAAGAQILTLAVDSRGIHVIKKVLGKIHY 798
             .||.:.:|....|.:.|...|     .|::.:...:.:                  |..|...:
Zfish   293 GARLKQGKDQSKARRSRSASSP-----SPRRSSRDKEQS------------------KAAGSSKF 334

  Fly   799 SLYNLYNCK---QEQNCLFPTDCNSFIGSTPGNILMACNDDCSGNSSTIVLRDGNGALYPLAKDC 860
            ...:.:|.|   .:.....|....:...|.||.         ||..:.                 
Zfish   335 DWASRFNSKVNLPKPKLSLPGSAKAETSSKPGP---------SGLQAK----------------- 373

  Fly   861 LGSIKDPQWFDLPPVKSITMSTISLPAMLSGVNLKSKVCMTALLFDTQKLMPHILRCDVKNSFAA 925
            |.|::          ||....:.|.||.|......::                            
Zfish   374 LASLR----------KSTKKRSESPPAELPSCRRSTR---------------------------- 400

  Fly   926 LGRLEREDQADTALVVEERCDGARNIFHACVIMCAPSSNKDSPPDSPSGGVEKKSLVGLSVARSI 990
                             ::..|:          ||.:|.:.|       |:.|:   |.:.||..
Zfish   401 -----------------QKTTGS----------CASTSRRGS-------GLGKR---GAAEARRQ 428

  Fly   991 PTVSTSAYVSSIAFGASASSSNENSSFATMSSSAAGSASSTSRDNRTNLRDMMNRLINSDQA--E 1053
            ..::.|......| .:||:.:.|....|:.|||.||:...|:.....:....|.||    ||  |
Zfish   429 EKMADSDNNQDGA-NSSAARTEETPQGASASSSVAGAVGMTTSGESESDDSEMGRL----QALLE 488

  Fly  1054 QSGSQPMATNNEDHAYIPWPAETPAASNL-------SASS---------------SQNVSDSIE- 1095
            ..|..|       |.:.|:   .|..|.|       .|||               ||.:..:|| 
Zfish   489 ARGLPP-------HLFGPF---GPRMSQLFHRTIGSGASSKAQQLLQGLQATGDESQQLQAAIEM 543

  Fly  1096 --------------DDISKIIPSSSQSSMLSNIKLGSPTYTFDLAQRREHALTILQQ------MC 1140
                          ..:..::|:.        |.|....:.||:......|||.:.:      ..
Zfish   544 CQLLVMGNEETLGGFPVKSVVPAL--------ITLLQMEHNFDIMNHASRALTYMMEALPRSSAV 600

  Fly  1141 VSPALRPYL--CHMLSTKDAQGQTPFMLSVSCRAYEAGII----LLNTILMLSEQDPQLKEAMIF 1199
            |..|:..:|  ..::...|...|....|.:..|.:...|:    |.:.:|.|.          .|
Zfish   601 VVDAIPVFLEKLQVIQFIDVAEQALTALEMLSRRHSKAILQAGGLADCLLYLE----------FF 655

  Fly  1200 PNGSPADQSPLHVICYNDTCSFTWTGADHINQNIFECKTCGLT-------GSLCCCTECAR-VCH 1256
            ...:..:...:...|    |........|...:.....|..||       .|.|.|  .|| |.:
Zfish   656 SINAQRNALAIAANC----CQSITPDEFHFVADSLPLLTQRLTHQDKKSVESTCLC--FARLVDN 714

  Fly  1257 KGHDCKLKR-----------------TAP--------------TAYCDCWEKCKCKA--LIAGNL 1288
            ..|:..|.:                 |.|              :..|   ..|.|.|  |:..|:
Zfish   715 FQHEENLLQQVASRDLLTNIQQLLVLTPPVLSSGMFIMVVRMFSLMC---SNCPCLAVQLMKQNI 776

  Fly  1289 --TKRF----------------------------ALLCKLVSC--------TDLVTKFNSKGESI 1315
              |.||                            :|:|:|:.|        .|.:.|   ||.: 
Zfish   777 AETLRFLLCGASNGSCQEQIDLVPRSPQELYELTSLICELMPCLPREGIFAVDAMLK---KGSA- 837

  Fly  1316 LLFLIQTVGRQIVEQRQYRFSVRVRNVSTAATGATGNNSVISNRKTSAAEIDNDMPDHDLEPPKF 1380
                 ||....|.:.|..|             |.....:.|.:|....|        |.....:.
Zfish   838 -----QTTEGAIWQWRDDR-------------GLWHPYNRIDSRIIETA--------HQNGEDEI 876

  Fly  1381 ARKALERL-LIDWNAVRSMIM-SGAERG--DVPNPAGSASENSNSEGFNMFIQTQHGSTLLDKFT 1441
            :...|.|: .||:|:::.:.. :|..|.  ..|||..    |.|:.| ::.::.:.....|.|..
Zfish   877 SLSTLGRVYTIDFNSMQQINEDTGTARAIQRKPNPLA----NPNTGG-HLEVRREDARAQLMKED 936

  Fly  1442 HSLIVKCTSDHLDTLLLTLVRELQNASVSNRSKEAEEVVR-RFVRSVARVFVIFNLEKQPNPEKR 1505
            ..| .||           .::.|........|..|...|| :.:|::.|:....:.|...:..:.
Zfish   937 PEL-AKC-----------FIKTLFGVLYEVYSSSAGPAVRHKCLRAILRIIYFADAELLKDVLRN 989

  Fly  1506 KSHSSCNKYVQSCVKVFQTLHKISIEELCEVSEALIAPV---------RLGVVRP---------- 1551
            .:.||   ::.|.:. .|.| ||.:..| :::|.|:..:         |.||:..          
Zfish   990 HAVSS---HIASMLS-SQDL-KIVVGSL-QMAEILMQKLPDVFSVYFRREGVMHQVKNLAESEVF 1048

  Fly  1552 -TAPFTMSSSNLDVRNSDDLFSVDPLAPSNVE----SPSEQILVHDAGNDQSANFNIQQNY-DVV 1610
             |:|....:|......:..:.:....|.|||.    |||.|   |..  |.|.:.:.|... ||:
Zfish  1049 LTSPPKACTSGTASLCTTTITTATTTAASNVTPDLGSPSFQ---HSM--DDSLDLSPQGRLSDVL 1108

  Fly  1611 AMETIRDASESEEVINREANSHNQDDELIENQ-RNEDGMQDDESD-----NDFTFNDAETESDSD 1669
            ..:.:.....     .|...|..:||:.::|| ::....|..:|.     |..|:....|::   
Zfish  1109 KRKRLPKRGP-----RRPKYSPPRDDDKVDNQAKSPTTTQSPKSSFLASLNPKTWGKLGTQA--- 1165

  Fly  1670 DNQSNQEVQRSVQAGATVGSENDIGVLFLEDESGDSSAQEEDGSEDGESDDQSDEFNFNEQQLER 1734
             |.:|.|..|:  ||.:       |:..:..:...|:.:::..:...|...:..|..||.:.::.
Zfish  1166 -NSANSEPSRT--AGVS-------GLARVPPKDSVSNNRDKIKAWIKEQASKFVERYFNSESVDG 1220

  Fly  1735 RSTNSNARSDLAPQTMQWAIRSRDTARSSVRVPTGSNMVFIDPMALRRSTVPASTTVTTPSIEPH 1799
            .:...|....|.            ||...:.:...|.:..::.:    |::.:.:.|::..|: |
Zfish  1221 SNPALNVLQRLC------------TATEQLNLQMDSGVECLEEI----SSIVSESDVSSFEIQ-H 1268

  Fly  1800 TMATTASNLARAFGITIRQISELISILSYNVLNDIETSLKIQNDEAIAVQAFVEKRLKATWDWMF 1864
            :            |:    :.:|:..|:.|...|     .|..||.|       ||.        
Zfish  1269 S------------GL----VKQLLLYLTSNSERD-----TISRDERI-------KRF-------- 1297

  Fly  1865 TVMDGTEAQLKFGAYLTNYTDP-------NHPL----HPLNLSAQASSSQTPAPATS-SSVNGVN 1917
                   ..:.||..:.....|       |.||    |.:| :..:...|.|..... .|.||..
Zfish  1298 -------LHVFFGCPIPGQEPPGRLDPTENGPLLALVHKMN-NCLSQMEQFPVKVHDFPSGNGNG 1354

  Fly  1918 IMGSNSRRDFFTYCLSLMRSHTSEHRDALPV---------LDITALRHIAYVLDAFVYYM--RND 1971
            ..||.:.:.|.|:.|   :.....|.|...|         :|..||      :.|...|:  |  
Zfish  1355 SRGSQALKFFNTHQL---KCQLQRHPDCTNVKQWKGGPVKIDPLAL------VQAIERYLVVR-- 1408

  Fly  1972 SGFYDKQDTISGRINNLSPMTESYDTDDELANLEEFNADVQMSASSMPSGSQGTRRHAFFARSES 2036
             |:        |||..     |..|:||:.::.|   .|..::|..:.|||  .|....|...|.
Zfish  1409 -GY--------GRIRE-----EDEDSDDDGSDDE---IDESLAAQFLNSGS--VRHRLQFYIGEH 1454

  Fly  2037 TLSLGCSAPEGFELPLDMAMPLADKPHLLQPNSKRQELFANLPLLVTTNANNSGATND-----GD 2096
            .            ||.:|.:..|.:...||...:|:                  :|:|     |.
Zfish  1455 L------------LPYNMTVYQAVRQFSLQAEEERE------------------STDDEANPLGR 1489

  Fly  2097 GGSIFDYTPTRLGFSNSLKRNERVYETVPIDSSKTGDGNVTNKAEGSTDSNIYVQLKKKQGSDDF 2161
            .|.   :|.|...:...::.:|                      ||..|:     :..|:|....
Zfish  1490 AGI---WTKTHTVWYKPVREDE----------------------EGCKDA-----VGGKRGRAQT 1524

  Fly  2162 KSHKEADGNQSKYEKVVLMETDDSLPSTSKSTEALMATRPEVIIAPNKASVSPATAARSVIVLAG 2226
            ...|.:..|..|.::   :..:...||.:...|..:...|...|..:..|:       .||:|  
Zfish  1525 APTKTSPRNAKKQDE---LWHEGVCPSVANPLETYLICDPPEGITFDDPSM-------EVILL-- 1577

  Fly  2227 GSCLKTIDSDINNY---------------SASNLSTAEQAKCDTQYQKSTSDHLLLFPARGSQFY 2276
               |:.:.| |:.|               :...:::...||.:.|.|    |.|::..       
Zfish  1578 ---LRVLHS-ISRYWFYLYDNAACKEIIPTGEFINSKLTAKANRQLQ----DPLVIMT------- 1627

  Fly  2277 QSNFSELPSWNFLLSRWKLTLDLFGRVFMDDVGMEHGSVLPELRGFPVKEMRF-------RRHME 2334
                ..:|:|        ||              |.|...|....|..::|.|       .|.|:
Zfish  1628 ----GNIPTW--------LT--------------ELGKTCPFFFPFDTRQMLFYVTAFDRDRAMQ 1666

  Fly  2335 KL--------RNGQQRDLVLCKLER-----NRESLIVQTFKELNTQFGNQSRRIQPPITFNRVKV 2386
            :|        ::..|...|..:|:|     ||:.|:.|.  |...|....||.:        :::
Zfish  1667 RLLDTNPEINQSDSQDSRVAPRLDRKKRTINRDELLKQA--ESVMQDLGSSRAM--------LEI 1721

  Fly  2387 TFKDEPGEGSGVARSFYTSIAEALLASAKIPNLESVQVGTNHSKYVVPFSSILRSRTVSGSSRDQ 2451
            .:::|.|.|.|..:.||..:::         .|:...:|                          
Zfish  1722 QYENEVGTGLGPTQEFYALVSQ---------ELQRADLG-------------------------- 1751

  Fly  2452 STLQRRGSNSKILWRSARERKALNLDARPYTPPNSSDNATPESLNDHLSVHLQQIGERL---YPK 2513
                        |||                                        ||.:   .||
Zfish  1752 ------------LWR----------------------------------------GEEVTLSNPK 1764

  Fly  2514 IHSINQTHAPKITGMLLEIPTPQLLSVISSDETLRQKVNEAIEIITFKQKSETSAQSSQPKKSPS 2578
            :.|...|.....:..|..:|.              .:..:...|...|.|               
Zfish  1765 VGSQEGTKYMFSSRGLFAVPF--------------GRTTKPAHIAKIKMK--------------- 1800

  Fly  2579 VVVVDPVDDDNEPLFYSPGKRGFYTPRQGFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVL 2643
                                                  ||.:|:|:...::...||.|.|.....
Zfish  1801 --------------------------------------FRFLGKLMAKAIMDFRLLDLPLGLPFY 1827

  Fly  2644 KYILGRK--IKFHDLAFFDPALYESFR---QIIQNAQTKEGEETINRMELCFVIDLMKEEGCG-- 2701
            |::|..:  |..|||...||.:.:|.:   .||:..:..|.:.:..|..|...::.:...||.  
Zfish  1828 KWMLRHESSISSHDLVNIDPGVAKSIQHLEDIIRQKKRIEQDRSHTRETLQQALESLNMNGCSVE 1892

  Fly  2702 ------------NRELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNS 2754
                        |.||..||:||.||..|:.:|:|....:.|.:...:..|:.::|...|.|.:.
Zfish  1893 DLGLDFTLPGFPNIELKKGGKDVPVTIHNLEDYLRLVVYWTLNEGVLRQFESFREGFESVFPLHH 1957

  Fly  2755 MINLTAEDLRLLLNG--VGDINVSTLISYTTFNDESSEGPDKLLKFKKWFWSIVEKMNIMERQDL 2817
            :.....|:|..||.|  ....:|.||:.... .|.......:.::|   .:.::...:..:::..
Zfish  1958 LQYFYPEELDQLLCGSKSESWDVKTLMECCR-PDHGYTHDSRAVRF---LFEVLSSFDAEQQRLF 2018

  Fly  2818 VYFWTGSPALPASEEGFQPL-PSVTI---------RPADDSHLPTANTCISRLYIPLYSSKSILR 2872
            :.|.||||.||..  ||:.| |.:||         .|  |..||:..||::.|.:|.|||..|:|
Zfish  2019 LQFVTGSPRLPVG--GFRSLNPPLTIVRKTFESTENP--DDFLPSVMTCVNYLKLPDYSSIEIMR 2079

  Fly  2873 SKMLMAIKSKNFGF 2886
            .|:|:|.:.....|
Zfish  2080 EKLLIAAREGQQSF 2093

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hydNP_001287262.1 E3_UbLigase_EDD 150..196 CDD:288409
ZnF_UBR1 1217..1284 CDD:197698 19/107 (18%)
ASF1_hist_chap 1535..1733 CDD:304562 45/228 (20%)
PolyA 2498..2561 CDD:197769 9/65 (14%)
HECTc 2589..2885 CDD:238033 80/326 (25%)
HECTc 2589..2884 CDD:214523 80/325 (25%)
trip12XP_005159283.1 WWE 842..907 CDD:280915 15/85 (18%)
HECTc 1693..2094 CDD:238033 111/573 (19%)
HECTc 1711..2090 CDD:214523 104/548 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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