DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hyd and HERC4

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	XP_011537894.1	Gene:	HERC4 / 26091	HGNCID:	24521	Length:	1081	Species:	Homo sapiens

Alignment Length:	393	Identity:	95/393 - (24%)
Similarity:	162/393 - (41%)	Gaps:	45/393 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly  2516 SINQTHAPKITGMLL---EIPTPQLLSVISSDETLRQKVNEAIEIITFKQKSETSAQSSQPKKSP 2577
            :|:|.|...::.:.|   |...|.|:.|:..:..    |.:|:|::       ...::...||..
Human   709 AIDQAHRQNVSSLFLPVIESVNPCLILVVRRENI----VGDAMEVL-------RKTKNIDYKKPL 762

  Fly  2578 SVVVV--DPVDDDN-EPLFYSPGKRGFYTPRQGF--------------ASFERINAFRNIGRLIG 2625
            .|:.|  |.||... ...|:....|....|:.|.              .:||..:.|..||.:.|
Human   763 KVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDLFHLIGVICG 827

  Fly  2626 LCLLQNELLPLFLQRHVLKYILGRKIKFHDLAFFDPALYESFRQIIQNAQTKEGEETINRMELCF 2690
            |.:....::.|.....:.|.:|.:|....||....|.:..|.:|::...: .:.|||..   |.|
Human   828 LAIYNCTIVDLHFPLALYKKLLKKKPSLDDLKELMPDVGRSMQQLLDYPE-DDIEETFC---LNF 888

  Fly  2691 VIDLMKEEGCGNRELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSM 2755
            .|.:........:||:..|.|.||...|..|:|..|.:|...||.....:|...|...|.....:
Human   889 TITVENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKVL 953

  Fly  2756 INLTAEDLRLLLNGVGDINVSTLISYTTFNDES-SEGPDKLLKFKKWFWSIVEKMNIMERQDLVY 2819
            :.....:|:.::.|..:.:...|...|.:..|. :|.|.     .|.||.:..::.:.:::..:.
Human   954 LLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPT-----IKIFWEVFHELPLEKKKQFLL 1013

  Fly  2820 FWTGSPALPASEEGFQPLPSV-TIRPADDSHLPTANTCISRLYIPLYSSKSILRSKMLMAIKSKN 2883
            |.|||..:|..  |.:.|..| ......:.:||.::||.:.|.:|.|:.|..||||::.|| ..|
Human  1014 FLTGSDRIPIL--GMKSLKLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLIQAI-DHN 1075

  Fly  2884 FGF 2886
            .||
Human  1076 EGF 1078

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	11/47 (23%)
		HECTc	2589..2885	CDD:238033	75/312 (24%)
		HECTc	2589..2884	CDD:214523	74/311 (24%)
HERC4	XP_011537894.1	RCC1	2..368	CDD:332518
HERC4	XP_011537894.1	HECTc	733..1079	CDD:238033	89/369 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900