DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment hyd and hecd-1

DIOPT Version :9

Sequence 1:NP_001287262.1 Gene:hyd / 41181 FlyBaseID:FBgn0002431 Length:2887 Species:Drosophila melanogaster
Sequence 2:NP_001368365.1 Gene:hecd-1 / 177486 WormBaseID:WBGene00016405 Length:2650 Species:Caenorhabditis elegans


Alignment Length:2921 Identity:546/2921 - (18%)
Similarity:931/2921 - (31%) Gaps:948/2921 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   395 SETENVYHPKTVSLNIVERVELISANFIR-CSVVTE---------TNRVATWMDEQLGYIGAKLE 449
            |..||  .|.|.|.||:..|..:..|..| .|::||         |...||..:::         
 Worm   244 SNDEN--SPTTASANILSIVLSLIGNLCRGSSLITEKVLTSPNMITGLKATLTNKE--------- 297

  Fly   450 HSCCAFNEFISDSITKIYVCSLYTVVKTESNNIYWWGVLPFDQ---------------RRFLWDK 499
                  ...::|.:.   .|.|..|:..|..:     .||...               .|.|.|.
 Worm   298 ------ERVVTDGLR---FCDLLLVLLCEGRS-----ALPLTSVVSGDYAAGSGAERVHRQLIDA 348

  Fly   500 FRTKTKKPFKVVATDINVGAQVIMKKCPMYQSGSIGFTCSNGVPKVGQLLNSVW--TFTDVCRMK 562
            .|.|          |:......|       :||.:..   |....|||.|.: |  .|..:..::
 Worm   349 IRQK----------DLTALVDAI-------ESGQVDV---NFADDVGQSLTN-WASAFGSIEMVQ 392

  Fly   563 IININTNSGVDKSQAAGN--------------NLNAHGITPD-KDLPKSTAMPSTGSS------- 605
            .: .:..|.|:|...:.:              .|...|..|| :|....||:......       
 Worm   393 YL-CDKGSDVNKGHKSSSLHYAACFGRPDVVKLLLQRGANPDLRDEDGKTALDKARERSDDDHNQ 456

  Fly   606 -----KNGQSFSNSKESTDRIDMPPPPSPASSTCSDTGSVTSHKRTKRATTKEDSNAPQEGRKD- 664
                 ::..:|..:||.         |...:||....|:          :||.:...|...||. 
 Worm   457 VANILESPSAFMRNKED---------PKVKASTSKQPGT----------STKPELPNPNLVRKVL 502

  Fly   665 EELWEVKDVVFVEDKVGPV--------GKVLKVDGDFVAVRFPAI---NAAAVAAA--------A 710
            .:|..:...:|.:...|.|        .|:::..||   :|..|:   ||.|..:|        |
 Worm   503 HQLLPIFCEIFQKSLNGSVRRTSLSLMRKIVENIGD---LRQSAVGDGNAPAAQSARKMSTDVSA 564

  Fly   711 AATSSTSNTASTSKEEGKEDDWQQCRL----LRREDVQIF------------RTAMSTRGPDWLQ 759
            .|.|..:...|...:|...:..:|..|    |..:|.:::            ..||:...|..|:
 Worm   565 GAESLVAVVVSVMDQEDDHEGHEQVLLILESLLEKDAELWVIELVRLGVFERVEAMAKEPPKGLE 629

  Fly   760 KQPKKINVGGDAAGAQILTLAVDSRGIHVIKKVLGKIHYSLYNLYNCKQEQNCLFPTDCNSFIGS 824
            :....|::.|   .:::..:.:|                     :..:...:...|| .|..:.:
 Worm   630 EVLNAIHLEG---RSRVTPMEID---------------------FENQPSSSTAVPT-ANDIMDT 669

  Fly   825 TPGNILMACNDDCSGNSSTIVLRDGNGALYPLAKDCLGSIKDPQWFDLPPVKSITMSTISLPAML 889
            |..:.....:.:.:.|.|||.:.|...:                     ...|.|..:||.|...
 Worm   670 TVPSSSGGADAESNSNPSTIEMADPESS---------------------TPSSSTQQSISKPKAT 713

  Fly   890 SGVNLKSKVCMTALLFDTQKLMPHILRCDVKNSFAALGR-LEREDQADTALVVEERCDGARNIFH 953
            :     |....:|:|....||          :|.|:|.: ....|:..|..|:.:          
 Worm   714 A-----SSTASSAILQVVSKL----------SSVASLDKSAAAVDKKPTKTVLSQ---------- 753

  Fly   954 ACVIMCAPSSNKDSPPDSPSGGVEKKSLVGLSVARSIPTVSTSAYVSS------IAFGASA---- 1008
                            .:|....|.:.:.|          :||.::.|      :.|.::.    
 Worm   754 ----------------GTPYRWKEWRIVRG----------TTSLFIWSDVLLIELPFQSNGWFRY 792

  Fly  1009 -SSSNENSSFATMSSSAAGSASSTSRDN--RTNLRDMMNR------LINSDQAEQSGSQPMATNN 1064
             :.::.:..|.|.::|.....:...:||  :|..|:|::|      :.:.|.:    |.|:|...
 Worm   793 LADNDSHVQFVTGTASVDQQMTEEEKDNFQKTERREMVSRWNAVKGVFDDDWS----SVPIAVLG 853

  Fly  1065 EDHAYIPWPA-------ETPAASNLSASSSQNVSDSIEDDISKIIPSSSQSSMLSNIKLGSPT-- 1120
                 ||..|       |.||....|:.||:....|    ||...|:...::||:.||:....  
 Worm   854 -----IPSNAKKVSQKLEVPAWELWSSKSSELQIKS----ISSSAPTGQANTMLTTIKIQDDAGG 909

  Fly  1121 YTFDLAQRR------EHALTILQQMCVSPALRPYLCHMLSTKDAQGQTPFMLSVSCR-AYEAGII 1178
            :.|:....|      ||||.       |.....:..|.:||:    :..|...:..| ..|....
 Worm   910 FLFETGTGRKTNVMPEHALP-------SDFHTGWSSHGVSTR----KMKFRQDIQKRKVQELAWK 963

  Fly  1179 LLNTILMLSEQDPQLKEAMI-FPNGSPADQSPLHVICYNDTCSFTWTGADHIN-QNIFECKTCGL 1241
            |.|..|..:...|  :||:: ..|.:...:|.:.                |:. |:.|:.:.   
 Worm   964 LWNDHLKEAHAKP--REALVRLENAARTIESTIR----------------HVKAQSNFKHRN--- 1007

  Fly  1242 TGSLCCCTECARVCHKGHDCKLKRTAPTAYCDCWEKCKCKALIAGNLTKRFALLCKLVSCTD--- 1303
                   .:..|:......|....|...:..|.......:..::|.:...|.||..:....|   
 Worm  1008 -------VKQPRIERVQEYCAAISTLHESIVDDRRLSTFEFSVSGIVPALFGLLSMMEKFPDSFP 1065

  Fly  1304 --LVTKFNSKGESILLFLIQTVGRQIVEQRQYRFSVRVRNVSTAATGATGNNSVISNRKTSAAEI 1366
              :..:..||||::                                      |.::.:..:..|.
 Worm  1066 SRIFKEQFSKGEAL--------------------------------------SYLALKIVAVLEA 1092

  Fly  1367 DNDMPDHDLEPP---KFARKALERLLIDWNAVRSMIMSGAERGDVPNPAGSASENSNSEGFNMFI 1428
            :...|.|..:.|   .|..:.|.|      .||:.:..      :|...|..:.:.|        
 Worm  1093 NEKFPQHLYDSPGGSSFGLQLLSR------RVRTKLEM------LPRADGKENNDEN-------- 1137

  Fly  1429 QTQHGSTLLDKFTHSLIVKCTSDHLDTLLLTLVRELQNASVSNRSKEAEEVVRRFVRSVARVFVI 1493
                   |::|  ...||||.    ....:..:|...:..|:.:..:.|....|:|:.:..:   
 Worm  1138 -------LVNK--TGKIVKCE----PLASVGAIRAYLHRMVTRQWHDRERANYRYVKEIQEL--- 1186

  Fly  1494 FNLEKQPNPEKRKSHSSCNKYVQSCVKVFQTLHKISIEELCEVSE-------------------- 1538
                      |.|..|                  |.:..:.:..|                    
 Worm  1187 ----------KTKGKS------------------IELRHVSDFDENGVIYWIGTNGRAAPLWTNP 1223

  Fly  1539 ALIAPVRLGVVRPTAPF-------TMSSSNLDVRNSDD----------LFSVDPLAPSNVESPSE 1586
            |.:..|::.......||       :...:.::...|||          ||.|          |:.
 Worm  1224 ATVKAVKITCSDTRQPFGKPEDLLSRDQNPINCHTSDDKNAHFTIDLGLFVV----------PTS 1278

  Fly  1587 QILVHDAGNDQSA--NFNIQQNYDVVAMETIRDASESEEVINREANSHNQDDELIENQRNEDGMQ 1649
            ..|.|..|..:||  |:.:|.:.         ||...|.||     .|..|..|.|.........
 Worm  1279 YSLRHSRGYGRSALRNWMLQGSV---------DAKRWENVI-----VHTDDKGLGEPGSTATWHV 1329

  Fly  1650 DDESDNDFTFNDAETESDSDDNQSNQEVQRSVQAGATVGSENDIGVLFLEDESGDSSAQEEDGSE 1714
            .::....|.|...   :.:..|.|.|....|.......|...|:....:.::.....:.....|.
 Worm  1330 GEKGTTAFRFFRI---AQNGKNSSGQTHYLSCSGFEIYGDIVDVVTEAICEDPPKKDSPAGTSST 1391

  Fly  1715 DGESDDQSDEFNFNEQQLE---RRSTNSNARSDLAPQTMQWAI-RSRDTARSSVRVPTGSNMVFI 1775
            .|.|...:......||.||   .|..|:..:|.|:.:|:...: |||..:|.|.::....:.|..
 Worm  1392 PGSSSSAALPPLTKEQVLEMLPARENNNRLKSGLSLETVTSMLQRSRHRSRGSYKISESKSKVVR 1456

  Fly  1776 ------------DPMALRRSTVPASTTVTTPSIEPHTMATTASNLARAFGITIRQISELISILSY 1828
                        :....|.::.|.|..|..      |.....:|..| ||.......|.::...:
 Worm  1457 GKDWRWEDQDGGEGKFGRITSPPESGWVDV------TWDNGNANSYR-FGANGNFDIERVTSTGH 1514

  Fly  1829 -----NVLNDIETSLKIQNDEAIAVQAFVEKRLKATWDWMFTVMDGTEAQLKFGAYLTNYTDPNH 1888
                 ::.:.:.||:.    ||:       :|.:|.:....|  .|..:...||.          
 Worm  1515 RYSTPSLASHVPTSVM----EAV-------RRNRAFYTPKTT--GGPPSSSVFGT---------- 1556

  Fly  1889 PLHPLNLSAQASSSQ---------------TPAPATSSSVNGVNIMGSNSRRDFFTYCLSLMRSH 1938
                   |:.|.||:               |||...||   |.:..|:..::...|..|...|..
 Worm  1557 -------SSSAGSSRGAASALSRFASVKNTTPAGTPSS---GGSSGGAIGKKSMSTTNLVDERQK 1611

  Fly  1939 TS----------------EHRDALPVLDITALRHIAYVLDAFVYYMRNDSGFYDKQDTISGRINN 1987
            ||                :|:  .|.|:....|.:.:   ||                  |||  
 Worm  1612 TSGPSVASTGQAASAESLQHQ--TPSLENLLARAMPH---AF------------------GRI-- 1651

  Fly  1988 LSPMTESYDTDDELANLEEFNADVQMSASSMPSGSQGTRRHAFFARSESTLSLGCSAPEGFELPL 2052
                .|:.:.:||....||.:     ||:||.|.          |.|.|.:|:|.|:.:..:...
 Worm  1652 ----AENQEPEDEPMGGEESD-----SAASMRSA----------ASSNSQMSMGSSSQQQQQQDS 1697

  Fly  2053 DMA-MPLADKPHLLQPNSKRQELFANLPLLVTTNANNSGATNDGDGGSIFDYTPTR---LGFSNS 2113
            ||. ...|..|...: :.|.|.|..:.|.|.......:.|..|||..:  |.|.:.   :|..::
 Worm  1698 DMTPRDSAGTPSTPR-DDKNQTLSVSAPDLAAARQRQASAETDGDADA--DETNSEDKTVGADDA 1759

  Fly  2114 LKRNERVYETVPIDSSKTGDGNVTNKAEGST--------DSNIYVQLKK----KQGSDDFKSHKE 2166
            ::.::...||:..:.....|.:..:..|...        :..::.:||:    :..||...|.|:
 Worm  1760 MEEDDEEEETMEDEEDDDDDDDDESSNENQEKLVELLGGERGLFDKLKEVITGESLSDASSSAKD 1824

  Fly  2167 ADGNQ----------------SKYEKVV------------------------LMETDDSL----- 2186
            |..|:                |.|..|:                        :|:.||..     
 Worm  1825 ATTNEAQKKGGKKPKKWFKKMSSYTDVLKGLMQNRYPVALLDPAAAGIEMDEMMDDDDYYDFSED 1889

  Fly  2187 -PSTSKSTEALMATRPEVIIAPNKASVSPATAARSVIVLAGGSCLKTIDSDINNYSASNLSTAEQ 2250
             |....|.|..:|..    :.....|.:...|||:.|.....|.|         .|.||...|..
 Worm  1890 GPDDGDSVEDEVAAH----LGMPVDSFASMVAARTPITWRQFSEL---------MSGSNRERAAM 1941

  Fly  2251 AKC----------DTQYQKSTSDHLLLFPARGSQFYQSNFS-----ELPS-----WNFLLSRWKL 2295
            |:.          |....|.|.:.|:  ||...:..:||.:     |||:     .:...|..|:
 Worm  1942 ARAVASSRGSPWEDDATVKCTFEALI--PAFDPRPGRSNVNQTLEVELPTVVKDFGSTKASSSKI 2004

  Fly  2296 TLDLFGRVFM--------DDVGME----------HGSVLPELRGFPVKEMRFRRHMEKLR----- 2337
            ..|...|.|:        |:|.:|          :..::.....:..|..|.||..|...     
 Worm  2005 DKDDQMRFFLRGPNMSGVDNVTIEMNDDSASLFRYMQIINNSVNWATKSDRSRRIWEPTYSICYC 2069

  Fly  2338 NGQQRDLVLCKLERNRESLIVQTFKELNTQFGNQSRRIQ-------PPITFNRVKVTFKDEPGEG 2395
            :..|.::.:.|:.....|...|..:.|.| .|..||..|       .|..|...|:|.|      
 Worm  2070 SADQTNVEVSKIPDEESSTPCQVNQCLET-IGLLSRIQQAMPEAEITPNVFISDKLTLK------ 2127

  Fly  2396 SGVARSFYTSI-AEALLASAK-IPNLESVQVGTNHSKYVVPFSSILRSRTVSGSSRDQSTLQRRG 2458
                   .|.: ::||:.:|: :|...|..|......:.|...::....|..|.||         
 Worm  2128 -------VTQVLSDALVVAARSLPEWCSRLVYKYPCLFTVETRNMYMQATAFGVSR--------- 2176

  Fly  2459 SNSKILWRSARERKALNLDARPYTPPNSSDNATPESLNDHLSVHLQQIGERLYPKIHSINQTHAP 2523
               .|:|...|.      ||.......|:......:...|...|..::|...:.::         
 Worm  2177 ---TIVWLQQRR------DAAVERARGSAQAGNSSAARQHDRYHEYRVGRLRHERV--------- 2223

  Fly  2524 KITGMLLEIPTPQLLSVISSDETLRQKVNEAIEIITFKQKSETSAQ------------------- 2569
            |:|               .::|||   :::||.::.|....:...:                   
 Worm  2224 KVT---------------RAEETL---LDQAIRLMKFHADRKAVLEIEYTNEEGTGLGPTLEFYA 2270

  Fly  2570 ---SSQPKKSPSVVVVDPVDDD--------NEPLFYSPGKR--GFYTPRQG-----------FAS 2610
               :...:||.::.|.|  |||        ...:....||:  |:|..|.|           ..:
 Worm  2271 LVAAELQRKSLALWVCD--DDDTHASKSGEEREVDLGEGKKPIGYYVRRVGGLFPAPLPPGTDET 2333

  Fly  2611 FERINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILGRKI-------KFHDLAFFDP------- 2661
            ....:.||.:|..:...||...|:.|.|.|..||.::..:|       ..|.:...|.       
 Worm  2334 KRAADMFRVLGVFLAKVLLDGRLVDLPLSRPFLKLLVHPQIGDDARGPNLHKILSLDDFEEVNPV 2398

  Fly  2662 --ALYESFRQIIQNAQTKEGEETIN---------------RMELCFVIDL---------MKEEGC 2700
              :..:..|.:.|..:..|.:.:|:               :...|.|.||         .|....
 Worm  2399 KGSFLKELRALAQRKRLIENDTSIDSNSKRRKIAELKLHIKGSTCRVEDLALNFTVNPPSKVFQY 2463

  Fly  2701 GNRELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINLTAEDLRL 2765
            ...||:.||.|:.||..|:.:||.:..|:.|.......:.|.:||...|.|..::...:.|:::.
 Worm  2464 AEMELVDGGSDIDVTIDNVEQYVEKCEEFYLNTGIAYQMRAFRDGFDRVFPLRTLRAYSPEEVQR 2528

  Fly  2766 LLNG--VGDINVSTLISYTTFN-DESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTGSPAL 2827
            ||:|  ..:.:...:::||... ..:.|.|..|.     |..::|.:...||::.:.|.||..:|
 Worm  2529 LLSGEQCPEWSRDDILNYTEPKLGYTRESPGFLR-----FVDVMEALTAQERKNFLQFATGCSSL 2588

  Fly  2828 PASEEGFQPL-PSVTI-RPAD--DSHLPTANTCISRLYIPLYSSKSILRSKMLMAIKSKNF 2884
            |..  |...| |.:|| |..:  |...|:.|||:..|.:|.|||.:|||.::|.||..|.|
 Worm  2589 PPG--GLANLHPRLTIVRKVESGDGSYPSVNTCVHYLKLPEYSSSAILRERLLTAINEKGF 2647

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hydNP_001287262.1 E3_UbLigase_EDD 150..196 CDD:288409
ZnF_UBR1 1217..1284 CDD:197698 7/67 (10%)
ASF1_hist_chap 1535..1733 CDD:304562 41/236 (17%)
PolyA 2498..2561 CDD:197769 10/62 (16%)
HECTc 2589..2885 CDD:238033 88/356 (25%)
HECTc 2589..2884 CDD:214523 87/354 (25%)
hecd-1NP_001368365.1 Ank_2 345..436 CDD:403870 22/112 (20%)
ANK repeat 345..372 CDD:293786 9/46 (20%)
ANK repeat 374..403 CDD:293786 8/30 (27%)
PTZ00322 383..>497 CDD:140343 21/133 (16%)
ANK repeat 405..436 CDD:293786 4/30 (13%)
F5_F8_type_C 1243..1365 CDD:419973 29/148 (20%)
MIB_HERC2 1452..1509 CDD:399589 11/63 (17%)
HECTc 2221..2648 CDD:238033 103/463 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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