|
Fly 1 MVSMQFVLQPLPGSDDQFIERIREVSDKVNRFGYGSH---RIFEQLKIPVKEVVIGPAHIGVLLE 62
|.|:.||:.||||::||..:|:||||:|:|::...|| .:.||..| |:.|:||.|...|||
Human 1 MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATI--KQCVVGPNHAAFLLE 63
Fly 63 DGKAFRVSFSINSEKLDLTKSD----AKCSTSGGSGTAS----ASKAP---SSSRPMARSRARLL 116
||:..|:.||:..::|:|.|.| :|.:::.|:|..| .|.:| |.|..:.|.....|
Human 64 DGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTSRPGRTSDSPWFLSGSETLGRLAGNTL 128
Fly 117 RATGRSNSTGQGSGS------------RSTGVII------GGSTSSRPLVTVPATYVPEELISQA 163
.:...|...|.|.|| |.|.||. .|...|:|...:||:.:||||||||
Human 129 GSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVIPASVIPEELISQA 193
Fly 164 EVVLQGKSRNLIIRELQRTNLDVNLAVNNLLSRDDEEAEDTEEGA-DNYVP-EDLISLLDNGFSG 226
:||||||||::|||||||||||||||||||||||||:.:|.::.| ::|:| |||:||||.....
Human 194 QVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASESYLPGEDLMSLLDADIHS 258
Fly 227 DNNSVIIDPSDGLFSEEI-FSNYSSIRNLLFDRIRSERSNANANAADSNQSTTRSTSSGTALTGN 290
.:.||||| :|.:|||:| :..|.|.|.....|:.|.|........||
Human 259 AHPSVIID-ADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLPLERDS----------------- 305
Fly 291 SGLSAQISVNADREAFSRWRDRQYYGPRRWISKDDYTWEKDADSKKKEP------SPMLSPIWIS 349
.:..:||:..|.|: |||:....:..|:.:.||:.|| :|:.||:.:.
Human 306 -------ELLRERESVLRLRE------RRWLDGASFDNERGSTSKEGEPNLDKKNTPVQSPVSLG 357
Fly 350 EELQPWPEKSSVRFKTIGALYSEFIALSESGDLYQWRWSDAEPYK-SETENVYHPKTVSLNIV-E 412
|:||.||:|...:|..|||||||.:|:|..|:||||:||::|||: ::..:::||:...|.:. |
Human 358 EDLQWWPDKDGTKFICIGALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLTNE 422
Fly 413 RVELISANFIRCSVVTETNRVATWMDEQLGYIGAKLEHSCCAFNEFISDSITKIYVCSLYTVVKT 477
::.|:|||.||.:|.||.|:||||:||.|..:.:||||:...::|...:.|..::.|:|||..:.
Human 423 KIVLLSANSIRATVATENNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCALYTCAQL 487
Fly 478 ESNNIYWWGVLPFDQRRFLWDKFRTKTKKPFKVVA----TDINVGAQVIMKKCPMYQSGSIGFTC 538
| |::|||||:||.||:.:.:|.|.|.|||..... .:|.||.||.::..|:|.:|::.|:.
Human 488 E-NSLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSI 551
Fly 539 SNGVPKVGQLLNSVWTFTDVCRMKIININTNSGVDKSQAAGNNLNAHGITPDKDLPKSTAMPSTG 603
|.|:||||.|:.|||...|.||.::.:..:...::|
Human 552 SAGIPKVGVLMESVWNMNDSCRFQLRSPESLKNMEK----------------------------- 587
Fly 604 SSKNGQSFSNSKESTDRIDMPPPPSPASSTCSDTGSVTS-----HKRTKRATTKEDSNAPQEGRK 663
:||..::...||:...:.:|.|||||| |||||..|:.| :|| :|:|. ||:|..|
Human 588 ASKTTEAKPESKQEPVKTEMGPPPSPA-STCSDASSIASSASMPYKR-RRSTP-----APKEEEK 645
Fly 664 -DEELWEVKDVVFVED-KVGPVGKVLKVDGDFVAVRFPAINAAAVAAAAAATSSTSNTASTSKEE 726
:||.|.:::|||||| |..||||||||||.:|||:|| .|||.:|..::|
Human 646 VNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFP------------GTSSNTNCQNSS--- 695
Fly 727 GKEDD----WQQCRLLRREDVQIFRTAMSTRGPDWLQKQPKKINVGGDAAGAQILTLAVDSRGIH 787
|.:.| .|.|||||.:::|:.:|..:.:.||..|:.|||:.: ....:||.:.|||:|:|
Human 696 GPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCI---PEKTEILAVNVDSKGVH 757
Fly 788 VIKKVLGKIHYSLYNLYNCKQEQNCLFPTDCNSFIGSTPGNILMACNDDCSGNSSTIVLRDGNGA 852
.:.|....:.|.:::|...|.||...|||...:|:|....|:.:. .:|..|.|:||||||.
Human 758 AVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIF----TAGQESPIILRDGNGT 818
Fly 853 LYPLAKDCLGSIKDPQWFDLPPVKSITM---STISLPAMLSGVNLKSKVCMTALLFDTQKLMPHI 914
:||:||||:|.|:||.|.||||:.|:.| |.|:||| ...:|.|..:..:..:.|.||.||
Human 819 IYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPA---NSTIKKKAAVIIMAVEKQTLMQHI 880
Fly 915 LRCDVKNSFAALGRLEREDQADTALVVEE-----------RCDGARNIFHACVIMCAPSSNKDSP 968
||||.:.....|..||: |:|:|: ||||.|||.||||.:|.|:|||::.
Human 881 LRCDYEACRQYLMNLEQ------AVVLEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETK 939
Fly 969 PDSPSGGVEKKSLVGLSVARSIPTVSTSAYVSSIAFGASASSSNENSSFATMSSSAAGSASSTSR 1033
.:..:...|:.:. ....:.|.:||...|..|||. ..:.|||:||.|
Human 940 EEEEAERSERNTF-----------AERLSAVEAIANAISVVSSNG-------PGNRAGSSSSRS- 985
Fly 1034 DNRTNLRDMMNRLINSDQAEQSGSQPMATNNEDH-----------AYIPWPAE-----------T 1076
..||:||.| |.:|...|......::.|| :::|.|.. .
Human 986 ---LRLREMMRR---SLRAAGLGRHEAGASSSDHQDPVSPPIAPPSWVPDPPAMDPDGDIDFILA 1044
Fly 1077 PAASNLSASSS---QNVSDSIEDDISKIIPSSSQSSMLSNIKLGSPTYTFDLAQRREHALTILQQ 1138
||..:|:.::: |..|.| .||..|....:...| .|:.:|..||:.
Human 1045 PAVGSLTTAATGTGQGPSTS-------TIPGPSTEPSVVESK-----------DRKANAHFILKL 1091
Fly 1139 MCVSPALRPYLCHMLSTKDAQGQTPFMLSVSCRAYEAGIILLNTI-------LMLSEQDPQLKEA 1196
:|.|..|:|||..:||.|||:|.||||.:||.|||.|.|.:|.|. :..||::..:...
Human 1092 LCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIAKAEISSSEKEEDVFMG 1156
Fly 1197 MIFPNGSPADQSPLHVICYNDTCSFTWTGADHINQNIFECKTCGLTGSLCCCTECARVCHKGHDC 1261
|:.|:|:..|.|||:|:|.|||||||||||:||||:||||:||||..||||||||||||||||||
Human 1157 MVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCGLLESLCCCTECARVCHKGHDC 1221
Fly 1262 KLKRTAPTAYCDCWEKCKCKALIAGNLTKRFALLCKLVSCTDLVTKFNSKGESILLFLIQTVGRQ 1326
|||||:||||||||||||||.||||..:.|..||.:|::.|:|||..||:||.:||||:|||.||
Human 1222 KLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQTVARQ 1286
Fly 1327 IVEQRQYRFSVRVRNVSTAATGATGNNSVISNRKTSAAEIDNDMPDHDLEPPKFARKALERLLID 1391
.||..||| ..|:|. ..||||::.| |:||||||||||:||:.||||:|.|
Human 1287 TVEHCQYR-PPRIRE--------------DRNRKTASPE-DSDMPDHDLEPPRFAQLALERVLQD 1335
Fly 1392 WNAVRSMIMSGAERGDVPNPAGSASENSNSEGFNMFIQTQHGSTLLDKFTHSLIVKCTSD--HLD 1454
|||::||||.|::....|..|.|...:...|. .:::..|.|:..||.|||.||||||:| .||
Human 1336 WNALKSMIMFGSQENKDPLSASSRIGHLLPEE-QVYLNQQSGTIRLDCFTHCLIVKCTADILLLD 1399
Fly 1455 TLLLTLVRELQNASVSNRSKEAEEVVRRFVRSVARVFVIFNLEKQPNPEKRKSHSSCNKYVQSCV 1519
|||.|||:||||.....|.:||..|..||:|||||||||.::|. ...:|.::...:.:..|.
Human 1400 TLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEM---ASSKKKNNFIPQPIGKCK 1461
Fly 1520 KVFQTLHKISIEELCEVSEALIAPVRLGVVRPTAPFTMSSSNLD-VRNSDDLFSVDPLAPSNVES 1583
:|||.|...::||||.|:|:||.|||:|:.|||||||::|:::| ::.|::||||:||.| .
Human 1462 RVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSIDAMQGSEELFSVEPLPP----R 1522
Fly 1584 PSEQILVHDAGNDQSANFNIQQNYDVVAMETIRDASESEEVINR--------------------- 1627
|| :|||::.:..|:..::.....|..|:|:.|..|
Human 1523 PS---------SDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEEQDDIVSADVEEVEVVEGV 1578
Fly 1628 --EANSHNQDDELIENQRNEDGMQD--DESDNDFTFN---DAETESDSDDNQSNQE---VQRSVQ 1682
|.:.|::.:|..|.....:|..| ||..:|...: .|||||||:.|.|||: .:|||.
Human 1579 AGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAAETESDSESNHSNQDNASGRRSVV 1643
Fly 1683 AGATVGSE---NDIGVLFLEDESGDSSAQEEDGSEDGESDDQSDEFNFNEQQLERRSTNSNAR-S 1743
..||.||| :.:...|.||:|..:.:.:.| |...:|||...|....::.|||.:.:|:|. :
Human 1644 TAATAGSEAGASSVPAFFSEDDSQSNDSSDSD-SSSSQSDDIEQETFMLDEPLERTTNSSHANGA 1707
Fly 1744 DLAPQTMQWAI------RSRDTARSSVRVPTGSN--MVFIDPMALRRS-TVPASTTVTTPSIEPH 1799
..||::||||: |:..||.||...|..|: :::|||..|||| |:..|......::|..
Human 1708 AQAPRSMQWAVRNTQHQRAASTAPSSTSTPAASSAGLIYIDPSNLRRSGTISTSAAAAAAALEAS 1772
Fly 1800 TMA---TTASNLARAFGITIRQISELISIL-SYN--VLNDIETSLKIQNDEAIAVQAFVEKRLKA 1858
..: |:||:||||:.|.|||||:|:.:: .|| |.:.|..::|:...:|:.:|.:||::|..
Human 1773 NASSYLTSASSLARAYSIVIRQISDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIP 1837
Fly 1859 TWDWMFTVMDGTEAQLKFGAYLTNYTDPNHPLHPLNLSAQASSSQTPAPATSSSVNGV------N 1917
||:||.::||.|||||::|:.|.:..||.||.|||:.|..::..:.......:|:..: .
Human 1838 TWNWMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRAT 1902
Fly 1918 IMGS-----NSRRDFFTYCLSLMRSHTSEHRDALPVLDITALRHIAYVLDAFVYYMR--NDSGFY 1975
::.: ::|.||..|.|||||||..||.|.|||||:.:|:|:|||..|.:|::: |.....
Human 1903 LLSARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTL 1967
Fly 1976 D--------KQDTISGRINNLSPMTESYDTDDELANLEEFNADVQMSASSMPSGSQGTRRHAFFA 2032
| .::.:...|:|.....|:.|..::.|.|.:.:.| |:| ::..:.|.||.
Human 1968 DTPQLERKRTRELLELGIDNEDSEHENDDDTNQSATLNDKDDD------SLP--AETGQNHPFFR 2024
Fly 2033 RSESTLSLGCSAPEGFELPLDMAMPLADKPHLLQPNSKRQELFANLPLLVTTNANNSG-----AT 2092
||:|...|||..|..||:||..|:||||:|||||||:::::||......:.:::.:|| .|
Human 2025 RSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVT 2089
Fly 2093 NDGDGGSIFDYTPTRLGFSNSLKRNERVYETVPIDSSKTGDGNVTNKAEGSTDSNIYVQLKKKQG 2157
.| .:..:..||::.::.:|| ||.|.. ..:||:|
Human 2090 VD---RNCLEVLPTKMSYAANLK-------------------NVMNMQ----------NRQKKEG 2122
Fly 2158 SDDFKSHKEADGNQSKYEKVVLMETDDSLPSTSKSTEALMATRPEVIIAPNKASVSPATAARSVI 2222
.: :.|:..||:.|.|..|....| |.:..:..|...:
Human 2123 EE---------------QPVLPEETESSKPGPSAHDLA--------------AQLKSSLLAEIGL 2158
Fly 2223 VLAGGSCLKTIDSDINNYSASNLSTAEQAKCDTQYQKSTSDHLLLFPARGSQFYQSNFSELPSWN 2287
..:.|..| |:.:.:| |....:.|.:
Human 2159 TESEGPPL----------------TSFRPQC------------------------SFMGMVISHD 2183
Fly 2288 FLLSRWKLTLDLFGRVFMDDVGMEHGSVLPELRGFPVKEMRFRRHMEKLRNGQQRDLVLCKLERN 2352
.||.||:|:|:|||||||:|||.|.||:|.||.||.|||.:|||.||||||.|.|||.| :::|:
Human 2184 MLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNQQSRDLSL-EVDRD 2247
Fly 2353 RESLIVQTFKELNTQFGNQSRRIQPPITFNRVKVTFKDEPGEGSGVARSFYTSIAEALLASAKIP 2417
|:.||.||.::||..||. |....|:..:||||||||||||||||||||||:||:|.|::.|:|
Human 2248 RDLLIQQTMRQLNNHFGR--RCATTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLP 2310
Fly 2418 NLESVQ---VGTNHSKYVVPFSSILRSRTVSGSSRDQSTLQRRGSNSKILWRSARE---RKALNL 2476
|||.:| .||:.| ....||:|......|::....||.|..:...|..|: |:.|::
Human 2311 NLECIQNANKGTHTS-----LMQRLRNRGERDREREREREMRRSSGLRAGSRRDRDRDFRRQLSI 2370
Fly 2477 DARPYTPP---NSSDNATPESLNDHLSVHLQQIGERLYPKIHSINQTHAPKITGMLLEIPTPQLL 2538
|.||:.|. |.||:..| |..|.|.:||||||::.::....|.||||||||:...|||
Human 2371 DTRPFRPASEGNPSDDPEP------LPAHRQALGERLYPRVQAMQPAFASKITGMLLELSPAQLL 2429
Fly 2539 SVISSDETLRQKVNEAIEIIT---------------FKQKSETSAQSSQPK--KSPSVVVVDPVD 2586
.:::|:::||.:|:||:|:|. ....||...|.::.: .|.|||.:|..|
Human 2430 LLLASEDSLRARVDEAMELIIAHGRENGADSILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDD 2494
Fly 2587 ----DDNEPLFYSPGKRGFYTPRQGFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYIL 2647
|||.||||.||||||||||.|..:..|:|.||||||::|||||||||.|:.|.|||:|.:|
Human 2495 TDDGDDNAPLFYQPGKRGFYTPRPGKNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLL 2559
Fly 2648 GRKIKFHDLAFFDPALYESFRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCGNRELIPGGRDV 2712
|||:.:||.|||||.:|||.||:|..:|:.:.:...:.|:|.|.|||.||||.|..||||.|.::
Human 2560 GRKVNWHDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNI 2624
Fly 2713 AVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVST 2777
.||..|::||||:|.|:|::...|:.|.|::.|:.||||.||:.:|||||.|||:||.|::||..
Human 2625 PVTPQNVYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQM 2689
Fly 2778 LISYTTFNDESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPLPSVTI 2842
|||:|:|||||.|..:|||:||:|||||||||::.||||||||||.||:||||||||||:||:||
Human 2690 LISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITI 2754
Fly 2843 RPADDSHLPTANTCISRLYIPLYSSKSILRSKMLMAIKSKNFGFV 2887
||.||.|||||||||||||:||||||.||:.|:|:|||:||||||
Human 2755 RPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2799
| 
