DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and ubr5

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	XP_021322301.1	Gene:	ubr5 / 334627	ZFINID:	ZDB-GENE-030131-6559	Length:	2833	Species:	Danio rerio

Alignment Length:	3116	Identity:	1247/3116 - (40%)
Similarity:	1758/3116 - (56%)	Gaps:	512/3116 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVSMQFVLQPLPGSDDQFIERIREVSDKVNRFGYGSHR---IFEQLKIPVKEVVIGPAHIGVLLE 62
            |.|:.||:.||||::||..:|:||||:|:|::...||.   ..||.|:  |:.|:||.|.|.|||
Zfish     1 MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNCNSHPHLIPLEQAKL--KQCVVGPNHAGFLLE 63

  Fly    63 DGKAFRVSFSINSEKLDLTKSDAKCSTSGGSGTASASKAPSSSRPMARS-----------RARLL 116
            ||:..|:||::..::|:|.|.|.    :.||..:|.|.|..||||...|           ..||.
Zfish    64 DGRICRISFAVQPDRLELGKPDG----NDGSKLSSVSGAGRSSRPGRTSDPPWFLSGSDTLGRLA 124

  Fly   117 RAT----------------GRSNSTGQGSGSRSTGVIIGG----------STSSR---------- 145
            ..|                |.|:..|.|.||.|.|...||          ||::|
Zfish   125 GNTLGTRWSSGVNGGGSGGGGSSGGGAGGGSGSGGGAGGGTGGGGSSGRSSTAARDSRRQTRVIR 189

  Fly   146 -------------PLVTVPATYVPEELISQAEVVLQGKSRNLIIRELQRTNLDVNLAVNNLLSRD 197
                         |...:||:.:||||||||:||||||||::|||||||||||||||||||||||
Zfish   190 TGRDRGSGLLGSQPQPVIPASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRD 254

  Fly   198 DEEAEDTEEGA-DNYVP-EDLISLLDNGFSGDNNSVIIDPSDGLFSEEI-FSNYSSIRNLLFDRI 259
            ||:.:|.::.| ::|:| |||:||||......:.||||| :|.:|||:| :..|.|.|.....|:
Zfish   255 DEDGDDGDDTASESYLPGEDLMSLLDADIHSAHPSVIID-ADAMFSEDISYFGYPSFRRSSLSRL 318

  Fly   260 RSERSNANANAADSNQSTTRSTSSGTALTGNSGLSAQISVNADREAFSRWRDRQYYGPRRWISKD 324
            .|.|........||                        .:..:||:..|.|:      |||:...
Zfish   319 GSSRVLLLPLERDS------------------------ELLRERESVLRLRE------RRWLDGA 353

  Fly   325 DYTWEKDADSKKKEPS------PMLSPIWISEELQPWPEKSSV-RFKTIGALYSEFIALSESGDL 382
            .:..|:.:.|::.|||      |:.||:.:.||||.||:|..| :|.:|||||||.:|:|..|:|
Zfish   354 SFDAERGSTSREGEPSLDKKSVPLQSPVTLGEELQWWPDKDYVTKFVSIGALYSELVAVSTKGEL 418

  Fly   383 YQWRWSDAEPYK-SETENVYHPKTVSLNIV-ERVELISANFIRCSVVTETNRVATWMDEQLGYIG 445
            |||:|::.|||: ::..:::||:...|.:. |::..:|||.||.:|.||.|:||||:||.|..:.
Zfish   419 YQWKWNEPEPYRNAQNPSIHHPRVPFLGLTNEKITHLSANSIRATVATENNKVATWVDETLSTVA 483

  Fly   446 AKLEHSCCAFNEFISDSITKIYVCSLYTVVKTESNNIYWWGVLPFDQRRFLWDKFRTKTKKPFKV 510
            |||||....|.|...:.|..::.|:|||..:.| |::|||||:||.||:.:.:|.|.|.|||...
Zfish   484 AKLEHGAQTFPELQGERIVSLHCCALYTCAQLE-NSLYWWGVVPFSQRKKMLEKARAKNKKPKSS 547

  Fly   511 VA----TDINVGAQVIMKKCPMYQSGSIGFTCSNGVPKVGQLLNSVWTFTDVCRMKIININTNSG 571
            ..    .:|.||.||.::..|:|.:|::.|:.:.|:||||.||.|||...|.||.::
Zfish   548 AGISSIPNITVGTQVCLRNNPLYHAGAVAFSVNAGIPKVGVLLESVWNMNDSCRFQL-------- 604

  Fly   572 VDKSQAAGNNLNAHGITPD--KDLPKSTAMPSTGSSKNGQSFSNSKESTDRIDMPPPPSPASSTC 634
                           .:|:  |::.|:|        |..::.:.||....:.:|.|||||| |||
Zfish   605 ---------------RSPESLKNMEKNT--------KTQETKTESKPELVKTEMGPPPSPA-STC 645

  Fly   635 SDTGSVTS-----HKRTKRATTKEDSNAPQEGRK-DEELWEVKDVVFVED-KVGPVGKVLKVDGD 692
            |||.|:.|     :|| :|:|.     ||:|..| :||.|.:::|||||| |..||||||||||.
Zfish   646 SDTSSIASSASLPYKR-RRSTP-----APKEEEKVNEEQWPLREVVFVEDVKNVPVGKVLKVDGA 704

  Fly   693 FVAVRFPAINAAAVAAAAAATSSTSNTASTSKEEGKEDDWQQCRLLRREDVQIFRTAMSTRGPDW 757
            :|||:||..:::..:.:||.|.|..::.           .|.|||||.:::|:.:|..:.:.||.
Zfish   705 YVAVKFPGTSSSVSSQSAAPTDSDPSSL-----------LQDCRLLRIDELQVVKTGGTPKVPDC 758

  Fly   758 LQKQPKKINVGGDAAGAQILTLAVDSRGIHVIKKVLGKIHYSLYNLYNCKQEQNCLFPTDCNSFI 822
            .|:.|||:.:   ...|:||.:.|||:|:|.:.|....:.|.:::|...|.||...|||...:|:
Zfish   759 FQRTPKKLCI---PEKAEILAVNVDSKGVHAVLKTGSWVRYCVFDLATGKAEQENHFPTSNLAFL 820

  Fly   823 GSTPGNILMACNDDCSGNSSTIVLRDGNGALYPLAKDCLGSIKDPQWFDLPPVKSITMSTISLPA 887
            |.:..|:.:.    .:|..|.|:||||||.:||:||||:|.|:||.|.||||:.|:.|...||..
Zfish   821 GQSERNVAIF----TAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPPIASLGMGVHSLAN 881

  Fly   888 MLSGVNLKSKVCMTALLFDTQKLMPHILRCDVKNSFAALGRLERE---DQADTAL--VVEERCDG 947
            :.|...:|.|..:..:..:.|.||.|:||||.:.....|..||:.   :|...||  ::..||||
Zfish   882 LPSNSTIKKKAAIIIMAVEKQTLMQHVLRCDYEACRQYLISLEQAMLLEQNPHALDTLLGHRCDG 946

  Fly   948 ARNIFHACVIMCAPSSNKDSPPDSPSGGVEKKSLVGLSVARSIPTVSTSAYVSSIAFGASASSSN 1012
            .||:.||||.:|.|.|||::..:..:...|:.:.           ....:.|.:||...|..|||
Zfish   947 NRNVLHACVSVCFPVSNKETKEEEEAERSERNTF-----------AERLSAVEAIANAISVVSSN 1000

  Fly  1013 ENSSFATMSSSAAGSASSTSRDNRTNLRDMMNRLINSDQAEQSGSQPMATNNED--------HAY 1069
                     ||...:.||:||..|  ||:||.|.:.:....:..|.|.:::::|        .::
Zfish  1001 ---------SSGNRTGSSSSRGLR--LREMMRRSLRAAGLGRHESGPSSSDHQDPVSPPIAPPSW 1054

  Fly  1070 IPWPAE-----------TPAASNLSASS---SQNVSDSIEDDISKIIPS-SSQSSMLSNIKLGSP 1119
            :|.|..           .||..:|:.:|   ||..|.|       .||. ||:.|::.:
Zfish  1055 VPDPPPMDPDGDIDFILAPAVGSLTTASTGTSQGPSTS-------TIPGPSSEPSVVES------ 1106

  Fly  1120 TYTFDLAQRREHALTILQQMCVSPALRPYLCHMLSTKDAQGQTPFMLSVSCRAYEAGIILLNTIL 1184
                  ..|:.:|..||:.||.|..|||:|..:||.|||:|.|||||:||.|||.|.|.:|....
Zfish  1107 ------KDRKANAHLILKLMCDSIVLRPHLRELLSAKDARGMTPFMLAVSGRAYPAAITVLEAAQ 1165

  Fly  1185 MLSEQDPQLKE---------AMIFPNGSPADQSPLHVICYNDTCSFTWTGADHINQNIFECKTCG 1240
            .:::.:|.|.|         .||.|:|:..|.|||:|:|.|||||||||||:||||:||||:|||
Zfish  1166 KIAKGEPGLGEKEDTASVFMEMICPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCG 1230

  Fly  1241 LTGSLCCCTECARVCHKGHDCKLKRTAPTAYCDCWEKCKCKALIAGNLTKRFALLCKLVSCTDLV 1305
            |..|||||||||||||||||||||||:||||||||||||||.||||....|..||.:|::.|:||
Zfish  1231 LLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKAARLDLLYRLLTTTNLV 1295

  Fly  1306 TKFNSKGESILLFLIQTVGRQIVEQRQYRFSVRVRNVSTAATGATGNNSVISNRKTSAAEIDNDM 1370
            |..||:||.|||||:|||.||.||..||| ..|:|.              ..|||.::|| |:||
Zfish  1296 TTPNSRGEHILLFLVQTVARQSVEHCQYR-PPRIRE--------------DRNRKAASAE-DSDM 1344

  Fly  1371 PDHDLEPPKFARKALERLLIDWNAVRSMIMSGAERGDVPNPAGSASENSNSEGFNMFIQTQHGST 1435
            ||||||||:||:.||||:|.||||::||||.|::....|..|.|...:...|. .|::..|.|:.
Zfish  1345 PDHDLEPPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIAHLLPEE-QMYLNQQSGTI 1408

  Fly  1436 LLDKFTHSLIVKCTSD--HLDTLLLTLVRELQNASVSNRSKEAEEVVRRFVRSVARVFVIFNLEK 1498
            .||.|||.|||||..|  .:||||.|||:||||.....|.:||..|.|||:|||||||||.::|.
Zfish  1409 RLDCFTHCLIVKCAPDITFIDTLLGTLVKELQNKYTPGRREEAINVTRRFLRSVARVFVILSVEM 1473

  Fly  1499 QPNPEKRKSHSSCNKYVQSCVKVFQTLHKISIEELCEVSEALIAPVRLGVVRPTAPFTMSSSNLD 1563
               ...:|.::...:.:..|.:|||.|...::||||.|:|:||.|||:|:.|||||||::|:::|
Zfish  1474 ---ASSKKKNNFIPQPIGKCRRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSID 1535

  Fly  1564 -VRNSDDLFSVDPLAP--------SNVESPSEQILVHD----AGNDQSANFNIQQNYDVVAMETI 1615
             |:.|::||||:||.|        |:.:|.|..|:.:.    :...|:|....::..|:|:
Zfish  1536 AVQGSEELFSVEPLPPRPSPDQSSSSSQSASSYIIRNPQPRRSSQSQTARGRDEEQDDIVS---- 1596

  Fly  1616 RDASESE--EVINREANSHNQDDELIENQRNEDGMQD--DESDNDFTFN---DAETESDSDDNQS 1673
            .|..|.|  |.:..|.:.|:..:|..|.....:|..|  ||..:|...:   .|||||||:.|.|
Zfish  1597 ADVEEVEVVEGVAGEEDHHDDQEEQGEENAEAEGQHDEHDEDGSDMELDLLAAAETESDSESNHS 1661

  Fly  1674 NQE---VQRSVQAGATVGSE---NDIGVLFLEDESGDSSAQEEDGSEDGESDDQSDEFNFNEQQL 1732
            ||:   .:|||...||.|||   :.:...|.||:|..:.:.:.| |...:|||...|....::.|
Zfish  1662 NQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSD-SSSSQSDDVDQETFLLDEPL 1725

  Fly  1733 ERRSTNSNARSDL-APQTMQWAIRSRDTARSSVRVPTGSN--------MVFIDPMALRRST-VPA 1787
            ||.:.:::|.|.. ||::||||:|:..:.||....|:.|:        :::|||..||||: :..
Zfish  1726 ERTTGSAHANSAAQAPRSMQWAVRTTPSQRSGGGAPSSSSAPAASSTGLIYIDPSNLRRSSAIST 1790

  Fly  1788 STTVTTPSIEPHTMA---TTASNLARAFGITIRQISELISIL-SYN--VLNDIETSLKIQNDEAI 1846
            |......::|....:   |:||:||||:.|.|||||:|:|:: .||  |.:....::|:...:|:
Zfish  1791 SAAAAAAALEASNSSSYLTSASSLARAYSIVIRQISDLMSLIPKYNHLVYSQYPAAVKLTYQDAV 1855

  Fly  1847 AVQAFVEKRLKATWDWMFTVMDGTEAQLKFGAYLTNYTDPNHPLHPLNLSAQASSSQTPAPATSS 1911
            .:|.|||.:|..||:||.::||.|||||::|:.|::..||.||.|||:.|..|...:.......:
Zfish  1856 NLQNFVEDKLIPTWNWMVSIMDSTEAQLRYGSALSSAGDPGHPSHPLHASQHAGRRERMTAREEA 1920

  Fly  1912 SVNGVNIMG--------------SNSRRDFFTYCLSLMRSHTSEHRDALPVLDITALRHIAYVLD 1962
            |:.  .:.|              .::|.||..|.|||||||..||.|.|||||:.:|:|:|||..
Zfish  1921 SLR--TLEGRRRAATLLTARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQ 1983

  Fly  1963 AFVYYMRNDSGFYDKQDTIS----GRINNLSPMTESYDTDD-ELANLEEFN-ADVQMSASSMPSG 2021
            |.:|:::    ..:.|.|:.    .|..|...:....|.:| |..|.|:.| :.........|..
Zfish  1984 ALIYWIK----AMNLQTTLDTTQIDRKRNRELLELGLDNEDSEHENDEDTNQSSTLQDKDEEPVP 2044

  Fly  2022 SQGTRRHAFFARSESTLSLGCSAPEGFELPLDMAMPLADKPHLLQPNSKRQELFA--NLPLLVTT 2084
            ::..:.|.||.||:|...|||..|..||:||..|:||||:|||||||:::::||.  :..|..::
Zfish  2045 AETGQHHPFFRRSDSMTFLGCIPPNPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSS 2109

  Fly  2085 NANNSGATNDGDGGSIFDYTPTRLGFSNSLKRNERVYETVPIDSSKTGDGNVTNKAEGSTDSNIY 2149
            ...:.|.|:.....:.....||::.:|.::|                               |:.
Zfish  2110 YMASKGLTDLTVDMNCLQILPTKMSYSANMK-------------------------------NVM 2143

  Fly  2150 VQLKKKQGSDDFKSHKEADGNQSKYEKVVLMETDDSLPSTSKSTEALMATRPEVIIAPNKASVSP 2214
            ....:::|.::              :.|...|.|.|.|..|          |..:.|..|:|:
Zfish  2144 SMESRQRGGEE--------------QPVAEQEMDVSKPGPS----------PHDLAAQLKSSL-- 2182

  Fly  2215 ATAARSVIVLAGGSCLKTIDSDINNYSASNLSTAEQAKCDTQYQKSTSDHLLLFPARGSQFYQSN 2279
              .|...:..:.|..|.|                                  ..|      :.|.
Zfish  2183 --LAEIGLTESDGPPLPT----------------------------------FIP------HCSF 2205

  Fly  2280 FSELPSWNFLLSRWKLTLDLFGRVFMDDVGMEHGSVLPELRGFPVKEMRFRRHMEKLRNGQQRDL 2344
            ...:.|.:.||.||:|:|:|||||||:|||.|.||:|.||.||.|||.:|||.||||||.|.|||
Zfish  2206 MGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREMEKLRNLQSRDL 2270

  Fly  2345 VLCKLERNRESLIVQTFKELNTQFGNQSRRIQPPITFNRVKVTFKDEPGEGSGVARSFYTSIAEA 2409
            .| :::|:||.||.||.::||..||.  |....|:..:||||||||||||||||||||||:||:|
Zfish  2271 AL-EVDRDREQLIQQTMRQLNAHFGR--RCTTTPMAVHRVKVTFKDEPGEGSGVARSFYTAIAQA 2332

  Fly  2410 LLASAKIPNLESVQVGTNHSKYVVPFSSILRSRTVSGSSRDQSTLQRRGSNSKILWRSARE---- 2470
            .|::.|:|||:.||   :.||.:...:.:.|.|     :||:.. :||....:...|..|:
Zfish  2333 FLSNDKLPNLDCVQ---SVSKGMQASNLMQRLR-----NRDRER-ERRSGGLRAASRRDRDSLKR 2388

  Fly  2471 ----------RKALNLDARPYTPP---NSSDNATPESLNDHLSVHLQQIGERLYPKIHSINQTHA 2522
                      |:.|::|.||:.|.   |.||...|      |..|.|.:||||||::|::....|
Zfish  2389 LFAVFDCRDSRRQLSIDTRPFRPASEGNPSDEPEP------LPAHRQALGERLYPRVHAMQPAFA 2447

  Fly  2523 PKITGMLLEIPTPQLLSVISSDETLRQKVNEAIE-IITFKQKS--------------ETSAQSSQ 2572
            .||||||||:...|||.:::|:::||.:|.||:| :||..:::              |.:.|.::
Zfish  2448 SKITGMLLELSPAQLLLLLASEDSLRARVEEAMELLITHGRENGADSILDLGLLDTPEKAQQENR 2512

  Fly  2573 PKKSPSVVVV-----DPVD-DDNEPLFYSPGKRGFYTPRQGFASFERINAFRNIGRLIGLCLLQN 2631
            .:...:..||     ||.| |||.||||.|||||||:||.|..:..|:|.||||||::|||||||
Zfish  2513 KRHGSTRSVVDMELDDPDDGDDNAPLFYQPGKRGFYSPRPGKNTEARLNCFRNIGRILGLCLLQN 2577

  Fly  2632 ELLPLFLQRHVLKYILGRKIKFHDLAFFDPALYESFRQIIQNAQTKEGEETINRMELCFVIDLMK 2696
            ||.|:.|.|||:|.:||||:.:||.|||||.:|||.||:|:::||:|.|.....|:|.|.|||.|
Zfish  2578 ELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLRQLIRHSQTEEAEAVFAAMDLAFAIDLCK 2642

  Fly  2697 EEGCGNRELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAE 2761
            |||.|..||:.||.::.||..|::||||||.|:|::...|:.|.|::.|:.||||.|::.:||||
Zfish  2643 EEGAGQVELLSGGVNMPVTPLNVYEYVRRYAEHRMLVVAEQPLHAMRKGLLDVLPKNALEDLTAE 2707

  Fly  2762 DLRLLLNGVGDINVSTLISYTTFNDESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPA 2826
            |.|||:||.|::||..|||:|:|||||.|..:|||:||:|||||||||::.||||||||||.||:
Zfish  2708 DFRLLVNGCGEVNVQMLISFTSFNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPS 2772

  Fly  2827 LPASEEGFQPLPSVTIRPADDSHLPTANTCISRLYIPLYSSKSILRSKMLMAIKSKNFGFV 2887
            ||||||||||:||:||||.||.|||||||||||||:||||||.||:.|:|:|||:||||||
Zfish  2773 LPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV 2833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409	38/45 (84%)
		ZnF_UBR1	1217..1284	CDD:197698	59/66 (89%)
		ASF1_hist_chap	1535..1733	CDD:304562	76/223 (34%)
		PolyA	2498..2561	CDD:197769	31/63 (49%)
		HECTc	2589..2885	CDD:238033	189/295 (64%)
		HECTc	2589..2884	CDD:214523	188/294 (64%)
ubr5	XP_021322301.1	E3_UbLigase_EDD	206..253	CDD:288409	38/46 (83%)
		ZnF_UBR1	1207..1274	CDD:197698	59/66 (89%)
		PolyA	2423..2486	CDD:197769	31/68 (46%)
		HECTc	2505..2830	CDD:214523	197/324 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594999
Domainoid	1	1.000	1351	1.000	Domainoid score	I8
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9295
Inparanoid	1	1.050	1985	1.000	Inparanoid score	I52
OMA	1	1.010	-	-		QHG45699
OrthoDB	1	1.010	-	-		D13816at33208
OrthoFinder	1	1.000	-	-		FOG0007203
OrthoInspector	1	1.000	-	-		oto40907
orthoMCL	1	0.900	-	-		OOG6_106470
Panther	1	1.100	-	-	LDO	PTHR46276
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3204
SonicParanoid	1	1.000	-	-		X5312
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940