DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hyd and HERC5

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	XP_011530324.2	Gene:	HERC5 / 51191	HGNCID:	24368	Length:	1100	Species:	Homo sapiens

Alignment Length:	1038	Identity:	186/1038 - (17%)
Similarity:	330/1038 - (31%)	Gaps:	304/1038 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  2001 LANLEEFNADVQMSASSMPSGSQGTRRHAFFARSESTLSLGCSAPEGFELPLDMAMPLADK--PH 2063
            ||.||...|.||:  ..:.:||.|.|                 .|:..:|..:|.:...|:  .|
Human   214 LAVLERGGAGVQV--HQLLAGSGGAR-----------------TPKCIKLGKNMKIHSVDQGAEH 259

  Fly  2064 LLQPNSKRQELFANLPLLVTTNANNSGATNDGDGGSIFDYTPTRLGFSNSLKRNERVYETVPIDS 2128
            :|..:|                        ||......:|:...|.|.:.|:..:.:..|
Human   260 MLILSS------------------------DGKPFEYDNYSMKHLRFESILQEKKIIQIT----- 295

  Fly  2129 SKTGDGNVTNKAEGSTDSNIYVQLKKKQGSDDFKSHKEADGNQSKYEKVVLMETDDSLPSTSKST 2193
              .||               |..|...:|.:.|...:...|......|         .|||
Human   296 --CGD---------------YHSLALSKGGELFAWGQNLHGQLGVGRK---------FPST---- 330

  Fly  2194 EALMATRPEVI---IAPNKASVSPATAARSVIVLAGG-----------------------SCLKT 2232
                 |.|:::   .....|.:|...|....:.::|.                       |.::.
Human   331 -----TTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEG 390

  Fly  2233 IDSDINNYSASNLSTAEQAKCDTQYQKSTSDHLLLFP----ARGSQFYQSNFSEL-PSWNFLLSR 2292
            :|:          ...|...|...:....:...|||.    ..|...:.|..:|| |.....|..
Human   391 LDN----------QKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVG 445

  Fly  2293 WKLTLDLFGR----VFMDDVG------------MEHGSVLPELRGFPVK-----EMRFRRHMEK- 2335
            :::|....||    .::.|:|            :.:|....:|...|||     |::...|..:
Human   446 YRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLESHTSEK 510

  Fly  2336 ----LRNGQQRDLVLCKLERN-----------RESLIVQ------------TFKELNTQFG---- 2369
                :..|.|..|:..|.|.:           .|..:.:            |.:|:...|.
Human   511 ELIMIAGGNQSILLWIKKENSYVNLKRTIPTLNEGTVKRWIADVETKRWQSTKREIQEIFSSPAC 575

  Fly  2370 ---------------------NQSRRIQPPIT-----FNRVKVTFKDE-----PGEGSGVARSFY 2403
                                 |::|.|...:|     .|.:....||.     |         |:
Human   576 LTGSFLRKRRTTEMMPVYLDLNKARNIFKELTQKDWITNMITTCLKDNLLKRLP---------FH 631

  Fly  2404 TSIAEALLASAKIPNLESVQVGTNHSKYVVPFSSILRSRTVSGSSRDQSTLQRRGSNSKIL---W 2465
            :...|||.....:|....:.:..|....||||:.::...:      |||:|        :|   |
Human   632 SPPQEALEIFFLLPECPMMHISNNWESLVVPFAKVVCKMS------DQSSL--------VLEEYW 682

  Fly  2466 RSARER---------KALNLDARPYTPPNSSDNATPESLNDHLSVHLQQIGERLYPKIHSINQTH 2521
            .:.:|.         |...:....|...::.:|...::|.:.|.            |:|...:..
Human   683 ATLQESTFSKLVQMFKTAVICQLDYWDESAEENGNVQALLEMLK------------KLHRSKKHK 735

  Fly  2522 APKITGMLLEIPTPQLLSVISSDETLRQKVNEAIEIITFKQKSETSAQSSQ-------------- 2572
            |...:..:.|....:.....:.|.|:|:  |..||.: ..|.|:...:..:
Human   736 AYLRSAAIEEERESEFALRPTFDLTVRR--NHLIEDV-LNQLSQFENEDLRKELWVSFSGEIGYD 797

  Fly  2573 ----PKKSPSVVVVDPVDDDNEPLFYSPGKRGFYTPRQGFASFERINAFRNIGRLIGL----CLL 2629
                .|:....:..:.:..:.....|..|....:.|.:  ..||:...| ..|.|.||    |.:
Human   798 LGGVKKEFFYCLFAEMIQPEYGMFMYPEGASCMWFPVK--PKFEKKRYF-FFGVLCGLSLFNCNV 859

  Fly  2630 QNELLPLFLQRHVLKYILGRKIKFHDLAFFDPALYESFRQIIQNAQTKEGEETINRMELCFVIDL 2694
            .|...||.|    .|.:|.:.....||....|.|.::.:.::.:    ||:    ..|..|.|..
Human   860 ANLPFPLAL----FKKLLDQMPSLEDLKELSPDLGKNLQTLLDD----EGD----NFEEVFYIHF 912

  Fly  2695 MKEEGCGNRELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLT 2759
            .......:..|||.|..:.|..:|..:||.:|..|....|.:...|..:.|.:.:..::.:....
Human   913 NVHWDRNDTNLIPNGSSITVNQTNKRDYVSKYINYIFNDSVKAVYEEFRRGFYKMCDEDIIKLFH 977

  Fly  2760 AEDLRLLLNGVGDINVSTLISYTTFN-DESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTG 2823
            .|:|:.::.|..|.:..|......:. ..:|..|..::     ||....|:.:.|::..:.|.||
Human   978 PEELKDVIVGNTDYDWKTFEKNARYEPGYNSSHPTIVM-----FWKAFHKLTLEEKKKFLVFLTG 1037

  Fly  2824 SPALPASEEGFQPLPSVTIRPADDSHLPTANTCISRLYIPLYSSKSILRSKMLMAIKSKNFGF 2886
            :..|...:.....:........::.....|.||.|.|::|.||:...:...:..|| :.|.||
Human  1038 TDRLQMKDLNNMKITFCCPESWNERDPIRALTCFSVLFLPKYSTMETVEEALQEAI-NNNRGF 1099

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	11/62 (18%)
		HECTc	2589..2885	CDD:238033	65/300 (22%)
		HECTc	2589..2884	CDD:214523	64/299 (21%)
HERC5	XP_011530324.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900