DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hyd and Arel1

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	NP_001100214.1	Gene:	Arel1 / 299197	RGDID:	1307597	Length:	823	Species:	Rattus norvegicus

Alignment Length:	812	Identity:	176/812 - (21%)
Similarity:	290/812 - (35%)	Gaps:	240/812 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  2172 SKYEKVVLMETDDSLPSTSK-----STEALMATRPEVI-IAPNKASVSPATAARSVIVLAGGSCL 2230
            |.|.|:  .:....:||.:|     ||..|...:|..: |.|.....:|...:.|:
  Rat   152 SPYYKI--FQPGMVVPSKTKIVCHFSTLVLTCGQPHTLQIVPRDEYDNPTNNSMSL--------- 205

  Fly  2231 KTIDSDINNYSAS--NLSTAEQAKCDTQYQKSTSDHLLLFPARGSQFYQSNFSELPSWNFLLSRW 2293
                .:.:|||.|  .|...|:...:..::||.:.:
  Rat   206 ----REEHNYSLSIHELGPQEEENSEVSFEKSVTSN----------------------------- 237

  Fly  2294 KLTLDLFGRVFMDDVGMEHGSVLPELRGFPVKEMRFRRHMEKLRNGQQRDLVLCKLERNRESLIV 2358
            :.|..:|.|:.:...|..|..:              ....:.:.||:...:||.:.|:|    ||
  Rat   238 RQTCQVFLRLTLHSRGCFHACI--------------SYQNQPINNGEFDIIVLSENEKN----IV 284

  Fly  2359 QTFKELNTQFGNQSRRIQPPITFNRVKVTFKDEPGEGSGVARSFYTSIAEALLASAKIPNLESVQ 2423
            :  :.::|                             |||:..|     ||.|.:|
  Rat   285 E--RNVST-----------------------------SGVSIYF-----EAYLYNA--------- 304

  Fly  2424 VGTNHSKYVVPFSSILRSRTVSGSSRDQSTLQRRGSNSKILWRSARERKALNLDARPYTPPNSSD 2488
                :|....|:.  |....:|.|.|..||              |.|.:..:..:..:||....
  Rat   305 ----NSYSSAPWH--LPPMHMSSSQRRPST--------------ALEEEEEDSPSECHTPEKVK- 348

  Fly  2489 NATPESLNDHLS--------VHLQQIGERLY-------PKIHSINQTHAPKITGMLLE--IPTPQ 2536
              .|:.:..::|        .:|:.|..|||       .|...:......|:..::::  |..|.
  Rat   349 --KPKKVYCYVSPKQFSVKEFYLKIIPWRLYTFRVCPGTKFSYLGPDPVHKLLTLVVDDGIQPPV 411

  Fly  2537 LLSV-----------------ISSDETLRQKVN----EAIEI--------ITFKQKSETSAQSSQ 2572
            .||.                 |...||.:.|||    |..::        :|.|.......:||.
  Rat   412 ELSCKERNILAATFIRSLHKNIGGSETFQDKVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSL 476

  Fly  2573 PKKSPSVVVVD------PVDDDNEPLFYSPGKRGFY---------TPRQGFASFE---------- 2612
             |.:.:..:.|      .|..|.|.|.:...:|.::         |..|.|..|.
  Rat   477 -KATRNFSISDWSKNFEVVFQDEEALDWGGPRREWFELICKALFDTTSQLFTRFSDNNQALVHPN 540

  Fly  2613 -------RINAFRNIGRLIGLCLLQNELLPLFLQ-------RHVLKYILGRKIKFHDLAFFDPAL 2663
                   |:..:...|||:|.||.::.|...:.|       |..|..|:|.::.:......||..
  Rat   541 PNRPAHLRLKMYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEF 605

  Fly  2664 YESFRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCGNR--ELIPGGRDVAVTSSNIFEYVRRY 2726
            |:|....|.|....|       |||.|..:...:.|..::  ||:.||....||::|...|:...
  Rat   606 YKSKVCFILNNDMSE-------MELVFAEEKYNKSGQLDKIVELMTGGAQTPVTNANKTFYLNLL 663

  Fly  2727 TEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVSTLISYTTFNDESSEG 2791
            .:|||....::.:|....|:.:::|:|.:......:|.||:.|.|||:||...::......|...
  Rat   664 AQYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHF 728

  Fly  2792 PDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPL-PSVTIRPA-DDSHLPTAN 2854
            .:|::   :|||::|..:...|...|:.|.|||..||..  ||..| ||..|..| ..|.||||:
  Rat   729 REKVM---RWFWTVVSSLTQEELARLLQFTTGSSQLPPG--GFAALCPSFQIIAAPTHSTLPTAH 788

  Fly  2855 TCISRLYIPLYSSKSILRSKMLMAIKSKNFGF 2886
            ||.::|.:|.|.|...:...:.:||.....||
  Rat   789 TCFNQLCLPTYDSYEEVHRMLQLAISEGCEGF 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	20/108 (19%)
		HECTc	2589..2885	CDD:238033	90/332 (27%)
		HECTc	2589..2884	CDD:214523	90/331 (27%)
Arel1	NP_001100214.1	Filamin	56..154	CDD:395505	1/1 (100%)
Arel1	NP_001100214.1	HECTc	486..820	CDD:214523	93/345 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900