DRSC/TRiP Functional Genomics Resources

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Protein Alignment hyd and yap1

DIOPT Version :9

Sequence 1:NP_001287262.1 Gene:hyd / 41181 FlyBaseID:FBgn0002431 Length:2887 Species:Drosophila melanogaster
Sequence 2:NP_001132952.1 Gene:yap1 / 561411 ZFINID:ZDB-GENE-030131-9710 Length:442 Species:Danio rerio


Alignment Length:449 Identity:99/449 - (22%)
Similarity:152/449 - (33%) Gaps:131/449 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  1492 VIFNLEKQPN----PEKRKSHS---SCNKYVQSCVKVFQTLHKISIEELCEVSEALIAPVRLGVV 1549
            |...|.|.|:    |.:.||||   |.:......|    |.|.:.       :.:..|.::||.|
Zfish    44 VPMRLRKLPDSFFTPPEPKSHSRQASTDAGTAGTV----TPHHVR-------AHSSPASLQLGAV 97

  Fly  1550 RPTAPFTMSSSNL---DVRNS-----DDLFSVDPLAP--SNVESPSEQ--ILVHDAGNDQSANFN 1602
            .|.|..:|..:|.   .:|.|     ||:    ||.|  ...::||.|  .|.|   |||:..:.
Zfish    98 SPGALTSMGPANAPPQHLRQSSYEIPDDM----PLPPGWEMAKTPSGQRYFLNH---NDQTTTWQ 155

  Fly  1603 ------IQQNYDV------VAMETIRDASES------EEVINREANSHNQDDELIENQRNEDGMQ 1649
                  :|.|...      |..:.|.:.:..      |:.|..|...:     .|.::.......
Zfish   156 DPRKALLQMNQAAPASPVPVQQQNIMNPASGPLPDGWEQAITSEGEIY-----YINHKNKTTSWL 215

  Fly  1650 DDESDNDFTFNDAETESDSDDNQSNQEVQRSVQAGATVGSENDIGV--LFLEDE----------- 1701
            |...|..|..|.......:...|.:| :..|.|:|...|: |.|.:  :.:|.|           
Zfish   216 DPRLDPRFAMNQQRISQSAPVKQGSQ-LPSSPQSGVMSGN-NPIRLQQIHIEKERLRIKQELLRQ 278

  Fly  1702 --------SGDSSAQEEDG------SEDGESDD-------QSDEF-NFNEQQLERRSTNS--NAR 1742
                    :...::.|:||      |..|...|       .||.| |.........||:|  :..
Zfish   279 RPQELALRNQLPTSMEQDGGTQNPVSSPGMGQDARNMTTNSSDPFLNSGTYHSRDESTDSGLSMS 343

  Fly  1743 SDLAPQTMQWAIRSRDTARSSVRVPTGSNMVFIDPMALRRSTVP------ASTTVTTPSIEPHTM 1801
            |...|:|....:.|.|...:...:..||       ||.:.|..|      ..|.|...::|..:|
Zfish   344 SYSVPRTPDDFLNSVDEMETGDTLGPGS-------MATQPSRFPDYLDAIPGTDVDLGTLEGESM 401

  Fly  1802 ATTASNLARAFGITIRQISELISILSYNVLNDIETSLKIQNDEAIAVQAFVEKRLKATW 1860
            |.....|          :..|...||.::|||:|:.|....         ::|....||
Zfish   402 AVEGEEL----------MPSLQEALSSDILNDMESVLAATK---------IDKENFLTW 441

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hydNP_001287262.1 E3_UbLigase_EDD 150..196 CDD:288409
ZnF_UBR1 1217..1284 CDD:197698
ASF1_hist_chap 1535..1733 CDD:304562 55/262 (21%)
PolyA 2498..2561 CDD:197769
HECTc 2589..2885 CDD:238033
HECTc 2589..2884 CDD:214523
yap1NP_001132952.1 FAM181 <41..186 CDD:291891 40/159 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 51..89 10/48 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 97..116 5/18 (28%)
WW 127..158 CDD:197736 11/33 (33%)
WW 188..217 CDD:278809 4/33 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 230..254 5/24 (21%)
Transactivation domain. /evidence=ECO:0000250|UniProtKB:P46937 247..442 48/222 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 286..374 21/94 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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