DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hyd and smurf2

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	NP_001107898.1	Gene:	smurf2 / 563633	ZFINID:	ZDB-GENE-030131-1830	Length:	765	Species:	Danio rerio

Alignment Length:	682	Identity:	147/682 - (21%)
Similarity:	236/682 - (34%)	Gaps:	193/682 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  2363 ELNTQFGNQSRRIQPPITFNRVKVTFKDEPGEGSGV---ARSFYTSI----AEALLASAKIPNLE 2420
            :||....|.|..::..|.   |.:..:|..|.|..|   :|.|...:    .|...||.:|..|.
Zfish   116 DLNKLGPNDSDTVRGQIV---VSLQSRDRIGSGGPVVDCSRLFDNDLPDGWEERRTASGRIQYLN 177

  Fly  2421 SVQVGTNHSKYVVPFSS-----------------ILRSRTVSGSSRDQSTLQRRGSNSKILWRSA 2468
            .:...|...:...|.|.                 |:.....:|...|...:|.|..      ||.
Zfish   178 HITRSTQWERPTRPASEYSSPGRPLSCLVDENTPIMTPNGAAGVPADDPRVQERRV------RSQ 236

  Fly  2469 RERKAL---NLDARPYTPPNSSDNAT-------------------PESLNDHLSVHLQQIGE--- 2508
            |.|..:   :|...|..|.......|                   |....|..:|:.:::|.
Zfish   237 RHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLSNVNCEELGPLPP 301

  Fly  2509 ----------RLYPKIHSINQTH--APKIT--------------------------GMLLE---- 2531
                      |:|...|:...|.  .|:::                          |.|.|
Zfish   302 GWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNPSPNGSRAAVEAQSSSRPGQLKEQAQS 366

  Fly  2532 ------IP-TPQLLSVISSDETLRQKVNEAIEIITFKQ------KSETSAQSSQPKKSPSVVVVD 2583
                  :| .|:.|:|......|.||:....:.::.:|      :.|.|.:....:....|:.:.
Zfish   367 VVSPGNLPEDPECLTVPKYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMR 431

  Fly  2584 PVDDDNEPLFYSPGKRG-----------------FYTPRQGFASF------------------ER 2613
            |.|.....:....|:.|                 ...|..|...:                  |.
Zfish   432 PKDLWKRLMVKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEH 496

  Fly  2614 INAFRNIGRLIGLCLLQNE------LLPLFLQRHVLKYILGRKIKFHDLAFFDPALYESFRQIIQ 2672
            ::.|..:||::|:.:....      .||.:      |.:||:.|...|:...||.|:.|...|:.
Zfish   497 LSYFHFVGRIMGMAVFHGHYIDGGFTLPFY------KQLLGKPITLDDMESVDPDLHNSLVWILD 555

  Fly  2673 NAQTKEGEETINRMELCFVIDLMKEEGCGNRELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEK 2737
            |..|...:.|       |.::..........||.|.|:.:.||.....||||.|..:|.::..|.
Zfish   556 NDITGVLDHT-------FCVEHNAYGEIIQHELKPNGKSIPVTQDTKKEYVRLYVNWRFLRGIEA 613

  Fly  2738 ALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINV-----STLISYTTFNDESSEGPDKLLK 2797
            ...||:.|..:|:|.:.:.....::|.|::.|:|.|::     :|.:.:.|        ||.  .
Zfish   614 QFLALQKGFNEVIPQHLLKAFDEKELELIVCGLGKIDINDWKSNTRLKHCT--------PDS--N 668

  Fly  2798 FKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPLPSV------TIRPADDS--HLPTAN 2854
            ..||||..||..:...|..|:.|.|||..:|.  :||:.|...      ||...|.|  :||.|:
Zfish   669 IVKWFWRAVESYDEERRARLLQFVTGSSRVPL--QGFKALQGAAGPRLFTIHQIDASTNNLPKAH 731

  Fly  2855 TCISRLYIPLYSSKSILRSKMLMAIKSKNFGF 2886
            ||.:|:.||.|.|...|..|:|.||: :..||
Zfish   732 TCFNRIDIPPYESYDKLYDKLLTAIE-ETCGF 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	17/114 (15%)
		HECTc	2589..2885	CDD:238033	87/349 (25%)
		HECTc	2589..2884	CDD:214523	87/348 (25%)
smurf2	NP_001107898.1	C2_Smurf-like	13..137	CDD:176028	6/23 (26%)
		WW	159..188	CDD:278809	6/28 (21%)
		WW	252..283	CDD:197736	2/30 (7%)
		WW	298..330	CDD:197736	5/31 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..375		3/33 (9%)
		HECTc	410..762	CDD:238033	92/377 (24%)
		HECTc	437..762	CDD:214523	87/350 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900