Protein Alignment hyd and Plekha7

DIOPT Version :9

• Sequence 1: NP_001287262.1
• Gene: hyd / 41181
• FlyBaseID: FBgn0002431
• Length: 2887
• Species: Drosophila melanogaster
• Sequence 2: XP_017177675.1
• Gene: Plekha7 / 233765
• MGIID: 2445094
• Length: 1359
• Species: Mus musculus
• Alignment Length: 1119
• Identity: 203/1119 - (18%)
• Similarity: 347/1119 - (31%)
• Gaps: 362/1119 - (32%)

  Fly  1712 GSEDGESDDQSDEF-NFNEQQLERRSTNSNARSDLAPQTMQWAIRS-----RDTARSSVRVPTGS 1770
            |.|:|.:::.:..| :.|:|....|.          |.|.|::..:     |:.....:..|..:
Mouse    58 GWEEGFTEEGASFFIDHNQQTTTFRH----------PVTGQFSSENSEYVLREEPHPHMSKPERN 112

  Fly  1771 NMVFIDPMALRRSTVPASTTVTTPSIEPHTMATTASNLARAFGITIRQISELISILSYNVLNDIE 1835
            ..    |.::...|..|.|| :|...:|......:|:...:||...:.|...:::
Mouse   113 QR----PSSMVSETSTAGTT-STLEAKPGPKIVKSSSKVHSFGKRDQAIRRNLNV---------- 162

  Fly  1836 TSLKIQNDEAIAVQAFVEK------RL-KATW----DW-MFTVMDGTEAQLKFGAYLTNYTDPNH 1888
                     .:.|:.::.|      || |..|    |: :|...|..|.     |.|.:...|::
Mouse   163 ---------PVVVRGWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREE-----AVLGSIPLPSY 213

  Fly  1889 PLHPL--------NLSAQASSSQTPAPATSSSVNGVNIMGSNSRRDFFTYCL------------- 1932
            .:.|:        ..|.:|..:...|...|::..|..:..|..|..:|:...
Mouse   214 VISPVAPEDRISRKYSFKAVHTGMRALIYSTTTAGSQMEHSGMRTYYFSADTLEDMNAWVRAMNQ 278

  Fly  1933 --------SLMRSHTSEHRDALPVLDIT-ALRHIAYV-------------LDAFVYYMR--NDSG 1973
                    ||.|......|.|:|..:.| |.:...:|             .|::.:..|  .:..
Mouse   279 AAQVLSRSSLRRDVDKVERQAMPQANHTDACQECGHVGPGHSRDCPRRGYEDSYGFNRREQEEER 343

  Fly  1974 FYDKQDTISGRINNLSPMTESYDTDDELANLEEFNADVQMSASSMPSGSQGTRRHAFFARSESTL 2038
            |..::|.:.||            .|...|......|:.......:|.|.:|.:.....|......
Mouse   344 FRAQRDPLEGR------------RDRSKARSPYLPAEEDALFVDLPGGPRGQQAQPQRAEKNGVP 396

  Fly  2039 SLGCSAPEGFELPLDMAMPLADKPHLLQPNSKRQELFANLPLLVTTNANNSGATNDGDGGSI-FD 2102
            ..|.....|.......|.|.|:.    :.:|:|:...|        .|.:......|||.|: .|
Mouse   397 PYGLGEQNGTNGYQRTAPPRANP----EKHSQRKTGLA--------QAEHWTKAQKGDGRSLPLD 449

  Fly  2103 YTPTRLGFSNSLKRNERVYETVPIDSSKTGDGNVTNKAEGSTDSNIYVQLKK---KQGSDDFKSH 2164
            .|..|.|.|..|...|. |:::| .|::...|:.:...........|.|.:.   |..|::.::|
Mouse   450 QTLPRQGPSQPLSFPEN-YQSLP-KSTRHLSGSSSPPPRNLPSDYKYAQDRASHLKMSSEERRAH 512

  Fly  2165 KEADG-------------------------------NQSKYEKVVLMETDDSLPSTSKSTEALMA 2198
            :  ||                               .|.:...::.:....|:|.:.........
Mouse   513 R--DGTVWQLYEWQQRQQFRHGSPTAPIGAGSPEFTEQGRSRSLLEVPRSISVPPSPSDIPPPGP 575

  Fly  2199 TRPEVIIAPN----KASVSPATAARSVIVLAGGSCLKTIDSDINN------------------YS 2241
            .||.....|:    :.:|.|....|||.:..|||..|.......|                  .|
Mouse   576 PRPFPPRRPHTPAERVTVKPPEQRRSVDISLGGSPRKARGHAAKNSSHVDRRSMPSMGYMTHTVS 640

  Fly  2242 ASNL---STAEQAKCDTQYQKSTS--------------DHLLLFPA-RGSQFYQSNFSEL----- 2283
            |.:|   |..|.:...|:.|:..|              .|.|.||| :....|.....:|
Mouse   641 APSLHGKSLEELSLLLTRLQRHQSKLASVRNFAVGQLLHHYLTFPACQADDTYLQLKKDLEYLDL 705

  Fly  2284 ------PSWNFLLSRWKLTL-------DLFGRVFMDD------------------VGMEHGSVLP 2317
                  |..|.|....|.:.       .:.||..:.|                  :..|...:|.
Mouse   706 KIKNNEPLINVLYKVLKKSARGCRPGRSMTGRDLLKDRSLKPMKIAESDIDVKLSIFCEQDRILQ 770

  Fly  2318 ELRG------------FPVKEMRFR---------RHMEKLRNGQ---QRDLVLCKLERNRESLIV 2358
            :|..            ..|.|:..|         :|:||:...|   |.|||..:.|..|||
Mouse   771 DLEDKIRALKENKDQLESVLEVLHRQTEQYRDQPQHLEKITCQQRLLQEDLVHIRAELCRES--- 832

  Fly  2359 QTFKELNTQFGNQSRRIQPPITFNRVKVTFKDEPGEGSGVARSFYTSIAEALLASAKIPNLESVQ 2423
               .|:...: |:..:::..:  .::|.|.:::.      .|:|:  ..|.......:..:|.|.
Mouse   833 ---TEMENAW-NEYLKLEKDV--EQLKQTLQEQH------RRAFF--FQEKSQIQKDLWRIEDVM 883

  Fly  2424 VGTNHSKYVVPFSSILRSRTVSGSSRDQSTLQRRGSNSKILWRSAR--ERKALNLDARPYTPPNS 2486
            .|.:.:|                            .|.::|..|.:  |||.:.|...|..|..|
Mouse   884 AGLSANK----------------------------ENYRVLVGSVKNPERKTVPLFPHPSVPSLS 920

  Fly  2487 SDNATP--------ESLNDHLSVHLQQIGERLYPKIHSINQTHAPKITGMLLEIPTPQLLSVISS 2543
            ...:.|        ..:...|.|       ||:|::    ||:.|      .....|||..|:|.
Mouse   921 PTESKPALQPSPPTSPVRTPLEV-------RLFPQL----QTYVP------YRPHPPQLRKVMSP 968

  Fly  2544 DETLRQKVNEAIEIITFKQKSETSAQSSQPKKSPSVVVVDPVDDDNEPLFYSPGKRGFYTPRQGF 2608
                          :....|::..|:...|.:.|...:..|.|   :|....|      .||:
Mouse   969 --------------LQSPTKAKPQAEDEAPPRPPLPELYSPED---QPPAVPP------LPRE-- 1008

  Fly  2609 ASFERINAFRNIGR 2622
            |:..|..:.|.:.|
Mouse  1009 ATIIRHTSVRGLKR 1022

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562	6/21 (29%)
		PolyA	2498..2561	CDD:197769	13/62 (21%)
		HECTc	2589..2885	CDD:238033	8/34 (24%)
		HECTc	2589..2884	CDD:214523	8/34 (24%)
Plekha7	XP_017177675.1	WW	10..39	CDD:366073
		WW	55..84	CDD:366073	7/35 (20%)
		PH_PEPP1_2_3	158..280	CDD:270068	22/145 (15%)
		Smc	<692..>894	CDD:224117	39/246 (16%)
		PHA03247	<903..1009	CDD:223021	31/147 (21%)
		PRK10263	<912..>1118	CDD:236669	31/153 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900