DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and Wwc1

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	XP_002727807.1	Gene:	Wwc1 / 303039	RGDID:	1308329	Length:	1108	Species:	Rattus norvegicus

Alignment Length:	1443	Identity:	256/1443 - (17%)
Similarity:	424/1443 - (29%)	Gaps:	520/1443 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 EAFSRWRD---RQYYGPRR-----WIS-KDDYT----------------WEKDADSKKKEPSPML 343
            |.:...||   :.||...|     ||. :|.||                ||:..|       |.:
  Rat    10 EGWEEARDFDGKVYYIDHRNRTTSWIDPRDRYTKPLTFADCISDELPLGWEEAYD-------PQV 67

  Fly   344 SPIWISEELQ---------PWPEKSSVRFKTIGALYSEFIALSESGDLYQWRWSDAEPYKSETEN 399
            ...:|....:         .|..:.....|....:..|  |||...::||.:....|..:.|.:.
  Rat    68 GDYFIDHNTKTTQIEDPRVQWRREQEHMLKDYLVVAQE--ALSAQKEIYQVKQQRLELAQQEYQQ 130

  Fly   400 VY----HPKTVSLNIVERVELISAN---------FIRCSVVTETNRVATWMDEQLGYIGAKLEHS 451
            ::    |      .:..:|.|:|.:         .::..:.|..:||.....|.:     .|:|.
  Rat   131 LHAVWEH------KLGSQVSLVSGSSSSSKYDPEILKAEIATAKSRVNKLKREMV-----HLQHE 184

  Fly   452 CCAFNEFISDSITKIYVCSLYTVVKTESNNIYWWGVLPFDQRRFLWDKFRTKTKKPFKVVATDIN 516
                                                |.|.:|.|       :|.|......:|..
  Rat   185 ------------------------------------LQFKERGF-------QTLKKIDERMSDAQ 206

  Fly   517 VG-----AQVIMKKCPMYQSGSIGFTCSNGVPKVGQLLNSVWTFTDVCRMKIININTNSGVDKSQ 576
            .|     ||.::::....:.   ..||
  Rat   207 GGYKLDEAQAVLRETKAIKK---AITC-------------------------------------- 230

  Fly   577 AAGNNLNAHGITPDKDLPKSTAMPSTGSSKNGQSFSNSKESTDRIDMPPPPSP-----ASSTCSD 636
                     |....:||.||.||...|...:..|.|:...|:..::....|.|     .||....
  Rat   231 ---------GEKEKQDLIKSLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPVPKQFLDVSSQTDI 286

  Fly   637 TGSVTSHK------------RTKRATTKEDSNAPQEGRKDEELWE-------------------V 670
            :||.::..            |.:.|..:..:...|..:.|.|.|.                   :
  Rat   287 SGSFSTSSSNQLAEKVRLRLRYEEAKRRIANLKIQLAKLDSEAWPGVLDSERDRLILINEKEELL 351

  Fly   671 KDVVFVEDKVGPVGKV-------LKVDGDFVAVRFPAINAAAVAAAAAATSSTSNTASTSKEEGK 728
            |::.|:..:....|:|       .:::.|..|.|                 .|.:.|.|
  Rat   352 KEMRFISPRKWTQGEVEQLEMARRRLEKDLQAAR-----------------DTQSKALT------ 393

  Fly   729 EDDWQQCRLLRREDVQIFRTAMSTRGPDWLQKQPKKIN------VGGDAAGAQILTLAVDSRGIH 787
                ::.:|..:.:..:.....:||....|..|.|.::      ..|.:.|:  ||   .|||..
  Rat   394 ----ERLKLNSKRNQLVRELEEATRQVAALHSQLKSLSSSMQSLSSGSSPGS--LT---SSRGSL 449

  Fly   788 VIKKVLGKIHYSLYNLYNCKQEQ---------NCLFPTDCNSFIGSTPGNILMACNDD------- 836
            ....:......|..:||....||         ..||......|   .|...:...::|
  Rat   450 AASSLDSSTSASFTDLYYDPFEQLDSELPSKVELLFLEGATGF---RPSGCITTIHEDEVAKTQK 511

  Fly   837 CSGNSSTIVLRDGNGALYPLAKDCL---GSIKDPQWFDLPPVKSITMSTISLPAMLSGVNLKSKV 898
            ..|.|....||..:|.  |.:...|   .|:..|.    ||     .|.:....:|:|     ..
  Rat   512 AEGGSRLQALRSLSGT--PRSMTSLSPRSSLSSPS----PP-----CSPLIADPLLAG-----DA 560

  Fly   899 CMTALLFDTQKLMPHILRCDVKNSFAALGRLEREDQADTALVVEERCDGARNIFHACVIMCAPSS 963
            .:|.|.|:..:|.|.:  |::     :||                 .||||..|..
  Rat   561 FLTPLEFEDTELSPTL--CEL-----SLG-----------------TDGARERFRL--------- 592

  Fly   964 NKDSPPDSPSGGVEKKSLV---GLSVARSIPTVSTSAYVSSIAFGASASSSNENSSFATMSSSAA 1025
            .:..|...|.|  :..|:.   ||.||    .||.:....|:|    ..|....:|...:.:|.|
  Rat   593 EEPGPEGKPLG--QAASVAPGCGLKVA----CVSAAVSDESVA----GDSGVYEASMQRLGTSEA 647

  Fly  1026 GSASSTSRDNRTNLRDMMNRLINSDQAEQSG-SQPMATNNEDHAYIPWPAETPAASNLSA---SS 1086
            .:                   .:||::|..| :|.......|.....:.......|||||   ..
  Rat   648 AA-------------------FDSDESEAVGVTQVQIALKYDEKSKQFAILVIQLSNLSALLLQQ 693

  Fly  1087 SQNVSDSIEDDISKIIPSSSQSSMLSNIK--------LGSPTYTFDLAQRREHALTILQQMCVSP 1143
            .|.|:..:     .|:|.|..|:.|...:        :.:..:...::....|..|:...:|.:.
  Rat   694 DQKVNIRV-----AILPCSESSTCLFRTRPLDSADSLVFNEAFWVSMSYPALHQKTLRVDVCTTD 753

  Fly  1144 ALRPYLCHMLSTKDAQGQTPFMLSVSCRAYEAGIILLNTI----LMLSEQDPQLKEAMIFPNGSP 1204
            ...        |::..|.....|:..||:.|......|.:    |....::||..||
  Rat   754 RSH--------TEECLGGAQISLAEVCRSGERSTRWYNLLSYKYLKKQGREPQPAEA-------- 802

  Fly  1205 ADQSPLHVICY--------------------NDTCSFTWTGADHINQNIFECKTCGLTGSLCCCT 1249
              ..|.||...                    :.|...:||..:..::|            .....
  Rat   803 --PGPDHVDAVSALLEQTAVELEKRQEGRSSSQTLEGSWTYEEEASEN------------EAVAE 853

  Fly  1250 ECARVCHKG-HDCKLKRTAPTAYCDCWEKCKCKALIAGNLTKRFALLCKLVSCTDLVTKFNSKGE 1313
            |..|...:| .|...::.:|.|.       :|.||.....|.           ||.||.
  Rat   854 EEEREEEEGEEDVFAEKVSPEAE-------ECPALKVDRETN-----------TDSVTP------ 894

  Fly  1314 SILLFLIQTVGRQIVEQRQYRFSVRVRNVSTAATGATGNNSVISNRKTSAA-----------EID 1367
                  ..||.|.           :.|.|...:.|.....:.|...||.:.           ..|
  Rat   895 ------SPTVVRP-----------KDRRVGAPSPGPFLRGNTIIRSKTFSPGPQSQYVCRLNRSD 942

  Fly  1368 NDMPDHDLEPPKFARKALERLLIDWNAVRSMIMSGAERGDVPNPAGS-ASENSNSEGFNMFIQTQ 1431
            :|......:|| |.|.:|||        ||:.|..      |:...| .:|.......::.:..|
  Rat   943 SDSSTLSKKPP-FVRNSLER--------RSVRMKR------PSSVKSLRTERLIRTSLDLELDLQ 992

  Fly  1432 HGSTLLDKFTHSL-IVKCTSDHLDTLLLTLVRELQNASVSNRSKEAEEVVR---RFVRSVARVFV 1492
            ...|...:.|..: ::|...:||:            .:.::..||..:.:|   || |.:.|:
  Rat   993 ATRTWHSQLTQEISVLKELKEHLE------------QAKNHGEKELPQWLREDERF-RLLLRM-- 1042

  Fly  1493 IFNLEKQPNPEKRKSHSSCNKYVQSCVKVFQTLHKISIEELCEVSEALIAPVRLGVVRPTAPFTM 1557
               |||:.:..:.||....:|.:::..|....|...|.:|..||.         ......|.||.
  Rat  1043 ---LEKRVDRGEHKSELQADKMMRAAAKDVHRLRGQSCKEPPEVQ---------SFREKMAFFTR 1095

  Fly  1558 SSSNLDVRNSDDL 1570
            ...|:...::||:
  Rat  1096 PRMNIPALSADDV 1108

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698	12/67 (18%)
		ASF1_hist_chap	1535..1733	CDD:304562	8/36 (22%)
		PolyA	2498..2561	CDD:197769
		HECTc	2589..2885	CDD:238033
		HECTc	2589..2884	CDD:214523
Wwc1	XP_002727807.1	WW	9..39	CDD:238122	8/28 (29%)
		WW	55..84	CDD:278809	5/35 (14%)
		ALDH-SF	378..>420	CDD:299846	9/68 (13%)
		C2_Kibra	661..784	CDD:176062	23/135 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900