DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and Hecw2

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	NP_001101688.1	Gene:	Hecw2 / 316395	RGDID:	1593244	Length:	1578	Species:	Rattus norvegicus

Alignment Length:	2000	Identity:	399/2000 - (19%)
Similarity:	661/2000 - (33%)	Gaps:	672/2000 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1129 REHALTILQQMCVSPALR----PYLCHMLSTKDAQGQTPFMLSVSCRAYEAGIILLNTILMLSEQ 1189
            |||.|.:.::   :|.:|    |.....|:|   |...|..:::. ||..      :|.|:.||.
  Rat     6 REHLLFVRRR---NPQMRYTLSPENLQSLAT---QNSMPENMALQ-RANS------DTDLVTSES 57

  Fly  1190 DPQLKEAM----------------IFPNGSPADQSPLHVICYNDTCSFTWTGADHINQNIF---- 1234
            ...|..:|                |.....|:|...|:.|..|...:| |   |..|:.:.
  Rat    58 RSSLTASMYEYTLGQAQNLIIFWDIKEEVDPSDWIGLYHIDENSPANF-W---DSKNRGVTGTQK 118

  Fly  1235 ----------------ECKTC-----GLTGSLCCCTECARVCHKGHDCKLKRTAPTAYCDCWEKC 1278
                            |.|.|     |::|:|...|.|..|         |..|.....:..|.|
  Rat   119 GQIVWRIEPGPYFMEPEIKICFKYYHGISGALRATTPCITV---------KNPAVMMGAEGMEGC 174

  Fly  1279 KCKALIAGNLTKRFALLCKLVSCT--DLVTKFNSKG-----ESILLFLIQTVGRQ-----IVEQR 1331
                 .:|:|..|     ||||.|  ||......||     :..|...||. |::     .....
  Rat   175 -----ASGSLHSR-----KLVSFTLSDLRAVGLKKGMFFNPDPYLKMSIQP-GKKSSFPTCAHHG 228

  Fly  1332 QYRFSVRVRNVSTAATGATGNNSVISNRKTSAAEIDNDMPDHDLEPPKFA--RKALERL------ 1388
            |.|.|..:.|.:         |.:....|.|...:..|:.:.::: .|||  |..::|.
  Rat   229 QERRSTIISNTT---------NPIWHREKYSFFALLTDVLEIEIK-DKFAKSRPIIKRFLGKLTI 283

  Fly  1389 ----LIDWNAVRSMIMS---GAE------------RGDVPNPAGSASENSNSE--GFNMFIQTQH 1432
                |::..||...::|   |..            |.:||:   ||.|:::.|  |..:.:.|.:
  Rat   284 PVQRLLERQAVGDQMLSYNLGRRLPADHVSGYLQFRVEVPS---SAQEDASPEAVGTILGVHTVN 345

  Fly  1433 GSTLLDKFTHSLIVKCTSDHLDTLLLTLVRELQNASVSNRSKEAEEVVRRFVRSVARVFV----I 1493
            |    |..:.|........|.|:.:..      |..||..| .|:...:...|:.:.:.:    :
  Rat   346 G----DLGSPSDDEDMPGSHHDSTICA------NGPVSEDS-VADGTPKHSFRTSSTLEIDTEDL 399

  Fly  1494 FNLEKQPNPEKRKSHSSCNKYVQSCVKVFQTLHKISIEELCEVSEALIAPVRLGVVRPTAPFTMS 1558
            .:...:.:| .|....|.|.|:.            :||.                ..|:.|.|.|
  Rat   400 ISTSSRNSP-PRGRQDSLNDYLD------------AIEH----------------NGPSRPGTAS 435

  Fly  1559 SSNLDVRNSDDLFSVDPL-----APSNVESPSEQILVHDAGNDQSANFNIQQNYDVV---AMETI 1615
            ||...:..|..|.|..|.     |..:::|..|.   ||...|.....::::...::   ....|
  Rat   436 SSERPMGASPKLRSSFPTDTRLNAMLHIDSDEED---HDFQQDLGYPSSLEEEGGLIMCSRTSRI 497

  Fly  1616 RDASESEEVINREANSHNQDDELIENQR---NEDGMQDDESDNDFTFNDAETESDS--DDNQSNQ 1675
            .|.|.:.:       :..:||..:||:.   :|....::..:|.....|....|.:  |:|:::.
  Rat   498 DDGSLTSQ-------TKPEDDNPVENEDASVHETASLEERPENLPEVEDGSLPSGTAPDENEASV 555

  Fly  1676 EVQRSVQAGATVGSENDIGVLFLEDESGDSSAQEEDGSEDGESDDQ--SDEFNFNEQQLERRSTN 1738
            |.|.|...|:|            |..|.....|...|::.|.||..  |.......:.|::.|..
  Rat   556 EPQPSADQGST------------ELCSSQEVDQPTSGTDAGASDTSVGSRRAASETESLDQGSEP 608

  Fly  1739 SNARSDLAPQTMQWAIRSRDTARSSVRVPTGSNMVFIDPMALRRSTVPASTTVTTPSIEPHTMAT 1803
            |...|:..|..   ..|:...:.:|.|....|::...|      |:...|.|....|:|     |
  Rat   609 SQVSSETEPSD---PARTESVSEASTRPEGESDLEGAD------SSCNESVTTQLSSVE-----T 659

  Fly  1804 TASNLARAFGITIRQISELISILSYNVLNDIETSLKIQNDEAIAVQAFVEKRLKATWDWMFTVMD 1868
            ..|:|..|      :..|..:..|             |.:|                       |
  Rat   660 RCSSLESA------RFPETPAFSS-------------QEEE-----------------------D 682

  Fly  1869 GTEAQLKFGAYLTNYTDPNHPLHPLNLSAQASSSQTPAPATSSSVNGVNIMGSNSRRDFFTYCLS 1933
            |.                            .::..|.:..|..|...|...||
  Rat   683 GA----------------------------CAAEPTSSGPTEGSQESVCTPGS------------ 707

  Fly  1934 LMRSHTSEHRDALPVLDITALRHIAYVLDAFVYYMRNDSGFYDKQDTISG-RINNLSPMTESYDT 1997
                        ||.:.:.:               |.:.|        || ....||...|..:.
  Rat   708 ------------LPAVQVPS---------------REEEG--------SGAEATALSEQGELGEV 737

  Fly  1998 DDELANLEEFNA-------DVQMSASSMPSGSQGTRRHAFFARSESTLSLGCSAPEGFELPLDMA 2055
            .....:||...|       |.|......|..:||....|......:|   |.|...|.:
  Rat   738 WQRRGSLEGAAAAATAAATDSQPQEDGDPGDTQGACEGATAQEEGAT---GGSQTNGHQ------ 793

  Fly  2056 MPLADKPHLLQPNSKRQELFANLPLLVTTNANNSGATNDGDGGSIF-DY--------------TP 2105
             ||...|.:.|..|:.|.:...||       .|..|..|..|...: |:              .|
  Rat   794 -PLRSLPSVRQDVSRYQRVDEALP-------PNWEARIDSHGRIFYVDHVNRTTTWQRPTAPPAP 850

  Fly  2106 TRLGFSNSLKRNE---RVYETVPIDSSKTGDGNVTNKAEGSTDSNIYVQLKKKQGSDDFKSHKEA 2167
            ..|..|||:::.|   |.|:::    .:|    :||:......|.|       .|:.:     ||
  Rat   851 QVLQRSNSIQQMEQLNRRYQSI----RRT----MTNERPEENTSAI-------DGAGE-----EA 895

  Fly  2168 DGNQSKYEKVVLMETDDSLP-STSKSTEALMATRPEV--IIAPNKASV--SPATAARSVIVLAGG 2227
            |.:|:..:    ...::.|| |||:|...|:...|.|  :|:|...:|  |..:|.|   :....
  Rat   896 DFHQASAD----FRRENVLPHSTSRSRLTLLLQSPPVKFLISPEFFTVLHSNPSAYR---MFTNN 953

  Fly  2228 SCLKTIDSDINNYSASNLSTAEQAKCDTQYQKSTSDHLLLFPARGSQFYQSNFSELPSWNFLLSR 2292
            :|||.:.:.:..              ||.:               .:.||.|...:...|...::
  Rat   954 TCLKHMITKVRR--------------DTHH---------------FERYQHNRDLVGFLNMFANK 989

  Fly  2293 -------WKLTLDLFGRVFMDDVGMEHGS--------VLPELRGFPVKEMRFRRHMEKLRNGQQR 2342
                   |::..|..|:.|.    ::|.|        .||.....|...:..|:|:.:.|:....
  Rat   990 QLELPRGWEMKHDHQGKAFF----VDHNSRTTTFIDPRLPLQSSRPTSALVHRQHLTRQRSHSAG 1050

  Fly  2343 DLVLCKLERNRESLIVQTFKELNTQFGNQSRRIQPPI------TFNRVKVTFKDEPGEGSGVARS 2401
            ::                        |..||...||:      |||.              |:|.
  Rat  1051 EV------------------------GEDSRHAGPPVLPRPASTFNT--------------VSRP 1077

  Fly  2402 FYTSIA-----EALLASAKIPN-LESVQ-----VGTNHSKYVVPFSSILRSRTVSGSSRDQSTLQ 2455
            .|..:.     :.::|..:.|| ||.:|     :..|||         ||.:.....:.....|.
  Rat  1078 QYQDMVPVAYNDKIVAFLRQPNILEILQERQPDLARNHS---------LREKIQFIRTEGTPGLV 1133

  Fly  2456 RRGSNSK-ILWRSARERKALNLDARPYTPPNS--------SDNATPESLNDHLSVHLQQIGERLY 2511
            |..|::. ::..|..|.:.::     |.||::        |...:|.|
  Rat  1134 RLSSDADLVMLLSLFEEEIMS-----YVPPHALLHPSYCQSPRGSPVS----------------- 1176

  Fly  2512 PKIHSINQTHAPKITGMLLEIPTPQLLSVISSDETLRQKVNEAIEIITFKQKSETSAQSSQPKKS 2576
                  :..::|.........|.|             .|.:...::..|.:|.||......|.|.
  Rat  1177 ------SPQNSPGTQRANARAPAP-------------YKRDFEAKLRNFYRKLETKGYGQGPGKL 1222

  Fly  2577 PSVVVVDPVDDD------------------------NEPLFYSPGKRGF--------YTPRQGFA 2609
            ..::..|.:.:|                        .|.|.||...|.|        :.|..|..
  Rat  1223 KLIIRRDHLLEDAFNQIMGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLF 1287

  Fly  2610 SFERINA------------------FRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIKFHDL 2656
            .:...:.                  ||..||::||.|:...||..|..|...|.:|.......||
  Rat  1288 EYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCDLSDL 1352

  Fly  2657 AFFDPALYESFRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCG---NRELIPGGRDVAVTSSN 2718
            .:.|    |.|.|.:|..:..:..:.   ::|.|.::   ||..|   .|||.|||.::.||..|
  Rat  1353 EYLD----EEFHQSLQWMKDNDIHDI---LDLTFTVN---EEVFGQITERELKPGGANIPVTEKN 1407

  Fly  2719 IFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVSTLISYTT 2783
            ..||:.|..::|:.:...:..|:|..|.::|:....:....|.:|.|::.|..:|:::...:.|.
  Rat  1408 KKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLNDWRNNTE 1472

  Fly  2784 FNDESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPLPSVTIRPADD- 2847
            :.....:....:    :|||:.||:.|..:|..|:.|.||:.::|  .|||     .::|.::.
  Rat  1473 YRGGYHDNHIVI----RWFWAAVERFNNEQRLRLLQFVTGTSSIP--YEGF-----ASLRGSNGP 1526

  Fly  2848 -----------SHLPTANTCISRLYIPLYSSKSILRSKMLMAI-KSKNFG 2885
                       :.||.|:||.:||.:|.|.|.|:|..|:|.|: ::..||
  Rat  1527 RRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFG 1576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698	17/91 (19%)
		ASF1_hist_chap	1535..1733	CDD:304562	42/212 (20%)
		PolyA	2498..2561	CDD:197769	4/62 (6%)
		HECTc	2589..2885	CDD:238033	87/337 (26%)
		HECTc	2589..2884	CDD:214523	87/336 (26%)
Hecw2	NP_001101688.1	HECW_N	45..162	CDD:406866	28/135 (21%)
		C2_NEDL1-like	185..321	CDD:176073	30/146 (21%)
		MDN1	<396..741	CDD:227596	89/526 (17%)
		NESP55	<464..632	CDD:115071	38/192 (20%)
		WW	815..844	CDD:395320	7/35 (20%)
		HECW1_helix	921..987	CDD:408233	18/97 (19%)
		WW	993..1024	CDD:197736	6/34 (18%)
		HECTc	1222..1576	CDD:238033	89/374 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900