DRSC/TRiP Functional Genomics Resources

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Protein Alignment hyd and NEDD4L

DIOPT Version :9

Sequence 1:NP_001287262.1 Gene:hyd / 41181 FlyBaseID:FBgn0002431 Length:2887 Species:Drosophila melanogaster
Sequence 2:XP_006722489.1 Gene:NEDD4L / 23327 HGNCID:7728 Length:1019 Species:Homo sapiens


Alignment Length:1210 Identity:256/1210 - (21%)
Similarity:418/1210 - (34%) Gaps:380/1210 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1812 FGITIRQISELISILSYNVLND--IETSLKI--QNDEAIAVQA-FVEKRLKATW--DWMFTVMDG 1869
            ||..||:|::..|..|    ||  ::.||.:  :|.|...||. .::|.|...|  ::.|.| :.
Human    51 FGRDIRKITKCESDNS----NDPYVKLSLYVADENRELALVQTKTIKKTLNPKWNEEFYFRV-NP 110

  Fly  1870 TEAQLKFGAYLTNYTDPNHPLHPLNLSAQASSSQTPA---PAT-----------SSSVNG----- 1915
            :..:|.|..:..|....:..|..:::......::.|.   |.|           .|.|.|     
Human   111 SNHRLLFEVFDENRLTRDDFLGQVDVPLSHLPTEDPTMERPYTFKDFLLRPRSHKSRVKGFLRLK 175

  Fly  1916 VNIMGSNSRRDFFTYCLSLMRSHTSEHRDALPVLDITALRHIAYVLDAFVYYMRNDS-------- 1972
            :..|..|..:|          ...|:.||        .:.|...|:|:      |||        
Human   176 MAYMPKNGGQD----------EENSDQRD--------DMEHGWEVVDS------NDSASQHQEEL 216

  Fly  1973 -------GFYDKQDTISGRI-----NNL-------SPMTESYDTDDELANLEEFNADVQMSASSM 2018
                   |:.:|.|.: ||.     ||.       |.|..|.::|:.:..:.:..|..:..    
Human   217 PPPPLPPGWEEKVDNL-GRTYYVNHNNRTTQWHRPSLMDVSSESDNNIRQINQEAAHRRFR---- 276

  Fly  2019 PSGSQGTRRHAFFARSESTLSLGCSAPEGFEL----------PLDMAMPLADKPHLLQPNSKR-- 2071
                  :||| .....|...|.|...||.:|.          .|.:|:|    |....|.|:.  
Human   277 ------SRRH-ISEDLEPEPSEGGDVPEPWETISEEVNIAGDSLGLALP----PPPASPGSRTSP 330

  Fly  2072 QELFANLP--LLVTTNANNSGATNDGDGGSIFDYTP-TRLGFSNSLKRNERVYET--VPIDSSKT 2131
            |||...|.  |.:|.::|..      ...|:....| :||   .|....:.|.|.  :|..|:..
Human   331 QELSEELSRRLQITPDSNGE------QFSSLIQREPSSRL---RSCSVTDAVAEQGHLPPPSAPA 386

  Fly  2132 G---DGNVTNKAEGSTDSNIYV-----------QLKKKQGSDDFKSHKEADGNQSKYEKVVLMET 2182
            |   ...||. .|..|.|..||           :.|..:|...:.:|.......::  .::.:..
Human   387 GRARSSTVTG-GEEPTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTR--PIMQLAE 448

  Fly  2183 DDSLPSTSKSTEALM---ATRPEVIIAPNKASVSPATAARSVIVLAGGSCLKTIDSDINNYSASN 2244
            |.:..|.:.|...|:   ..||..:.:|.....:|...|:              ||.:.......
Human   449 DGASGSATNSNNHLIEPQIRRPRSLSSPTVTLSAPLEGAK--------------DSPVRRAVKDT 499

  Fly  2245 LSTAEQAKCDTQYQKSTSDHLLLFPARGSQFYQSNFSELPSWNFLLSRWKLTLDLFGRVFMDDVG 2309
            ||. .|:...:.|......|.:                  :.:||...|::.:...||.|.    
Human   500 LSN-PQSPQPSPYNSPKPQHKV------------------TQSFLPPGWEMRIAPNGRPFF---- 541

  Fly  2310 MEHGSVL-----PELRGFPVKEMRFRRHMEKLRNGQQRDLVLCKLERNRESLIVQTFKELNTQFG 2369
            ::|.:..     |.|: |||       ||                 |::.||.......|     
Human   542 IDHNTKTTTWEDPRLK-FPV-------HM-----------------RSKTSLNPNDLGPL----- 576

  Fly  2370 NQSRRIQPPITFNRVKVTFKDEPGEGSGVARSFYTSIAEALLASAKIPNLESVQVGTNHSKYVVP 2434
                   ||....|:.:.           .|:||            |.:...|..|.|.::..||
Human   577 -------PPGWEERIHLD-----------GRTFY------------IDHSSQVLCGENDTRESVP 611

  Fly  2435 FSSILRSRTVSGSSRDQSTLQRRGSNSKILWRSAR-ERKALNLDARPYTP--------------- 2483
                         |.|....|         |...| :..|:...|.||:.               
Human   612 -------------SYDSKITQ---------WEDPRLQNPAITGPAVPYSREFKQKYDYFRKKLKK 654

  Fly  2484 ----PNSSDNATPESLNDHLSVHLQQIGERLYPKIHSINQTHAPKITGMLLEIPTPQLLSVISSD 2544
                ||..:          :.:|...|.|..|.:|.|:.                          
Human   655 PADIPNRFE----------MKLHRNNIFEESYRRIMSVK-------------------------- 683

  Fly  2545 ETLRQKVNEAIEIITFKQKS---------ETSAQSSQPKKSPSVVVVDPVDDDNEPLFYSPGKRG 2600
               |..|.:|...|.|:.:.         |.....|:...:|...:.:....||           
Human   684 ---RPDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDN----------- 734

  Fly  2601 FYT----PRQGFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIKFHDLAFFDP 2661
             ||    |..|..:.:.::.|..|||:.||.:...:||..|..|...|.:||::|..:|:...|.
Human   735 -YTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDMESVDS 798

  Fly  2662 ALYESFRQIIQNAQTKEGEETINRMELCFVIDLMKEEGCGNR---ELIPGGRDVAVTSSNIFEYV 2723
            ..|.|.:.|::|..|:        ::|.|.||   ||..|..   :|.|.|.::.||:.|..||:
Human   799 EYYNSLKWILENDPTE--------LDLMFCID---EENFGQTYQVDLKPNGSEIMVTNENKREYI 852

  Fly  2724 RRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRLLLNGVGDINVSTLISYTTFNDES 2788
            ....::|.:...:|.:.|..:|..::||.:.:......:|.||:.|:||::|:....::.:.:..
Human   853 DLVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGY 917

  Fly  2789 SEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPL-----PSV-TIRP-AD 2846
            ......:    :|||..|..|:..:|..|:.|.||:..:|.:  ||..|     |.: ||.. ..
Human   918 CPNHPVI----QWFWKAVLLMDAEKRIRLLQFVTGTSRVPMN--GFAELYGSNGPQLFTIEQWGS 976

  Fly  2847 DSHLPTANTCISRLYIPLYSSKSILRSKMLMAIKSKNFGF 2886
            ...||.|:||.:||.:|.|.:...||.|:|||:::.. ||
Human   977 PEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQ-GF 1015

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hydNP_001287262.1 E3_UbLigase_EDD 150..196 CDD:288409
ZnF_UBR1 1217..1284 CDD:197698
ASF1_hist_chap 1535..1733 CDD:304562
PolyA 2498..2561 CDD:197769 10/62 (16%)
HECTc 2589..2885 CDD:238033 86/309 (28%)
HECTc 2589..2884 CDD:214523 86/308 (28%)
NEDD4LXP_006722489.1 C2_NEDD4_NEDD4L 21..179 CDD:175999 30/132 (23%)
WW 224..250 CDD:278809 7/26 (27%)
WW 413..442 CDD:278809 3/30 (10%)
WW 526..556 CDD:238122 6/33 (18%)
WW 575..625 CDD:197736 17/106 (16%)
HECTc 662..1016 CDD:238033 103/423 (24%)
HECTc 686..1015 CDD:214523 94/358 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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