DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and Herc6

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	XP_008761185.1	Gene:	Herc6 / 362376	RGDID:	1561739	Length:	1027	Species:	Rattus norvegicus

Alignment Length:	956	Identity:	186/956 - (19%)
Similarity:	326/956 - (34%)	Gaps:	277/956 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  2065 LQPNSKRQELFA--NLPLLVTTNA--------NNSGATNDGD----GGSIFDYTPTRLGFSNSLK 2115
            |..||.:::::.  ::..|.|.|.        :.|..|.||.    |||          .|..|:
  Rat   213 LSGNSAKEQIYKPHSIGALKTLNVVYISCGYEHTSVLTEDGQVFTFGGS----------SSEQLQ 267

  Fly  2116 RNERVYETVPIDSSKTG-------DGNVTNKAEGS--TDSNIY-----VQLKKKQGSDDFKSHKE 2166
            .:.|        |.:.|       .|:|:....||  |.:.:|     |.|.:........:|:|
  Rat   268 HSPR--------SGRGGPQLIEGIGGHVSQIECGSYHTIAYVYTTGQVVSLGRGPSCTSNATHQE 324

  Fly  2167 ADGNQ----SKYEKVVLMETDDSLPST----------SKSTEALMATRPEVI----------IAP 2207
            |..:.    ...:.:|.:|..|.....          ::||...|...||:|          .|.
  Rat   325 AACSDVTCLLSAKDLVDIEVKDIFAGAHANFVTTCRHTRSTSVSMKILPEIIRITQPLVKKWRAA 389

  Fly  2208 NKASVSPATAARSVIVLAGGSC-----LKTIDSDINNYSASNLSTAEQAKCDTQYQKSTSDHLLL 2267
            .|..|.........::.:..:|     ||..|:..||:...:|..|...     ::..|::
  Rat   390 KKGKVHEDAKREISLIFSSPACLTASFLKKRDAGENNFINVDLKLARDV-----FKMLTAE---- 445

  Fly  2268 FPARGSQFYQSNFSELPSWNFLLSRWKLTLDLFGRVFMDDVGMEHGSVLPE--LRGFPVKEMRFR 2330
                                    :|..:|..              :.|.|  |||.|...
  Rat   446 ------------------------KWISSLIT--------------TCLEETLLRGLPYSS---- 468

  Fly  2331 RHMEKLRNGQQRDLVLCKLERNRESLIVQ---TFKELNTQFGNQSRRIQPPITFNRVKVTFKDEP 2392
            .|.|.|       ||...|.   |..|:|   .:|.|..:|.:...:::..      .:||
  Rat   469 PHQEAL-------LVFLLLP---ECSIMQDPKNWKTLAFEFASAIHKMRSK------SLTF---- 513

  Fly  2393 GEGSGVARSFYTSIAEALLASAKIPNLESVQVGTNHSKYVVPFSSILRSRTVS--GSSRDQSTLQ 2455
                  .|:::.|:..:.|.|. :..|:...|...|::  ||......:..||  .....|..|:
  Rat   514 ------LRNWWASLEVSSLNSL-VQMLKKTIVSQLHNE--VPMMKDTSNLKVSLEMMKEVQKILE 569

  Fly  2456 RRG-------------SNSKILWRSARERKALNLDARPYTPPNSSDNATPES---LNDHLSVHLQ 2504
            :..             ||.|:|....:|....|..             .||:   :||..:.:.:
  Rat   570 KTNSHLHNEVPKMEDTSNLKVLLEVMKEVHEANCQ-------------LPENAFIMNDIFNFNTE 621

  Fly  2505 QIG-----ERLYPKIHSINQTHAPKITGMLLEIPTPQLL-----SVISSDET------------- 2546
            : |     :..:.|.:|:.....|    .:|::|:..:|     ||..|||.
  Rat   622 E-GIMAKQQMFFIKYYSMVFNDFP----FILDLPSKIILMKHDSSVKLSDEVKVAASPEKMGCPF 681

  Fly  2547 --LRQKVNEAIEIITFKQKSETSAQSSQPKKSPSVVVVDPVDDD----NEPLFY-------SPGK 2598
              |:.:.:..:| .|.:|..:  |:....:|:.||..::.:..:    :...|:       .|..
  Rat   682 FILKVRRSHLVE-DTLRQLRQ--AEDFDLRKTLSVGFINEIRPEGGGVSSEFFHCIFEEMTDPKY 743

  Fly  2599 RGFYTPRQGF-------ASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIKFHDL 2656
            ..|..|..|.       ..||:...|. .|.|.||.|....::.|.....:.|.:|.:|....||
  Rat   744 EMFMYPENGSNMWFPVNPKFEKSRYFL-FGILCGLSLNNLNVINLSFPLALYKKLLEQKPSLEDL 807

  Fly  2657 AFFDPALYESFRQIIQNAQTKEGEETINRMELCFVI-----DLMKEEGCGNRELIPGGRDVAVTS 2716
            ......|..:.:::: |.:.    ..|..:.:.|.|     |:         :|||.|..|.|..
  Rat   808 KDLSLLLGRNLQEVL-NCEA----GVIEELHMYFSIYWDQRDV---------DLIPDGISVPVNE 858

  Fly  2717 SNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVSTLISY 2781
            :|..:||.:..:|....|.:...:....|.:.|...:|:.:...|:|...:.|....:.....:.
  Rat   859 TNKRDYVSKCVDYIFNISIKTIYDEFHRGFYKVCNRDSIRHFQPEELMAAIIGNPTCDWKQFENN 923

  Fly  2782 TTF-NDESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPA---SEEGFQ-PLPSVT 2841
            :.: |..|...|..||     ||....::.:.|::..:.|.||...|..   ..||.: ..|.|
  Rat   924 SKYENGYSKSHPTILL-----FWKAFHELTLDEKKKFLLFLTGCDRLHVKGLQNEGIRFRCPEV- 982

  Fly  2842 IRPADDSHLPTANTCISRLYIPLYSSKSILRSKMLMAIKSKNFGFV 2887
               ..:...|.:.||.|.|.:|.||:...::..:.:|| :.|.||:
  Rat   983 ---FSERDNPRSLTCHSILDLPKYSTMRRMKEALQVAI-NNNKGFI 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	15/87 (17%)
		HECTc	2589..2885	CDD:238033	69/319 (22%)
		HECTc	2589..2884	CDD:214523	68/318 (21%)
Herc6	XP_008761185.1	RCC1	39..88	CDD:278826
		RCC1	92..141	CDD:278826
		RCC1	144..194	CDD:278826
		RCC1_2	182..210	CDD:290274
		RCC1_2	236..265	CDD:290274	8/38 (21%)
		RCC1	252..299	CDD:278826	15/64 (23%)
		HECTc	682..1023	CDD:238033	77/368 (21%)
		HECTc	706..1023	CDD:214523	72/341 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900