DRSC/TRiP Functional Genomics Resources

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Protein Alignment hyd and WWC3

DIOPT Version :9

Sequence 1:NP_001287262.1 Gene:hyd / 41181 FlyBaseID:FBgn0002431 Length:2887 Species:Drosophila melanogaster
Sequence 2:NP_056506.2 Gene:WWC3 / 55841 HGNCID:29237 Length:1092 Species:Homo sapiens


Alignment Length:1223 Identity:226/1223 - (18%)
Similarity:383/1223 - (31%) Gaps:395/1223 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  1579 SNVESPSEQ-------------ILVHDAGNDQSANFNIQQNYDVVAMETIR-------DASES-- 1621
            :.:|.|.||             |:..:|.|.:...:.|:|....:|.|..:       |.|.|  
Human     8 TQIEDPREQWRREQERMLKEYLIVAQEALNAKKEIYQIKQQRFELAQEEYQQLHKMCEDDSRSYA 72

  Fly  1622 ------------------EEVINREANSHNQDDELI----ENQRNEDGMQDDESDNDFTFNDAET 1664
                              .|:.:|.........||.    |.|..|.|::..: :.|...:...|
Human    73 SSFSGYSTNTKYDPHQIKAEIASRRDRLSRLKRELTQMKQELQYKEKGVETLQ-EIDRKMSSTHT 136

  Fly  1665 ESDSDDNQSNQEVQRSVQAGATVGSE------------------------------NDIGVLFLE 1699
            ....|:.|:.....|:::.....|.:                              :.:||    
Human   137 SYKLDEAQAIMSELRTIKKAICTGEKERRDLMHSLAKLTDSFKNSCSVTDSLVDFPHHVGV---- 197

  Fly  1700 DESGDSSAQE---EDGSED---GE--SDDQS---DEFNFNEQQLERRSTNSNARSDLA------- 1746
              .||:...:   :.||:.   ||  .||::   |....|.|..|.|...:|.:..||       
Human   198 --PGDAGVPQQFCDAGSQTDIIGEFVFDDKTRLVDRVRLNWQYEEARKRVANIQQQLARLDNESW 260

  Fly  1747 PQTMQ------WAIRSRDTARSSVRVPTGSNMVFIDPMALRRSTVPASTTVTTPSIEPHTMATTA 1805
            |.|.:      ..|:.::.....:::          .:|.|||    :..|.....|...:   .
Human   261 PSTAEADRDRLQLIKEKEALLQELQL----------IIAQRRS----AGDVARLEEERERL---E 308

  Fly  1806 SNLARAFGITIRQISELISILSYNVLNDIETSLKIQNDEAIAVQAFVEKRLKATWDWMFTVMDGT 1870
            ..|.||...:.:..:|.|      :|.:....|.:|.:||..:.::::.:||:......||..|:
Human   309 EELRRARATSAQGATERI------LLQEKRNCLLMQLEEATRLTSYLQSQLKSLCASTLTVSSGS 367

  Fly  1871 EAQLKFGAYLTNYTDPNHPLHPLNLSAQASSSQTPAPATSSSVNGVNIMGSNSRRDFFTYCLSLM 1935
            ..    |:.                 |.:..|...:..:.|||:..:|.|              :
Human   368 SR----GSL-----------------ASSRGSLASSRGSLSSVSFTDIYG--------------L 397

  Fly  1936 RSHTSEHRDALPVLDITALRHIAYVLDAFVYYMRNDSGFYDKQ---DT------ISGR--INNLS 1989
            ..:.....:...:|....:...:...||........|||:.::   ||      :|.|  :::||
Human   398 PQYEKPDAEGSQLLRFDLIPFDSLGRDAPFSEPPGPSGFHKQRRSLDTPQSLASLSSRSSLSSLS 462

  Fly  1990 PMTESYDT-------DDELANLEEFNADVQMSASSMPSGSQGT----RRHAFFARSESTLSLGCS 2043
            |.:...||       |..||.|          |.|......|.    |.||.....|....:...
Human   463 PPSSPLDTPFLPASRDSPLAQL----------ADSCEGPGLGALDRLRAHASAMGDEDLPGMAAL 517

  Fly  2044 APEGF----ELPLDMAMPLADKP-----HLLQPNSKRQELFA---NLPLLVTTNANNSGATNDGD 2096
            .|.|.    |.|.:...|.|..|     .|.:.::||.|..|   :..|...:.|::||.     
Human   518 QPHGVPGDGEGPHERGPPPASAPVGGTVTLREDSAKRLERRARRISACLSDYSLASDSGV----- 577

  Fly  2097 GGSIFDYTPTRLGFSNSLKRNERVYETVPIDSSKTGDGNV---TNKAEGSTDSNIYV-QLKKKQG 2157
                         |....||||...|....|::..||..:   ..:..||....::| |||...|
Human   578 -------------FEPLTKRNEDAEEPAYGDTASNGDPQIHVGLLRDSGSECLLVHVLQLKNPAG 629

  Fly  2158 ---SDDFKSHKEADGNQSKYEKVVLMETDDSLPST--SKSTE------------------ALMAT 2199
               .:|.|.|          .:|.|...|...|:|  ||:.|                  ||...
Human   630 LAVKEDCKVH----------IRVYLPPLDSGTPNTYCSKALEFQVPLVFNEVFRIPVHSSALTLK 684

  Fly  2200 RPEVIIAPNKASVSPATAARSVIVLAGGSCLKTIDSD-----------INNYSASNLSTAEQAKC 2253
            ..::.:    .||:|.....    |.|.:.:...|.|           :..:::|..|...:|.|
Human   685 SLQLYV----CSVTPQLQEE----LLGIAQINLADYDSLSEMQLRWHSVQVFTSSEPSRTREAGC 741

  Fly  2254 DTQYQKSTSDHLLLFPARGSQFYQSNFSELPSWNFLLSRWKLTLDLFGRVFMDDVGMEHGSVLPE 2318
              ..:.|..|     ||.                        |:.:.|:.  |.|.:.......:
Human   742 --AGESSARD-----PAH------------------------TISISGKT--DAVTVLLARTTAQ 773

  Fly  2319 LRGFPVKEMRFRRHMEKLRNGQQRDLVLCKLERNRESLIVQTFKELNTQFG-NQSRRIQPPI--- 2379
            |:..   |........||...::..|.:.:.|...|::..::::..:...| :...:..||.   
Human   774 LQAV---ERELAEERAKLEYTEEEVLEMERKEEQAEAISERSWQADSVDSGCSNCTQTSPPYPEP 835

  Fly  2380 -----------TFNRVKVTFKDEPGEGSGVARSFYTSIAEALLASAKIPNLESVQVGTNHSKYVV 2433
                       .|......:..|..:.|.:.....|:..:..|..|.....|........|.: |
Human   836 CCMGIDSILGHPFAAQAGPYSPEKFQPSPLKVDKETNTEDLFLEEAASLVKERPSRRARGSPF-V 899

  Fly  2434 PFSSILRSRTVSGSSRDQ-----------------------STLQRRGSNSKILWRS------AR 2469
            ...:|:||:|.|..:|.|                       :||:||....|...||      ||
Human   900 RSGTIVRSQTFSPGARSQYVCRLYRSDSDSSTLPRKSPFVRNTLERRTLRYKQSCRSSLAELMAR 964

  Fly  2470 ERKALNLDARPYTPPNSSDNATPESLNDHLSVHLQQIGERLYPKIHSINQTHAP-------KITG 2527
            ....|.||.:       :.......||:.|.. |:::.:|| .......||..|       ::.|
Human   965 TSLDLELDLQ-------ASRTRQRQLNEELCA-LRELRQRL-EDAQLRGQTDLPPWVLRDERLRG 1020

  Fly  2528 MLLEI---------------PTPQLLSVISSD--ETLRQKVNEAIEIITFKQK 2563
            :|.|.               ...::|...|.:  :...|...|.|::.||::|
Human  1021 LLREAERQTRQTKLDYRHEQAAEKMLKKASKEIYQLRGQSHKEPIQVQTFREK 1073

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hydNP_001287262.1 E3_UbLigase_EDD 150..196 CDD:288409
ZnF_UBR1 1217..1284 CDD:197698
ASF1_hist_chap 1535..1733 CDD:304562 41/238 (17%)
PolyA 2498..2561 CDD:197769 16/86 (19%)
HECTc 2589..2885 CDD:238033
HECTc 2589..2884 CDD:214523
WWC3NP_056506.2 THOC7 <4..119 CDD:283305 20/110 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 363..384 5/41 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 422..488 19/75 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 510..544 7/33 (21%)
C2_Kibra 602..725 CDD:176062 27/140 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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