DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment hyd and yap-1

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	NP_001369894.1	Gene:	yap-1 / 181267	WormBaseID:	WBGene00008748	Length:	442	Species:	Caenorhabditis elegans

Alignment Length:	496	Identity:	89/496 - (17%)
Similarity:	163/496 - (32%)	Gaps:	184/496 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  2151 QLKKKQGSDDFKSHKEADGNQS----------KYEKVVLMETDDSLPST---SKSTEALMATRP- 2201
            |...:|..:.|..|...|.|||          |||| ...:..:.|||:   .|......|..|
Worm    11 QENSQQDKNQFSVHHYLDPNQSIHALISCSEKKYEK-NQNQKKNPLPSSYYHQKRNPGSSAHSPY 74

  Fly  2202 EVIIAPNKASVSPATAARSVIVLAGGSCLKT-------IDSDINN-YSASNLSTAEQAKCDTQYQ 2258
            ..:...::.:||||     :.:::..:.:.|       :.:.:|| .|::.:..........|:.
Worm    75 GSVDESSRTAVSPA-----MDMVSNQAPIHTRQVSAPNLHTSVNNGQSSATVPHPSHHNVHHQHS 134

  Fly  2259 KSTS------------DHLLLFPARGSQFYQSNFSELPSWNFLLSRWK---LTLDLFGRVFMDDV 2308
            ||.|            .|:.......:..| :..||:|....::.:.:   |:||...|.||...
Worm   135 KSVSALPMTIGYSPVPSHVKSVSHEANYSY-AGLSEIPQQQGMMQQNREKSLSLDPMRRPFMTPQ 198

  Fly  2309 GMEHGSVLPELRGFPVKEMRFRRHMEKLRNGQQRDLVLCKLERNRESLIVQTFKELNTQFGNQSR 2373
            .:|.   ||..:|:   ||.:                        :|..|:.||:.|:
Worm   199 DVEQ---LPMPQGW---EMCY------------------------DSDGVRYFKDHNS------- 226

  Fly  2374 RIQPPITFNRVKVTFKDEP----------GEGSGVARSFYTSIAEALLASAKIPNLESVQVGTNH 2428
                       |.|..|:|          |.|..:.::.|.:..:...:|..:|::.      .|
Worm   227 -----------KTTTWDDPRLKQQEQTGFGLGENIGQNRYNNCYDNGHSSRSLPSIH------QH 274

  Fly  2429 SKYVVPFSSILRSRTVSGSSRDQSTLQRRGSNSKILWRSARERKALNLDARPYTPPNSSDNATPE 2493
            .:.:                                                   ||   :..|:
Worm   275 QQMI---------------------------------------------------PN---HPQPQ 285

  Fly  2494 SLNDHLSVHLQQI-GERLYPKIHSINQTHAPKITGMLLEIPTP--QLLSVISSDETLRQKVNEAI 2555
            ..:.....::||: .||:     .|.:.:|..|...|::.|.|  |.:|.:||........|
Worm   286 YSSQQQMDYIQQLQNERM-----MIQEKNAQLINSGLVDSPQPPYQAISPMSSTMMHSHDPN--- 342

  Fly  2556 EIITFKQKSETSAQSSQPKKSPSVVVVDP-------VDDDN 2589
                |..:.:..||:||.:::|..:...|       ::||:
Worm   343 ----FMYQQQQQAQNSQQQQTPHTLHQIPNQYQNSQMNDDS 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	15/65 (23%)
		HECTc	2589..2885	CDD:238033	0/1 (0%)
		HECTc	2589..2884	CDD:214523	0/1 (0%)
yap-1	NP_001369894.1	WW	206..236	CDD:238122	12/74 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900