DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and Magi1

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	XP_038964101.1	Gene:	Magi1 / 500261	RGDID:	1586025	Length:	1491	Species:	Rattus norvegicus

Alignment Length:	1795	Identity:	312/1795 - (17%)
Similarity:	511/1795 - (28%)	Gaps:	697/1795 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   968 PPDSPSGGVEKKSLVGLSVARSIPTVSTSAYVSSIAFGASASSSNENSSFATMSSSAAGSASSTS 1032
            ||..|..|                .|.|:..:.|:..|:..|:.....|:..|.:  ||.. .|.
  Rat   192 PPSQPVSG----------------KVITTDALHSLQSGSKQSTPKRTKSYNDMQN--AGIV-HTE 237

  Fly  1033 RDNRTNLRDMMNRLINSDQAEQSGSQPMATNNEDHAYIPWPAETPAASNLSASSSQNVSD----S 1093
            .:...::.:|     ||.....||.|...|..|  |.:| |..:.|.:......||....    |
  Rat   238 NEEEEDVPEM-----NSSFTADSGDQDEPTLQE--ATLP-PVNSSALAAPITDPSQKFPQYLPLS 294

  Fly  1094 IEDDISKIIPSSSQSSMLSNIKLGSPTYTFDLAQRREHALTILQQMCVSPALRPYLCHMLSTKDA 1158
            .||::.. :|.:.:.:...|    ...|..|   ......:.|...|::...:|.
  Rat   295 AEDNLGP-LPENWEMAYTEN----GEVYFID---HNTKTTSWLDPRCLNKQQKPL---------- 341

  Fly  1159 QGQTPFMLSVSCRAYEAGIILLNTILMLSEQDPQLKEAMIFPNGSPADQSPLHVICYNDTCSFTW 1223
                     ..|...|.|:       ...|.|.:|:    .|.|....:.|::.:.|
  Rat   342 ---------EECEDDEEGV-------HTEELDSELE----LPAGWEKIEDPVYGVYY-------- 378

  Fly  1224 TGADHINQNIFECKTCGLTGSLCCCTECARVCHKGHDCKLKRTAPTAYCDCWEKCKCKALIAGNL 1288
              .||||:     ||
  Rat   379 --VDHINR-----KT-------------------------------------------------- 386

  Fly  1289 TKRFALLCKLVSCTDLVTKFNSKGESILLFLIQTVGRQIVEQRQYRFSVRVRNVSTAATGATGNN 1353
                                                       ||                  .|
  Rat   387 -------------------------------------------QY------------------EN 390

  Fly  1354 SVISNRKTSAAEIDNDMPDHDLEPPKFARKALERLLIDWNAVRSMIMSGAERGDVPNPAGSASEN 1418
            .|:..::....|.......|..:|.:......|    :|.         .:...|..|...:...
  Rat   391 PVLEAKRKRQLEQQQQQQQHQQQPQQPQPPQPE----EWT---------EDHASVVPPVAPSHPP 442

  Fly  1419 SNSE--------GFNMFIQTQHGSTLLDKFTHSLIVKCT---------SDHLDTLLLTLVRELQN 1466
            ||.|        |...|  |::.|.|..||.|:.:.|.:         .|..|..|......|..
  Rat   443 SNPEPAREAPLQGKPFF--TRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDG 505

  Fly  1467 ASVSNRSKEAEEVVRRFVRSVARVFVIFNLEKQPNPEKRKSHSSCNKYVQSCVKVFQTLH-KISI 1530
            .:..:...|..:|    :.||....|:.:...|                  .||:||::. ..|:
  Rat   506 PAALDGKMETGDV----IVSVNDTCVLGHTHAQ------------------VVKIFQSIPIGASV 548

  Fly  1531 E-ELC----------EVSEALIAPVRL---------GVVRPTAPFTMSSSNLDVRNSDDLFSVDP 1575
            : |||          :.:.:|:..|.:         |.....:|.:.||....|.|..|   ..|
  Rat   549 DLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVSNMKD---ARP 610

  Fly  1576 LAPSNVESPS-------------------EQILVHDAGNDQSANFNI--------QQNYDVVAME 1613
            .:|::|.|.|                   |.|.||.........|.|        |:...:|...
  Rat   611 SSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSP 675

  Fly  1614 TIRDASESEEVI-----NREANSHNQ-DDELIENQRNEDGMQDDESDNDFTFNDAETESDSDDNQ 1672
            ..|...|.:.::     |.:|.:||| .|.|||..:
  Rat   676 RCRGLKEGDLIVEVNKRNVQALTHNQVVDMLIECPK----------------------------- 711

  Fly  1673 SNQEVQRSVQAGATVGSENDIGVLFLEDESGDSSAQEEDGSEDGESDDQSDEFNFNEQQLERRST 1737
             ..||...||.|.          |.:..:|..|                        |.|||:.:
  Rat   712 -GSEVTLLVQRGG----------LPVPKKSPKS------------------------QPLERKDS 741

  Fly  1738 NSNARSDLAPQTMQWAIRSRDTARSSVRVPTGSNMVFID-PMALRRSTVPA-----STTVTTPS- 1795
            .::::..::      ::||..||.     |:.|..|..: |.|    .|||     |:....|.
  Rat   742 QNSSQHSVS------SLRSLHTAS-----PSHSAQVLPEYPPA----DVPAPDQTDSSGQKKPDP 791

  Fly  1796 ----------IEPHTMA-TTASNLARAFGITIRQISELISILSYNVLNDIETSLKIQNDEAIAVQ 1849
                      .|...|: :.||.|::  |...|:|         |..|..|..:....::.|.:
  Rat   792 FKIWAQSRSMYENRPMSPSPASGLSK--GERDREI---------NSTNFGECQIPDYQEQDIFL- 844

  Fly  1850 AFVEKRLKATWDWMFTVMDGTEAQLKFGAYLTNYTDPNHPL---HPLNLSAQASSSQTPAPATSS 1911
                        |        ..:..||..:....:|..|:   |.:.|.|..:..:..:.....
  Rat   845 ------------W--------RKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELI 889

  Fly  1912 SVNGVNIMGSNSRRDFFTYCLSLMRSHTSEHRDALPVLDITALRHIAYVLDAFVYYMRNDSGFYD 1976
            .|:|..::|.:.:     ..:.||:....:..     :::|..|.:.:
  Rat   890 CVDGTPVIGKSHQ-----LVVQLMQQAAKQGH-----VNLTVRRKVVF----------------- 927

  Fly  1977 KQDTISGRINNLSPMTESYDTDDELANLEEFNADVQMSASSMPSGSQGTRRHAFFARSESTLSLG 2041
               |:....|.:.....|:.:.::.|:|.|.....|.|.:|:.:.|.|         |.||..:|
  Rat   928 ---TVPKAENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSG---------SGSTSGIG 980

  Fly  2042 CSAPEGFELPLDMAMPLADKPHLLQPNSKRQELF-------ANLPLLVTTNANNSGATNDGDGGS 2099
            .....|     ...:....:|:.::......|.|       .:.|...||.|.|:...
  Rat   981 SGGGGG-----SGVVSAVLQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFAGNACVA------- 1033

  Fly  2100 IFDYTPTRLGFSNSLKRNERVYETVPID---SSKTGDG-------NVTNKAEGSTDSNIYVQLKK 2154
                .|.::|         |:.|..|.|   ..|.||.       ::|||:.    |:| |.|.|
  Rat  1034 ----MPHKIG---------RIIEGSPADRCGKLKVGDRILAVNGCSITNKSH----SDI-VNLIK 1080

  Fly  2155 KQGSDDFKSHKEADGNQS-------KYEKVVLMETDDSLPSTSKSTEALMATRPEVIIAPNKASV 2212
            :.|:.  .:.:...|::|       ..||:..:.|..: ||...:.|....|:|:.
  Rat  1081 EAGNT--VTLRIIPGDESSNATLLTNAEKIATITTTHA-PSQQGTQETRTTTKPKP--------- 1133

  Fly  2213 SPATAARSVIVLAGGSCLKTIDSDINNYSASNLSTAEQAKCDTQYQKSTSDHLLLFPARGSQFYQ 2277
                                 ||........  :|.||.....:.::....  ..|..||.:.|
  Rat  1134 ---------------------DSQFEFKGPQ--ATQEQDFYTVELERGAKG--FGFSLRGGREY- 1172

  Fly  2278 SNFSELPSWNFLLSRWKLTLDLFGRVFMDDVGMEH------GSVLPELRGFPVKEMRFRRHMEKL 2336
                              .:||:.....:|...|.      |..:.|:.|...|.|:..|.:|.:
  Rat  1173 ------------------NMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELI 1219

  Fly  2337 RNGQQRDLVLCK------------LERNRESLIVQTFKELNTQFGNQSRRIQPPITFNRVKVTFK 2389
            :||.:|..:..:            .:||..|...|...|:         |:.||        ..:
  Rat  1220 KNGGRRVRLFLRRGDGSVPEYDPSSDRNGPSTGAQGVPEV---------RLGPP--------DHR 1267

  Fly  2390 DEPGEGSGVARSFYTSIAEA-LLASAKIP--NLE-SVQVGTNHSKYVVPFSSILRSRTVSGSSR- 2449
            ..|...|......:.|...| ..|.||.|  |.| |.|...:|              |.:|:||
  Rat  1268 SHPALESSYPPDLHKSSQHAEKRAHAKDPKGNREHSGQPNEHH--------------TWNGTSRK 1318

  Fly  2450 DQSTLQRRGSNSKILWRSARERKALNLDARPYTPPNSSDNATPESLNDHLSVHLQQIGERLYPKI 2514
            ..|...|........||.|:..         :|..|.....:||...:         |.|
  Rat  1319 PDSGACRPKDRPPDTWREAQPE---------WTATNGPKRRSPEKRRE---------GTR----- 1360

  Fly  2515 HSINQTHAPKITGMLLEIPTPQLLSVISSDETL--RQKVNEAIEII--TFKQKSETSAQSSQPKK 2575
                                       |:|.||  |:|..:..|:.  ..:::|.|..:.|.|.:
  Rat  1361 ---------------------------SADNTLERREKHEKRREMSPERKRERSPTRRKDSSPSR 1398

  Fly  2576 SPSVV--VVDPVDDDNEPLFYSPGKRGFYTPRQGFASFER 2613
            ....:  ::|...........||.:|...|.|:...|.||
  Rat  1399 RRRSLERLLDQRRSPERRRGGSPERRAKSTDRRRARSPER 1438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698	6/66 (9%)
		ASF1_hist_chap	1535..1733	CDD:304562	42/239 (18%)
		PolyA	2498..2561	CDD:197769	9/66 (14%)
		HECTc	2589..2885	CDD:238033	8/25 (32%)
		HECTc	2589..2884	CDD:214523	8/25 (32%)
Magi1	XP_038964101.1	NK	122..293	CDD:418433	28/127 (22%)
		WW	302..331	CDD:395320	5/35 (14%)
		WW	362..393	CDD:197736	13/156 (8%)
		PDZ	469..555	CDD:214570	22/107 (21%)
		PDZ	640..723	CDD:214570	23/112 (21%)
		MAGI_u5	724..806	CDD:406953	22/120 (18%)
		PDZ_signaling	847..922	CDD:238492	13/84 (15%)
		PDZ_signaling	996..1091	CDD:238492	26/121 (21%)
		PDZ	1152..1234	CDD:214570	18/102 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900