DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hyd and yki

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	NP_001350857.1	Gene:	yki / 37851	FlyBaseID:	FBgn0034970	Length:	418	Species:	Drosophila melanogaster

Alignment Length:	482	Identity:	94/482 - (19%)
Similarity:	173/482 - (35%)	Gaps:	125/482 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 LVTVPATYVPEELISQAEVVLQGKSRNLIIRELQRTNLDVNLAVNNLLSRDDEEAEDTEEGADNY 211
            |.|:.|.|:...:.:.:      .:.:||.:|:...::...:..|||:.|.:::.:|
  Fly    16 LYTISAFYMLTTMSASS------NTNSLIEKEIDDEDMLSPIKSNNLVVRVNQDTDD-------- 66

  Fly   212 VPEDLISLLDNGFSGDNNSVIIDPSDGLFSEEIFSNYSSIRNLLFDRIRSERSNANANAADS--- 273
               :|.:|.|:         :::|.|.....::......:.|..|  .....|::.||:|||
  Fly    67 ---NLQALFDS---------VLNPGDAKRPLQLPLRMRKLPNSFF--TPPAPSHSRANSADSTYD 117

  Fly   274 --NQSTTRSTSSGTAL---TGNSGLSA------QISVNADREAFSRWRDR-------QYYGPRRW 320
              :||:....:..:.:   .|.|.::|      |.|....|.|....|.|       |.|..|.
  Fly   118 AGSQSSINIGNKASIVQQPDGQSPIAAIPQLQIQPSPQHSRLAIHHSRARSSPASLQQNYNVRA- 181

  Fly   321 ISKDDYTWEKDADSKKKEPSPMLSPIWISEELQP----WPEKSSVRFKTIGALYSEFIALSESGD 381
                    ..||.:..   :|..:|   |.:.||    :||.|:..|.: ||..|..|.|    |
  Fly   182 --------RSDAAAAN---NPNANP---SSQQQPAGPTFPENSAQEFPS-GAPASSAIDL----D 227

  Fly   382 LYQWRWSDAEPYKSETENVYHPKTVSLNIVERVEL-------------ISANFIRCSVVTETNRV 433
            ......|...|...:|   .|.|..|.:::..::|             ...|..:...:..|.:.
  Fly   228 AMNTCMSQDIPMSMQT---VHKKQRSYDVISPIQLNRQLGALPPGWEQAKTNDGQIYYLNHTTKS 289

  Fly   434 ATWMDEQLGYIGAKLEHSCCAFNEFISDSITKIYVCSLYTVVKTESNNIYWWGVLPFDQRRFLWD 498
            ..|.|.::.|    .:.......|.|..:  .:...:..|...|.:||:   |.||..     |:
  Fly   290 TQWEDPRIQY----RQQQQILMAERIKQN--DVLQTTKQTTTSTIANNL---GPLPDG-----WE 340

  Fly   499 KFRTKTKKPFKVVATDINVGAQVIMKKCPMYQSGSIGFTCSNGVPKVGQLLNSVWTFTDVCRMKI 563
            :..|::...:.:...|     :......|..|||.....|.:      .|::|:....::|
  Fly   341 QAVTESGDLYFINHID-----RTTSWNDPRMQSGLSVLDCPD------NLVSSLQIEDNLC---- 390

  Fly   564 ININTNSGVDKSQAAGNNLNAHGITPD 590
                 ::..:.:||..|..::|  .||
  Fly   391 -----SNLFNDAQAIVNPPSSH--KPD 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409	8/45 (18%)
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769
		HECTc	2589..2885	CDD:238033
		HECTc	2589..2884	CDD:214523
yki	NP_001350857.1	HUL4	<261..>404	CDD:227354	28/176 (16%)
		WW	266..295	CDD:395320	3/28 (11%)
		WW	335..364	CDD:395320	5/38 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900