DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hyd and MAGI3

DIOPT Version :9

Sequence 1:NP_001287262.1 Gene:hyd / 41181 FlyBaseID:FBgn0002431 Length:2887 Species:Drosophila melanogaster
Sequence 2:NP_001136254.1 Gene:MAGI3 / 260425 HGNCID:29647 Length:1481 Species:Homo sapiens


Alignment Length:1646 Identity:291/1646 - (17%)
Similarity:495/1646 - (30%) Gaps:614/1646 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   494 RFLWDKFRTKTKKPFKVVATDINVGAQVIMKKCPMYQSGSIGFTCSNGVPKVGQLLNSVWTFTDV 558
            |...:..|.||.||.||:..|:.....:      .:|.|||..       |:.|::.      |.
Human    92 RHFREPIRLKTVKPGKVINKDLRHYLSL------QFQKGSIDH-------KLQQVIR------DN 137

  Fly   559 CRMKIININTNSGVDKSQAAGNNLNAHGITPDKDLPKSTAMPSTGSSKNGQSFSNSKESTDRIDM 623
            ..::.|...|.:..| .:..|.:.|...:...|.|.:|.|:..:| :.:|..:...|...:    
Human   138 LYLRTIPCTTRAPRD-GEVPGVDYNFISVEQFKALEESGALLESG-TYDGNFYGTPKPPAE---- 196

  Fly   624 PPP--PSPASSTCSDT--GSVTSHKRTKRATTKE--DSNAPQEGRKDEELWEVKDVVFVEDKVGP 682
            |.|  |.|......|.  .:.:..|||...:..|  ||:.|:|   :|:          |||   
Human   197 PSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMDSSLPEE---EED----------EDK--- 245

  Fly   683 VGKVLKVDGDFVAVRFPAINAAAVAAAAAATSSTSNTASTSKEEGKEDDWQQCR--LLRREDVQ- 744
                            .|||.:..|......|.:|:...|.....:.:.....|  ::|.|.:: 
Human   246 ----------------EAINGSGNAENRERHSESSDWMKTVPSYNQTNSSMDFRNYMMRDETLEP 294

  Fly   745 --------------IFRTAMSTRGPDWLQ-------KQPKKINVGGDAAG------AQILTLAVD 782
                          |:....:|:...||.       |.|:....|....|      .|..|..||
Human   295 LPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVD 359

  Fly   783 SRGIHV--------------IKKVLGKIHYSLYNLYNCKQE-QNCLFPTDCNSFIG--------- 823
                |:              .||.||::     .:.:.|.: :...|..|.:...|         
Human   360 ----HLNQKTQFENPVEEAKRKKQLGQV-----EIGSSKPDMEKSHFTRDPSQLKGVLVRASLKK 415

  Fly   824 STPG------------------NILM---ACNDDCSGNSSTIVLRDGNGALYPLAKDCLGSIKDP 867
            ||.|                  |:|.   |..|........||..:||..|.....|.:      
Human   416 STMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVV------ 474

  Fly   868 QWFDLPPVKSITMSTI----SLP--------------AMLSGVNL-KSKVCMT-------ALLFD 906
            |.|.|.||......|:    .||              .:::|.:| |.:.||.       |::.:
Human   475 QMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLE 539

  Fly   907 TQKLMPHILRCDVKN----------SFAALGRLEREDQADTALVVEERCDGARNIFHACVIMCAP 961
            ......|.|..|..|          |.|:.|..:.|      ||......|.:....|..     
Human   540 QNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPE------LVTIPLIKGPKGFGFAIA----- 593

  Fly   962 SSNKDSPPDSPSG-------------GVEK------------KSLVGLSVARSIPTVSTSAYVSS 1001
                    |||:|             |::|            ::|..|.|...:......|.|..
Human   594 --------DSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPL 650

  Fly  1002 IAFGASASSSNENSSFATMSSSAAGSASSTS---------------------------------- 1032
            :.......|..:.:...|.....|||..:.:                                  
Human   651 LILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLY 715

  Fly  1033 RDNRTNLRDM-----------MNRLINSDQAEQS----GSQPMATNNEDHAYIPWPAETPAASNL 1082
            .|...|.:|:           ..|::..|..:||    ...|:....:|       ....||..|
Human   716 EDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKD-------GRLRAADEL 773

  Fly  1083 --------SASSSQNVSDSI------------------------EDDISK-IIPSSSQSSMLSNI 1114
                    ...|.:.|.|.:                        |||.|: .|.:.:.|..|:..
Human   774 MCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRA 838

  Fly  1115 KL---GSPTYTFDLA-QRREHA----LTILQQMCVSPALRPY------------LCHMLSTKD-- 1157
            ::   .:|...:|:. ||:|:.    :.:..:....|.:.|:            .|..|...|  
Human   839 EVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHI 903

  Fly  1158 --AQGQTPFMLS---VSCRAYEAGIILLNTILMLSE------------QDPQLKEAMIFPNGS-- 1203
              ..||:...||   :.....:||:.:..|::...|            |.|.|:..   |.|.  
Human   904 SAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHR---PMGQSQ 965

  Fly  1204 ----PADQSPLHVICYNDTCS---FTWTGADHINQNIFECKTCGLTGS-----LCCCTECARVCH 1256
                |.|:|.|......|..:   .:|:...|:.|.  :.....:.||     |.|         
Human   966 ANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQP--DTAVISVVGSRHNQNLGC--------- 1019

  Fly  1257 KGHDCKLKRTAPTAYCDCWEKCKCKALIAGNLTKRFALLCKLVSCTDLVTKFNSKGESILLFLIQ 1321
              :..:|:| .|..:                   .|:|.             ..|..::.||:::
Human  1020 --YPVELER-GPRGF-------------------GFSLR-------------GGKEYNMGLFILR 1049

  Fly  1322 T-------------VGRQIVE--QRQYRFSVRVRNVSTAATGATGNNSVISNRKTSAAEIDNDMP 1371
            .             ||.||||  ....:.....|.:.....|  ||..::..|..:..     :|
Human  1050 LAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAG--GNKVLLLLRPGTGL-----IP 1107

  Fly  1372 DHDLEPPKFARKALERLLIDWNAVRSMIMSGAERGDVPNPAGSASENSNSEGFNMFIQTQ----- 1431
            ||.                ||              |:.||:.|          |:....|     
Human  1108 DHG----------------DW--------------DINNPSSS----------NVIYDEQSPLPP 1132

  Fly  1432 --HGSTLLDKFTHSLIVKCTSDHLDTLLLTLVRELQNASVSNRSKEAEEVVRRFVRSVARVFVIF 1494
              |.:::.:: :|               :.::.|.....:..:::|.:::|.....::.      
Human  1133 SSHFASIFEE-SH---------------VPVIEESLRVQICEKAEELKDIVPEKKSTLN------ 1175

  Fly  1495 NLEKQP----------NPEKR---KSHSSCNKYVQSCVKVFQTLHKISIEELCEVSEALIAPVRL 1546
              |.||          |..||   .||...||                 :.|.:|...:   .|.
Human  1176 --ENQPEIKHQSLLQKNVSKRDPPSSHGHSNK-----------------KNLLKVENGV---TRR 1218

  Fly  1547 G-VVRPTAPFTM-SSSNLDVRNSDDLFSVDPLAPSNVESPSEQILVHDAGNDQSANFNIQ--QNY 1607
            | .|.|..|.:. |..:||...|       ||..:....|.:|.|....|.::|...:.:  ...
Human  1219 GRSVSPKKPASQHSEEHLDKIPS-------PLKNNPKRRPRDQSLSPSKGENKSCQVSTRAGSGQ 1276

  Fly  1608 DVVAMETIRDAS-ESEEVINREANSHNQDDELIENQ---------RNEDGMQDDESDNDFTFNDA 1662
            |.......|.|| :.::.|.......|.:.:|:|.:         .|.:.:.|.:..:|....||
Human  1277 DQCRKSRGRSASPKKQQKIEGSKAPSNAEAKLLEGKSRRIAGYTGSNAEQIPDGKEKSDVIRKDA 1341

  Fly  1663 ------ETESDSDDNQSNQEVQRSVQAGATVGSENDIGVLFLEDESGDSSAQEEDGSE--DGESD 1719
                  ::.:.|.:.:..:.|::|:.:..|            ...:....::.|.|.:  .||:.
Human  1342 KQNQLEKSRTRSPEKKIKRMVEKSLPSKMT------------NKTTSKEVSENEKGKKVTTGETS 1394

  Fly  1720 DQSDEFNFNEQQLERR-------STNSNARSDLAPQTMQWAIRSRDTAR------SSV------- 1764
            ..:|:...|.|..|:|       ...||...|...:.::.|.::::|.|      |.|       
Human  1395 SSNDKIGENVQLSEKRLKQEPEEKVVSNKTEDHKGKELEAADKNKETGRFKPESSSPVKKTLITP 1459

  Fly  1765 ---RVPTGSNMVFIDPMALRR 1782
               :||:|:.:.....||.:|
Human  1460 GPWKVPSGNKVTGTIGMAEKR 1480

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hydNP_001287262.1 E3_UbLigase_EDD 150..196 CDD:288409
ZnF_UBR1 1217..1284 CDD:197698 11/74 (15%)
ASF1_hist_chap 1535..1733 CDD:304562 41/219 (19%)
PolyA 2498..2561 CDD:197769
HECTc 2589..2885 CDD:238033
HECTc 2589..2884 CDD:214523
MAGI3NP_001136254.1 Interaction with ADRB1 and TGFA. /evidence=ECO:0000250 18..106 5/13 (38%)
PDZ_signaling 24..101 CDD:238492 2/8 (25%)
NK 123..>197 CDD:327404 18/92 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 182..273 26/126 (21%)
WW 294..326 CDD:197736 4/31 (13%)
WW 342..372 CDD:238122 6/33 (18%)
Interaction with PTEN. /evidence=ECO:0000269|PubMed:10748157 410..492 19/87 (22%)
PDZ 413..493 CDD:214570 19/85 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 542..570 6/27 (22%)
PDZ 575..656 CDD:214570 16/99 (16%)
Interaction with ADGRB1. /evidence=ECO:0000269|PubMed:10748157 726..808 12/88 (14%)
PDZ_signaling 726..807 CDD:238492 12/87 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 821..843 4/21 (19%)
PDZ_signaling 849..935 CDD:238492 16/85 (19%)
Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000269|PubMed:10748157, ECO:0000269|PubMed:16904289 851..938 16/86 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..976 9/39 (23%)
PDZ_signaling 1022..1100 CDD:238492 18/112 (16%)
Red1 <1132..1461 CDD:311769 67/391 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1170..1481 68/358 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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