DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and wwp2

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	XP_005163228.1	Gene:	wwp2 / 564527	ZFINID:	ZDB-GENE-000607-82	Length:	867	Species:	Danio rerio

Alignment Length:	987	Identity:	190/987 - (19%)
Similarity:	336/987 - (34%)	Gaps:	295/987 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1972 SGFYDKQDTI---SGRINN--LSPMTESYDTDDELANLEEFNA---DVQMSASSMPSGS------ 2022
            |...|..||:   .|::.|  ||.:.::.:....:|. .|.|.   .:.:...|:|:||
Zfish   101 SATIDLLDTLRTHDGKMENVQLSLVLQTENKGSVVAG-GELNVCLDGLVVDLGSLPNGSAASDKI 164

  Fly  2023 QGTRRHAFFARSESTLSLGCSAPEGFELPLDMAMPLADKPHLLQPNSKRQELFANLPLLVTTNAN 2087
            ..:|.....|.||.|.|  .|:|.|..|.........|.|             |.:.....||.:
Zfish   165 HSSRSSLHRAHSEETPS--TSSPRGRSLGQSSRGSCGDSP-------------AEIQGAALTNGD 214

  Fly  2088 NSGATNDGDGGSIFDYTPTRLGFSNSLKRNERVYETVPIDSSKTGDGNVTNKAEGSTDSNIYVQL 2152
            .:||                            :.||....:|||...|:::..:|.|.:|
Zfish   215 VNGA----------------------------LAETTSRHNSKTTVNNLSSAGKGETAAN----- 246

  Fly  2153 KKKQGSDDFKSHKEADGNQSKYEKVVLMETDDSLPSTSKSTEALMATRPEVIIAPNKASVSPATA 2217
                            |.:|.:           |...:.|:.:|.:..|:..:.| .|:..||:.
Zfish   247 ----------------GLESAH-----------LTCPAPSSPSLSSNPPDGTVPP-PAAEPPAST 283

  Fly  2218 ARSVIVLAGGSCLKTIDSDINNYSASNLSTAEQAKCDTQYQKSTSDHLLLFPA--------RGSQ 2274
            .:|                                 ||......:|.|   ||        .|..
Zfish   284 EQS---------------------------------DTTSDTQNTDAL---PAGWEQRILPHGRV 312

  Fly  2275 FYQSNFSELPSWNF-LLSRWKLTLDLFGRVFMDDVGMEHGSVLPELRGFPVKEMRFRRHMEKLRN 2338
            :|..:.::..:|.. |...|:..:|..||.:.    ::|.:.....:         |...|.:||
Zfish   313 YYVDHNTKTTTWERPLPPGWEKRVDQRGRFYY----VDHNTRTTTWQ---------RPTAESVRN 364

  Fly  2339 GQQRDLVLCKLERNRESLIVQTFKELNTQF---------GNQSRRIQPP-------------ITF 2381
            .:|        .:::.|.:....::.|.::         .|......||             :..
Zfish   365 YEQ--------WQSQRSQLQGAMQQFNQRYLYQPSGAVVENDPLGALPPGWEKRQDNGRVYYVNH 421

  Fly  2382 NRVKVTFKDEPGEGSGVARSFYTSIAEALLASAKIP-------NLESVQVGTNHSKYVVPFSSIL 2439
            |.....::|...:|              ::....:|       ..|.|:...:|:.....|.. .
Zfish   422 NTRTTQWEDPRTQG--------------MIQEPPLPPGWEMKYTAEGVRYFVDHNSRTTTFKD-P 471

  Fly  2440 RSRTVSGSSRDQSTLQRRGSNSKILWRSAR----ERKALNLDARPYTPPNSSDNATPESLNDHLS 2500
            |....|||        |:|.:.....||.|    :.:.|           ...||.|..:.  :|
Zfish   472 RPGFESGS--------RQGGSPGAYDRSFRWKYHQFRFL-----------CHSNALPSHVK--IS 515

  Fly  2501 VHLQQIGERLYPKIHSINQTHAPKITGMLLEIPTPQLLSVISSDETLRQK--VNEAIEIITFKQK 2563
            |..|.:.|..:.:|.::......:           :|..::..:|.|...  ..|...:::.:
Zfish   516 VSRQTLFEDSFQQIMNMKPYDLRR-----------RLYIIMRGEEGLDYGGIAREWFFLLSHE-- 567

  Fly  2564 SETSAQSSQPKKSPSVVVVDPVDDDNEPLFYSPGKRGFYTPRQGFASF--ERINAFRNIGRLIGL 2626
                             |::|:    ..||...||..:.......:|.  :.:..||.|||.|.:
Zfish   568 -----------------VLNPM----YCLFEYAGKNNYCLQINPASSINPDHLTYFRFIGRFIAM 611

  Fly  2627 CLLQNELLPLFLQRHVLKYILGRKIKFHDLAFFDPALYESFRQIIQNAQTKEGEETINRMELCFV 2691
            .|...:.:.........|.:|.:|....||...||..|.|...:.:|...:.|      :||.|.
Zfish   612 ALYHGKFIDTGFTLPFYKRMLNKKPTLKDLESIDPEFYNSIMWVKENDLEECG------VELYFA 670

  Fly  2692 IDLMKEEGCGNRELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMI 2756
            .|:.........:|...|.:..||..|..||:...|::|..:..|:..:|..||..:|:|...:.
Zfish   671 QDMEILGKVTTHQLKDDGENELVTQDNKEEYIGLLTDWRFTRGVEEQTKAFLDGFNEVVPLEWLR 735

  Fly  2757 NLTAEDLRLLLNGVGDINV-----STLISYTTFNDESSEGPDKLLKFKKWFWSIVEKMNIMERQD 2816
            ....::|.|:|.|:.:|::     :|:..:.|.|.:...          |||.:|::|:..:|..
Zfish   736 YFDEKELELMLCGMQEIDLNDWQKNTIYRHYTKNSKQIH----------WFWQVVKEMDNEKRIR 790

  Fly  2817 LVYFWTGSPALPASEEGFQ-------PLPSVTIRPADDSHLPTANTCISRLYIPLYSSKSILRSK 2874
            |:.|.||:..||..  ||.       |......:...::.||.::||.:||.:|.|.:...||.|
Zfish   791 LLQFVTGTCRLPVG--GFAELIGSNGPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKNLEQLREK 853

  Fly  2875 MLMAI-KSKNFG 2885
            :|.|| :::.||
Zfish   854 LLFAIEETEGFG 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	9/64 (14%)
		HECTc	2589..2885	CDD:238033	79/310 (25%)
		HECTc	2589..2884	CDD:214523	79/309 (26%)
wwp2	XP_005163228.1	C2_E3_ubiquitin_ligase	17..145	CDD:175988	11/44 (25%)
		WW	298..327	CDD:197736	6/31 (19%)
		WW	328..357	CDD:278809	6/41 (15%)
		WW	403..431	CDD:278809	3/27 (11%)
		WW	441..473	CDD:197736	5/32 (16%)
		HECTc	513..865	CDD:238033	90/405 (22%)
		HECTc	536..864	CDD:214523	85/379 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900