DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hyd and Ube3a

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	NP_001380595.1	Gene:	Ube3a / 22215	MGIID:	105098	Length:	870	Species:	Mus musculus

Alignment Length:	948	Identity:	194/948 - (20%)
Similarity:	338/948 - (35%)	Gaps:	257/948 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  2082 VTTNANNSGATNDGDGGSIFDYTPTRLGFSNS---------LKRNERVYETVP---------IDS 2128
            :|....|...||:     .....||.|...|:         .|.|.::.:..|         :::
Mouse    38 LTEGCGNEACTNE-----FCASCPTFLRMDNNAAAIKALELYKINAKLCDPHPSKKGASSAYLEN 97

  Fly  2129 SKTGDGN---VTNKAEGS--------TDSNIY--------------------------------V 2150
            ||....|   ..||.||.        |:..:|                                .
Mouse    98 SKGASNNSEIKMNKKEGKDFKDVIYLTEEKVYEIYEFCRESEDYSPLIRVIGRIFSSAEALVLSF 162

  Fly  2151 QLKKKQGSDDFKSHKEADGNQSKYEK------VVLMETDDSLPSTSKSTEALMATRPEVIIAPNK 2209
            :..|:...::.||.:|.|.::.:.||      ...|| :||..|:|:..::.........:.|:.
Mouse   163 RKVKQHTKEELKSLQEKDEDKDEDEKEKAACSAAAME-EDSEASSSRMGDSSQGDNNVQKLGPDD 226

  Fly  2210 ASVSPATAARSVIVLAGGSCLKTIDSDINNYSASNLSTAEQAKCDTQYQK-STSD----HLLLFP 2269
            .:|......|....|.....|:|...:...|.:.|:      :||..|.. .|.|    :|.:..
Mouse   227 VTVDIDAIRRVYSSLLANEKLETAFLNALVYLSPNV------ECDLTYHNVYTRDPNYLNLFIIV 285

  Fly  2270 ARGSQFYQSNFSELPSWNFLLSRWKLTLDLFGRV------FMDDVGMEHGSVLPELRGFPVKEMR 2328
            ...|..:...:.|:....|..:..||.|:..|::      :..|                    :
Mouse   286 MENSNLHSPEYLEMALPLFCKAMCKLPLEAQGKLIRLWSKYSAD--------------------Q 330

  Fly  2329 FRRHMEKLRNGQQRDLVLCKLERNRESLIVQTFKELNTQFGNQSRRIQPPITFNRVKVTFKDEPG 2393
            .||.||..                 :.||  |:|.::.:|.:::              ...|:
Mouse   331 IRRMMETF-----------------QQLI--TYKVISNEFNSRN--------------LVNDD-- 360

  Fly  2394 EGSGVARSFYTSIAEALLASAK------IPNLESVQVGTNHS----KYVVPFSSILRSRTVSGSS 2448
                          :|::|::|      ..|:....|.|||:    :..:|.||.|..:.:.|.
Mouse   361 --------------DAIVAASKCLKMVYYANVVGGDVDTNHNEEDDEEPIPESSELTLQELLGD- 410

  Fly  2449 RDQSTLQRRGSNSKILWRSARERKALNLDARPYTPPNSSDNATPESLNDHLSVHLQQIGERLYPK 2513
                  :||......:.....|.....||.|  .|..|.:....|.|||.|.:.    .:..:.|
Mouse   411 ------ERRNKKGPRVDPLETELGVKTLDCR--KPLISFEEFINEPLNDVLEMD----KDYTFFK 463

  Fly  2514 IHSINQ----------THAPKITG--------MLLEIPTPQLLSVISSDET---LRQKVNE---- 2553
            :.:.|:          ....|..|        |..|.....|.|::...:.   ||.||..
Mouse   464 VETENKFSFMTCPFILNAVTKNLGLYYDNRIRMYSERRITVLYSLVQGQQLNPYLRLKVRRDHII 528

  Fly  2554 -----AIEIITFKQKSETSAQ-------------SSQPKKSPSVVVVDPVDDDNEPLFYSPGKRG 2600
                 .:|:|..:..::...|             ....|:...:||.:..:.|.....|....:.
Mouse   529 DDALVRLEMIAMENPADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDEATKL 593

  Fly  2601 F-YTPRQGFASFERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKIKFHDLAFFDPALY 2664
            | :.|    :|||....|..||.::||.:..|.:|.:.....|.:.::|:|..|.||....|.||
Mouse   594 FWFNP----SSFETEGQFTLIGIVLGLAIYNNCILDVHFPMVVYRKLMGKKGTFRDLGDSHPVLY 654

  Fly  2665 ESFRQIIQNAQTKEGEETINRMELCFVI---DLMKEEGCGN---RELIPGGRDVAVTSSNIFEYV 2723
            :|.:.:::...:.|.:     |.:.|.|   ||.     ||   .:|...|..:.:|:.|..|:|
Mouse   655 QSLKDLLEYEGSVEDD-----MMITFQISQTDLF-----GNPMMYDLKENGDKIPITNENRKEFV 709

  Fly  2724 RRYTEYRLIKSQEKALEALKDGVFDVLPDNSMIN--LTAEDLRLLLNGVGDINVSTLISYTTFND 2786
            ..|::|.|.||.||..:|.:.| |.::.:.|.:.  ...|::.||:.|..:::...|...|.::.
Mouse   710 NLYSDYILNKSVEKQFKAFRRG-FHMVTNESPLKYLFRPEEIELLICGSRNLDFQALEETTEYDG 773

  Fly  2787 ESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPALPASEEGFQPLPSVTIRPADDS-HL 2850
                |..:.....:.||.||......:::..:.|.||:...|..  |...|..:..:...|: .|
Mouse   774 ----GYTRESVVIREFWEIVHSFTDEQKRLFLQFTTGTDRAPVG--GLGKLKMIIAKNGPDTERL 832

  Fly  2851 PTANTCISRLYIPLYSSKSILRSKMLMAIK-SKNFGFV 2887
            ||::||.:.|.:|.||||..|:.::|.||. :|.||.:
Mouse   833 PTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGML 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	15/92 (16%)
		HECTc	2589..2885	CDD:238033	82/306 (27%)
		HECTc	2589..2884	CDD:214523	82/305 (27%)
Ube3a	NP_001380595.1	AZUL	27..81	CDD:406862	10/47 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..223		12/52 (23%)
		HECTc	518..868	CDD:238033	93/370 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900