DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and Trip12

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	XP_038939619.1	Gene:	Trip12 / 316575	RGDID:	1306607	Length:	2074	Species:	Rattus norvegicus

Alignment Length:	2286	Identity:	410/2286 - (17%)
Similarity:	723/2286 - (31%)	Gaps:	771/2286 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   962 SSNKDSPPDSPSGGVEKKSLVGLSVARSIPTVSTSAYVSSIAFGASASSSNENSSFATMSSSAAG 1026
            ||...|...|.|.|.|::|        :.||...|...:|...|.|..:.:.:::..:.||||..
  Rat   196 SSCVKSGSGSESTGAEERS--------AKPTKLASKSATSAKAGCSTITDSSSAASTSSSSSAVA 252

  Fly  1027 SASST------SRDNRTNLRDMMNRLINSDQAEQSGSQPMATNNEDHAYIPWPAE-TPAASNLSA 1084
            |||||      .:..:...:...:|..:|....:|..:...:.....:...|.|. :|..|  ..
  Rat   253 SASSTVPAGARVKQGKDQNKARRSRSASSPSPRRSSREKEQSKTGGSSKFDWAARFSPKVS--LP 315

  Fly  1085 SSSQNVSDSIEDDISKIIPSSSQSSMLS---NIKLGSPTYTFDLAQRREHALTILQQMCVSPALR 1146
            .:..::..|.:.:.||..||..|:.:.|   :.|..|.:...:|...|..........|.|.:.|
  Rat   316 KTKLSLPGSSKSETSKPGPSGLQAKLASLRKSTKKRSESPPAELPSLRRSTRQKTTGSCASTSRR 380

  Fly  1147 ---------PYLCHMLSTKDAQGQTPFMLSVSCRAYE-----------AGIILLNTILMLSEQDP 1191
                     ..........|.:|....:.|.:.|..|           ||.:.:.|.......|.
  Rat   381 GSGLGKRGAAEARRQEKMADPEGNQETVNSSAARTDEAPQGAAASSSVAGAVGMTTSGESESDDS 445

  Fly  1192 QL--KEAMIFPNGSP----ADQSPLHVICYNDTCSFTWTGADHINQNIFECKTCGLTGS-----L 1245
            ::  .:|::...|.|    ....|.....::.|..   :||....|.:.:    ||..|     |
  Rat   446 EMGRLQALLEARGLPPHLFGPLGPRMSQLFHRTIG---SGASSKAQQLLQ----GLQASDESQQL 503

  Fly  1246 CCCTECARVCHKGHDCKL-----KRTAPTAYC--------DCWEKCKCKAL--IAGNLTKRFALL 1295
            ....|..::...|::..|     |...|....        |..... |:||  :...|.:..|::
  Rat   504 QAVIEMCQLLVMGNEETLGGFPVKSVVPALITLLQMEHNFDIMNHA-CRALTYMMEALPRSSAVV 567

  Fly  1296 CKLVSCTDLVTKFNSKGESILLFLIQTVGRQIVEQRQYRFSVRVRNVSTAATGATGNNSVI---- 1356
                  .|.:..|..|     |.:||.:  .:.||......:..|..|.|...|.|....:
  Rat   568 ------VDAIPVFLEK-----LQVIQCI--DVAEQALTALEMLSRRHSKAILQAGGLADCLLYLE 619

  Fly  1357 ---SNRKTSAAEIDNDMPDHDLEPPKFARKALERLLI-------DWNAVRSMIMSGAERGDVPNP 1411
               .|.:.:|..|..:. ...:.|.:|...|....|:       |..:|.|..:..|...|
  Rat   620 FFSINAQRNALAIAANC-CQSITPDEFHFVADSLPLLTQRLTHQDKKSVESTCLCFARLVD---- 679

  Fly  1412 AGSASENSNSEGFNMFIQTQHGSTLLDKFTHSLIVKCTSDHLDTLLLTLVRELQNASVSNRSKEA 1476
                    |.:.....:|......||......|:|  |...|.:.:..:|..:.:...||....|
  Rat   680 --------NFQHEENLLQQVASKDLLTNVQQLLVV--TPPILSSGMFIMVVRMFSLMCSNCPTLA 734

  Fly  1477 EEVVRRFVRSVARV--FVIFNLEKQPNPEKRKSHSSCNKYVQSCVKVFQTLHKISIEELCEVSEA 1539
            .:::::....:|..  |::..          .|:.||.:.:....:..|.|:::: ..:||
  Rat   735 VQLMKQSFTDIAETLHFLLCG----------ASNGSCQEQIDLVPRSPQELYELT-SLICE---- 784

  Fly  1540 LIAPVRLGVVRPTAPFTMSSSNLDVRNSDDLFSVDPLA-----------------------PSN- 1580
                     :.|..|            .:.:|:||.:.                       |.|
  Rat   785 ---------LMPCLP------------KEGIFAVDTMLKKGNAQNTDGAIWQWRDDRGLWHPYNR 828

  Fly  1581 VESPSEQILVHDAGNDQSANFNIQQNY--DVVAMETIRDASESEEVINREANSHNQDDELIENQR 1643
            ::|...::..|..|.|:.:...:.:.|  |..:|:.|.:.:.:...|.|:.|.       :.| .
  Rat   829 IDSRIIEVAAHQVGEDEISLSTLGRVYTIDFNSMQQINEDTGTARAIQRKPNP-------LAN-T 885

  Fly  1644 NEDGMQDDESDNDFTFNDAETESDSDDNQSNQEVQRSVQAGATVGSENDIGVLFLEDESGDSSAQ 1708
            |..|..|.:.|      ||..:...:|.:..:...:::           .|||:   |...|||.
  Rat   886 NTSGYSDLKKD------DARAQLMKEDPELAKSFIKTL-----------FGVLY---EVYSSSAG 930

  Fly  1709 EEDGSE------------DGESDDQSDEFNFNEQQLERRSTNSNARSDLAPQTMQWAIRSRDTA- 1760
            .....:            |.|         ..:..|:..:.:|:..|.|:.|.::..:.:...|
  Rat   931 PAVRHKCLRAILRIIYFADAE---------LLKDVLKNHAVSSHIASMLSSQDLKIVVGALQMAE 986

  Fly  1761 ---------------RSSV-----RVPTGSNMVFIDPMALRR------STVPASTTVTTPSIEPH 1799
                           |..|     .:....:::...|.|...      ||.|||:..
  Rat   987 ILMQKLPDIFSVYFRREGVMHQVKHLAESESLLTSPPKACTNGSGSLGSTTPASSGT-------- 1043

  Fly  1800 TMATTASNLARAFGITIRQIS--ELISILSYNVLNDIETSLKI-------------QNDEAIAVQ 1849
              ||.|:|.:...|....|.|  :.:.:.....|:|:....::             ::|:.:..|
  Rat  1044 --ATAATNASADLGSPSLQHSRDDSLDLSPQGRLSDVLKRKRLPKRGPRRPKYSPPRDDDKVDNQ 1106

  Fly  1850 AFVEKRLKATWDWMFTVMDGTEAQLKFGAYLTNYTDPNHPLHPL---NLSAQASSSQTPAPATSS 1911
            |                ...|..|....::|.:       |:|.   .|||| |:|....||.::
  Rat  1107 A----------------KSPTTTQSPKSSFLAS-------LNPKTWGRLSAQ-SNSNNIEPARTA 1147

  Fly  1912 SVNGV-----------------------------------NIMGSNS-----------------R 1924
            .|:|:                                   |:.|||.                 :
  Rat  1148 GVSGLARAASKDTISNNREKIKGWIKEQAHKFVERYFSSENMDGSNPALNVLQRLCAATEQLNLQ 1212

  Fly  1925 RDFFTYCLSLMRSHTSEHRDALPVLDITA--LRHIAYVLDAFVYYMRNDSGFYDKQDTISGRI-- 1985
            .|....||..:||..||.       |:::  ::|..:|....:|....     .::|.:|..|
  Rat  1213 VDGGAECLVEIRSIVSES-------DVSSFEIQHSGFVKQLLLYLTSK-----SEKDAVSREIRL 1265

  Fly  1986 ------------------NNLSPMTES------YDTDDELANLEEFNADVQMSASSMPSG----- 2021
                              ..:.|:..:      :..::.|:.:|:|...|....|...||
  Rat  1266 KRFLHVFFSSPLPGEEPVGRVEPVGHAPLLALVHKMNNCLSQMEQFPVKVHDFPSGNGSGGSFSL 1330

  Fly  2022 SQGTRRHAFFARSESTLSLGCSAP-----------EGFELPLDMAMPLADKPHLLQPNSKRQELF 2075
            ::|::...||    :|..|.|...           :|..:.:|   |||    |:|...:
  Rat  1331 NRGSQALKFF----NTHQLKCQLQRHPDCANVKQWKGGPVKID---PLA----LVQAIER----- 1379

  Fly  2076 ANLPLLVTTNANNSGATNDGDGGSIFDYTPTRLG------FSNS---------------LKRNER 2119
                .||.......|...:.|..|..|.:...:.      |.||               |..|..
  Rat  1380 ----YLVVRGIFRYGRVREDDEDSDDDGSDEEIDESLAAQFLNSGNVRHRLQFYIGEHLLPYNMT 1440

  Fly  2120 VYETVPIDSSKTGDGNVTNKAEGSTDSNIYVQLKK-----KQGSDDFKSHKEADG---------- 2169
            ||:.|...|.:..|...:...|.:......:..|.     |...:|.:|.|:..|
  Rat  1441 VYQAVRQFSVQAEDERESTDDESNPLGRAGIWTKTHTIWYKPVREDEESSKDCVGGKRGRAQTAP 1505

  Fly  2170 ------NQSKYEKVVLMETDDSLPSTSKSTEA-LMATRPEVIIAPNKASVSPATAARSVIVLAGG 2227
                  |..|:::   :..|...||.:...|. |:.|.||        :::....:..||:|
  Rat  1506 TKTSPRNAKKHDE---LWHDGVCPSVANPLEVYLIPTPPE--------NITFEDPSLDVILL--- 1556

  Fly  2228 SCLKTIDSDINNY---------------SASNLSTAEQAKCDTQYQKSTSDHLLLFPARGSQFYQ 2277
              |:.:.: |:.|               ::..:::...||.:.|.|    |.|::..
  Rat  1557 --LRVLHA-ISRYWYYLYDNAMCKEIIPTSEFINSKLTAKANRQLQ----DPLVIMT-------- 1606

  Fly  2278 SNFSELPSWNFLLSRWKLTLDLFGRVFMDDVGMEHGSVLPELRGFPVKEMRF-------RRHMEK 2335
               ..:|:|        ||              |.|...|....|..::|.|       .|.|::
  Rat  1607 ---GNIPTW--------LT--------------ELGKTCPFFFPFDTRQMLFYVTAFDRDRAMQR 1646

  Fly  2336 L--------RNGQQRDLVLCKLER-----NRESLIVQTFKELNTQFGNQSRRIQPPITFNRVKVT 2387
            |        ::..|...|..:|:|     |||.|:.|.  |...|....||.:        :::.
  Rat  1647 LLDTNPEINQSDSQDSRVAPRLDRKKRTVNREELLKQA--ESVMQDLGSSRAM--------LEIQ 1701

  Fly  2388 FKDEPGEGSGVARSFYTSIAEALLASAKIPNLESVQVGTNHSKYVVPFSSILRSRTVSGSSRDQS 2452
            :::|.|.|.|....||..:::         .|:...:|
  Rat  1702 YENEVGTGLGPTLEFYALVSQ---------ELQRADLG--------------------------- 1730

  Fly  2453 TLQRRGSNSKILWRSARERKALNLDARPYTPPNSSDNATPESLNDHLSVHLQQI-GERLYPKIHS 2516
                       |||.  |...|       :.|..|...|.         ::|.: |....|...:
  Rat  1731 -----------LWRG--EEVTL-------SNPKGSQEGTK---------YIQNLQGLFALPFGRT 1766

  Fly  2517 INQTHAPKITGMLLEIPTPQLLSVISSDETLRQKVNEAIEIITFKQKSETSAQSSQPKKSPSVVV 2581
            ....|..|:                                   |.|
  Rat  1767 AKPAHIAKV-----------------------------------KMK------------------ 1778

  Fly  2582 VDPVDDDNEPLFYSPGKRGFYTPRQGFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYI 2646
                                               ||.:|:|:...::...|:.|.|.....|::
  Rat  1779 -----------------------------------FRFLGKLMAKAIMDFRLVDLPLGLPFYKWM 1808

  Fly  2647 LGRK--IKFHDLAFFDPALYES---FRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCG----- 2701
            |.::  :..|||...||.:..|   ...|::..:..|.:::..:..|.:.::.:...||.
  Rat  1809 LRQETSLTSHDLFDIDPVVARSVYHLEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLG 1873

  Fly  2702 ---------NRELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMIN 2757
                     |.||..||:|:.||..|:.||:|....:.|.:...:..::.:||...|.|.:.:..
  Rat  1874 LDFTLPGFPNIELKKGGKDIPVTIHNLEEYLRLVIFWALNEGVCRQFDSFRDGFESVFPLSHLQY 1938

  Fly  2758 LTAEDLRLLLNG--VGDINVSTLISYTTFNDESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYF 2820
            ...|:|..||.|  ....:..||:.... .|.......:.:||   .:.|:...:..:::..:.|
  Rat  1939 FYPEELDQLLCGSKADTWDAKTLMECCR-PDHGYTHDSRAVKF---LFEILSSFDNEQQRLFLQF 1999

  Fly  2821 WTGSPALPASEEGFQPL-PSVTI---------RPADDSHLPTANTCISRLYIPLYSSKSILRSKM 2875
            .||||.||..  ||:.| |.:||         .|  |..||:..||::.|.:|.|||..|:|.|:
  Rat  2000 VTGSPRLPVG--GFRSLNPPLTIVRKTFESTENP--DDFLPSVMTCVNYLKLPDYSSIEIMRDKL 2060

  Fly  2876 LMAIKSKNFGF 2886
            |:|.:.....|
  Rat  2061 LIAAREGQQSF 2071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698	17/86 (20%)
		ASF1_hist_chap	1535..1733	CDD:304562	36/235 (15%)
		PolyA	2498..2561	CDD:197769	5/63 (8%)
		HECTc	2589..2885	CDD:238033	77/326 (24%)
		HECTc	2589..2884	CDD:214523	77/325 (24%)
Trip12	XP_038939619.1	SRP1	489..>714	CDD:227396	48/257 (19%)
		WWE	814..876	CDD:397111	10/61 (16%)
		HECTc	1672..2072	CDD:238033	110/571 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900