DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment hyd and hecw-1

DIOPT Version :9

Sequence 1:	NP_001287262.1	Gene:	hyd / 41181	FlyBaseID:	FBgn0002431	Length:	2887	Species:	Drosophila melanogaster
Sequence 2:	NP_001317872.1	Gene:	hecw-1 / 175438	WormBaseID:	WBGene00009738	Length:	1247	Species:	Caenorhabditis elegans

Alignment Length:	1496	Identity:	280/1496 - (18%)
Similarity:	477/1496 - (31%)	Gaps:	527/1496 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1507 SHSSCNKYVQSCVKVFQTLHKISIEELCEVSEALIAPVRLGVVRPTAPFTMS----SSNLDVRNS 1567
            |.:.|..:|     .|:.:.::||.:           ...||.|.|..|..|    ..||:::|.
Worm   147 SRAICENFV-----AFKKVERLSIFQ-----------TNYGVERNTLNFAQSFDWICDNLEIKNI 195

  Fly  1568 DDLFSVDPLAPSNVESPS------------EQILVHDAGNDQSANFNIQQNYDVVAMETIRDASE 1620
            .  ...|.|.|..|:..:            ||:|..|....|.|                 |...
Worm   196 H--IGADVLEPKMVQKTNGEFDIKLCARRFEQVLTMDHIYLQHA-----------------DWIT 241

  Fly  1621 SEEVINREANSHNQDDELIENQRNEDGM-----QDDESDND----------FTFNDAETESDSDD 1670
            ||:::|.:.    |...||||...|..:     |...||:|          ..||..|...|.|
Worm   242 SEDLLNLDV----QTAMLIENNLTEQDLNAFIKQWLRSDSDKLWWLEVKGKMMFNREEVLKDLD- 301

  Fly  1671 NQSNQEVQRSVQAGATVGSENDIGVLFLEDESGDSSAQEEDGSEDGESDDQSDEFNFNEQQLERR 1735
              ...:..||:.....|...:      ..:.||:..|:::.||
Worm   302 --VQDDAYRSLNTRWYVARRS------RANPSGNGCARKKMGS---------------------- 336

  Fly  1736 STNSNARSDLAPQ-TMQWAIRSRDTARSSVRVPTGSNMVFIDPMALRRSTVPASTTVTTPSIEPH 1799
                     |.|: |..|..:        |.:..||.::...|.||.|.
Worm   337 ---------LRPKLTELWPFK--------VYIIFGSILIVFGPAALNRM---------------- 368

  Fly  1800 TMATTASNLARAFGITIRQISELISILSYNVLNDIETSLKIQNDEAI-----AVQAFVEKR--LK 1857
                          ||:|::             |:||.....::..|     ||..|..|.  :|
Worm   369 --------------ITLRRM-------------DVETDRPSGSETGIFVSKSAVYPFGNKNEVVK 406

  Fly  1858 ATWDWMFTVMDGTEAQLKFGAYLTNYTDPNHPLHPLNLSAQASSSQTPAPATSSSVNGVNIMGSN 1922
            ..|                     |...|.:
Worm   407 VWW---------------------NIDKPEN---------------------------------- 416

  Fly  1923 SRRDFFTYCLSLMRSHTSEHRDALPVLDITALRHIAYVLDAFVYYMRNDSGFYDKQDTISGRINN 1987
                    ||           |.:.:.|                  .|||.||..|.::.   .:
Worm   417 --------CL-----------DWIGLFD------------------NNDSSFYLDQKSLR---QH 441

  Fly  1988 LSPMTESYDTDDELANLEEFNADVQMSASSMPSGSQGTRRHAFFARSESTLSLGCSAPEGFELPL 2052
            :||:..:. |...|.|..|.       ...:..|..|    ...|:||:
Worm   442 ISPVVFTL-TSKNLLNASEV-------YFGLIDGMTG----RLLAKSEN---------------- 478

  Fly  2053 DMAMPLADKPHLLQPNSKRQELFANLPLLVTTNANNSGATNDGDGGSIFDYTPTRLGFSNSLKRN 2117
               :.:.....|:....|:.|   |:.:.:.||           .|.|  ..|.:..||..
Worm   479 ---VEICKSASLVVHEVKKPE---NINVYLNTN-----------HGRI--EIPKKRSFSRK---- 520

  Fly  2118 ERVYETVPIDSSKTGDGNVTNKAEGSTD-SNIYVQL---KKKQGSDDFKSHKEADGN--QSK-YE 2175
                           :|:..:..|...| .::::.|   .:|...|.|.:..:...|  ||| :.
Worm   521 ---------------NGSFRSSFEFDFDVEDLHISLVENSEKLNFDHFIASNQLQNNYIQSKSFS 570

  Fly  2176 KVVLMETDDSL-PSTSKSTEALMATRPEVIIAPNKASVSPATAARSVIVLAGGSCLKT-IDSDIN 2238
            ...::|...|: |.|||.      :.|:::...:.:...|.            |..|| :|:...
Worm   571 HSHVVEIVFSIEPKTSKK------SAPDIMEIASSSQTPPE------------SHWKTYLDAKKR 617

  Fly  2239 NYSASNLSTAEQ-AKCDT----QYQKSTSDHLLLFPARGSQFYQSNFSELPSWNFLLSRWKLTLD 2298
            .:..::::...: .|.||    ..:..|..|..|          |:.|..|..:|:..|..:|:
Worm   618 KFYVNHVTKETRWTKPDTLNNNHIEPETPVHKRL----------SDRSASPRNSFITPRRTITV- 671

  Fly  2299 LFGRVFMDDVGMEHGSVLPELRGFPVKEM-RFRRHMEKLRNGQQRDLVLCKLERNRESLIVQTFK 2362
                               ...|.|..:: :|          .|||.....|..|::::  |.:.
Worm   672 -------------------RSAGCPKSDLIQF----------FQRDEFKTALYENQDAM--QIYN 705

  Fly  2363 ELNTQFGNQSRRIQ----PPITFNR--VKVTFKDEPGEGSGVARSFYTSIAEALLASAKIPNLES 2421
            |.:. ..:...|||    ||..|..  :.|.|.           :.:..|.:.|.:..:...:.:
Worm   706 ECSV-VRHAIHRIQKDLDPPSKFENQPLFVRFV-----------NLFADITQPLPSGWECITMNN 758

  Fly  2422 VQVGTNHSKYVVPFSSILRSRTVSGSSRDQSTLQRRGSNSKILWRSARERKALNLDARPYTPPNS 2486
            ..|..||:.....|.. .|.|      |.::...|||.:  :..||:...|            ..
Worm   759 RTVFLNHANKETSFYD-PRIR------RFETKTSRRGRS--VPSRSSTAHK------------GK 802

  Fly  2487 SDNATPESLNDHLSV---HLQQIGERLYPKIHSINQTHAPKITGMLLEIPTPQLLSVISSDETLR 2548
            .|:|......|...:   :..||.||:..|:..|.:.....:..:..::.....||::.|:....
Worm   803 IDHALISKCEDLRKIAQDNFPQIAERISKKLMLIERFGGLAVASLANDLDITLALSMLDSNTEKL 867

  Fly  2549 QKVNEAIEIITFKQKSETSAQSSQPKKSPS------------------VVVVDP---------VD 2586
            ....:.|::.....|.|...      |.||                  ::.|||         :.
Worm   868 AGEGDNIKMFYEDMKKEKLG------KGPSRLCWKVSRDRLLDDAFRIILNVDPFVLKKSRLHIR 926

  Fly  2587 DDNE-PLFYSPGKRGFYT--------PRQGFASFERINAFRNI-----------------GRLIG 2625
            .:.| .|.|....|.|:.        |:.|:..:|..:....:                 ||::.
Worm   927 FEGELALDYGGLSREFFILLSRELFHPKNGYFEYEGNDYHLQLRPRGCETEKEKKWLILCGRVLA 991

  Fly  2626 LCLLQNELLPLFLQRHVLKYILGRKIKFHDLAFFDPALYESFRQIIQNAQTKEGEETINRMELCF 2690
            |.::....:.:|......|.:..|.:...|....|...|:|...:::|        .:..:|:.|
Worm   992 LAVIHRCYIDVFFTNVFYKSLQKRPVTLMDFKESDAEFYKSMNWLLEN--------DVVDLEMSF 1048

  Fly  2691 VIDLMKEEGCGNRELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSM 2755
            |...|.......:||:|||....||.:|..|::....:.:.|:..||.||.|......:|.||.:
Worm  1049 VYSSMVNGKLAEQELVPGGESQMVTEANKAEFIDLMCQKKAIRGVEKPLEILLTSFNQILNDNLL 1113

  Fly  2756 INLTAEDLRLLLNGVGDINVSTLISYTTFNDESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYF 2820
            .:|.:.||:.:|:|..:::::...:.|.:....|:....:    :|||.::|.|...||.||:.|
Worm  1114 NSLESSDLKRILSGSLELDLNDWRTNTIYKGGYSDCHIVV----EWFWEVIETMTNQERFDLLLF 1174

  Fly  2821 WTGSPALPASEEGFQPLPS-------VTIRPADDSHLPTANTCISRLYIPLYSSKSILRSKMLMA 2878
            .|||.::|.  |||..|..       ...:..|.:..|.|:||.:||.:|.|::|..|:||:..|
Worm  1175 VTGSSSVPF--EGFSALRGNEEISKFCIEKWGDATSFPRAHTCFNRLQLPSYNTKQQLKSKLQQA 1237

  Fly  2879 I 2879
            |
Worm  1238 I 1238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562	46/228 (20%)
		PolyA	2498..2561	CDD:197769	10/65 (15%)
		HECTc	2589..2885	CDD:238033	81/324 (25%)
		HECTc	2589..2884	CDD:214523	81/324 (25%)
hecw-1	NP_001317872.1	FBA_2	230..285	CDD:311601	17/75 (23%)
		WW	603..634	CDD:197736	6/42 (14%)
		WW	746..777	CDD:197736	5/31 (16%)
		HECTc	918..1244	CDD:214523	81/335 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900