DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hyd and Nedd4

DIOPT Version :9

Sequence 1:NP_001287262.1 Gene:hyd / 41181 FlyBaseID:FBgn0002431 Length:2887 Species:Drosophila melanogaster
Sequence 2:NP_648993.1 Gene:Nedd4 / 39958 FlyBaseID:FBgn0259174 Length:1007 Species:Drosophila melanogaster


Alignment Length:1182 Identity:233/1182 - (19%)
Similarity:408/1182 - (34%) Gaps:369/1182 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1895 LSAQAS----SSQTPAPATSSSVNG------------VNIMG-SNSRRDF---FTYCLSLMRSHT 1939
            :||::|    ::..|.|::||||.|            .::.| ..:|::|   :|...||...:.
  Fly     1 MSARSSGLVAAAALPVPSSSSSVAGGDVPRPPPRRRAASVAGQQQTRQEFGNGYTPRRSLAAVND 65

  Fly  1940 SEHRDALPVLDIT----ALRHIAYVLDAFVYYMRNDSGFYDKQDTISGRINNLSPMTESYDT--- 1997
            |.....|.::.:|    |.:.|....|.   |:|.|      .:||:|.||..|.:|::...   
  Fly    66 SGDSCHLRIVVLTGQSLAKKDIFGASDP---YVRID------LNTINGDINIDSVLTKTKKKTLN 121

  Fly  1998 -----------------------DDELANLEEFNADVQMSASSMPS-------GSQ--------- 2023
                                   |:.....::|...|:::..::|:       |.|         
  Fly   122 PTWNEEFIFRVKPSEHKLVFQVFDENRLTRDDFLGMVELTLVNLPTEQEGRTIGEQSYTLRPRRS 186

  Fly  2024 --------GTRR--HAFF--ARSESTLSLGCSAPEGFELPLDMAMPLADKPHLLQPN-------- 2068
                    ||.|  |||.  .|.:|..|.|.|..|...:....|...:.:||.....        
  Fly   187 VGAKSRIKGTLRIYHAFIRETREQSEPSSGNSDGEWEHVEATNAGETSAQPHPFPTGGHDALPAG 251

  Fly  2069 -SKRQELFANLPLLVTTNANNSGATNDGDGGSIFDYTPTRLGFSNSLKRNERVYET------VPI 2126
             .:||:....     |...|::..|...|       .||.|...:|...::::...      :.:
  Fly   252 WEERQDANGR-----TYYVNHTARTTQWD-------RPTVLNSHSSQSTDDQLASDFQRRFHISV 304

  Fly  2127 DSSKTG------------DGN------------VTNKAEGSTDSN-------IYVQLKKKQGSDD 2160
            |.:::|            |.|            .|:.|..:|.:|       |.:|.:.::..|.
  Fly   305 DDTESGRSADSISHNSIEDNNNAAGLAYTPKTAATSSAPPNTPTNNNGILAQIAMQYRAEEDQDP 369

  Fly  2161 FKSHKEADGNQSKYEKVVLMETDDSLPSTSKSTEALMATRP--EVIIAPNKASVSPATAARSVIV 2223
            ...|.....|..::.   :......:.:||...:    .||  |....|:.|..:|.| .|:...
  Fly   370 TVDHTSFVYNSLRHP---VAHRQPEISATSLQND----LRPVREAPGVPDIAITNPFT-RRAAGN 426

  Fly  2224 LAGGSCLKTIDSDINNYSASNLSTAEQAKCDTQYQKSTSDHLLLFPARGSQFYQSNFSELPSWNF 2288
            :|||                  :..:|.:...|.|.....|     .:..|..|.|         
  Fly   427 MAGG------------------AGWQQERRRQQMQLHIQQH-----QQRQQQQQQN--------- 459

  Fly  2289 LLSRWKLTLDLFGRVFMDDVGMEHGSVLPELRGFPVKEMRFRRHMEKLRNGQQ----------RD 2343
                         |:.:|   ::|....|:.||        :||.::.|...:          .|
  Fly   460 -------------RILLD---VDHRQQEPQHRG--------QRHQQQHRPSNEDTDHTDSHNPSD 500

  Fly  2344 LVLCKLERNRESLIVQTFKELNTQFGNQSRRIQPPITFNRVKVTFKDEPGEGSGVARSFYTSIAE 2408
            :......||.|                :.....||:..|   ...::||                
  Fly   501 ISAPSTRRNSE----------------EDNAAVPPMEQN---TGGEEEP---------------- 530

  Fly  2409 ALLASAKIPNLESVQVGTNHSKYVVPFSSILRSRTV-----SGSSRDQSTLQRR----------- 2457
                   :|...|:||..|...:.:..:|   .||.     :|.:.......||           
  Fly   531 -------LPPRWSMQVAPNGRTFFIDHAS---RRTTWIDPRNGRASPMPNQTRRVEDDLGPLPEG 585

  Fly  2458 -----GSNSKILWRSARERKALNLDARPYTPPNSSDNATPESLNDHLSVHLQQIGERLYPKIHSI 2517
                 .::.::.:.....|.....|.| .:.||.:..|.|.|              |.|.:.:..
  Fly   586 WEERVHTDGRVFYIDHNTRTTQWEDPR-LSNPNIAGQAVPYS--------------RDYKQKYEY 635

  Fly  2518 NQTHAPKITGM------------LLEIPTPQLLSVISSDETLRQKVNEAIEIITFKQKSETSAQ- 2569
            .::|..|.|.:            :|| .:.:::|.::..:.|:.|:....|       .||... 
  Fly   636 FKSHIRKPTNVPNKFEIRIRRTSILE-DSYRIISSVTKTDLLKTKLWVEFE-------GETGLDY 692

  Fly  2570 ----------SSQPKKSPSVVVVDPVDDDNEPLFYSPGKRGFYTPRQGFASFERINAFRNIGRLI 2624
                      .|:...:|...:.:....||..|..:.|        .|..:.|.::.|:.|||:.
  Fly   693 GGLAREWFYLLSKEMFNPYYGLFEYSAMDNYTLQINNG--------SGLCNEEHLSYFKFIGRIA 749

  Fly  2625 GLCLLQNELLPLFLQRHVLKYILGRKIKFHDLAFFDPALYESFRQIIQNAQTKEGEETINRMELC 2689
            |:.:...:||..|..|...|.:|.:.|...|:...|...|.|...|      ||.:..|  :||.
  Fly   750 GMAVYHGKLLDAFFIRPFYKMMLQKPIDLKDMESVDTEYYNSLMWI------KENDPRI--LELT 806

  Fly  2690 FVIDLMKEEGCGNR---ELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLP 2751
            |.:|   |:..|.:   ||.|||.::.||:.|..||::...|:|.:...::.:.:..||...::|
  Fly   807 FCLD---EDVFGQKSQHELKPGGANIDVTNENKDEYIKLVIEWRFVARVKEQMSSFLDGFGSIIP 868

  Fly  2752 DNSMINLTAEDLRLLLNGVGDINVSTLISYTTFNDESSEGPDKLLKFKKWFWSIVEKMNIMERQD 2816
            .|.:......:|.||:.|:.:|:|......|.:..:.......:    :|||..|...:...|..
  Fly   869 LNLIKIFDEHELELLMCGIQNIDVKDWRENTLYKGDYHMNHIII----QWFWRAVLSFSNEMRSR 929

  Fly  2817 LVYFWTGSPALPASEEGFQPL-----PSV-TIRP-ADDSHLPTANTCISRLYIPLYSSKSILRSK 2874
            |:.|.||:..:|.:  ||:.|     |.: ||.. ...::.|.|:||.:||.:|.|.....|:.|
  Fly   930 LLQFVTGTSRVPMN--GFKELYGSNGPQMFTIEKWGTPNNFPRAHTCFNRLDLPPYEGYLQLKDK 992

  Fly  2875 MLMAIKSKNFGF 2886
            ::.||:... ||
  Fly   993 LIKAIEGSQ-GF 1003

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hydNP_001287262.1 E3_UbLigase_EDD 150..196 CDD:288409
ZnF_UBR1 1217..1284 CDD:197698
ASF1_hist_chap 1535..1733 CDD:304562
PolyA 2498..2561 CDD:197769 11/74 (15%)
HECTc 2589..2885 CDD:238033 82/305 (27%)
HECTc 2589..2884 CDD:214523 82/304 (27%)
Nedd4NP_648993.1 C2_NEDD4_NEDD4L 71..204 CDD:175999 26/141 (18%)
WW 248..277 CDD:278809 6/40 (15%)
WW 531..560 CDD:278809 8/31 (26%)
WW 581..613 CDD:197736 3/32 (9%)
HECTc 650..1003 CDD:238033 93/386 (24%)
HECTc 674..1003 CDD:214523 90/361 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45446999
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.830

Return to query results.
Submit another query.