DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and Smurf

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	NP_001261061.1	Gene:	Smurf / 36999	FlyBaseID:	FBgn0029006	Length:	1061	Species:	Drosophila melanogaster

Alignment Length:	1485	Identity:	283/1485 - (19%)
Similarity:	451/1485 - (30%)	Gaps:	563/1485 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1526 HKISIEELCEVSEALIAPVRLGVVRPTAPFT--------------MSSSNLDVR-NSD-DLFSVD 1574
            ||:.|..||..:.|     |..:.|...||.              :|.|:||.: |:. |||.
  Fly    13 HKVRITILCARNLA-----RKDLFRLPDPFAKVQVDGTGQVYSTEISKSSLDPKWNAHYDLFL-- 70

  Fly  1575 PLAPSNVESPSEQILVHDA----GNDQSANFNIQ-------QNYDVVAMETIRDASESEEVINRE 1628
            .:..:...:...|..:|..    |..:...||||       |..|:..:..
  Fly    71 GIGDAITITVWNQRKIHKGSGFLGCVRIPAFNIQSLKGAGFQRLDLGKLSP-------------- 121

  Fly  1629 ANSHNQDDELIENQ-----RNEDG-------------------MQDDESDNDFTFNDAETESDSD 1669
                 .||||:..|     .::||                   .:||.|::.......|..:|:.
  Fly   122 -----DDDELVRGQIIISLLSKDGPSSGNPLAIVGPSGDVRGPSEDDSSEDSLPEGWEERRTDNG 181

  Fly  1670 D----NQSNQEVQ--RSVQAGATVGSENDIGVLFLEDESGDSSAQEEDGSEDGESDDQSDEFNFN 1728
            .    |.:.:..|  |..|.| .|||            |..:|.|:...:.:|.|.|
  Fly   182 RVYYVNHATKSTQWDRPRQPG-VVGS------------SHATSPQQRHNTHNGNSGD-------- 225

  Fly  1729 EQQLERRSTNSNARSDLAPQTMQWAIRSRDTA-------RSSVRVPTGSNMVFIDPMALRRSTVP 1786
                 |::.....||......|....||||.:       |.|..:.:........|      |.|
  Fly   226 -----RQAPAGPTRSTTCTNLMNNGHRSRDLSVTASDERRHSTEILSSVGKENTSP------TTP 279

  Fly  1787 ASTTVTTPSIEPHTMATTASNLARAFGITIRQISELISILSYNVLNDIETSLKIQNDEAIAVQAF 1851
            .|.| |||.     ..|::||.:.|.|.|:.|                    :..|:.|....:
  Fly   280 VSAT-TTPG-----KKTSSSNSSSAGGRTLEQ--------------------RPTNEPATPTSS- 317

  Fly  1852 VEKRLKATWDWMFTVMDGTEAQLKFGAYLTNYTDPNH---PLHPLNLSAQASSSQTPAPATSSSV 1913
                             .|.|.::.      :::.||   |.|..|..|...|:.|......:.|
  Fly   318 -----------------TTSASVRL------HSNDNHVKTPKHQTNGHAPPESTPTSPTGQQNYV 359

  Fly  1914 NGVNIMGSNSRRDFFTYCLSLMRSHTSEHRDAL----PVLDITALRHIAYVLDAFVYYMRNDSGF 1974
            ||....||.|.............|:.....||.    |....:..||
  Fly   360 NGNAQNGSTSGNGSGQAAQPQSASNGWTQEDAATTTSPSTTTSPPRH------------------ 406

  Fly  1975 YDKQDTISGRINNLSPMTESYDTDDELANLEEFNADVQMSASSMPSGSQGTRRHAFFARSESTLS 2039
                 :.|....|:||....  |.....|:...|      |:|.|:||.|..| ::.|.:....|
  Fly   407 -----SQSPPTPNISPPASV--TPSANGNVHSPN------ANSTPAGSGGGSR-SYTAATPGQRS 457

  Fly  2040 LGCSAPEGFELPLDMAMPLADKPHLLQPNSKRQELFANLPLLVTTNANNSGATNDGDGGS----- 2099
                                      |..|.||:...:.....::....:|.|:.|.||.
  Fly   458 --------------------------QRRSSRQQGEESSTRRRSSRGTRNGGTSGGGGGGGSGQR 496

  Fly  2100 ---------------IFDYTPTRLGFSNSLKRNERVY-ETVPIDSSKTGDGNV---------TNK 2139
                           ..|..|   |:.....:..:|| ..:|...|...|..:         |..
  Fly   497 YASAAIAAANQAARPFLDLPP---GYEMRTTQQGQVYFYHIPTGVSTWHDPRIPRDFDTQHLTLD 558

  Fly  2140 AEGSTDSNIYVQLKKKQGSDDFKSHKE-----ADGNQSKYEKVVLMETDDSLPSTSKSTEALMAT 2199
            |.|...|. :.|.|...|...|..|..     .|...|  ..::.|....::|.||    |..|.
  Fly   559 AIGPLPSG-WEQRKTASGRVYFVDHNNRTTQFTDPRLS--GSILQMIRRGTVPPTS----AANAG 616

  Fly  2200 RPEVIIAPNKASVSPATAARSVIVLAGGSCLKTIDSDINNYSASNLSTAEQAKCDTQYQKSTSDH 2264
            .|    ||..|:.:..:||.:|...|         :..:|.:.:.|:|.           :...|
  Fly   617 TP----APPSATPATPSAAAAVPPQA---------TPASNATPTTLTTT-----------TNPPH 657

  Fly  2265 LLLFPARGSQFYQSNFSELPSWNFLLSRWKLTLDLFGRVFMDDVGMEHGS-VLPELRGFPVKEMR 2328
            .::             .:||.                       |:..|: :||:.|...|.::|
  Fly   658 RIV-------------PDLPQ-----------------------GLLEGADLLPKYRRDLVGKLR 686

  Fly  2329 -FRRHMEKL--RNGQQRDLVLCKLERNRESLIVQTFKELNTQFGNQSRRIQPPITFNRVKVTFKD 2390
             .|..::.:  ::|.      |:||.:|..:..::::.:........|:        |:.|.||.
  Fly   687 ALRTELQTMQPQSGH------CRLEVSRNEIFEESYRLIMKMRAKDMRK--------RLMVKFKG 737

  Fly  2391 EPG-EGSGVARSFYTSIAEALLASAKIPNLESVQVGTNHSKYVVPFSSILRSRTVSGSSRDQSTL 2454
            |.| :..||||.:...::..:|         :.|.|.  .:|               |..|..||
  Fly   738 EEGLDYGGVAREWLHLLSREML---------NPQYGL--FQY---------------SRDDHYTL 776

  Fly  2455 QRRGSNSKILWRSARERKALNLDARPYTPPNSSDNATPESLNDHLSVHLQQIGERLYPKIHSINQ 2519
            |                  :|        |:|..|.      ||||.
  Fly   777 Q------------------IN--------PDSGVNP------DHLSY------------------ 791

  Fly  2520 THAPKITGMLLEIPTPQLLSVISSDETLRQKVNEAIEIITFKQKSETSAQSSQPKKSPSVVVVDP 2584

  Fly   792 ----------------------------------------------------------------- 791

  Fly  2585 VDDDNEPLFYSPGKRGFYTPRQGFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGR 2649
                                            |..:||.:|:.:.....|.........|.:|.:
  Fly   792 --------------------------------FHFVGRTLGIAVFHGHCLDGGFTTPFYKQLLNK 824

  Fly  2650 KIKFHDLAFFDPALYESFRQIIQNAQTKEGEETINR-MELCFVIDLMKEEGCGNRELIPGGRDVA 2713
            .|...|:...||.|:.|...::        |..|:. :|..|.::..........||.|||..:.
  Fly   825 PITLGDIEGVDPDLHRSLTWML--------ESNISGIIESTFSVENNSFGALVVHELKPGGASIP 881

  Fly  2714 VTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVSTL 2778
            ||..|..|||:.|..||.::..|:...||:.|..:::|.:.:......:|.|::.|:..|:|:..
  Fly   882 VTEENKREYVKLYVNYRFMRGIEQQFLALQKGFCELIPSHLLRPFDERELELVIGGISSIDVNDW 946

  Fly  2779 ISYTTFNDESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPLPSVT-- 2841
            .:.|.....::|....|     |||.:||..:...|..|:.|.|||..:|.  :||:.|...|
  Fly   947 RNNTRLKHCTNETTQVL-----WFWQVVESYSSEMRARLLQFVTGSSRVPL--QGFRALQGSTGA 1004

  Fly  2842 IRP--------AD--DSHLPTANTCISRLYIPLYSSKSILRSKMLMAIKSKNFGF 2886
            :.|        ||  ..:||.|:||.:|:.:|.|.:..:|..|:..|:: :..||
  Fly  1005 VGPRLFTIHLTADVPTQNLPKAHTCFNRIDLPPYETYQLLCDKLTQAVE-ETCGF 1058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562	48/254 (19%)
		PolyA	2498..2561	CDD:197769	3/62 (5%)
		HECTc	2589..2885	CDD:238033	74/308 (24%)
		HECTc	2589..2884	CDD:214523	74/307 (24%)
Smurf	NP_001261061.1	C2_Smurf-like	14..135	CDD:176028	31/146 (21%)
		WW	169..198	CDD:278809	4/28 (14%)
		WW	514..546	CDD:197736	8/34 (24%)
		WW	562..594	CDD:197736	7/32 (22%)
		HECTc	702..1058	CDD:238033	106/552 (19%)
		HECTc	726..1058	CDD:214523	102/528 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446964
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830