DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and herc5.1

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	XP_017211386.1	Gene:	herc5.1 / 559981	ZFINID:	ZDB-GENE-090311-56	Length:	884	Species:	Danio rerio

Alignment Length:	931	Identity:	175/931 - (18%)
Similarity:	312/931 - (33%)	Gaps:	285/931 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  2022 SQGT--RRHAFFARSESTL--SLGCSAP----EGFELPLDMAMPLADKPHLLQPNSKRQELFANL 2078
            ||.|  |.|...:.:...|  |.||...    .|.::...:.:|: |:|.........|:|.|
Zfish   170 SQVTCGRNHTLVSTASPKLIYSFGCGMQGQLGNGEQVKQSVPLPV-DQPTEYNDEYTIQKLVA-- 231

  Fly  2079 PLLVTTNANNSGATNDGDGGSIFDYTPTR--LGFSN--------------SLKRNERVYETVPID 2127
                  ..|:|.|....:.|:..:..|||  :.|.|              ::|..::|:.:.
Zfish   232 ------GENHSFALYFKELGNEANPDPTRGIMTFDNGMIEQCECGKDPRKAIKDLKKVFSSA--- 287

  Fly  2128 SSKTG-------DGNVTNKAEGSTDSNIYVQLKKKQGSDDFKSHKEADGNQSKYEKV---VLMET 2182
            :|..|       ||:.....|       |..|       ||...:.:....|:.|::   ||...
Zfish   288 ASLNGSFLKTRHDGHYQTSEE-------YCGL-------DFGLVESSIATLSRNERLISTVLKVL 338

  Fly  2183 DDSL-----PS-TSKSTEALMATRPEVII---APNKASVSPATAARSVIVLAGGSCLKTIDSDIN 2238
            .:||     |: |.:.:..|....||:|.   :..||.::.|.|::.:
Zfish   339 QESLLPTLNPNPTGEESLRLYILLPELISHLKSEQKAELTEALASKIL----------------- 386

  Fly  2239 NYSASNLSTAEQAKCDTQYQKSTSDHL----LLFPARGSQFYQSNFSELPSWNFLLSRWKLTLDL 2299
                 |||.|.....:..:.|...|.|    .||....::|
Zfish   387 -----NLSPAALRVLEIYWSKLPDDWLKNLVKLFKKASAKF------------------------ 422

  Fly  2300 FGRVFMDDVGMEHGSVLPELRGFPVKEMRFRRHMEKLRNGQQRDLVLCKLERN---------RES 2355
            |||:.:::|.             .|.:....:.:|.|:...|   |.|...||         ..:
Zfish   423 FGRIIVENVN-------------NVAKTHMLKFVEILQRVYQ---VCCSANRNIKKRYFIIHEVN 471

  Fly  2356 LIVQTFKELNTQFGNQSRRIQPPITFNRVKVTFKDEPGEGSGVARSFYTSIAEALLASAKIPNLE 2420
            .::...:.:|....|.    .|  .||   :|.:....|..   |:.|......|.:...|.|||
Zfish   472 NLLDVLQTMNADVNNN----WP--WFN---LTGQIHALEAQ---RNAYEETFRKLTSFPCIFNLE 524

  Fly  2421 SVQVGTNHSKYVVPFSSILRSRTVSGSSRDQSTLQRRGSNSKILWRSARERKALNLDARPYTPPN 2485
            :.             .|.:|:|...|  |.:.|::          |:|.....|.|
Zfish   525 AK-------------CSYMRNRVWKG--RFELTVR----------RTALLEDCLCL--------- 555

  Fly  2486 SSDNATPESLNDHLSVHLQQIGERLYPKIHSINQTHAPKITGMLLEIPTPQLLSVISSDE-TLRQ 2549
                     ||.....||:.                              :.||::.::. :.|.
Zfish   556 ---------LNPGTQQHLRD------------------------------KWLSILFTENVSKRT 581

  Fly  2550 KVNEA-IEIITFKQKSETSAQSSQPKKSPSVVVVDPVDDDNEPLFYSPGKRGFYTPRQGFASFER 2613
            .|::. ..:..||:..:.::|..             :.:|||.:.:.|.|          .:.|:
Zfish   582 DVHKRDFFLNVFKELCDPASQLF-------------MYNDNETMIWFPAK----------LTVEK 623

  Fly  2614 INAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIKFHDLAFFDPALYESFRQIIQNAQTKE 2678
            ...|. .|.|.||....:.::.|.....:.|.:|..|....|...|:|....|.:.|::.:.
Zfish   624 KKYFL-FGILCGLAFNNSSVVNLPFPLALFKKLLNIKPSLEDFIEFNPVHGRSLQYILEYSN--- 684

  Fly  2679 GEETINRMELCFVIDLMKEEGC--------GNRELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQ 2735
                          |:::|...        ...:|.|...:..:|:||..::|..|.::...:|.
Zfish   685 --------------DVLEESSLPLTIIWSGSELDLDPAEPEQHITTSNRTKFVDEYVDHIFNQSV 735

  Fly  2736 EKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVSTLISYTTFNDESSEGPDKLLKFKK 2800
            ::|.|..:.|.|.......:.....|:||.:|.|..:.:.:.|...||:....:.....::.
Zfish   736 KEAFEEFRRGFFRGCEKRLVEMFEPEELRGVLVGNEEYDWNILKQNTTYEGVFNADHPVIIS--- 797

  Fly  2801 WFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPLPSVTIRPADDSHLPTANTCISRLYIPLY 2865
             ||.:.:.:...|::..:.|.||...:|........:....:..:.:.|||...||.|.|.:|.|
Zfish   798 -FWEVFDDLTPNEKKSFLLFLTGFERVPILGMSAVKMRVTHLANSTEDHLPETLTCHSLLQLPKY 861

  Fly  2866 SSKSILRSKMLMAIKSKNFGF 2886
            ..:..||:|::.||..|. ||
Zfish   862 EKRETLRAKVIEAISHKR-GF 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	6/64 (9%)
		HECTc	2589..2885	CDD:238033	63/303 (21%)
		HECTc	2589..2884	CDD:214523	63/302 (21%)
herc5.1	XP_017211386.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900