DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and Wwc2

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	NP_598552.2	Gene:	Wwc2 / 52357	MGIID:	1261872	Length:	1187	Species:	Mus musculus

Alignment Length:	1251	Identity:	234/1251 - (18%)
Similarity:	388/1251 - (31%)	Gaps:	444/1251 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1586 EQILVHDAGNDQSANF---------NIQQNYDVVAMETIRDASESEEVINREANSHNQDDELIEN 1641
            |.:.::||..::|::.         :.:.:.|::..| |.......:.:.||. ||.:.:.|.:.
Mouse   131 EYVRLNDAYKEKSSSHTSLFSGSSSSTKYDPDILKAE-ISTTQLRVKKLKREL-SHMKQELLYKQ 193

  Fly  1642 QRNEDGMQDDE----SDNDFTFNDAE---TESDS----------------------------DDN 1671
            |..|...|.||    ..:.:..|:|:   ||..|                            |.|
Mouse   194 QGFETLQQIDEKMSGGQSGYELNEAKAILTELKSIRKAISSGEKEKQDLMQSLAKLQERFHLDQN 258

  Fly  1672 QSNQE--------------VQRSVQAGATVGSENDIGV-----------LFLEDESGDSSAQE-- 1709
            ..:.|              .::::.||:......||||           |.|:.|....|...
Mouse   259 MGSSEPDLRSSPVNSHLSLSRQTLDAGSQTSISGDIGVRSRSNLAEKVRLSLQYEEAKRSMANLK 323

  Fly  1710 -EDGSEDGES-----DDQSDE---FNFNEQQL--------ERRSTNSNARSDLAPQTMQWAIRSR 1757
             |....|||:     |.:.::   .|..|:.|        ::||.....|.:...|.::..:.:
Mouse   324 IELSKLDGEAWPGALDIEKEKLMLINEKEELLKELQFITPQKRSQEELERLEAERQHLEEELMA- 387

  Fly  1758 DTARSSVRVPTGSNMVFIDPMALRRSTVP--ASTTVTTPSIEPHTMATTASNLARAFGITIRQIS 1820
              ||.|   |:.:....:.....|:..:.  ..||..|.|:.....:.::|.|:.:.|.::..::
Mouse   388 --ARGS---PSRALTERLKLEEKRKELLQKLEETTKLTTSLYSQLQSLSSSTLSMSSGSSLGSLA 447

  Fly  1821 ELISIL------SYNVLNDIETSLKIQNDEAIAVQAFVEKRLKATWDWMFTVMDGTEAQLKF--- 1876
            .....|      |.|.|:..|.....|.|:                      || |:.|.|.
Mouse   448 SSRGSLNTSSRGSLNSLSSSELYYSSQGDQ----------------------MD-TDYQYKLDFL 489

  Fly  1877 ----GAYLTNYTDPNHPLHPLNLSAQASSSQTPAPATSSSVNGVNIMGSNSRRDFFTYCLSLMRS 1937
                |.|:     |:.|:..::.:....|...|.   .|.:.||.:..|               |
Mouse   490 LQEKGGYI-----PSGPITTIHENEVVKSPSQPG---QSGLCGVGVTAS---------------S 531

  Fly  1938 HTSEHRDALPVLDITALRHIAYVLDAFVYYMRNDSGFYDKQDTISGRINNLSPMTESYDTDDELA 2002
            ||                                                 :|:||:
Mouse   532 HT-------------------------------------------------TPLTEA-------- 539

  Fly  2003 NLEEFNADVQMSASSMPSGSQGTRRHAFFARSESTLSLGCSAPEGFELPLDMAMPLAD---KPHL 2064
                     ..|.:|:.|.|                ||...:|.|..|.||...|.:.   .||.
Mouse   540 ---------SKSVASLSSRS----------------SLSSLSPPGSPLVLDSVFPGSSHDTSPHQ 579

  Fly  2065 LQPNSKRQEL---FANLPLLVTTNANNSGATNDGDGGSIFDYTPTRLGFSNSLKRNERVYETVPI 2126
            ...:.:..||   ||::.|      ..:.|..|.|.|          |.|..|..::.:.:.
Mouse   580 FPTDFEDCELSRRFADVGL------GENQALLDSDSG----------GASQPLLEDKGLSDC--- 625

  Fly  2127 DSSKTGDGNVTNKAEGSTDSNIYVQLKKKQGSDDFKSHKEADGNQSKYEKVVLMETDDSLPSTSK 2191
                  .|.:.  .||:||  :...|.|::|     .|...|    |..:|....:|:|:...|.
Mouse   626 ------PGELL--CEGATD--VEKSLPKRRG-----LHLRGD----KTTRVSAAASDESVAGDSG 671

  Fly  2192 STEALMATRPEVIIAP-NKASVSPATAARSVIVL---AGGSCLKTIDSDINNYSASNLSTAEQAK 2252
            ..||.|....|:...| ::..|:....|:..|.|   ...|....|.:.:.|..|.::..:.:..
Mouse   672 VYEASMKQPGEMEDVPYSEEDVTIVETAQVQIGLRYDTKSSSFMVIIAQLRNLHAFSIPHSSKVY 736

  Fly  2253 CDTQYQKSTSDHLLLF-----PARGSQFY------------------------------------ 2276
            .......|::|...||     |...|..|
Mouse   737 FRVALLPSSADVSCLFRTKVHPPTESVLYNDVFRVAVSQAALQQKTLRVDLCSASKHRREECLAG 801

  Fly  2277 -QSNFSELPSWNFLLSRWKLTLDLFGRVFMDDVGMEHGSVLPELRG-----FPV----------- 2324
             |.:.::||..|.:...|   .:|.....|.....|.|:..|..|.     .|:
Mouse   802 TQISLADLPFSNEIFMLW---YNLLPSKQMPCKKNEDGNEEPGARSQQPMLDPIDLDAVSALLAR 863

  Fly  2325 ---------KEMRFRRHMEKL---RNGQQRDLVLCKLERNRESLIVQTFKELNTQFGNQSRRIQP 2377
                     :|:......|:|   |.|..||.:....|.:.|.   ...:|........||..:.
Mouse   864 TSAELLAVEQELAQEEEEEELRPERRGPGRDCLTMLREASDEP---AALRESGVPLAEGSRCTED 925

  Fly  2378 PITFNRVKVT--FKDEPGEGSGVARSFYTSIAEALLASAKIPNLESVQVGTNH----------SK 2430
            |....|...|  .:.||.|..|...|...::.:      |..|.:.| |.:|.          |.
Mouse   926 PKPCPRGPETSQCRKEPAEDPGQLPSGLPTLVD------KETNTDEV-VDSNMAVRPKDRSSLSS 983

  Fly  2431 YVVPF---SSILRSRTVSGSSRDQ--STLQRRGSNSKIL------WRSARERKALNLDARPYTPP 2484
            ...||   |.|:||:|.|...|.|  ..|.|..|:|..|      .|::.||::|.:......|.
Mouse   984 RQHPFVRNSVIVRSQTFSPGERSQYICRLNRSDSDSSTLAKKSLFVRNSTERRSLRVKRAVCQPT 1048

  Fly  2485 -----------NSSD-------NATPES-LNDHLSVHLQQIGERLYPKIHSINQTHAPKITGMLL 2530
                       .|.|       :.|.:| |||.|.. |:.:.::| .::.:..:|..|  .|:|.
Mouse  1049 LRRTAQECPVRTSLDLELDLQASLTRQSRLNDELQA-LRGLRQKL-EELKAQGETDLP--PGVLE 1109

  Fly  2531 EIPTPQLLSV---------------ISSDETLRQKVNEAIEIITFKQKSETSAQSSQPK------ 2574
            :....:||..               ::::..:||...:...:....||.....||.:.|
Mouse  1110 DERFQKLLKQAEKQAEQTKEEQKQDLNAERLMRQVSKDVCRLREQSQKEPRQVQSFREKIAYFTR 1174

  Fly  2575 ---KSPSVVVVDPVDD 2587
               ..||:    |.||
Mouse  1175 AKISIPSL----PADD 1186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562	43/234 (18%)
		PolyA	2498..2561	CDD:197769	11/77 (14%)
		HECTc	2589..2885	CDD:238033
		HECTc	2589..2884	CDD:214523
Wwc2	NP_598552.2	WW	12..41	CDD:278809
		WW	59..88	CDD:278809
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	438..464		4/25 (16%)
		C2_Kibra	699..822	CDD:176062	19/125 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	830..849		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	874..963		21/97 (22%)
		Phage_Nu1	<1088..>1146	CDD:294991	9/60 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900