DRSC/TRiP Functional Genomics Resources

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Protein Alignment hyd and PLEKHA5

DIOPT Version :9

Sequence 1:NP_001287262.1 Gene:hyd / 41181 FlyBaseID:FBgn0002431 Length:2887 Species:Drosophila melanogaster
Sequence 2:NP_001243399.1 Gene:PLEKHA5 / 54477 HGNCID:30036 Length:1282 Species:Homo sapiens


Alignment Length:1365 Identity:251/1365 - (18%)
Similarity:425/1365 - (31%) Gaps:457/1365 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly  1445 IVKCTSDHLDTLLLTLVRELQNASV-SNRSKEAEEVVRRFVRSVARVFVIFNLEKQPNPEKRKSH 1508
            :...||:......::::.|..|.:| |:.:......|.|..|:..:|   .|..|:.|..||..:
Human   106 VATMTSEEKKERPISMINEASNYNVTSDYAVHPMSPVGRTSRASKKV---HNFGKRSNSIKRNPN 167

  Fly  1509 SSCNK----YVQSC--VKVFQTLHKISIEELC------EVSEALIAPVRLGVVRPTAPFTMSSSN 1561
            :...:    |.|..  :|:::....: :.:||      |..|.::..:.|    |:....:.:|.
Human   168 APVVRRGWLYKQDSTGMKLWKKRWFV-LSDLCLFYYRDEKEEGILGSILL----PSFQIALLTSE 227

  Fly  1562 LDVRNSDDLFSVDPLAPSNVESPSEQILVHDAGNDQSANFNIQQNYDVVAMETIR--------DA 1618
             |..|....|..   |..|:.:   .....|.|.:.........:..:|..|.::        |.
Human   228 -DHINRKYAFKA---AHPNMRT---YYFCTDTGKEMELWMKAMLDAALVQTEPVKRITFNFRVDK 285

  Fly  1619 SESEEVINREANSHNQDDELIE-----NQRNED---------------GMQDDESD------NDF 1657
            ..||....:|.|:......||:     ||:|::               |.|.|..|      |..
Human   286 ITSENAPTKETNNIPNHRVLIKPEIQNNQKNKEMSKIEEKKALEAEKYGFQKDGQDRPLTKINSV 350

  Fly  1658 TFNDAETESDSDDNQSNQEVQ-RSVQAGATVGSENDIGVLFLEDESGDSSAQEEDGSEDGESDDQ 1721
            ..|...:|.:|......|.|. |.:...:   |||.|..:.|.|..|.:  :...|....|:|..
Human   351 KLNSLPSEYESGSACPAQTVHYRPINLSS---SENKIVNVSLADLRGGN--RPNTGPLYTEADRV 410

  Fly  1722 SDEFNFNEQQLER-------RSTNSNARSDLAPQTMQWAIRSRDTARSSV--RVPTGSNMVFIDP 1777
            ....| :.||||:       |......|..::.||:.   |:..:.|:.:  |.|.|..     .
Human   411 IQRTN-SMQQLEQWIKIQKGRGHEEETRGVISYQTLP---RNMPSHRAQIMARYPEGYR-----T 466

  Fly  1778 MALRRSTVPASTTVTTPSIEPHTMATTASNLARAFGITIRQISELISILSYNVLNDIETSLKIQN 1842
            :.....|.|.|....|||....|:...|.                                    
Human   467 LPRNSKTRPESICSVTPSTHDKTLGPGAE------------------------------------ 495

  Fly  1843 DEAIAVQAFVEKRLKATWDWMFTVMDGTEAQLKFGAYLTNYTDPNH-----PLHPLNLSAQASSS 1902
                      |||.....|.|:.:.:..:.|.    |....|.|.|     |...:|:|.|...|
Human   496 ----------EKRRSMRDDTMWQLYEWQQRQF----YNKQSTLPRHSTLSSPKTMVNISDQTMHS 546

  Fly  1903 --QTPAPATSSSVNGVNIMGSNSRRDFFTYCLSLMRSHTSEHRDALPVLDITA-LRHIAYVLDAF 1964
              .:|:..:.::..|                .|..|::.||....:...|:|. .||.|:     
Human   547 IPTSPSHGSIAAYQG----------------YSPQRTYRSEVSSPIQRGDVTIDRRHRAH----- 590

  Fly  1965 VYYMRNDSGFY--DKQDTISG-RINNLSPMTESYDTDDELANLEEFNADVQMSASSMPSGSQGTR 2026
                 :....|  |::...:| .:.::||.:....|.:||..|.......|...||:       |
Human   591 -----HPKHVYVPDRRSVPAGLTLQSVSPQSLQGKTPEELTLLLIKLRRQQAELSSI-------R 643

  Fly  2027 RHAFFARSESTLSLGCSAPEGFELPLDMAMPLADKPHLLQPNSKRQELF------ANLPL--LVT 2083
            .|        ||:      :..:|.|:...|   |..:|..:.:|..::      .|.|:  :|.
Human   644 EH--------TLA------QLMQLKLEAHSP---KNEILSHHLQRNTIYLDHQMKENEPIITMVH 691

  Fly  2084 TNANNSG--------------------ATNDGDGGSIFDYTPTRLGFSNSLKRNERVYETVPIDS 2128
            |...||.                    .:.|...|:::.|.|                |.|.||:
Human   692 TMIENSALRPQLYQQFLRQKSKISLYCLSQDEGRGTLYKYRP----------------EEVDIDA 740

  Fly  2129 SKTGDGNVTNKAEGSTDSNIYVQLKKKQGSDDFKSHKEADGNQSKYEKVVLMETDDSLPSTSKST 2193
                  .::...|  .|..::...:|.|     :.|||      ||      ..:.:|.|.|:..
Human   741 ------KLSRLCE--QDKVVHALEEKLQ-----QLHKE------KY------TLEQALLSASQEI 780

  Fly  2194 EALMATRPEVIIAPNKASVSPATAARSVIVLAGGSCLKTIDSDINNYSAS-----NLSTAEQAKC 2253
            |         :.|.|.|::......|               .|:.|...|     :.:|||..:.
Human   781 E---------MHADNPAAIQTVVLQR---------------DDLQNGLLSTCRELSRATAELERA 821

  Fly  2254 DTQYQKSTSDHLLLFPARGSQFYQSNFSELPSWNFLLSRWKLTLDLFGRVFMDDVGMEHGSVLPE 2318
            ..:|.|...|..:.         ::...|             .||..|.|..:..|::...:..|
Human   822 WREYDKLEYDVTVT---------RNQMQE-------------QLDHLGEVQTESAGIQRAQIQKE 864

  Fly  2319 LRGFPVKEMRFRRHMEKLRNGQQRDLVLCKLERNRESLIVQTFKELNT-QFGNQSRRIQPP---- 2378
            |       .|.:..||.|...:|        :|....:.:...|..:| ::.|:...:.||    
Human   865 L-------WRIQDVMEGLSKHKQ--------QRGTTEIGMIGSKPFSTVKYKNEEEEVVPPRPPL 914

  Fly  2379 -----------------------ITFNRVKVTFKDE---------PGEGSGVARSF--------Y 2403
                                   :.::|..|...:|         |..||.....:        .
Human   915 PRSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEEKKMYQVQGYPRNGSHCGPDYRLYKSEPEL 979

  Fly  2404 TSIAEALLA-----SAKIPNLESVQVGTNH---------SKYVVPFSSILRSRTVSGSSRDQSTL 2454
            |::||...:     |..:..:|:..|..:|         :|...|.||.:.|......::....|
Human   980 TTVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRAKSPTPESSTIASYVTLRKTKKMMDL 1044

  Fly  2455 QRRGSNSKI----LWRSARER----------------------KALNL----DARP-YTPPNSSD 2488
            :.....|.:    |..|.|.|                      |.||:    |..| .:|.|..|
Human  1045 RTERPRSAVEQLCLAESTRPRMTVEEQMERIRRHQQACLREKKKGLNVIGASDQSPLQSPSNLRD 1109

  Fly  2489 NA---------------TPESLNDHLSVHLQQIGERLYPKIHSINQTHAPKIT------------ 2526
            |.               |....||....|     |....:|..:.:|....:.            
Human  1110 NPFRTTQTRRRDDKELDTAIRENDVKPDH-----ETPATEIVQLKETEPQNVDFSKELKKTENIS 1169

  Fly  2527 -GMLLEIPTPQLLSVISSDETLRQKVNEAIEIITFKQKSETSAQSSQPKKSPSVVVVDPVDDDNE 2590
             .||.| |.|..::.:...:..|.| ::..|.:||..:.||...:.:|::.|.....:.||:..|
Human  1170 YEMLFE-PEPNGVNSVEMMDKERNK-DKMPEDVTFSPQDETQTANHKPEEHPEENTKNSVDEQEE 1232

  Fly  2591  2590
            Human  1233  1232

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hydNP_001287262.1 E3_UbLigase_EDD 150..196 CDD:288409
ZnF_UBR1 1217..1284 CDD:197698
ASF1_hist_chap 1535..1733 CDD:304562 48/232 (21%)
PolyA 2498..2561 CDD:197769 13/75 (17%)
HECTc 2589..2885 CDD:238033 1/2 (50%)
HECTc 2589..2884 CDD:214523 1/2 (50%)
PLEKHA5NP_001243399.1 WW 12..41 CDD:278809
WW 58..87 CDD:278809
PH_PEPP1_2_3 164..267 CDD:270068 18/114 (16%)
PH 170..266 CDD:278594 17/107 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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