DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hyd and HERC6

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	XP_005263140.1	Gene:	HERC6 / 55008	HGNCID:	26072	Length:	1034	Species:	Homo sapiens

Alignment Length:	903	Identity:	178/903 - (19%)
Similarity:	318/903 - (35%)	Gaps:	209/903 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  2106 TRLGF-SNSLKRNERVYETVPIDSSK----------------TGDGNVTNKAEGSTDSNIYVQLK 2153
            |..|: |||..:.......||:.|:|                .||.:.   |..:.|..::....
Human   213 TSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHT---AVLTQDGKVFTFGD 274

  Fly  2154 KKQGSDDFKSHKEADGNQSKYEKVVLMETDDSLPST----SKSTEALMATRPEVI-IAPNKASVS 2213
            .:.|...:....|..|.|       |:|..|.|.|.    |..|.|.:.|..:|: .....:..|
Human   275 NRSGQLGYSPTPEKRGPQ-------LVERIDGLVSQIDCGSYHTLAYVHTTGQVVSFGHGPSDTS 332

  Fly  2214 PATAARSVIVLAGGSCLKT----IDSDINNYSA---SNLSTAEQAKCDTQYQKSTSDHLLLFPAR 2271
            ..|...::......|||.:    :|..:.:..|   :|..|..|....|:....|...:
Human   333 KPTHPEALTENFDISCLISAEDFVDVQVKHIFAGTYANFVTTHQDTSSTRAPGKTLPEI------ 391

  Fly  2272 GSQFYQSNFSELPSWNFLLSRWKLTLDLFGRVFMDDVGMEHGSVLPELRGFPVKEMRFRRHMEKL 2336
             |:..||          :..:|         :.:.....||.....|:|..............|.
Human   392 -SRISQS----------MAEKW---------IAVKRRSTEHEMAKSEIRMIFSSPACLTASFLKK 436

  Fly  2337 RNGQQRDLVLCKLERNRESLIVQTFKELNTQFGNQSRRIQPPITFNRVKVTFKDEPGEGSGVARS 2401
            |...:...:...||..|:     |||:|     .:...|...||     ...:|:      :.|:
Human   437 RGTGETTSIDVDLEMARD-----TFKKL-----TKKEWISSMIT-----TCLEDD------LLRA 480

  Fly  2402 F--YTSIAEALLASAKIPNLESVQVGTNHSKYVVPFSSI---LRSRTVSGSSRDQSTLQRRGSN- 2460
            .  ::...|||.....:|....:....|....||||:..   :..:::....:..:.||....|
Human   481 LPCHSPHQEALSVFLLLPECPVMHDSKNWKNLVVPFAKAVCEMSKQSLQVLKKCWAFLQESSLNP 545

  Fly  2461 ----------SKILWRSARERKALNLDA-----RPYTPPNSSDNATPES------LNDHLSVHLQ 2504
                      |::|.::..|:...|:.|     :.....|.::...||:      |::.|:.::.
Human   546 LIQMLKAAIISQLLHQTKTEQDHCNVKALLGMMKELHKVNKANCRLPENTFNINELSNLLNFYID 610

  Fly  2505 QIGERLYPKIHSINQTHAPKITGMLLEIPTPQLLS-------------VISSD------------ 2544
            : |.:|:...|.|.           .|.|:|.:.|             ::.:|
Human   611 R-GRQLFRDNHLIP-----------AETPSPVIFSDFPFIFNSLSKIKLLQADSHIKMQMSEKKA 663

  Fly  2545 -----ETLRQKVNE-------AIEIITFKQKSETSAQSSQPKKSP--SVVVVDPVDD-------D 2588
                 ||:.||.:|       .:.:...:...:...|.||.:.:.  .|:||:.:::       .
Human   664 YMLMHETILQKKDEFPPSPRFILRVRRSRLVKDALRQLSQAEATDFCKVLVVEFINEICPESGGV 728

  Fly  2589 NEPLFY-------SPGKRGFYTPRQGFASF-------ERINAFRNIGRLIGLCLLQNELLPLFLQ 2639
            :...|:       .|....|..|..|...:       |:...|. .|.|.||.|....:..|...
Human   729 SSEFFHCMFEEMTKPEYGMFMYPEMGSCMWFPAKPKPEKKRYFL-FGMLCGLSLFNLNVANLPFP 792

  Fly  2640 RHVLKYILGRKIKFHDLAFFDPALYESFRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCGNRE 2704
            ..:.|.:|.:|....||....|.|.:|.::::.:|....|:      .||....:..::  .:.:
Human   793 LALYKKLLDQKPSLEDLKELSPRLGKSLQEVLDDAADDIGD------ALCIRFSIHWDQ--NDVD 849

  Fly  2705 LIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNG 2769
            |||.|..:.|..:|..:||.:|.:|....|.:...|..:.|.:.|.....:.:...|:|...:.|
Human   850 LIPNGISIPVDQTNKRDYVSKYIDYIFNVSVKAVYEEFQRGFYRVCEKEILRHFYPEELMTAIIG 914

  Fly  2770 VGDINVSTLISYTTF--NDESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEE 2832
                  :|...:..|  |.:..:|..|.....:.||....|:.:.|::..::|.||...|.|  .
Human   915 ------NTDYDWKQFEQNSKYEQGYQKSHPTIQLFWKAFHKLTLDEKKKFLFFLTGRDRLHA--R 971

  Fly  2833 GFQPLPSVTIRP---ADDSHLPTANTCISRLYIPLYSSKSILRSKMLMAIKSKNFGFV 2887
            |.|.:..|...|   ::..| ||:.||.:.|.:|.||:...:...:.:|| :.|.|||
Human   972 GIQKMEIVFRCPETFSERDH-PTSITCHNILSLPKYSTMERMEEALQVAI-NNNRGFV 1027

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	15/99 (15%)
		HECTc	2589..2885	CDD:238033	72/314 (23%)
		HECTc	2589..2884	CDD:214523	71/313 (23%)
HERC6	XP_005263140.1	RCC1_2	27..54	CDD:290274
		RCC1_2	89..118	CDD:290274
		RCC1	105..155	CDD:278826
		RCC1	158..208	CDD:278826
		RCC1	215..263	CDD:278826	11/50 (22%)
		RCC1_2	250..279	CDD:290274	4/31 (13%)
		RCC1	266..313	CDD:278826	12/53 (23%)
		HECTc	684..1026	CDD:238033	78/360 (22%)
		HECTc	711..1026	CDD:214523	75/333 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900