DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hyd and Hectd1

DIOPT Version :9

Sequence 1:NP_001287262.1 Gene:hyd / 41181 FlyBaseID:FBgn0002431 Length:2887 Species:Drosophila melanogaster
Sequence 2:XP_006240148.1 Gene:Hectd1 / 362736 RGDID:1561653 Length:2610 Species:Rattus norvegicus


Alignment Length:2635 Identity:476/2635 - (18%)
Similarity:837/2635 - (31%) Gaps:860/2635 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   824 STPGNILMACNDDCSGNSSTIVLRDGNGALYPLAKDCLGSIKDPQWFDLPPVKSITMSTISLPAM 888
            ||.|....|.:...|...||||..        |:..|.||          |:.:..:....||..
  Rat   259 STTGAPSAAADSKLSNQVSTIVSL--------LSTLCRGS----------PLVTHDLLRSELPDS 305

  Fly   889 LSGVNLKSKVC----------MTALLFDTQKLMPHILRCDVKNSFAALGRLEREDQADTALVVEE 943
            :.......:.|          :..|||:.:|.:|       |:|..:.||:....:.|::     
  Rat   306 IESALQGDERCVLDTMRLVDLLLVLLFEGRKALP-------KSSAGSTGRIPGLRRLDSS----- 358

  Fly   944 RCDGARNIFHACVIMCAPSSNKDSPPDS-PSGGVEKKSL--VGLSVARSIPTVSTSAYVSSIA-F 1004
               |.|:  |..:|.|..|.:.|:..|: .:|..|...:  ||.::........|...|..:. .
  Rat   359 ---GERS--HRQLIDCIRSKDTDALIDAIDTGAFEVNFMDDVGQTLLNWASAFGTQEMVEFLCER 418

  Fly  1005 GASASSSNENSSFATMSSSAAGSASSTSRDNRTNLRDMMNRLINSDQAEQSGSQPMATNNE-DHA 1068
            ||..:....:||....:.......:.|          ::....|.|..::.|..|:....| .|:
  Rat   419 GADVNRGQRSSSLHYAACFGRPQVAKT----------LLRHGANPDLRDEDGKTPLDKARERGHS 473

  Fly  1069 YIPWPAETPA--ASNLSASSSQNVSDSIEDD----------------ISKIIP---SSSQSSMLS 1112
            .:....::|.  ...::....:...|:.:|:                :.:::|   .:.|.:||.
  Rat   474 EVVAILQSPGDWMCPVNKGDDKKKKDTNKDEEECNEPKGDPEMAPVYLKRLLPVFAQTFQHTMLP 538

  Fly  1113 NIKLGSPTYTFDLAQRREH--ALTILQQMCVSPA---LRPYLCHMLST-----KDAQGQTPFMLS 1167
            :|:..|    ..|.::..|  :..:|:::|.|.|   |...|..:.:|     .|..|....:..
  Rat   539 SIRKAS----LALIRKMIHFCSEALLKEVCDSDAGHNLPTALVEITATVLDQEDDDDGHLLALQI 599

  Fly  1168 VSCRAYEAGIILLNTILML-------------------------SEQDPQLKEAMIFPNGSPADQ 1207
            :.....:.|.|.|:.:..|                         .|.:|| ::|.....|.|...
  Rat   600 IRDLVDKGGDIFLDQLARLGVISKVSALAGPSSDDENEEESKPEKEDEPQ-EDAKELQQGKPYHW 663

  Fly  1208 SPLHVICYNDTCSFTWTGADHINQN---------IFECK--TCGLTGSLCCCTECARVCHKGHDC 1261
            ....||...| |.:.|:.|..:..:         |.:.|  |...:||          ...|.|.
  Rat   664 RDWSVIRGRD-CLYIWSDAAALELSNGSNGWFRFILDGKLATMYSSGS----------PEGGSDS 717

  Fly  1262 ---------KLKRT-----------------APTAYCDCWEKCKCKALIAGNLTKRFALLCKLVS 1300
                     ||:|.                 .||            .|..||    ::|.|..  
  Rat   718 SESRSEFLEKLQRARGQVKPSTSSQPILSAPGPT------------KLTVGN----WSLTCLK-- 764

  Fly  1301 CTDLVTKFNSKGESILLFLIQTVGRQIVEQR--QYRFSVRVRNVSTAATGATGNNSVISNRKTSA 1363
             ...:...||.|:...:......|......|  ::.|:......|...||.||..    .||..:
  Rat   765 -EGEIAIHNSDGQQATILKEDLPGFVFESNRGTKHSFTAETSLGSEFVTGWTGKR----GRKLKS 824

  Fly  1364 AEIDNDMPDHDLEPPKFARKALERLLID--WNAVRSMIMSGAERGDVPNPAGSASENSNS----- 1421
                      .||..|...:.:.|.|.|  :.||.||     .||.|......|::..:|     
  Rat   825 ----------KLEKTKQKVRTMARDLYDDHFKAVESM-----PRGVVVTLRNIATQLESSWELHT 874

  Fly  1422 -----EGFNMFIQTQHGS------TLLDKFTHSLIVKCTSDHLDTLLLTLVRELQNASVS-NRSK 1474
                 ||.|.:......:      .|.|:.|.|....|:|..:..||..|     |:|:. :..:
  Rat   875 NRQCIEGENTWRDLMKTALENLIVLLKDESTISPYEMCSSGLVQALLTVL-----NSSIDLDMKQ 934

  Fly  1475 EAEEVVRRFVRSVARVFVIFNLEKQPNPEKRKSHSSCNKYVQSCVKVFQTLHKISIEELCEVS-- 1537
            :..::|.|.     .||.....|.: :.|.|.:.:    .::..:.|.:::.::.: .|.:..  
  Rat   935 DCSQLVERI-----NVFKTAFSESE-DDESRPAVA----LIRKLIAVLESIERLPL-HLYDTPGS 988

  Fly  1538 ----EALIAPVRLGVVRPTAPFTMSSSNLDVRNSDDLFSVDPLAPSNVESPSEQIL--------- 1589
                :.|...:|..:.|......:      :..:..:..::|||  .|||..:.:|         
  Rat   989 TYNLQILTRRLRFRLERAPGETAL------IDRTGRMLKMEPLA--TVESLEQYLLKMVAKQWYD 1045

  Fly  1590 --------VHDAGNDQSANFNIQQNYD------------VVAMETIRDA---------SES---- 1621
                    |......|:..|..|.::|            ..|.|.:..|         ||.    
  Rat  1046 FDRSSFVFVRKLREGQNFIFRHQHDFDENGIIYWIGTNAKTAYEWVNPAAYGLVVVTSSEGRNLP 1110

  Fly  1622 ----EEVINRE---ANSHNQDDE----------------------------LIEN---QRNEDGM 1648
                |::::|:   .|.|:.||:                            .:.|   |.::||.
  Rat  1111 YGRLEDILSRDNSALNCHSNDDKNAWFAIDLGVWVIPSAYTLRHARGYGRSALRNWVFQVSKDGQ 1175

  Fly  1649 Q--------DDESDND------FTFNDAETESDS---------DDNQSNQEVQRSVQAGATVGSE 1690
            .        ||.|.|:      :..:.|:.|...         ..|.|.|....|:......|:.
  Rat  1176 NWTSLYTHVDDCSLNEPGSTATWPLDPAKDEKQGWRHVRLKQMGKNASGQTHYLSLSGFELYGTV 1240

  Fly  1691 NDIGVLFLEDESGDSSAQEEDGSEDGESDDQSDEFNFNEQQLERRSTNSNARSDLAP-----QTM 1750
            |.:    .||:.|.::.:.              |.|...|   ||...|.....:.|     :.:
  Rat  1241 NGV----CEDQLGKAAKEA--------------EANLRRQ---RRLVRSQVLKYMVPGARVIRGL 1284

  Fly  1751 QWAIRSRDTARSSVRVPT---------------GSNMVFI--------------DPMALRRSTVP 1786
            .|..|.:|.:.......|               |||...:              ||..: .|..|
  Rat  1285 DWKWRDQDGSPQGEGTVTGELHNGWIDVTWDAGGSNSYRMGAEGKFDLKLAPGYDPDTV-ASPKP 1348

  Fly  1787 ASTTV--TTPSIEPHTMATTASNLARAFGITIRQISELISILSYNVLNDIET-SLKIQNDEAIAV 1848
            .|:||  ||.|.............:.|.|.:.|:.|. .|:.|....:||.. |.|.:....|.:
  Rat  1349 VSSTVSGTTQSWSSLVKNNCPDKTSAAAGSSSRKGSS-SSVCSVASSSDISLGSTKTERRSEIVM 1412

  Fly  1849 QAFVEKRLKATWDWMFTVMDGTEAQLKFGAYLTNYTDPNHPLHPLN---------LSAQASSSQT 1904
            :              .:::.|              .|.:.|:..|:         :.:.:|:|.:
  Rat  1413 E--------------HSIVSG--------------ADVHEPIVVLSSAENVPQTEVGSSSSASTS 1449

  Fly  1905 PAPATSSSVNGVNIMGSNSRRDFFTYCLSLMRSHTSEHRDALPVLDITA--LRHIAYVLDAFVYY 1967
            ...|.:.|.|....:|.:|.          :|:.......::.::.:::  :..::.:.:.....
  Rat  1450 TLTAETGSENAERKLGPDSS----------VRAPGESSAISMGIVSVSSPDVSSVSELTNKEAAS 1504

  Fly  1968 MRNDSGFYDKQDTISGRINNLSPMTESYDTDD----ELANLEEFNADVQMSASSMPSGSQGTRRH 2028
            .|..|.....:.::|..:...:||:.|....:    |.::||.|...|...|.:..:.:....|.
  Rat  1505 QRPLSSSASNRLSVSSLLAAGAPMSSSASVPNLSSRETSSLESFVRRVANIARTNATNNMNLSRS 1569

  Fly  2029 AFFARSESTLSLGCSAPEGFELPLDMAMPLADKPHLLQPNSKRQELFANLPLLVTTNANNSGATN 2093
               :...:|.:||.:.......||   |.....|:|..|.:......:...  ||:::|.:.|| 
  Rat  1570 ---SSDNNTNTLGRNVMSTATSPL---MGAQSFPNLTTPGTTSTVTMSTSS--VTSSSNVATAT- 1625

  Fly  2094 DGDGGSIFDYTPTRLGFSNSLKRNERVYETVPIDSSKTG---DGNVTNKAEGSTDSNIYVQLKKK 2155
                        |.|....||........|.....|.||   :.::.:..:....|.:..:|...
  Rat  1626 ------------TVLSVGQSLSNTLTTSLTSTSSESDTGQEAEYSLYDFLDSCRASTLLAELDDD 1678

  Fly  2156 QG--SDDFKSHKEADGNQ--SKYEKVVLMETDDSLPSTSK--------STEALMATRPEVIIAPN 2208
            :.  ..|.:..:..|.||  .:||:|:::..    ||..:        :..|:.:..|:|   |:
  Rat  1679 EDLPEPDEEDDENEDDNQEDQEYEEVMILRR----PSLQRRAGSRSDVTHHAVTSQLPQV---PS 1736

  Fly  2209 KASVSPATAARSVIVLAGGSCLKTIDSD--INNYSASNLSTAEQAKCDTQYQKSTSDHLLLFPAR 2271
            .|...|............|...:|.|.|  :....::.:...:.....|..|::|.   |..|..
  Rat  1737 GAGSRPIGEQEEEEYETKGGRRRTWDDDYVLKRQFSALVPAFDPRPGRTNVQQTTD---LEIPPP 1798

  Fly  2272 GSQFYQ------------------------SNFSELPSWNF------------------------ 2288
            |:...:                        :...|||..||                        
  Rat  1799 GTPHSELLEEVECTPSPRLALTLKVTGLGTTREVELPLSNFRSTIFYYVQKLLQLSCNGNVKSDK 1863

  Fly  2289 LLSRWKLTLDLFGRVFMD-DVGMEHGSV----------------LP--ELRGFPVK--EMRFRRH 2332
            |...|:.|..:..|...| |...|:|.:                ||  :|..:..|  :..|.||
  Rat  1864 LRRIWEPTYTIMYREMKDSDKEKENGKMGCWSIEHVEQYLGTDELPKNDLITYLQKNADAAFLRH 1928

  Fly  2333 MEKLRNGQQRDLVLCKLERNRESLIV--QTFKELNTQFG-NQ--SRRIQPPITFNRVKVTFKDEP 2392
            . || .|..:.:   :..||...||.  :.|.|..|:.| ||  |..:|.....|..|...:.:.
  Rat  1929 W-KL-TGTNKSI---RKNRNCSQLIAAYKDFCEHGTRSGLNQGASSSLQSSDILNLTKEQPQAKA 1988

  Fly  2393 GEGSG----------------VARSFYTSIAE--------------------------------A 2409
            |.|..                ||...|:.|::                                .
  Rat  1989 GNGQNPCGVEDVLQLLRILYIVASDPYSRISQEDGDEQPQFTFPPDEFTSKKITTKILQQIEEPL 2053

  Fly  2410 LLASAKIPN-LESVQVGTNHSKYVVPFSS--ILRSRTVSGSS--------RDQSTLQRRGSNSKI 2463
            .|||..:|: .|.:   |:...:::||.:  :..:.|..|:|        |.::|::|..:.|.:
  Rat  2054 ALASGALPDWCEQL---TSKCPFLIPFETRQLYFTCTAFGASRAIVWLQNRREATVERTRTTSSV 2115

  Fly  2464 LWRSARERKALNLDARPYTPPNSSDNATPESLNDHLSVHLQQIGERLYPKIHSINQTHAPKITGM 2528
            ......|.:...|.......|.                     ||.|.....::.|.||.:.:.:
  Rat  2116 RRDDPGEFRVGRLKHERVKVPR---------------------GESLMEWAENVMQIHADRKSVL 2159

  Fly  2529 LLEI---------PTPQLLSVISSDETLRQKVNEAIEIITFKQKSETS---AQSSQPKKSPSVVV 2581
            .:|.         ||.:..::::::                .|:::..   ...:.|        
  Rat  2160 EVEFLGEEGTGLGPTLEFYALVAAE----------------FQRTDLGTWLCDDNFP-------- 2200

  Fly  2582 VDPVDDDNEPLFYSPGKR--GFYTPR----------QGFASFERI-NAFRNIGRLIGLCLLQNEL 2633
                ||::..:....|.:  |:|..|          |.....||| ..|..:|..:..|:..|.|
  Rat  2201 ----DDESRHVDLGGGLKPPGYYVQRSCGLFTAPFPQDSDELERITKLFHFLGIFLAKCIQDNRL 2261

  Fly  2634 LPLFLQRHVLKYILGRKIKF-----------------------------HDL------------- 2656
            :.|.:.:...|.:....||.                             ||.             
  Rat  2262 VDLPISKPFFKLMCMGDIKSNMSKLIYESRGDRDLHCTESQSEASTEEGHDSLSVGSFEEDSKSE 2326

  Fly  2657 -----------AFFDPAL-YESF---------------------RQIIQNAQTKEGEETINRMEL 2688
                       |:|:..| :|.|                     |||:.|....|.|:.....||
  Rat  2327 FILDPPKPKPPAWFNGILTWEDFELVNPHRARFLKEIKDLAIKRRQILGNKSLSEDEKNTKLQEL 2391

  Fly  2689 CFVIDLMKEEGCG-----------------NR-------ELIPGGRDVAVTSSNIFEYVRRYTEY 2729
            .    |....|.|                 :|       :|.|.|.|..:|..|..|||....::
  Rat  2392 V----LKNPSGSGPPLSIEDLGLNFQFCPSSRIYGFTAVDLKPSGEDEMITMDNAEEYVDLMFDF 2452

  Fly  2730 RLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVS------TLISYTTFNDES 2788
            .:....:|.:||.:||...|.|...:.:.:.|:::::|.|    |.|      .:|:||......
  Rat  2453 CMHTGIQKQMEAFRDGFNKVFPMEKLSSFSHEEVQMILCG----NQSPSWAAEDIINYTEPKLGY 2513

  Fly  2789 SEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPL-PSVT-IRPAD--DSH 2849
            :......|:|.:    ::..|:..||:..:.|.||...||..  |...| |.:| :|..|  |:.
  Rat  2514 TRDSPGFLRFVR----VLCGMSSDERKAFLQFTTGCSTLPPG--GLANLHPRLTVVRKVDATDAS 2572

  Fly  2850 LPTANTCISRLYIPLYSSKSILRSKMLMAIKSKNF 2884
            .|:.|||:..|.:|.|||:.|:|.::|.|...|.|
  Rat  2573 YPSVNTCVHYLKLPEYSSEEIMRERLLAATMEKGF 2607

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hydNP_001287262.1 E3_UbLigase_EDD 150..196 CDD:288409
ZnF_UBR1 1217..1284 CDD:197698 16/103 (16%)
ASF1_hist_chap 1535..1733 CDD:304562 48/306 (16%)
PolyA 2498..2561 CDD:197769 9/71 (13%)
HECTc 2589..2885 CDD:238033 92/418 (22%)
HECTc 2589..2884 CDD:214523 91/416 (22%)
Hectd1XP_006240148.1 Ank_2 366..457 CDD:289560 18/100 (18%)
ANK repeat 366..393 CDD:293786 7/26 (27%)
ANK 369..479 CDD:238125 21/119 (18%)
ANK repeat 396..426 CDD:293786 5/29 (17%)
ANK repeat 428..457 CDD:293786 5/38 (13%)
F5_F8_type_C 1107..1240 CDD:304887 21/132 (16%)
MIB_HERC2 1277..1335 CDD:284184 7/57 (12%)
HECTc 2131..2608 CDD:238033 106/540 (20%)
HECTc 2155..2607 CDD:214523 98/493 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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