DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hyd and Wwp1

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	XP_006237992.1	Gene:	Wwp1 / 297930	RGDID:	1311734	Length:	968	Species:	Rattus norvegicus

Alignment Length:	959	Identity:	188/959 - (19%)
Similarity:	329/959 - (34%)	Gaps:	278/959 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  2061 KPHLLQPNSKRQELFANLPLLVTTNANNSGATNDGDGGSIFD---YTPTRLGFSNSLKRNERVYE 2122
            |..||..|.|.:::...|.|.:   .|.:|....|:...:.|   ..|..:...:|
  Rat   152 KQVLLTHNRKLEKVKEQLKLSL---ENKNGIVQTGELTVVLDGLVIEPEAVTNRSS--------- 204

  Fly  2123 TVPIDSSKTGDGNVTNKAEGSTDSNIYVQLKKKQGSDDFKSHKEADGNQSKYEKVVLMETDDSLP 2187
            :.||:..:.||. |....:..|.:...:.::...|.|:..|                  |...:|
  Rat   205 SPPIEIQQNGDA-VHENGDPLTRTTPRLAVEGTIGIDNHVS------------------TSTVVP 250

  Fly  2188 ST----------SKSTEALMATRPEVIIAPNKASVSPAT---AARSVIVLAG-----GSCLKTID 2234
            |:          :.|:...:||||:...||...:..|.:   ...|..|||.     |:.|.:.|
  Rat   251 SSCCSHIVNGENTPSSPPQVATRPQNTPAPKPLTSEPTSDTVNGESSSVLADSTSAMGTSLPSED 315

  Fly  2235 SDINNYSASNLSTAEQAKCDTQYQKSTSDHLLLFPARGS-------------------------- 2273
            |.    |.||.::....:...|...::|:|....|:..:
  Rat   316 ST----STSNCTSTTVQEPPVQEPPASSEHSECIPSASAEVGPEARSLIDPDSDSRNNSGFDKVR 376

  Fly  2274 -----------QFYQSNFSELPSWNFLLSRWKLTLDLFGRVFMDD-----VGMEHGSVLPELRGF 2322
                       |...:|...||      |.|:...|..||.:..|     ...|....||
  Rat   377 QPEGCVEPLRPQSGNTNTESLP------SGWEQRKDPHGRTYYVDHNTRTTTWERPQPLP----- 430

  Fly  2323 PVKEMRF-------------------RRHMEKLRNGQQRDLVLCKLERNRESLIVQTFKEL---- 2364
            |..|.|.                   |..||.:||.:|     .:.:||:....:|.|.:.
  Rat   431 PGWERRVDDRGRVYYVDHNTRTTTWQRPTMESVRNFEQ-----WQSQRNQLQGAMQQFNQRYLYS 490

  Fly  2365 -------NTQFG----NQSRRIQPP-----ITFNRVKVTFKDEPGEGSGVARSFYTSIAEALLAS 2413
                   |..:|    ...:|:...     :..|.....::|...:|
  Rat   491 ASMLAAENDPYGPLPPGWEKRVDSTDRVYFVNHNTKTTQWEDPRTQG------------------ 537

  Fly  2414 AKIPNLESVQVG-----TNHS-KYVVPFSSILRSRTVSGSSRDQSTLQRRGS----NSKILWRSA 2468
              :||.|.:..|     |... :|.|..::  |:.|.......:|::.:.|.    .....|:.|
  Rat   538 --LPNEEPLPEGWEIRYTREGVRYFVDHNT--RTTTFKDPRNGKSSVTKGGPQIAYERSFRWKLA 598

  Fly  2469 RERKALNLDARPYTPPNSSDNATPESLNDHLSVHLQQIGERLYPKIHSINQTHAPKITGMLLEIP 2533
            ..|.....:|.|                .|:             ||:...||        |.|..
  Rat   599 HFRYLCQSNALP----------------SHV-------------KINVSRQT--------LFEDS 626

  Fly  2534 TPQLLSVISSDETLRQKVNEAIEIITFKQKS---------ETSAQSSQPKKSPSVVVVDPVDDDN 2589
            ..|::::...|  ||:::     .:.|:.:.         |.....|....:|...:.:....:|
  Rat   627 FQQIMALKPYD--LRRRL-----YVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNN 684

  Fly  2590 EPLFYSPGKRGFYTPRQGFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIKFH 2654
            ..|..:|...  ..|       :.::.|..|||.|.:.|...:.:.........|.:|.:|:...
  Rat   685 YCLQINPAST--INP-------DHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIK 740

  Fly  2655 DLAFFDPALYESFRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCGNRELIPGGRDVAVTSSNI 2719
            ||...|...|.|...|..|...:.|      :|:.|.:|:.......:.:|..||.::.||..|.
  Rat   741 DLESIDTEFYNSLIWIRDNNIEECG------LEMYFSVDMEILGKVTSHDLKLGGSNILVTEENK 799

  Fly  2720 FEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINV-----STLI 2779
            .||:...||:|..:..::..:|..||..:|:|...:.....::|.::|.|:.::::     :|:.
  Rat   800 DEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVY 864

  Fly  2780 SYTTFNDESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQ-------PL 2837
            .:.|.|.:      :::    |||..|::.:...|..|:.|.||:..||..  ||.       |.
  Rat   865 RHYTRNSK------QII----WFWQFVKETDNEVRMRLLQFVTGTCRLPLG--GFAELMGSNGPQ 917

  Fly  2838 PSVTIRPADDSHLPTANTCISRLYIPLYSSKSILRSKMLMAI-KSKNFG 2885
            .....:...|:.||.::||.:||.:|.|.|...|:.|:|.|| :::.||
  Rat   918 KFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFG 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	11/62 (18%)
		HECTc	2589..2885	CDD:238033	75/308 (24%)
		HECTc	2589..2884	CDD:214523	75/307 (24%)
Wwp1	XP_006237992.1	C2_E3_ubiquitin_ligase	67..190	CDD:175988	10/40 (25%)
		PARM	243..>400	CDD:293666	31/184 (17%)
		WW	397..426	CDD:278809	9/34 (26%)
		WW	429..458	CDD:278809	5/33 (15%)
		WW	504..533	CDD:278809	2/28 (7%)
		WW	545..574	CDD:238122	6/30 (20%)
		HECTc	614..966	CDD:238033	89/393 (23%)
		HECTc	637..965	CDD:214523	82/361 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900