Protein Alignment hyd and CG4238

DIOPT Version :10

• Sequence 1: NP_001287262.1
• Gene: hyd / 41181
• FlyBaseID: FBgn0002431
• Length: 2887
• Species: Drosophila melanogaster
• Sequence 2: NP_608640.2
• Gene: CG4238 / 33377
• FlyBaseID: FBgn0031384
• Length: 977
• Species: Drosophila melanogaster
• Alignment Length: 1022
• Identity: 208/1022 - (20%)
• Similarity: 359/1022 - (35%)
• Gaps: 300/1022 - (29%)

  Fly  2081 LVTTNANNSGATNDGDGGSIFDYTPTRLGFSNSLKRN--------ERVYETVPIDSSKTGDGNVT 2137
            ::.::.|..|..:...||..|.....:|.|..|:..:        ||:.|..|:|..:.
  Fly    41 MLVSHINVGGVMHAATGGKTFPTLKVKLCFGESMGISSLSSCGDPERLPELPPLDEQRL------ 99

  Fly  2138 NKAEGSTDSNIYVQLKKKQGSDDF-KSHKEADGNQSKYEKVVLMET---------DDS------- 2185
                    ....:.|::|....:: |.|:    .|..|::::.:|.         :||
  Fly   100 --------QRAALHLQQKLILREWLKDHR----LQHHYQRLLAVEVASLEDVYWLEDSRASKILG 152

  Fly  2186 ------------LPSTSKSTEALMATRPEVIIAPNK------------ASVSPATAARSVIVLAG 2226
                        ||::....:||.|.....::..::            .|||.|    .::.||
  Fly   153 KDWQLWSGARQNLPTSKAQLDALKAQLWSTVVKSSQHQDAWTWGGMLVVSVSVA----GLVTLA- 212

  Fly  2227 GSCLKTIDSDINNYSASNLSTAEQAKCDTQYQKSTSDHLLLFPAR--------------GS---- 2273
                          :.:..|.|.:|: .:..|..|..:||  ||.              |:
  Fly   213 --------------AMTQPSLAPEAR-HSLLQYVTGKYLL--PANCKVQWDWKDPASVGGTMCFV 260

  Fly  2274 -QFYQSN-------------------------FSELPSW----NFLLSRWKLTLDLFGRVFMDD- 2307
             :|:|.|                         .|||.|.    |..:::.|.|:...|:..:..
  Fly   261 VRFFQRNGQPYPICDTDHFFVEVTEGTRKVVTISELGSSTDPNNANIAKVKFTVRTAGQYKISVL 325

  Fly  2308 VGMEHGSVLPELRGF-----PVKEMRFRR---------------HMEKLRNGQQRDLV--LCKLE 2350
            :|..|.:..|.||.|     ..:..||.|               |:|      .||..  .|..:
  Fly   326 IGASHIAGSPFLRSFLPGAIDARRSRFIRPASTVICCAGAPTLMHIE------PRDEFGNSCLFD 384

  Fly  2351 RNRESLIVQTFK-ELNTQFGNQSRRIQPPITF------NRVKVT-FKDEPGEGSGVARSFYTSIA 2407
            :|:....:|.:: .:....|....::|..|.|      :||.|| ...||            :..
  Fly   385 QNQSDEALQGYQVAIYDLHGVPVEKLQHAIVFAYDKVNSRVSVTALFPEP------------TCL 437

  Fly  2408 EALLA--SAKIPN-------LESVQVGTNHS-----KYVVPFSSILRSRTVSGSSRDQSTLQRRG 2458
            .|:::  ..::||       |.|......|.     |:.:.:.:.|.|......::.:..|...|
  Fly   438 RAVISYRDQQLPNGDFDIIVLSSSDTTLVHKNIASRKHNICYEAKLLSIFGVSKNKPRKVLCYVG 502

  Fly  2459 --SNSKILWRSARERKALNLDARPYTPPNSSDNATPESLNDHLSVHLQQIGERLYPKIHSINQTH 2521
              .||.|...:.:|.      ...:.|...:......|...|.   |.|:..:|:..:..|:...
  Fly   503 PKQNSLIFQVTIKEM------ILKFIPKRIATFRLCPSTKFHF---LPQLVSQLHGPVFIIDDGA 558

  Fly  2522 APKI------TGMLLEIPTPQLLSVISSDETLRQK------------VNEAIEIITFKQKSETSA 2568
            .|||      ..::....|..||..|...||.:.|            .:...|.:..|.:.|...
  Fly   559 QPKIELASKDRNIIAATFTHFLLKNIGGSETFKDKQDFFYHEVRKFHASYYHEKMALKVQREKIL 623

  Fly  2569 QSSQPKKSPSVVVVDPVDDDNEPLFYSPGKRG-----------------FYTPRQG-FASFE--- 2612
            :||.  |:.....|.....:.|..|  .|::|                 .:..|.| |.:|.
  Fly   624 ESSM--KAVKGFSVSDWCGNFEVTF--QGEQGIDWGGLRREWFELVCSALFDARGGLFCTFHDKH 684

  Fly  2613 --------------RINAFRNIGRLIGLCLLQNELLPLFLQ-------RHVLKYILGRKIKFHDL 2656
                          ::..|...|:::|.||.::.|...:.|       |..|..::|.::.:...
  Fly   685 QALVHPNPTRPAHLKLKHFEFAGKMVGKCLFESALGGTYRQLVRARFSRSFLAQLIGLRVHYKYF 749

  Fly  2657 AFFDPALYESFRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCGNR----ELIPGGRDVAVTSS 2717
            ...||.||.|..:.|.:...    :..:.:||.|| :.|.:...|..    ||||.|....||::
  Fly   750 EQDDPDLYLSKIKYILDTDL----DATDTLELYFV-EEMYDSSSGQLSKTIELIPNGAKTRVTNA 809

  Fly  2718 NIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVSTLISYT 2782
            ...:|:....:.||..:.:..:::...|:..::|||.:......:|.||:.|.|:.::|...::.
  Fly   810 TKNQYLDALAQQRLCNNVKDEVDSFLKGLNSIIPDNLLSIFDENELELLMCGTGEYSISDFKAHH 874

  Fly  2783 TFNDESSEGPDKLLKFKK---WFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPL-PSVTIR 2843
            ..|..|:|       |::   |||:.|...:..|...|:.|.||...||..  |||.| |...|.
  Fly   875 IANGNSAE-------FRRVLAWFWAGVSNFSQTEMARLLQFTTGCSQLPPG--GFQELNPQFQIT 930

  Fly  2844 PADD-SHLPTANTCISRLYIPLYSSKSILRSKMLMAIK--SKNFGFV 2887
            .|.. .:||||:||.::|.:|.|.|.......:|:||.  |:.||.|
  Fly   931 AAPTFGNLPTAHTCFNQLCLPDYESYEQFEKSLLLAISEGSEGFGMV 977

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	UBA_like_SF	150..196	CDD:473871
		UBR-box_UBR5	1211..1286	CDD:439073
		MDN1	<1551..>1724	CDD:444083
		PolyA	2498..2561	CDD:197769	16/80 (20%)
		HECTc	2589..2884	CDD:214523	86/347 (25%)
CG4238	NP_608640.2	Filamin	238..336	CDD:395505	16/97 (16%)
		HECTc	615..975	CDD:238033	92/377 (24%)