DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and CG5087

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	NP_648279.1	Gene:	CG5087 / 39035	FlyBaseID:	FBgn0035953	Length:	1078	Species:	Drosophila melanogaster

Alignment Length:	1244	Identity:	222/1244 - (17%)
Similarity:	391/1244 - (31%)	Gaps:	417/1244 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1821 ELISILSYNVLNDIETSLKIQNDEAIAVQAFVEKRLKATWDWMFTVMDGTEAQLKFGA------- 1878
            ||::...|.||....|.:::...:..|     .:||:....::...|:....:|.:.|
  Fly    71 ELVASNVYPVLRRYLTQIRLDKSDVRA-----RERLERICRYIIKAMESENTKLSYAALCLFKER 130

  Fly  1879 ----------YLTN-------YTDPNHP--------LHPLNL-----------SAQASSSQTPAP 1907
                      .|||       ....||.        ||.|.:           :||....|   |
  Fly   131 SLPWIAHIKILLTNCLTLLPELKPENHADSLSLALFLHTLVVFTAPKSWAILRNAQFEKLQ---P 192

  Fly  1908 ATSSSVNGVNIMGSNSRRDFFTYC-LSLMRSHTSEHRDALPVLDITAL----------------- 1954
            |.....  .||.|...:.||:... |.|:|....|.....||..:..:
  Fly   193 AMQKIC--CNIQGHLVQHDFYKIMRLVLIRGTVREELSVKPVTLVAIITLCLRPLIDGNFSRNLL 255

  Fly  1955 -RHIAYVLD--AFVYYMR----------NDSGFYDKQDTISGRINNLSPMTESYDTDDELANLEE 2006
             :.::.:|.  |.:|:::          :..|...|..:|||                ::...||
  Fly   256 AKFLSEILSVPALIYHLQQSVPQCLEQFSSMGLLKKALSISG----------------DVQWFEE 304

  Fly  2007 FNADVQMSASSMPSGSQGTRRHAFFARSESTLSLGCSAPEGFELPLDMAMPLADKPHLLQPNSKR 2071
            |       .:|||    ||:..||.....:..::     :|.....::|.||     |.:..:..
  Fly   305 F-------GTSMP----GTKSLAFLGNIVNLFNI-----DGQGESKELAYPL-----LTETTTSL 348

  Fly  2072 QELFANLPLLVTTNANNSGATNDGDGGSIFDYTPTRLGFSNSLKRNERVYETVPIDSSKTGDGNV 2136
            .||   :|..|||.             .:|......||:.
  Fly   349 LEL---IPNTVTTK-------------GVFTQWHELLGWH------------------------- 372

  Fly  2137 TNKAEGSTDSNIYVQLKKKQGSDDFKSHKEADGNQSKYEKVVLMETDDSLPSTSKSTEALMATRP 2201
            |...|.:.:.|  |.|.|||      .|...|      .:.:.:...|.|...:.:.|.:....|
  Fly   373 TPGPEPAQNQN--VALIKKQ------FHMLWD------HRCIKLLLGDLLKQINLNYERIEFQSP 423

  Fly  2202 EVIIAPNKASVSPATAARSVIVLAGGSCLKTIDSDINNYSASNLSTAEQAKCDTQYQKSTSDHLL 2266
            :   .|:.:::......|               |.....:...:::::|:|  .|::|..|..::
  Fly   424 Q---QPSISNLLRRALER---------------SSTRGVNLMGVASSKQSK--QQWRKLDSAEVV 468

  Fly  2267 LFPARGSQFYQSNFSELPSWNFLLSRWKLTLDLFGRVFMD----DVGMEHGSVLPELRGFPVKEM 2327
            ........:|.:..:        ||:.||.: |.|..:.|    |:.:...|:.|..
  Fly   469 QVSRICGMYYAALNT--------LSQMKLDI-LTGICYSDNVLYDIWLLITSLGPNC-------- 516

  Fly  2328 RFRRHMEKLRNGQQRDLVLCKLERN---RESLIVQTFKELNTQF-----GNQSRRIQPPITFN-R 2383
                       |.:..|.|.|.|.|   .::.::..|.:..|.:     .::....|.|...| .
  Fly   517 -----------GMKEYLELLKSETNLQKPQTAMLMLFCDCMTHYVTILDEHEMYTEQNPFKLNDY 570

  Fly  2384 VKVTFKDEPGEGSGVARSFYTSIAEALLASAKIPNLESVQVGTNHSKYVVPFSSILRSRTVSGSS 2448
            |.:|:        .:....|..|.:.|||.||  |:      ..|..::...:.:|
  Fly   571 VLLTY--------FLNNILYKLINDNLLAGAK--NI------VQHPVFLSLHTLML--------- 610

  Fly  2449 RDQSTLQRRGSNSKILWRSARERKALNLDARPYTPPNSSDNATPESLNDHLSVHLQQIGERLYPK 2513
                .|.||...                  ||:|||.                      ..|.|:
  Fly   611 ----CLYRRDCR------------------RPFTPPK----------------------HWLIPE 631

  Fly  2514 IHS---INQTHAPKITGMLLEIPTPQLLSVISSDETLRQKVNEAIEIITFKQKSETSAQS----- 2570
            :..   ||.....|...|||....|.::......:..|:.|.....::...:.:..|.:|
  Fly   632 VKPSTFINDLEKAKRNAMLLLAKMPHIIPHEDRVKLFRKFVQNEKAVMGLTESACASPRSALIVI 696

  Fly  2571 --------------SQPKKSPSVVV----------------------------VDPVDDDNEPLF 2593
                          :||.::...|:                            :..|.|.:..||
  Fly   697 HRDRIVEDGYRQLAAQPTQALKGVIRVRFINQQGLHEAGIDQDGVFKEFLEETIKKVFDPSLNLF 761

  Fly  2594 YSPGKRGFYTPRQGFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIK-----F 2653
            .:...:..|.....:.....:..|..:||::|..:.:..::.:......|..:||:..:     .
  Fly   762 KTTSDQRLYPSPISYVQDNHLELFEFVGRMLGKAVYEGIVVDVPFASFFLSQLLGQTQQALYSCM 826

  Fly  2654 HDLAFFDPALYESFRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCG---NRELIPGGRDVAVT 2715
            .:|...|..||.|...|      |..::.::.:.|.|.:|   ::..|   ...|.|||:...|.
  Fly   827 DELPSLDNELYRSLTFI------KHYKQDVSDLNLTFSVD---QDVMGKIVTLALHPGGKARVVN 882

  Fly  2716 SSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNG-VGDINVSTLI 2779
            ..|...|:.....:.:.....:...|...|...::....:...:..:|:.|::| ...:::..|.
  Fly   883 DHNKLVYIHYMAFFHMNTQIREQTIAFNRGFRSIVNPEWLSLFSPPELQRLISGDTSPLDLKDLQ 947

  Fly  2780 SYT----TFNDESSEGPDKLLKFKKWFWSIVEK-MNIMERQDLVYFWTGSPALPASEEGFQPL-P 2838
            .:|    .|:|..        :...|.|.|:.| ....||:..:.|.|.....|..  ||..| |
  Fly   948 KHTHYYGGFHDTH--------QVVCWLWDILAKDFTEEERKLFLKFVTSCSKPPLL--GFAHLEP 1002

  Fly  2839 SVTIR---PADD-----------------------SHLPTANTCISRLYIPLYSSKSILRSKMLM 2877
            ..:||   .:||                       :.|||::||.:.|.:|.|..||.||.|:..
  Fly  1003 PFSIRCVEVSDDEDTGDTIGSVIRGFFAIRKKDPLNRLPTSSTCFNLLKLPNYQKKSTLRDKLRY 1067

  Fly  2878 AIKSKNFGF 2886
            |: |.|.||
  Fly  1068 AV-SSNTGF 1075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	11/65 (17%)
		HECTc	2589..2885	CDD:238033	70/336 (21%)
		HECTc	2589..2884	CDD:214523	69/335 (21%)
CG5087	NP_648279.1	HECTc	694..1076	CDD:238033	77/402 (19%)
CG5087	NP_648279.1	HECTc	718..1075	CDD:214523	73/376 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447009
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830