DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and hecw1b

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	XP_021336549.1	Gene:	hecw1b / 563730	ZFINID:	ZDB-GENE-060503-2	Length:	1555	Species:	Danio rerio

Alignment Length:	1628	Identity:	304/1628 - (18%)
Similarity:	544/1628 - (33%)	Gaps:	554/1628 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1458 LTLVRELQNASVSNRSKEAEEVVRRFV----RSVARVFVIFNLEKQPNPEKRKSHS--------S 1510
            ::|..::....|.::..::..:::||:    ..|.|:     |||....::..|::        .
Zfish   280 VSLPTDVLEIEVKDKFAKSRPIIKRFLGKLSMPVQRL-----LEKHAIGDRVVSYTLGRRLPTEH 339

  Fly  1511 CNKYVQSCVKVFQTLH------KISIEELCEVSEALIAPVRLGVVRPTAPFTMSSSNLDVRNSDD 1569
            .:..:|...::..::|      .:|.|:....:||...|                      .::|
Zfish   340 VSGQLQFRFEITSSIHPDDEDMSLSTEQPVAAAEAQAQP----------------------QAED 382

  Fly  1570 LFSVDPLAP--------SNVESPSEQILVHDAGNDQSANFNIQQNYDVVAMETIRDASESEEVIN 1626
            ..|:|..||        ::||.|.      |..:.||.    ....||:..|.:.:..:..|...
Zfish   383 TMSLDLGAPELPLDGDTASVEMPM------DVESGQSC----AAEADVIEEECLEEEQQEGEAAA 437

  Fly  1627 REANSHNQDDELIENQRNED---GMQDDESDNDFTFNDAETESDSDDNQSNQEVQRSVQAGATVG 1688
            ..|.....:....|..:..|   |.:::|::|:..|  ||..||:             :||
Zfish   438 AAAAMEQSETNAEETTQVLDPINGAEEEEAENNCAF--AEESSDA-------------RAG---- 483

  Fly  1689 SENDIGVLFLEDESGDSSAQEEDGSEDGESDDQSDEFNFNEQQLERRSTNSNARSDLAPQTMQWA 1753
                        |..::.:..:..||:.::|.:.|                            .:
Zfish   484 ------------EEDEAISDPQPASEEPDADLEED----------------------------CS 508

  Fly  1754 IRSRDTARSSVRVPTGSNMVFIDPMALRRSTVPAS---TTVTTPSIEPHTMATTASNLARAFGIT 1815
            :|.|.|.|   |.|             |..::|.|   |.:.:...||.|        .|:..|.
Zfish   509 LRIRTTPR---RKP-------------RPCSLPVSELETVIASACGEPET--------PRSHYIR 549

  Fly  1816 IRQISELISILSYNVLNDIETSLKIQNDEAIAVQAFVEKRLKATWDWMFTVMDGTEAQLKFGAYL 1880
            |           :::|:.:..:.....|.|           ....|....|.:..|.:.:.|..|
Zfish   550 I-----------HHLLHSLPATQPQTGDSA-----------GPEPDRPMGVEEEDEEEEEEGVTL 592

  Fly  1881 TNYT-DPNHPL-----------------------HPLNLSAQASSSQTP-----------APATS 1910
            .::. .||.|.                       |||....|..:.::|           :|..|
Zfish   593 EDHALTPNGPRRTLPRSRSHERLSDLIQMLDGDGHPLGAEGQTGNQRSPDLSPVACCSHMSPRAS 657

  Fly  1911 SSVNGVNIMGSNSRRDFFTYCLSLMRSHTSEHRDALPVLDITALRHIAYVLDAFVYYMRNDSGFY 1975
            ..:...::  .::||.                                   ::.|:..::|....
Zfish   658 GPIRAQSL--DSARRS-----------------------------------ESTVFSSQDDEDEM 685

  Fly  1976 DKQDTISGRINNLSPMTESYDTDDELANLEEF-NADVQ----MSASSMPSGSQGTRRHAFFARSE 2035
            ::.:.|.|.........:..:..|.....||. ::.||    :..:...:|..|.|.
Zfish   686 EQPNGILGSETETEQGAQCREPGDGSCQWEEAPDSHVQSPHGIVGNGEVAGPSGRRE-------- 742

  Fly  2036 STLSLGCSAPEGFELPLDMAM-------PLADKPHLLQPNSK-------RQELFANLPLLVTTNA 2086
              ..|.|:.|...:||   |:       |..|:|  |.||.:       |.....::....|...
Zfish   743 --CPLPCNHPAVSQLP---ALRPDPHHYPTIDEP--LPPNWEARIDSHGRVFYVDHINRTTTWQR 800

  Fly  2087 NNSGATNDGDGGSIFDYTPTRLGFSNSLKRNERVYETV----PIDSSKTGDGNVTNKAEGSTDSN 2147
            ..|.||.||         ..|.|....:::..|.|:|:    ..:..:...|:..|....:|:::
Zfish   801 PTSAATPDG---------LRRSGSVQQMEQLNRRYQTIQRTMATERREEESGSPRNDRTANTETD 856

  Fly  2148 IYVQLKKKQGSDDFKSHKEADGNQSKYEKVVLMETDDSLPSTSKSTEALMATRPE--VIIAPNKA 2210
            ..:|..:.:        ::...:....:|:.|:         .:|......|.||  .::..|..
Zfish   857 SPLQTNELR--------RDTSCSPGHCQKITLL---------LQSPAVKFITHPEFFTVLHANYG 904

  Fly  2211 SVSPATAARSVIVLAGGSCLK----TIDSDINNYSASNLSTAEQAKCDTQYQKSTSDHLLLFPAR 2271
            :..         :....||||    .|..|..|:.              :||.:..  |:.|..|
Zfish   905 AYR---------MFTNSSCLKHMVLKIRRDARNFE--------------RYQHNRD--LVTFLNR 944

  Fly  2272 GSQFYQSNFSELPSWNFLLSRWKLTLDLFGRVFMDDVGMEHGS--------VLPELRGFPVKEMR 2328
               |..:.. |||      ..|::..|..|:.|.    ::|.|        .:|...|.....:.
Zfish   945 ---FADAQL-ELP------RGWEIKTDPQGKSFF----VDHNSRATTFIDPRIPLQNGRLPNHLT 995

  Fly  2329 FRRHMEKLRN---GQQRDLVLCKLERNR-ESLIVQTFKELNTQFGNQSRRIQPPITFNRVKVTFK 2389
            .|:|:::||:   |:..:     :.|.| .||:.:....|.....|||::...|:.:|...|.|.
Zfish   996 HRQHLQRLRSYSAGEASE-----VSRTRGVSLLARPGNSLVAAIRNQSQQEPVPLAYNDKIVAFL 1055

  Fly  2390 DEPGEGSGVARSFYTSIAEALLASAKIPNLESVQVGTNHSKYVVPFSSILRSRTVSGSSRDQSTL 2454
            .:|            :|.|.|  ..:.|:.     ..|||         |:.:.....:.....|
Zfish  1056 RQP------------NIFEVL--QERQPSF-----ARNHS---------LKDKVHHIRTEGTQRL 1092

  Fly  2455 QRRGSNSKILWRSARERKALNL---DARPYTP-----------PNSSDNATPESLNDHLSVHLQQ 2505
            ::...::.::       ..|:|   |...|.|           |..|..::|::....|
Zfish  1093 EKLSCDADLV-------MLLSLFEEDIMSYVPLASFHPGFNFSPRCSPGSSPQNSPGFL------ 1144

  Fly  2506 IGERLYPKIHSINQTHAPKITGMLLEIPTPQL----LSVISSDETLRQKVN-------EAIEIIT 2559
              ||                        ||.:    ||..||..|.|.:..       || ::..
Zfish  1145 --ER------------------------TPLVPACCLSGESSPGTQRARAPAPYRRDFEA-KLRN 1182

  Fly  2560 FKQKSETSAQSSQPKKSPSVVVVDPVDD------------------------DNEPLFYSPGKRG 2600
            |.:|.|.......|.|...:|..|.:.:                        ..|.|.||...|.
Zfish  1183 FYRKLEAKGYGQGPGKIKLIVRRDHLLEGTFNQVMAYSRKELQRNKLYITFVGEEGLDYSGPSRE 1247

  Fly  2601 FY---------------------------TPRQGFASFERINAFRNIGRLIGLCLLQNELLPLFL 2638
            |:                           :|...|.. ..:..||..||::||.|:...||..|.
Zfish  1248 FFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFVE-NHLEWFRFSGRILGLALIHQYLLDAFF 1311

  Fly  2639 QRHVLKYILGRKIKFHDLAFFDPALYESFRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCG-- 2701
            .|...|.:|.......||.:.|    |.|.|.:|  ..||.:.| :.::|.|.::   ||..|
Zfish  1312 TRPFYKALLRLPTDLSDLEYLD----EEFHQSLQ--WMKENDIT-DVLDLTFTVN---EEVFGQV 1366

  Fly  2702 -NRELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRL 2765
             .|||..||.:|.||..|..||:.|..::|:.:...:..:||..|.::|:....:....|.:|.|
Zfish  1367 TERELKSGGTNVQVTEKNKKEYIERMVKWRVERGVVQQTQALVRGFYEVVDSRLVSVFDARELEL 1431

  Fly  2766 LLNGVGDINVSTLISYTTFNDESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPAS 2830
            ::.|..:|:::...:.|.:.....:|...:    :|||..||:.|..:|..|:.|.||:.::|
Zfish  1432 VIAGTAEIDLNDWRNNTEYRGGYHDGHIVI----RWFWGAVERFNNEQRLRLLQFVTGTSSVP-- 1490

  Fly  2831 EEGFQPLPSVTIRPADD------------SHLPTANTCISRLYIPLYSSKSILRSKMLMAI-KSK 2882
            .|||     ..:|.::.            :.||.|:||.:||.:|.|.|.::|..|:|:|: ::.
Zfish  1491 YEGF-----TALRGSNGLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYTMLYEKLLIAVEETS 1550

  Fly  2883 NFG 2885
            .||
Zfish  1551 TFG 1553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562	36/208 (17%)
		PolyA	2498..2561	CDD:197769	13/73 (18%)
		HECTc	2589..2885	CDD:238033	90/338 (27%)
		HECTc	2589..2884	CDD:214523	90/337 (27%)
hecw1b	XP_021336549.1	HECW_N	73..192	CDD:318711
		C2_NEDL1-like	213..349	CDD:176073	11/73 (15%)
		WW	771..803	CDD:197736	6/33 (18%)
		WW	952..983	CDD:197736	8/40 (20%)
		HECTc	1223..1552	CDD:214523	90/350 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900