DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and Ube3a

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	NP_001178766.1	Gene:	Ube3a / 361585	RGDID:	1306361	Length:	868	Species:	Rattus norvegicus

Alignment Length:	885	Identity:	188/885 - (21%)
Similarity:	335/885 - (37%)	Gaps:	197/885 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  2087 NNSGATNDGDGGSIFDYTPTRLGFSNSLKR-----NERVYETVPIDSSKTG-------DGNVTNK 2139
            |:.||:|:.:         .::......|.     .|:|||.......:..       .|.:.:.
  Rat    97 NSKGASNNSE---------IKMNKKEEFKEVDYLTEEKVYEIYEFCREREDYSPLIRVIGRIFSS 152

  Fly  2140 AEGSTDSNIYVQLKKKQGSDDFKSHKEADGNQSKYEK------VVLMETDDSLPSTSKSTEALMA 2198
            ||....|   .:..|:...::.||.:|.|.::.:.||      ...|| :||..|:|:..::...
  Rat   153 AEALVQS---FRKVKQHTKEELKSLQEKDEDKDEDEKEKAACSAAAME-EDSEASSSRMGDSSQG 213

  Fly  2199 TRPEVIIAPNKASVSPATAARSVIVLAGGSCLKTIDSDINNYSASNLSTAEQAKCDTQYQKSTSD 2263
            ......:.|:..:|......|....|.....::|...:...|.:.|:      :||..
  Rat   214 DNNVQKLGPDDVTVDIDAIRRVYSSLLSDEKIETAFLNALVYLSPNV------ECDLT------- 265

  Fly  2264 HLLLFPARGSQFYQSNFSELPSWNFLLSRWKLTLDLFGRVFMDDVGMEHGSVLPELRGFPVKEMR 2328
                        |.:.::..|::          |:|| .:.|::..: |.....|: ..|:
  Rat   266 ------------YHNVYTRDPNY----------LNLF-IIVMENRNL-HSPEYLEM-ALPL---- 301

  Fly  2329 FRRHMEKLRNGQQRDLV--LCKLERNRESLIVQTFKELNTQFGNQSRRIQPPITFNRVKVTFKDE 2391
            |.:.|.||....|..|:  ..|...::...:::||::|              ||:..:...|.
  Rat   302 FCKAMSKLPLAAQGKLIRLWSKYSADQIRRMMETFQQL--------------ITYKVISNEFN-- 350

  Fly  2392 PGEGSGVARSFYTSIAEALLASAK------IPNLESVQVGTNHS----KYVVPFSSILRSRTVSG 2446
                   :|:.... .:|::|::|      ..|:....|.|||:    :..:|.||.|..:.:.|
  Rat   351 -------SRNLVND-DDAIVAASKCLKMVYYANVVGGDVDTNHNEEDDEEPIPESSELTLQELLG 407

  Fly  2447 SSRDQSTLQRRGSNSKILWRSARERKALNLDARPYTPPNSSDNATPESLNDHLSVHLQQIGERLY 2511
            .       :||......:.....|.....||.|  .|..|.:....|.|||.|.:.    .:..:
  Rat   408 E-------ERRNKKGPRVDPLETEIGVKTLDCR--KPLISFEEFINEPLNDVLEMD----KDYTF 459

  Fly  2512 PKIHSINQ----------THAPKITG--------MLLEIPTPQLLSVISSDET---LRQKVNE-- 2553
            .|:.:.|:          ....|..|        |..|.....|.|::...:.   ||.||..
  Rat   460 FKVETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDH 524

  Fly  2554 -------AIEIITFKQKSETSAQ-------------SSQPKKSPSVVVVDPVDDDNEPLFYSPGK 2598
                   .:|:|..:..::...|             ....|:...:||.:..:.|.....|....
  Rat   525 IIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDEAT 589

  Fly  2599 RGF-YTPRQGFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIKFHDLAFFDPA 2662
            |.| :.|    :|||....|..||.::||.:..|.:|.:.....|.:.::|:|..|.||....|.
  Rat   590 RLFWFNP----SSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFCDLGDSHPI 650

  Fly  2663 LYESFRQIIQNAQTKEGEETINRMELCFVI---DLMKEEGCGN---RELIPGGRDVAVTSSNIFE 2721
            ||:|.:.:::.....|.:     |.:.|.|   ||.     ||   .:|...|..:.:|:.|..|
  Rat   651 LYQSLKDLLEYEGNVEDD-----MMITFQISQTDLF-----GNPMMYDLKENGDKIPITNENRKE 705

  Fly  2722 YVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMIN--LTAEDLRLLLNGVGDINVSTLISYTTF 2784
            :|..|::|.|.||.||..:|.:.| |.::.:.|.:.  ...|::.||:.|..:::...|...|.:
  Rat   706 FVSLYSDYILNKSVEKQFKAFRRG-FHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEY 769

  Fly  2785 NDESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPLPSVTIRPADDS- 2848
            :.    |..:.....:.||.||......:::..:.|.||:...|..  |...|..:..:...|:
  Rat   770 DG----GYTRESVVIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVG--GLGKLKMIIAKNGPDTE 828

  Fly  2849 HLPTANTCISRLYIPLYSSKSILRSKMLMAIK-SKNFGFV 2887
            .|||::||.:.|.:|.||||..|:.::|.||. :|.||.:
  Rat   829 RLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGML 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	15/92 (16%)
		HECTc	2589..2885	CDD:238033	83/306 (27%)
		HECTc	2589..2884	CDD:214523	83/305 (27%)
Ube3a	NP_001178766.1	AZUL	27..81	CDD:406862
Ube3a	NP_001178766.1	HECTc	516..866	CDD:238033	94/370 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900