DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and Ufd4

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	NP_609369.1	Gene:	Ufd4 / 34378	FlyBaseID:	FBgn0032208	Length:	2727	Species:	Drosophila melanogaster

Alignment Length:	3013	Identity:	551/3013 - (18%)
Similarity:	939/3013 - (31%)	Gaps:	1024/3013 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   458 FISDSITKIYVCSLYTVVKTESNNIYWWGVLPFDQRRFLWDKFRTKTKKPFKVVATDINVGAQVI 522
            ||.|..::::..:|::.:...|                   :..||.:.....:...:...:.::
  Fly   150 FIRDCGSQVHKDTLHSAMSVVS-------------------RLCTKVEPNTPCIQNCVESLSTLL 195

  Fly   523 MKKCPMYQSGSIGFTCSNGVPKVGQLLNSVWTFTDVCRMKIININTNSGVDKSQAAGNNLNAHGI 587
            ..:.||...|::....|     |.......|  .|...:....:.|.. :.:.|:.|.|.:: .:
  Fly   196 QHEDPMVSDGALKCFAS-----VADRFTRKW--VDPAPLAEYGLTTEL-LKRLQSVGGNTHS-SL 251

  Fly   588 TPDKDLPKSTAMPSTGSSKNG--------QSFSNSK--ESTDRIDMPPPPSPA----SSTCSDTG 638
            |.....|.|::.|:..::.:.        .:.|||.  :|:|....|...|..    |:.|..:.
  Fly   252 TAAGTQPTSSSQPAATTNSDAINENVAGTATISNSTKVKSSDAAASPQSISTTISLLSTLCRGSP 316

  Fly   639 SVTSHK--RTKRATTKE---------------------------------DSNAPQEGR------ 662
            |:| |.  |::.|...|                                 .||.|.:|:
  Fly   317 SIT-HDILRSQLADALERALQGDERCVLDCMRFADLLLLLLFEGRQALNRGSNNPNQGQLAPRPR 380

  Fly   663 -------------------KDEEL------------------------W-----EVKDVVFVEDK 679
                               ||.|.                        |     .::.|.::.:|
  Fly   381 RNNTNTDRTHRQLIDCIRSKDSEALREAIESGGIDVNCMDDVGQTLLNWASAFGTLEMVEYLCEK 445

  Fly   680 VGPVGKVLKVDGDFVAVRF--PAINAAAVAAAAAATSSTSNTASTSKEEGKE--DDWQQCRLLRR 740
            ...|.|..:......|..|  ||| |..:....|..........|..::.:|  ||.      .|
  Fly   446 GADVNKGQRSSSLHYAACFGRPAI-AKILLKFGAYPDLRDEDGKTPLDKARERLDDG------HR 503

  Fly   741 EDVQIFRTAMSTRGPD--WLQKQPKKINV---GGDAAGAQI----------------LTLAVDSR 784
            |...|.::......||  .|.|..||..:   .||...|.|                :..:|...
  Fly   504 EVAAILQSPGEWMSPDHSLLNKDGKKYTLMEPRGDPEMAPIYLKVLLPIFCRTFLGSMLGSVRRA 568

  Fly   785 GIHVIKKVLGKIHYSLYNLYNCKQEQNCLFPTDCNSFIGSTPGNILMAC------NDDCSGNSST 843
            .:.:|||:   :.|:...:.....|.:  |..|..|..|...||:|:..      |:|
  Fly   569 SLALIKKI---VQYAYPTVLQSLSETS--FSEDAASTSGQNGGNLLIEVIASVLDNED------- 621

  Fly   844 IVLRDGNGALYPLAKDCLGSIKDPQWFDLPPVKSITMSTISLPAMLSGVNLKSKVCMTALLFDTQ 908
                ||:|.|                        |.::.|           :..:|.|     .:
  Fly   622 ----DGDGHL------------------------IVLNII-----------EEIMCKT-----QE 642

  Fly   909 KLMPHILRCDVKNSFAALGRLEREDQADTAL----VVEERCDGARNIFHACVIMCAPSSNKDSPP 969
            :.:.|..|..|   ||.:..|...|..:..:    .|||.....|:   :..::.||....|.|.
  Fly   643 EFLDHFARLGV---FAKVQALMDTDAEELYVQLPGTVEEPAAAQRS---STSVVVAPRPTSDDPM 701

  Fly   970 DSPSGGVEKKSLVG-------LSVARSIPTVSTSAYV--SSIAFGASASSSN-----ENSSFATM 1020
            :.     .|:.|.|       .|:.|.    ....||  .|:|...|..|:.     .:...|||
  Fly   702 ED-----AKEILQGKPYHWREWSICRG----RDCLYVWSDSVALELSNGSNGWFRFIIDGKLATM 757

  Fly  1021 SSSAAGSASSTSRDNRTNLRDMMNRLINSDQAEQSG--SQP---------MATNNEDHAYIPWPA 1074
            .||.:....:.|.:||   .:.:.:|:.:.....:|  |||         :...|       |..
  Fly   758 YSSGSPENGNDSSENR---GEFLEKLMRARSCVIAGVVSQPILPTASALRLVVGN-------WVL 812

  Fly  1075 ETPAASNLSASSSQNVSDSI-EDDISKIIPSSSQSSMLSNIKLGSPTYTFDLAQRREHALTILQQ 1138
            ::...:.|...:::....:: :||:                    |.:.|:..:..:|..:
  Fly   813 QSQKTNQLQIHNTEGHQVTVLQDDL--------------------PGFIFESNRGTKHTFS---- 853

  Fly  1139 MCVSPALRPYLCHMLST-------KDAQGQTPFMLSVSCRAY-----EAGIILLNTILMLSEQDP 1191
              ....|.|......||       ...:||...:.::|...|     .|.||....:.:|::...
  Fly   854 --AETVLGPDFASGWSTAKKKRNKSKTEGQKFQVRNLSREIYNKYFKSAQIIPRGAVAILTDIVK 916

  Fly  1192 QL----KEAMIFPNGSPADQSPLHVICYNDTCSFTW--TGADHINQ-----------NIFECKTC 1239
            |:    :|..:.|||:                   |  |..|.:.:           :.:|..:.
  Fly   917 QIELSFEEQHMAPNGN-------------------WETTLTDALMKLSQLIHEDGVVSAYEMHSS 962

  Fly  1240 GLTGSLCCC-------TECARVCHKGHDCKLKRTAPTAYCDCWEKCKCKALIAGNLTKRFA--LL 1295
            ||..:|...       |...| |.:.   |:::...:.:..|..:...::......||..|  |:
  Fly   963 GLVQALVAVLSVNHWETNSPR-CKRN---KMQKQRVSVFKKCILEDNVESATNKPRTKSTASILI 1023

  Fly  1296 CKLVS----------------CTDL-------------------VTKFNSKGESILLFLIQTVGR 1325
            .||||                ||..                   .|.|:..|.::.:..:.|:|:
  Fly  1024 QKLVSVLESTEKLPVYLYDSPCTGYSLQILQKRLRFRLERAECESTLFDRSGRTLKMEPLATIGQ 1088

  Fly  1326 ------QIVEQRQYRF---------SVRVRNVSTAATGATGNNS------VISNRKT-------- 1361
                  ::|.::.|..         .:|....:|..|.:...:.      :.||.||
  Fly  1089 LSKYLLKMVAKQWYDLDRSTYFYLKKIREHRTATVFTHSFDFDEEGLLFYIGSNAKTCDWVNPAQ 1153

  Fly  1362 ------SAAEIDNDMPDHDLEP------------PKFARKALERLLIDWNAVRSMIMSGAERGDV 1408
                  :::| ...:|...||.            .|..:||       |.|:        :.|..
  Fly  1154 YGLVQVTSSE-GKTLPYGKLEDILSRDSISLNCHTKDNKKA-------WFAI--------DLGVY 1202

  Fly  1409 PNPAGSASENSNSEG----FNMFIQ-TQHGSTLLDKFTH----SLI---------VKCTSDHLDT 1455
            ..|......::...|    .|..:| ::.|||.....||    ||:         :.|.:|  |:
  Fly  1203 IIPTAYTLRHARGYGRSALRNWLLQGSKDGSTWTTLSTHVDDKSLVEPGSTATWPINCATD--DS 1265

  Fly  1456 LLLTLVRELQNA--------------------------SVSNRSKEAEEVVRRFVRSV------- 1487
            :....:|..||.                          .:....||||...||..|.:
  Fly  1266 VWYRHIRIQQNGRNASGQTHYLSLSGFEIYGRVVGVADDIGKSVKEAEAKTRRERRQIRAQLKHM 1330

  Fly  1488 ---ARVF--VIFNLEKQPN--------------PEKRKSHSSCNKYVQSCVKVFQTLHKISIEEL 1533
               |||.  |.:..|:|..              .:.:..|...|.|....    :..:.:.:.:
  Fly  1331 TTGARVIRGVDWRWEEQDGCAEGTITGEIHNGWIDVKWDHGVRNSYRMGA----EGKYDLKLAD- 1390

  Fly  1534 CEVSEALIAPVRLGVVRPTA-PFTMSSSNLDVRNSDDLFSVDPLAP------SNVESPSEQILVH 1591
            ||...|......:|.....| |.....:.|..|.|    |..|..|      .|.|..|.|.:..
  Fly  1391 CEYLSAFDGNQSMGSASTAAKPSEKGGNTLTSRKS----SSTPSLPEATEKNQNPEGASNQTVSA 1451

  Fly  1592 DAGNDQSANFNIQQNYDVVAMETIRDASESEEVINREANSHNQDDELIENQRNEDGMQDDESDN- 1655
            |       |...:|..:.:|....  ||...::|:.:...:.........:..|.|......||
  Fly  1452 D-------NLAWKQTVETIAENVF--ASAKTQIISNQLAMNTSSSREARAKHKESGTNQMHKDNI 1507

  Fly  1656 ---DFTFNDAETESD-SDDNQSNQEVQRSVQAGATVGSENDIGVLFLEDE--------------- 1701
               .....:.|..|| |..|.|...:..|..:.....||| :.:..|..|
  Fly  1508 SGPSPLSRELEHISDLSAINNSMPAINSSNVSDLATISEN-LSLTELSKENICRVLTPSYKPAES 1571

  Fly  1702 ---SGDSSAQEEDGSEDGESD-------DQSDEFNFNE--------------------------- 1729
               |..||..:...|...|:|       :::::.|.|.
  Fly  1572 VTASQSSSHPDVQSSSPRENDIKNISNIEENNKMNANNSVNKISKDLLANLRTSNIAGCPPVTQL 1636

  Fly  1730 --QQLE------------RRSTNSNARSDLAP------------QTMQWAIRSRDTAR------S 1762
              :.||            |..:||...:|..|            .....|:.:.|.|.      :
  Fly  1637 STEALEMIDKMRDGVDMIRNMSNSILSTDTFPVPCTNVPVGGKKTPKAQALINPDNANQKQIIVT 1701

  Fly  1763 SVRVPTGSN----------------MVFID----PMALRRSTVPASTTVTTPSIE-------PHT 1800
            |...||.|:                :..:|    |::....:||:..:::.|::.       |.|
  Fly  1702 SEEFPTKSSKKPSVTLKPAQQPNAVLSIVDIKEQPISNENVSVPSQMSISVPNLTTTSASEVPST 1766

  Fly  1801 --MATTASNLARAFGITIRQISELISILSYNVLNDIETSLKIQNDE-------AIAVQAFVEKRL 1856
              :||....|.....|..|:.|:..:|....::| .|.::....|:       ..:|.:.|:..|
  Fly  1767 SEVATHTGLLETFAAIARRRTSQGTNIQDNQIMN-AEANVNEHGDQNASGSFLGHSVTSLVKLAL 1830

  Fly  1857 KATWDWMFTVMDG--TEAQLKFGAYLTNYTDPNHPLHPLNLSAQASSSQT-----PAPATSSSVN 1914
            .:.:.      .|  :.|| .:.:..:|.::...|.:|.|.||...|:.|     ....||:|.:
  Fly  1831 SSNFH------SGLLSTAQ-SYPSLSSNNSENIAPSNPSNTSAGQQSASTINHTLTMSLTSTSSD 1888

  Fly  1915 GVNIMGSNSRRDFFTYCL--SLM-----------RSHTSEHRDALPVLDITALRHIAYVLDAFVY 1966
            ...:    |..||...|.  :|:           .:...|:.|....:..|.|:         |.
  Fly  1889 SEQV----SLEDFLESCRAPALLGDLDDEDDMDEDNDEEENEDEYEEVGNTLLQ---------VM 1940

  Fly  1967 YMRNDSGFYDKQDTISGRINNLSPMTESYDTDDELANLEEFNADVQMSASSMPSGSQGTRRHAFF 2031
            ..||...|.|.:    ...|.|..:|:....|||.....:|:|       .:|:......|....
  Fly  1941 VSRNLLTFMDDE----AMENRLVGVTKRKSWDDEFVLKRQFSA-------LIPAFDPRPGRTNVN 1994

  Fly  2032 ARSESTLSLGCSAPEGFELPLDMAMPLADKPHLL-QPNSKRQELFANLPLLVTTNANNSGATNDG 2095
            ..|:..:|     |.|.|||         ||... .|.:..|      |||        |....|
  Fly  1995 QTSDLEIS-----PLGAELP---------KPQQSGGPETIEQ------PLL--------GLKLRG 2031

  Fly  2096 DG-GSIFDYTPTRLGFSNSLKRNERVYETVPIDSSKTGDGNVTNKAEGSTDSNIY------VQLK 2153
            .| |.|                     ..|.||.|             :||..|:      :|..
  Fly  2032 PGIGGI---------------------PEVEIDLS-------------NTDWTIFRAVQELLQCS 2062

  Fly  2154 KKQGSDDFKSHKEADGNQSKYEKVVLMETDDSLPSTSKSTEALMATRPEVIIAPNKASVSPATAA 2218
            :....|.|:...|     ..|..|....:.::..||...:|....| |:|......:::||.:..
  Fly  2063 QLNKLDKFRKIWE-----PTYTIVYREVSPEAQESTCLESEEFPQT-PDVSSKSGASTLSPNSPM 2121

  Fly  2219 R-----------------SVIVLAGGSCLKTIDSDINNYSASNLS--TAEQAKCDTQYQKSTSDH 2264
            .                 .::....|.....||||:..:..|.||  .....|...:.|:...|.
  Fly  2122 HIGFNVADNNLCSVDDVLELLTQINGLNQSEIDSDVKEHGVSVLSEDLFISKKITNKLQQQIQDP 2186

  Fly  2265 LLLFPARGSQFYQSNFSELPSW------------------------NFLLSRWKLTLDLFGRVFM 2305
            |:|         .||  .||:|                        :|..||..:.|
  Fly  2187 LVL---------ASN--ALPNWCENLNQSCPFLFPFETRQLYFNCTSFGASRSIVCL-------- 2232

  Fly  2306 DDVGMEHGSVLPELRGFPVKEMRFRRHMEKLRNGQ-QRDLVLCKLERNRESLIVQTFKELNTQFG 2369
                .....|..|.:..|:  |..||...:.|.|: :.:.|  |:.|| |.|::...:.:.|...
  Fly  2233 ----QSQRDVTVERQRIPI--MSPRRDDHEFRIGRLKHERV--KVPRN-EDLLMWAMQVMKTHCN 2288

  Fly  2370 NQSRRIQPPITFNRVKVTFKDEPGEGSGVARSFYTSIAEALLASAKIPNLESVQVGTNHSKYVVP 2434
            .:|          .::|.|.||.|.|.|....||..:|
  Fly  2289 RKS----------VLEVEFLDEEGTGLGPTLEFYALVA--------------------------- 2316

  Fly  2435 FSSILRSRTVS-------GSSRDQSTLQRRGSNSKILWRSARERKALNLDARPYTPPNSSDNATP 2492
             :.|.||....       |...:.||....|::..:.:...|....:    .|...|.:|
  Fly  2317 -AEIQRSDLCMWLCDDDLGEDTENSTQSAEGNSKPVGYYVNRREHGI----FPAPLPQNS----- 2371

  Fly  2493 ESLNDHLSVHLQQIGERLYPKIHSINQTHAPKITGM-LLEIP-TPQLLSVISSDETLRQKVNEAI 2555
                        :|.|.:...........|..:..| |::|| :...|.::..::.|.:.:.
  Fly  2372 ------------EICENVLKYFWFFGVFVAKVLQDMRLVDIPLSTSFLQLLCHNKVLSRNLQ--- 2421

  Fly  2556 EIITFKQKSETSAQSSQPKKSPSVVVVDPVDDDNEPLFYSPGKRGFYTPRQGFASFERINAFRNI 2620
            ::|:.::..:.|..|...         |.|:...:.|.....|.               |||.
  Fly  2422 KVISDRRNGDLSVVSEDS---------DIVETCTKLLRTDSNKS---------------NAFG-- 2460

  Fly  2621 GRLIGLCLLQN--ELLPL---FLQRHVLKYILGRKIKFHDLAFFDPALYESFRQIIQ--NAQTKE 2678
                |:..|:|  |:.|.   |||.  ::.:|.||   ..:.|.|....|...::|.  ..||:.
  Fly  2461 ----GILSLENLKEIDPTRYQFLQE--MQNLLLRK---QSIEFDDTISAEKKHELINELKLQTQN 2516

  Fly  2679 G-EETINRMELCFV-IDLMKEEGCGNRELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALEA 2741
            | |.::..:.|.|. :......|....||:|.|..|.||..|:..|......:.|.....:.::|
  Fly  2517 GLEVSLEDLALTFTYLPSSSIYGYTQAELLPNGSSVNVTIDNLEAYCELLMNFILQDGIAQQMKA 2581

  Fly  2742 LKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVS--TLISYTT----FNDESSEGPDKLLKFKK 2800
            ..||..:|.|...:...|..:.|:::.|....:.|  .:||||.    :|.:|.       .|::
  Fly  2582 FSDGFNEVFPLKKLAAFTPSEARMMICGEQFPHWSREDIISYTEPKLGYNKDSP-------GFQR 2639

  Fly  2801 WFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPL-PSVTIRPADDSHL---PTANTCISRLY 2861
             |.:::..|:..||:..:.|.||..:||..  |...| |.:|:....|:.:   |:.|||:..|.
  Fly  2640 -FVNVLLSMSGDERKAFLQFTTGCSSLPPG--GLANLHPRLTVVRKVDAGVGSYPSVNTCVHYLK 2701

  Fly  2862 IPLYSSKSILRSKMLMAIKSKNF 2884
            :|.|.::.|::.::|.|.|.|.|
  Fly  2702 LPDYPTEEIMKERLLTATKEKGF 2724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698	12/86 (14%)
		ASF1_hist_chap	1535..1733	CDD:304562	46/263 (17%)
		PolyA	2498..2561	CDD:197769	10/64 (16%)
		HECTc	2589..2885	CDD:238033	80/315 (25%)
		HECTc	2589..2884	CDD:214523	79/313 (25%)
Ufd4	NP_609369.1	ANK repeat	393..420	CDD:293786	3/26 (12%)
		ANK	396..509	CDD:238125	21/119 (18%)
		ANK repeat	422..453	CDD:293786	5/30 (17%)
		ANK repeat	455..484	CDD:293786	7/29 (24%)
		F5_F8_type_C	1173..1298	CDD:329041	24/141 (17%)
		MIB_HERC2	1333..1389	CDD:310955	9/59 (15%)
		DamX	1576..>1725	CDD:330571	21/148 (14%)
		HECTc	2265..2725	CDD:238033	123/570 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447006
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830