DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hyd and Smurf2

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	NP_001100531.1	Gene:	Smurf2 / 303614	RGDID:	1310067	Length:	748	Species:	Rattus norvegicus

Alignment Length:	703	Identity:	155/703 - (22%)
Similarity:	251/703 - (35%)	Gaps:	223/703 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  2339 GQQRDLVLCKLERN-----RESLIVQTFKELNTQFGNQSRRIQPPITFNRVKVTFKDEPGEGSGV 2398
            |.|| |.||||..|     |..::|..          |||                |..|.|..|
  Rat   111 GYQR-LDLCKLGPNDNDTVRGQIVVSL----------QSR----------------DRIGTGGQV 148

  Fly  2399 ---ARSFYTSI----AEALLASAKIPNLESV----------QVGTNHSKYVVPFSSILRSRT--- 2443
               :|.|...:    .|...||.:|..|..:          :..:.:|....|.|..:...|
  Rat   149 VDCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPIT 213

  Fly  2444 -VSGSSRDQSTLQRRGSNSKILWRSARERKALNLDARP--YTPPNS------------------- 2486
             .:|::..||      |:.::..|..|.::..|..:|.  :|||:.
  Rat   214 GTNGATCGQS------SDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHT 272

  Fly  2487 -------SDNATPESLNDHLSVHLQQIGE-------------RLYPKIHSINQTH--APKITGML 2529
                   .|...|..|:   :::.:::|.             |:|...|:...|.  .|:::..|
  Rat   273 QTGVSTWHDPRVPRDLS---NINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANL 334

  Fly  2530 -------LEIPTPQLLSVIS--SDETLRQKVNEAIEIITFKQ---------KSETSAQSSQ---- 2572
                   .::...|...|:|  .|:|      |.:.:..:|:         :.|.|.|..|
  Rat   335 HLVLNRQNQLKDQQQQQVVSLCPDDT------ECLTVPRYKRDLVQKLKILRQELSQQQPQAGHC 393

  Fly  2573 ----------PKKSPSVVVVDPVDDDNEPLFYSPGKRG-----------------FYTPRQGFAS 2610
                      .:....|:.:.|.|.....:....|:.|                 ...|..|...
  Rat   394 RIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQ 458

  Fly  2611 F------------------ERINAFRNIGRLIGLCLLQNE------LLPLFLQRHVLKYILGRKI 2651
            :                  |.::.|..:||::|:.:....      .||.:      |.:||:.|
  Rat   459 YSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFY------KQLLGKSI 517

  Fly  2652 KFHDLAFFDPALYESFRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCGNRELIPGGRDVAVTS 2716
            ...|:...||.|:.|...|::|..|...:.|       |.::..........||.|.|:.:.||.
  Rat   518 TLDDMELVDPDLHNSLVWILENDITGVLDHT-------FCVEHNAYGEIIQHELKPNGKSIPVTE 575

  Fly  2717 SNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVS----- 2776
            .|..||||.|..:|.::..|....||:.|..:|:|.:.:.....::|.|::.|:|.|:||
  Rat   576 ENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVSDWKAN 640

  Fly  2777 TLISYTTFNDESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPLPSV- 2840
            |.:.:.|        ||.  ...||||..||..:...|..|:.|.|||..:|.  :||:.|...
  Rat   641 TRLKHCT--------PDS--NVVKWFWKAVELFDEERRARLLQFVTGSSRVPL--QGFKALQGAA 693

  Fly  2841 -----TIRPAD--DSHLPTANTCISRLYIPLYSSKSILRSKMLMAIKSKNFGF 2886
                 ||...|  .::||.|:||.:|:.||.|.|...|..|:|.||: :..||
  Rat   694 GPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIE-ETCGF 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	13/86 (15%)
		HECTc	2589..2885	CDD:238033	89/349 (26%)
		HECTc	2589..2884	CDD:214523	89/348 (26%)
Smurf2	NP_001100531.1	C2_Smurf-like	13..137	CDD:176028	11/36 (31%)
		PRP40	155..>236	CDD:227435	16/86 (19%)
		WW	159..188	CDD:395320	5/28 (18%)
		WW	252..283	CDD:197736	1/30 (3%)
		WW	298..330	CDD:197736	5/31 (16%)
		HECTc	393..745	CDD:238033	92/377 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000