DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and WWC1

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	XP_011532787.1	Gene:	WWC1 / 23286	HGNCID:	29435	Length:	1185	Species:	Homo sapiens

Alignment Length:	1311	Identity:	250/1311 - (19%)
Similarity:	419/1311 - (31%)	Gaps:	440/1311 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1550 RPTAPFTMSSSNLDVRNSDDLFSVDPLAPSNVESP--SEQILVHDAGNDQSANFNIQ-------- 1604
            |.|.|.|.:..     .||:|    ||.......|  .:..:.|:....|..:..:|
Human    40 RYTKPLTFADC-----ISDEL----PLGWEEAYDPQVGDYFIDHNTKTTQIEDPRVQWRREQEHM 95

  Fly  1605 -QNYDVVAMETIRDASESEEV-----------------------------INREANSHNQDDELI 1639
             ::|.|||.|.:....|..:|                             ::..::|...|.|::
Human    96 LKDYLVVAQEALSAQKEIYQVKQQRLELAQQEYQQLHAVWEHKLGSQVSLVSGSSSSSKYDPEIL 160

  Fly  1640 -----------------------ENQRNEDGMQDDESDNDFTFNDAETESDSDDNQSNQEVQRSV 1681
                                   |.|..|.|.|..:. .|...:||:.....|:.|:.....:::
Human   161 KAEIATAKSRVNKLKREMVHLQHELQFKERGFQTLKK-IDKKMSDAQGSYKLDEAQAVLRETKAI 224

  Fly  1682 QAGATVGSENDIGVLFLEDESGD---SSAQEEDG--SEDGESDD--------QSDEFNFNEQQLE 1733
            :...|.|          |.|..|   |.|..:||  ::.|...|        :|..|...:|.|:
Human   225 KKAITCG----------EKEKQDLIKSLAMLKDGFRTDRGSHSDLWSSSSSLESSSFPLPKQYLD 279

  Fly  1734 RRSTNS-------NARSDLAPQTMQWAIRSRDTAR----------------SSVRVPTGSNM--- 1772
            ..|...       |:.:.|| :.::..:|..:..|                :..::|..|:.
Human   280 VSSQTDISGSFGINSNNQLA-EKVRLRLRYEEAKRRLSCQCGQATPSNSELTHYQLPQASSKTAR 343

  Fly  1773 -VFIDP---MALRRSTVPASTTVTTPSIEPHTMATTASNLARAF-----GITIRQISELISILSY 1828
             :::|.   .:|:|:|:...:..:..:.....:|.....||:..     |:...:...||
Human   344 HLYLDSHFLFSLKRTTLNLGSVPSCRNACLRWIANLKIQLAKLDSEAWPGVLDSERDRLI----- 403

  Fly  1829 NVLNDIETSLKIQN------------DEAIAVQAFVEKRLKATWDWMFTVMDGTEAQLKFGA--- 1878
             ::|:.|..||...            ::....:..:||.|:|..|   |.......:||..:
Human   404 -LINEKEELLKEMRFISPRKWTQGEVEQLEMARKRLEKDLQAARD---TQSKALTERLKLNSKRN 464

  Fly  1879 ----YLTNYTDPNHPLH----PLNLSAQA-SSSQTPAPATSS--SVNGVNIMGSNSRRDFFTYCL 1932
                .|...|.....||    .|:.|.|: ||..:|...|||  |:...::..|.|
Human   465 QLVRELEEATRQVATLHSQLKSLSSSMQSLSSGSSPGSLTSSRGSLVASSLDSSTS--------- 520

  Fly  1933 SLMRSHTSEHRDALPVLDITALRHIAYVLDAFVYYMRNDSGFYDKQDTISGRINNLSPMTESYDT 1997
               .|.|..:.|....||......:.::|      :...:||..     ||.|..:.
Human   521 ---ASFTDLYYDPFEQLDSELQSKVEFLL------LEGATGFRP-----SGCITTIH-------- 563

  Fly  1998 DDELANLEEFNADVQMSASSMPSGSQGTRRHAFFARSESTLSLGCSAPEGFELPLDMAMPLADKP 2062
            :||:|..::.....::.|....||:                            |..|. .|:.:.
Human   564 EDEVAKTQKAEGGGRLQALRSLSGT----------------------------PKSMT-SLSPRS 599

  Fly  2063 HLLQPNSKRQELFANLPLLVTTNANNSGATNDGDGGSIFDYTPTRLGFSNSLKRNERVYETVPID 2127
            .|..|:.....|.|: |||......||....|.:    ...|...|...||.:...|:.|  |..
Human   600 SLSSPSPPCSPLMAD-PLLAGDAFLNSLEFEDPE----LSATLCELSLGNSAQERYRLEE--PGT 657

  Fly  2128 SSKTGDGNVTNKAEGSTDSNIYVQLKKKQGSDDFKSHKEADGNQSKYE-KVVLMETDDSLPSTSK 2191
            ..|. .|...|.|:|   ..:.|.......||:     ...|:...|| .|..:...::....|.
Human   658 EGKQ-LGQAVNTAQG---CGLKVACVSAAVSDE-----SVAGDSGVYEASVQRLGASEAAAFDSD 713

  Fly  2192 STEALMATRPEVIIAPNKASVSPATAARSVIVLAGGSCLKTIDSDINNYSASNLSTAEQAKCDTQ 2256
            .:||:.|||.::.:   |........|..:|.|:..|.|........|...:.|..:|...|
Human   714 ESEAVGATRIQIAL---KYDEKNKQFAILIIQLSNLSALLQQQDQKVNIRVAVLPCSESTTC--- 772

  Fly  2257 YQKSTSDHLLLFPARGSQFYQSNFSELPSWNFLLSRWKLTLD-----LFGRVFMDDVGMEHGSVL 2316
                      ||..|                        .||     :|..||.  |.|.:
Human   773 ----------LFRTR------------------------PLDASDTLVFNEVFW--VSMSY---- 797

  Fly  2317 PELRGFPVKEMRF------RRHMEKLRNGQQRDLV-LCKL-ERNRESLIVQTFKELNTQFGNQSR 2373
            |.|.   .|.:|.      |.|:|:...|.|..|. :|:. ||:.....:.::|.|.    .|||
Human   798 PALH---QKTLRVDVCTTDRSHLEECLGGAQISLAEVCRSGERSTRWYNLLSYKYLK----KQSR 855

  Fly  2374 RIQP------------PITFNRVKV----------------------TFKD-----EPGEGSGVA 2399
            .::|            .:::::..|                      |.:|     |..|...||
Human   856 ELKPVGVMAPASGPASTVSWDQDAVSALLEQTAVELEKRQEGRSSTQTLEDSWRYEETSENEAVA 920

  Fly  2400 RSFYTSIAEA-----LLASAKIPNLE-----SVQVGTN-----HSKYVV-------------PF- 2435
            ......:.|.     :......|:::     .|...||     .|..||             ||
Human   921 EEEEEEVEEEEGEEDVFTEKASPDMDGYPALKVDKETNTETPAPSPTVVRPKDRRVGTPSQGPFL 985

  Fly  2436 --SSILRSRTVSGSSRDQ--STLQRRGSNSKIL------WRSARERKALNLDARPYTPPNSSDNA 2490
              |:|:||:|.|...:.|  ..|.|..|:|..|      .|::.||:::.: .||..||..|...
Human   986 RGSTIIRSKTFSPGPQSQYVCRLNRSDSDSSTLSKKPPFVRNSLERRSVRM-KRPSPPPQPSSVK 1049

  Fly  2491 TPES-----------------------LNDHLSVHLQQIGERLYPKIHSINQTHAPK-------- 2524
            :..|                       |...:|| |:::.|:| .:..|..:...|:
Human  1050 SLRSERLIRTSLDLELDLQATRTWHSQLTQEISV-LKELKEQL-EQAKSHGEKELPQWLREDERF 1112

  Fly  2525 --ITGMLL-----------EIPTPQLLSVISSD-ETLR-QKVNEAIEIITFKQKSETSAQSSQPK 2574
              :..||.           |:.|.:::...:.| ..|| |...|..|:.:|::|   .|..::|:
Human  1113 RLLLRMLEKRQMDRAEHKGELQTDKMMRAAAKDVHRLRGQSCKEPPEVQSFREK---MAFFTRPR 1174

  Fly  2575 KSPSVVVVDPV 2585
            .:...:..|.|
Human  1175 MNIPALSADDV 1185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562	47/258 (18%)
		PolyA	2498..2561	CDD:197769	17/85 (20%)
		HECTc	2589..2885	CDD:238033
		HECTc	2589..2884	CDD:214523
WWC1	XP_011532787.1	WW	9..39	CDD:238122
		WW	55..84	CDD:278809	6/32 (19%)
		ALDH-SF	429..>481	CDD:299846	10/54 (19%)
		C2_Kibra	721..844	CDD:176062	35/171 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900