DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and Wwc2

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	NP_001102581.1	Gene:	Wwc2 / 498630	RGDID:	1559427	Length:	1194	Species:	Rattus norvegicus

Alignment Length:	1149	Identity:	217/1149 - (18%)
Similarity:	389/1149 - (33%)	Gaps:	348/1149 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 RSNSTGQGSGSRSTGVIIGGSTSSRPLVTVPATYVPEELISQAEVVLQGKSRNLIIRELQRTNLD 185
            |.|...:...|..|.:..|.|:|::        |.|:  |.:||:    .:..|.:::|:|.
  Rat   134 RLNDAYKEKSSSHTSLFSGSSSSTK--------YDPD--ILKAEI----STTRLRVKKLKRE--- 181

  Fly   186 VNLAVNNLLSRDDEEAEDTEEGADNYVPEDLISLLDNGFSGDNNSVIIDPSDGLFSEEIFSNYSS 250
                    ||:..:|....::|.:.      :..:|...||..:...:..:..:.:|     ..|
  Rat   182 --------LSQMKQELLYKQQGFET------LQQIDEKMSGGQSGYELSEAKAILTE-----LKS 227

  Fly   251 IRNLLF-------DRIRS-----ERSNANAN-----------AADSNQSTTRST---SSGTALTG 289
            ||..:.       |.::|     ||.:.:.|           ..:|:.|.:|.|   .|.|:::|
  Rat   228 IRKAISSGEKEKQDLMQSLAKLQERFHLDQNMGSSEPDLRCSPVNSHLSLSRQTLDAGSQTSISG 292

  Fly   290 NSGLSAQISVNADREAFSRWRDRQYYGPRRWISK--------DDYTWEKDADSKKKEPSPMLSPI 346
            :.|:.::.:: |::...|    .||...:|.::.        |...|....|.:|::...:....
  Rat   293 DIGVRSRSNL-AEKVRLS----LQYEEAKRSMANLKIELSKLDGEAWPGALDVEKEKLMLINEKE 352

  Fly   347 WISEELQ-PWPEKSSVRFKTIGALYSEFIALSESGDLYQWRWSDAEPYKSETENVYHPKTVSLNI 410
            .:.:||| ..|:|.:         ..|...|            :||..:.|.|.|......|..:
  Rat   353 ELLKELQFITPQKRT---------QDELERL------------EAERQRLEEELVAARGLPSRAL 396

  Fly   411 VERVELISANFIRCSVVTETNRVATWMDEQLGYIGAK-LEHSCCAFNEFISDSITKIYVCSLYTV 474
            .||::|..........:.||.::.|::..||..:.:. |..|..:....::.|...:...|..::
  Rat   397 AERLKLEEKRKELLQKLEETTKLTTYLYSQLKSLSSSTLSMSSGSSLGSLASSRGSLNTSSRGSL 461

  Fly   475 VKTESNNIYWWGVLPFDQRRFLWDKFRTKTKKPFKVVATDINVGAQVIMKKCPMY-QSGSIGFTC 538
            ....|:::|:..  ..||                  :.||.......::::...| .||.|....
  Rat   462 NSLSSSDLYYSS--QGDQ------------------MDTDYQYKLDFLLQEKGGYIPSGPITTIH 506

  Fly   539 SNGVPKVGQLLNSVWTFTDVCRMKIININTNSGVDKSQAAGNNLNAHGITPDKDLPKSTAMPSTG 603
            .|.|.|                            ..||...:.|...|:......|     |.|.
  Rat   507 ENEVVK----------------------------SPSQPGQSGLCGLGVAATSHTP-----PLTE 538

  Fly   604 SSKNGQSFSNSKESTDRIDMPPPPSPASSTCSDTGSVTS-HKRT-------------------KR 648
            :||:..|.| |:.|...:..|..|....||...:...|| |:.|                   .:
  Rat   539 ASKSVTSLS-SRSSLSSLSPPGSPLVLDSTFPGSSHDTSPHQFTADLEDCELSRHFADIGLGENQ 602

  Fly   649 ATTKEDSNAPQEG-RKDEELWEVKDVVFVE-----DKVGPVGKVLKVDGDFVAVRFPAINAAAVA 707
            .....||..|.:. .:|::|.|....:..|     :|..|..:.|.:.||         ..|.|:
  Rat   603 VLLDSDSGGPSQSLLEDKDLDECTGGLLYEGSADVEKSLPKRRGLHLRGD---------KTARVS 658

  Fly   708 AAAAATSSTSNTA---STSKEEGKEDDWQQCRLLRREDVQIFRTAMSTRGPDWLQKQPKKINVGG 769
            |||:..|...::.   ::.|:.|:.:|..    .|.|||.|..||.            .:|.:..
  Rat   659 AAASDESVAGDSGVYEASVKQPGEIEDIP----YREEDVTIVETAQ------------VQIGLRY 707

  Fly   770 DAAGAQILTLAVDSRGIHVIK-KVLGKIHYSLYNLYNCKQEQNCLFPTDCNSFIGSTPGNILMAC 833
            |...:..:.:....|.:|... ....|:::.:..|.: ..:.:|||.|..:      |....:..
  Rat   708 DTKSSSFMVIIAQLRNLHAFSIPHSSKVYFRVAVLPS-SADVSCLFRTKVH------PPTESVLY 765

  Fly   834 NDDCSGNSSTIVLRDG--NGALYPLAK----DCLG----SIKD--------PQWFDLPPVKSITM 880
            ||......|.:||:..  ...|..::|    :||.    |:.|        ..|::|.|.|.|..
  Rat   766 NDVFRVAISQVVLQQKTLRVDLCSVSKRRREECLAGTQISLADLPFSNEIFMLWYNLLPSKQIPC 830

  Fly   881 -----------STISLPAMLSGVNLKSKVCMTALLFDTQ-KLMPHILRCDVKNSFAALGRLERED 933
                       :....|| |...:|.:   ::|||..|. :|:.      |:...|.    |.|:
  Rat   831 KKKEEGGGQPGAQSPQPA-LDSADLDA---VSALLARTSAELLA------VEQELAQ----EEEE 881

  Fly   934 QADTALVVEERCDGARNIFHACVIMCAPSSNKDSPPDSPSGGVEKKSLVGLSVARSIPTVSTSAY 998
            :.:..|..|.|..|     ..|:.|...:|                       |.::....:..:
  Rat   882 EEEEELRPEHRGPG-----EDCLTMLREAS-----------------------AETVAAKESGVH 918

  Fly   999 VSSIAFGASASSSNENSSFATMSSSAAGSASSTSRDN--------------RTNLRDMMNRLINS 1049
            :      |......|:.|..|       ....||||.              .|.:..::::..|:
  Rat   919 L------AEGGHCPEDPSPCT-------RGPGTSRDQCRKEKGRTEDPGQPATAVPTLVDKETNT 970

  Fly  1050 DQAEQSGSQPMATNNEDHAYIPWPAETPAASNLSASSSQNVSDSI------------EDDISKII 1102
            |:|..|.   :|...:|.            |:||:.....|..|:            ...|.::.
  Rat   971 DEAVDSN---IAVRPKDR------------SSLSSQHHPFVRSSVIVRSQTFSPGERSQYICRLN 1020

  Fly  1103 PSSSQSSMLSNIKLGSPTYTFDLAQRREHALTILQQMCVSPALR 1146
            .|.|.||.|:...|    :..:..:||  :|.:.:.:| .|.||
  Rat  1021 RSDSDSSTLAKKSL----FVRNSTERR--SLRVKRAVC-QPTLR 1057

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409	9/45 (20%)
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769
		HECTc	2589..2885	CDD:238033
		HECTc	2589..2884	CDD:214523
Wwc2	NP_001102581.1	WW	12..41	CDD:278809
		WW	59..88	CDD:278809
		DUF342	<283..385	CDD:302792	23/127 (18%)
		YlqD	351..>420	CDD:287979	18/89 (20%)
		C2_Kibra	699..822	CDD:176062	24/141 (17%)
		Phage_Nu1	<1095..>1153	CDD:294991
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900