DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hyd and Nedd4l

DIOPT Version :9

Sequence 1:NP_001287262.1 Gene:hyd / 41181 FlyBaseID:FBgn0002431 Length:2887 Species:Drosophila melanogaster
Sequence 2:XP_038952600.1 Gene:Nedd4l / 291553 RGDID:735047 Length:1259 Species:Rattus norvegicus


Alignment Length:1549 Identity:301/1549 - (19%)
Similarity:486/1549 - (31%) Gaps:523/1549 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly  1552 TAPFTMSSSNLDVRNSDDLFSVDPLAPSNVESPSEQILVHDAGNDQSANFNIQQNYDVVAMETIR 1616
            |||   .|..||....:|.|......|.. .||..  ...:||.|.    .:|:.  |.|::...
  Rat    16 TAP---ESEILDQEREEDFFMAFQTLPRR-SSPHP--FTQNAGEDS----GLQEG--VGALKRSS 68

  Fly  1617 DASESEEVINREANSHNQDDELIENQRN-EDGMQDDESDNDFTFNDAETESDSDDNQSNQEVQRS 1680
            .....:.:...:|.........|..||. .||..|          ....:...||...:.:....
  Rat    69 SMFIPQLLAGVDARPTRSSSMKISLQRKAADGATD----------SCGPQEGPDDRPPSAQGDLG 123

  Fly  1681 VQAGAT-----VGSENDIGVLFLEDESGDS---SAQEEDGSEDGESDDQSDEFNFNEQ------- 1730
            .||.||     :||.....|    |..|.|   :|.:.....:|..|.:.......|.       
  Rat   124 DQAAATRVSAQIGSSEPSPV----DTPGSSPPRAAWDPGTLVNGTCDHRGPSPRLAEDTEEATPG 184

  Fly  1731 -QLERRSTNSNARS--------DLAPQTMQWAIRSRDTARSS---------VRVP---------- 1767
             :::.|:::::.|.        |...:..:|:::....|..|         ::.|          
  Rat   185 LRIQHRASSADVRQVRLLPFGPDGQAEPRRWSLQHVPDASGSSGKRCFVFQLQQPHQGTVGLGSD 249

  Fly  1768 --------TGSNMVFIDPMALRRS----TVPASTTVT------TPSIEPHTMATTASNLARAFGI 1814
                    .|..:|....:.|.||    |.|.:..|:      ||...|.               
  Rat   250 FNFGFTGTKGDRLVRYPRIRLERSTSYPTQPRAGRVSPTEDRGTPEASPR--------------- 299

  Fly  1815 TIRQISELISILSYNVLNDIETSLKIQNDEAIAVQAFVEKRLKATWDWMFTVMDGTEAQLKFGAY 1879
              |.:.|:....|...........||:.|:....|.|           ...|..|.|.     |.
  Rat   300 --RMVPEIRRTNSERTPQSPGCMFKIRQDQNAGQQHF-----------RILVTRGPEE-----AP 346

  Fly  1880 LTNYTDPNHPLHPLNLSAQASSSQTPAPATSSSVNGVNIMGSN------------SRRDFFTYCL 1932
            ......|..|.||          .|..|.....:..|::..|:            :.:||    |
  Rat   347 QNQEETPKSPGHP----------GTGVPTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDF----L 397

  Fly  1933 SLMRSH------------------------TSEHRDALPVLDITALRHIAYVLDAFVYYMRNDS- 1972
            ...|||                        .||.||        .:.|...|:|:      ||| 
  Rat   398 LRPRSHKSRVKGFLRLKMAYMPKNGGQDEENSEQRD--------DMEHGWEVVDS------NDSA 448

  Fly  1973 --------------GFYDKQDTISGRI-----NNLSP-------MTESYDTDDELANLEE----- 2006
                          |:.:|.|.: ||.     ||.|.       |..|.::|:.:..:.:     
  Rat   449 SQHQEELPPPPLPPGWEEKVDNL-GRTYYVNHNNRSTQWHRPSLMDVSSESDNNIRQINQEAAHR 512

  Fly  2007 -FNADVQMSASSMPSGSQGTRRHAFFARSESTLSLGCSAPEGFE------------LPLDMAMPL 2058
             |.:...:|....|..|:|                |...||.:|            |.|.:..|.
  Rat   513 RFRSRRHISEDLEPEASEG----------------GGEGPEPWETISEEVNMAGDSLSLALPPPP 561

  Fly  2059 ADKPHLLQPNSKRQELFANLPLLVTTNANNSGATNDGDGGSIFDYTPTRLGFSNSLKRNERVYET 2123
            |.......|....:||...|.:...:|.....|        :....|      :|..|:..|.:|
  Rat   562 ASPVSRTSPQELSEELSRRLQITPDSNGEQFSA--------LIQREP------SSRLRSCSVTDT 612

  Fly  2124 V--------PIDSSKTGDGNVTNKAEGSTDSNIYV-----------QLKKKQGSDDFKSHKEADG 2169
            |        |...::....:.....|.||.|..||           :.|..:|...:.:|.....
  Rat   613 VAEQAHLPPPSTPTRRARSSTVTGGEESTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTT 677

  Fly  2170 NQSKYEKVVLMETDDSLPSTSKSTEALM---ATRPEVIIAPNKASVSPATAARSVIVLAGGSCLK 2231
            ..::  .::.:..|.:..|.:.|...|:   ..||..:.:|.....:|...|:            
  Rat   678 TWTR--PIMQLAEDGASGSATNSNNHLVEPQIRRPRSLSSPTVTLSAPLEGAK------------ 728

  Fly  2232 TIDSDINNYSASNLSTAEQAKCDTQYQKSTSDHLLLFPARGSQFYQSNFSELPSWNFLLSRWKLT 2296
              ||.|.......||. .|:...:.|......|.:                  :.:||...|::.
  Rat   729 --DSPIRRAVKDTLSN-PQSPQPSPYNSPKPQHKV------------------TQSFLPPGWEMR 772

  Fly  2297 LDLFGRVFMDDVGMEHGSVL-----PELRGFPVKEMRFRRHMEKLRNGQQRDLVLCKLERNRESL 2356
            :...||.|.    ::|.:..     |.|: |||       ||                 |::.||
  Rat   773 IAPNGRPFF----IDHNTKTTTWEDPRLK-FPV-------HM-----------------RSKASL 808

  Fly  2357 IVQTFKELNTQFGNQSRRIQPPITFNRVKVTFKDEPGEGSGVARSFYTSIAEALLASAKIPNLES 2421
            .......|            ||....|:.:.           .|:||            |.:...
  Rat   809 NPNDLGPL------------PPGWEERIHLD-----------GRTFY------------IDHSSQ 838

  Fly  2422 VQVGTNHSKYVVPFSSILRSRTVSGSSRDQSTLQRRGSNSKIL-WRSAR-ERKALNLDARPYTP- 2483
            |..|.|.::..||.                       .:|||. |...| :..|:...|.||:. 
  Rat   839 VLCGENDTRESVPL-----------------------YDSKITQWEDPRLQNPAITGPAVPYSRE 880

  Fly  2484 ------------------PNSSDNATPESLNDHLSVHLQQIGERLYPKIHSINQTHAPKITGMLL 2530
                              ||..:          :.:|...|.|..|.:|.|:.            
  Rat   881 FKQKYDYFRKKLKKPADIPNRFE----------MKLHRNNIFEESYRRIMSVK------------ 923

  Fly  2531 EIPTPQLLSVISSDETLRQKVNEAIEIITFKQKS---------ETSAQSSQPKKSPSVVVVDPVD 2586
                             |..|.:|...|.|:.:.         |.....|:...:|...:.:...
  Rat   924 -----------------RPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSA 971

  Fly  2587 DDNEPLFYSPGKRGFYT----PRQGFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYIL 2647
            .||            ||    |..|..:.:.::.|..|||:.||.:...:||..|..|...|.:|
  Rat   972 TDN------------YTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMML 1024

  Fly  2648 GRKIKFHDLAFFDPALYESFRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCGNR---ELIPGG 2709
            |::|..:|:...|...|.|.:.|::|..|:        ::|.|.||   ||..|..   :|.|.|
  Rat  1025 GKQITLNDMESVDSEYYNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNG 1078

  Fly  2710 RDVAVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDIN 2774
            .::.||:.|..||:....::|.:...:|.:.|..:|..::||.:.:......:|.||:.|:||::
  Rat  1079 SEIMVTNENKREYIDLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVD 1143

  Fly  2775 VSTLISYTTFNDESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPL-- 2837
            |:....::.:.:........:    :|||..|..|:..:|..|:.|.||:..:|.:  ||..|  
  Rat  1144 VNDWRQHSIYKNGYCPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMN--GFAELYG 1202

  Fly  2838 ---PSV-TIRP-ADDSHLPTANTCISRLYIPLYSSKSILRSKMLMAIKSKNFGF 2886
               |.: ||.. .....||.|:||.:||.:|.|.:...||.|:|||:::.. ||
  Rat  1203 SNGPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ-GF 1255

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hydNP_001287262.1 E3_UbLigase_EDD 150..196 CDD:288409
ZnF_UBR1 1217..1284 CDD:197698
ASF1_hist_chap 1535..1733 CDD:304562 40/197 (20%)
PolyA 2498..2561 CDD:197769 10/62 (16%)
HECTc 2589..2885 CDD:238033 86/309 (28%)
HECTc 2589..2884 CDD:214523 86/308 (28%)
Nedd4lXP_038952600.1 C2 <365..418 CDD:417471 8/56 (14%)
WW 463..489 CDD:395320 8/26 (31%)
WW 653..682 CDD:395320 3/30 (10%)
WW 766..796 CDD:238122 6/33 (18%)
WW 815..865 CDD:197736 17/107 (16%)
HECTc 926..1255 CDD:214523 94/358 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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