DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and oxi-1

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	NP_499392.1	Gene:	oxi-1 / 176515	WormBaseID:	WBGene00003898	Length:	1066	Species:	Caenorhabditis elegans

Alignment Length:	1344	Identity:	261/1344 - (19%)
Similarity:	447/1344 - (33%)	Gaps:	496/1344 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly  1729 EQQLERRSTNSNARSDLA----PQTMQWAIRSRDTARSSVRVPTGSNMVFIDPMALRRSTVP-AS 1788
            |::.:||      |.:||    |..:.:..|.:...:.....||..| .|.|.....::.:| |.
Worm    17 EEETQRR------RIELAHKLEPYLIGYLTRKKFHGKIKTFRPTFFN-DFNDLEKSNKTLLPVAQ 74

  Fly  1789 TTVTTPSIEPHTMAT----TASNLARAFGITI----RQISELISILSYNVLND---IETSLKIQ- 1841
            ..|..|.:..::...    ...|:.|...|:|    ::||.:.:.|:.:.:.:   :.||:..|
Worm    75 MLVKVPRVIENSRENKDIQMLCNICRHLIISIDSPSKEISFVAAFLNKDTIKEATSLITSIFSQI 139

  Fly  1842 -------NDEAIAVQAFVEKRLKATW--------------DWMF--------TVMDGTEAQLKFG 1877
                   |.|..|       .|| .|              :|:.        ||::|...::
Worm   140 PQILCSINGERAA-------ELK-QWQCLIHFVIVFSSSSNWLLVRNAPQVQTVLNGLCVKM--- 193

  Fly  1878 AYLTNYTDPNHPLHPLNLSAQASSSQTPAPATSSSVNG----VNIMGSNSRRDFFTYCLSLMRSH 1938
                           ::|..:....:..|.:...||||    :|:...|::  |...|..|
Worm   194 ---------------MSLFYEPKGYEQMATSLFVSVNGHKPLINVETVNAQ--FSILCKPL---- 237

  Fly  1939 TSEHRD-----ALPVLDITAL------RHI-----AYVLDAFVYYMRNDSGFYDKQDTISGRINN 1987
            .:|:.:     .|.||...||      :|:     ..:.:..::::|.::...:....:...||.
Worm   238 KTENPELFSIFVLKVLTCPALLVHLNAQHVELLKTTKIFEKTLHWLRANAEEIETGMDVRLLINL 302

  Fly  1988 LSPMTE-SYDTDDEL-ANLEEFNADVQMSASSMPSGSQGTRRHAFFARSESTLSLGCSAPEGFEL 2050
            |:.:.. :|..|..| :.|.|:...|.:|.|..               :|.|:..|     |.:.
Worm   303 LANLVHFAYINDKTLESKLYEWTWAVGVSLSRC---------------TELTVKHG-----GTKT 347

  Fly  2051 PLDMAMPLADKPHLLQPNSKRQE------LFANLPLLVTTNANNSGATNDGDGGSIFDYTPTRLG 2109
            .|....|:..  |.|.|..||.|      || .|.:|.::..                   .|..
Worm   348 SLHYWHPVFG--HYLLPIDKRTEGALRNVLF-QLKMLWSSRV-------------------VRCL 390

  Fly  2110 FSNSLKRNERVYETVPIDSSKTGDGNVTNKAEGSTD-SNIYVQLKKKQGSDDFKSHKEADGNQSK 2173
            |.|.:            :::||...:||:..:.|.| |..:.:|.:|.|.
Worm   391 FGNIM------------ENTKTASFSVTDGQKNSKDISAAFSKLWRKLGG--------------- 428

  Fly  2174 YEKVVLMETDDSLPSTSKSTE----ALMATRPEVIIAPNKASVSPATAARSVIVLAG----GSC- 2229
                    :.||..|:|||..    .|:|...:|.:          ||..:::.:.|    |.|
Worm   429 --------STDSASSSSKSESEPPPTLIAIVCQVYM----------TALNTMVHMKGEIISGLCR 475

  Fly  2230 ----LKTIDSDINNYSASNLSTAEQAKCDTQYQKSTSDHLLLFPARGSQFYQSNFSE-------L 2283
                ||.:.:.:..:......|:                       ||.|..||..:       |
Worm   476 DDQLLKQLWTYLREWGEKAGGTS-----------------------GSIFNSSNAEQWGPVSASL 517

  Fly  2284 PSWNFLLSRWKLTLDLFGRVFMDDVGMEHGSVLPELRGFPVKEMRF-RRHMEKLRNGQQRDLVLC 2347
            .|.....|....||.||     .|......|:|.|...|. ||..| .:.:|.          :|
Worm   518 QSLKRPSSPHTATLRLF-----VDCAAAIISILDEEEIFE-KETPFSNKELES----------IC 566

  Fly  2348 K-----------------LERNRESLIVQTFKELNTQFGNQSRR--------------IQPPITF 2381
            |                 ...|...|.......|...:...|||              ::|.
Worm   567 KYVNIFCFRSIWSGAVDETSANTTGLFHSMHSLLTVLYERDSRRSFAANDSKFWLISEVKPS--- 628

  Fly  2382 NRVKVTFKDEPGEGSGV----ARSFYTSIAEALL--------------ASAKIPNLES------- 2421
               .:|.:.|...|.||    ..:....|.:.:|              .|...|.:::
Worm   629 ---SLTIEYEKKSGKGVLMMRKMAHLVPIKDRMLLFRRQVQDDKNRVATSLNDPQMQTWITVQRN 690

  Fly  2422 --VQVGTNH-SKYVVP-FSSILRSRTVSGSSRDQSTLQRRGSNSKILWRSARERKALNLDARPYT 2482
              ::.|.|| ||..:| ..|.:|.:.|:....|::.:.:.|
Worm   691 RIIEDGFNHLSKLTIPALKSTIRVKFVNEQGLDEAGIDQDG------------------------ 731

  Fly  2483 PPNSSDNATPESLNDHLSVHLQQIGERLYPKIHSINQTHAPKITGMLLEIPTPQLLSVISSDETL 2547
                       ...:.|.:.|:::.:   |:::..:.|.    ||:|...||..|
Worm   732 -----------VFKEFLELTLKKVFD---PQLNLFSTTS----TGVLYPSPTSSL---------- 768

  Fly  2548 RQKVNEAIEIITFKQKSETSAQSSQPKKSPSVVVVDPVDDDNEPLFYSPGKRGFYTPRQGFASFE 2612
                                                  .||:..||                :|
Worm   769 --------------------------------------HDDHLALF----------------TF- 778

  Fly  2613 RINAFRNIGRLIGLCLLQNELLPLFLQRHVLKYILG--RKIKFHDLAFFDPALYESFRQIIQNAQ 2675
                   :||::|..:.:..::.:.|...:|..:||  |...|.:|:..||.||.|...:    :
Worm   779 -------VGRMLGKAVYEGIVVDVQLAPVLLAAVLGSHRLCAFDELSQLDPELYRSLTFV----K 832

  Fly  2676 TKEGEETINRMELCFVIDLMKEEGCG---NRELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEK 2737
            ..|||  :..:.|.|.:|   |:..|   ..:|:|.||.::||:.|..:||.|...:|:.:..::
Worm   833 RYEGE--MADLSLTFSVD---EDFMGKISTVDLVPSGRTISVTNENKIDYVHRMAHHRVFRRTQE 892

  Fly  2738 ALEALKDGVFDVLPDNSMINLTAEDLRLLLNGV-GDINVSTL---ISYTTFNDESSEGPDKLLKF 2798
            ..:|...|:..:|....:......||:.|::|| .||:::.|   :.|  |.  ...|..:|:
Worm   893 QCKAFVTGMQSILQPTWLSLFAPNDLQCLISGVNSDIDLADLKRNVQY--FG--GFHGNHRLI-- 951

  Fly  2799 KKWFWSIVE-KMNIMERQDLVYFWTGSPALPASEEGFQPL-PSVTIR---PADD----------- 2847
             ||.|.|:| |....||:..:.|.|.....|..  ||..| |..:||   .:||
Worm   952 -KWLWDILENKFTSEERKLFLKFVTSCSRPPVL--GFSYLEPPFSIRCVEVSDDQDQGDTLGSVV 1013

  Fly  2848 ------------SHLPTANTCISRLYIPLYSSKSILRSKMLMAI 2879
                        :.||||:||.:.|.:|.|:.||:|..|:..||
Worm  1014 RGFLALRKGTAATRLPTASTCFNLLKLPNYNKKSLLLEKLRYAI 1057

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562	1/3 (33%)
		PolyA	2498..2561	CDD:197769	10/62 (16%)
		HECTc	2589..2885	CDD:238033	86/328 (26%)
		HECTc	2589..2884	CDD:214523	86/328 (26%)
oxi-1	NP_499392.1	HECTc	684..1064	CDD:238033	109/506 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900