Protein Alignment hyd and etc-1

DIOPT Version :9

• Sequence 1: NP_001287262.1
• Gene: hyd / 41181
• FlyBaseID: FBgn0002431
• Length: 2887
• Species: Drosophila melanogaster
• Sequence 2: NP_495842.1
• Gene: etc-1 / 174388
• WormBaseID: WBGene00008429
• Length: 1001
• Species: Caenorhabditis elegans
• Alignment Length: 1166
• Identity: 224/1166 - (19%)
• Similarity: 397/1166 - (34%)
• Gaps: 361/1166 - (30%)

  Fly  1816 IRQISELISILSYNVLNDIETSLKIQNDEAIAVQAFVEKRLK-ATWDWMF-----TVMDGT---- 1870
            :..:|||:.:.:    :|.|...:|:..:.:.:.....|.|| ||.:.:|     .:.|..
 Worm    90 VMTLSELVKLKT----SDKEFEKRIRETQRLLLARCCIKFLKNATENTIFFHIFRYLEDYVTCHS 150

  Fly  1871 ---EAQLKFGAY-------------LTNYTDPNHPLHPLNLSAQASSSQT---PAPATSSSVNGV 1916
               ||..|.|.:             .|..|.....|:|..|.......:|   |:.:||.|||..
 Worm   151 KLFEASSKLGLFNAEFHLLEALIGKPTGKTVERASLNPRILQLLTRIFETFVNPSRSTSVSVNVA 215

  Fly  1917 NIMGSNSRRDFFTYCLSLMRSHTSEHRDALPVLDITALRHIAYVLDAFVYYMRNDSGFYDKQDTI 1981
            |       |...|.|                 ::||.|....|:|    ||::         |.|
 Worm   216 N-------RLLKTIC-----------------VNITDLNFSNYIL----YYIK---------DHI 243

  Fly  1982 SGRINNLSPMTESYDTDDELANLEEFNADVQMSASSMPSGSQGTRRHAFFARSESTLSLGCSAPE 2046
            .....|.:.:.|:..:.|.|.|.:......:.::..:.|.......|....:||.......|
 Worm   244 KPTSPNFTNLFEAMKSVDILNNWKVRPEIAETASLRLQSIFVSQIVHVSNTQSEDVKQYFNS--- 305

  Fly  2047 GFELPLDMAMPLADKPHLLQPNSKRQEL--FANLPLLVTTNANNSGATNDGDGGSIFDYTPTRLG 2109
                   :|:.|.....:::..:.:::|  |..|    .|:.||          .:..|....|
 Worm   306 -------LAVFLEHHSKIMRSLNVKEDLSEFGRL----RTSVNN----------HLKQYCEEML- 348

  Fly  2110 FSNSLKRNERVYETVPIDSSKTGDGNVTNKAEGSTDSNIYVQLKKKQGSDDFKSHKEADGNQSKY 2174
            .||..:|...:|..:|                 .......:.|:                   ||
 Worm   349 ISNEFRRAACIYANLP-----------------GVQVETIISLR-------------------KY 377

  Fly  2175 EKVVLMETDDSLPSTSKSTEALMATRPEVIIAPNKA-----SVSPATAARSVIVLAGGSCLKTID 2234
            ....|    |.|.:::...|||.|....  :.||..     :.||...|..:..    :||
 Worm   378 FSQFL----DLLAASNTFVEALYAFIAR--LCPNGEFDPIDAKSPKVNALELFC----NCL---- 428

  Fly  2235 SDINNYSASNLSTAEQAKCD--------TQYQKSTSDHL--LLFP--ARGSQFYQSNFSELPSWN 2287
                |...|:::.::....|        .::.:..|..|  |:||  ||| ..|..|..|  ...
 Worm   429 ----NKRVSSVADSDFVPTDIFVDFDHTVEFLRDVSIKLIHLMFPTMARG-DLYSGNLKE--KMY 486

  Fly  2288 FLLSRWK-LTLDLF---GRVFMDDVGME---------HG----SVLPELRGFPVKEMRFRRHMEK 2335
            ...:.|| :|..:|   |.::..|:.::         ||    |.:.|.|..|      ||.|.
 Worm   487 KAETDWKDVTESVFSILGAIYQKDIRLKYFPEEFWTNHGREVLSGIGEHRRMP------RRRMP- 544

  Fly  2336 LRNGQQRDLVLCKLERNRESLIVQ---TFKELNTQFGNQSRRIQPPITFNRVKVTFKDEPGEGSG 2397
              ||:      .::||..::..|:   ...|:::...|..                :||......
 Worm   545 --NGR------LQIERTMDTEFVERLAAIYEMDSDSENDD----------------EDEDNNLPA 585

  Fly  2398 VARSFYTSIAEALLASAKIPNLESVQVGTNHSKYVVPFSSILRSRTVSGSSRDQSTLQRRGSNSK 2462
            |.|       .|:.....||             ::|||...::..|
 Worm   586 VLR-------RAICVMKHIP-------------FIVPFMDRVKLFT------------------- 611

  Fly  2463 ILWRSARERKALNLD-ARPYTPPNSSDNATPESLNDHLSVHLQQIGERLYPKIHSINQTHAPKIT 2526
                     :.||.| .:.||.........|.     ::|...|:....:       :|.|||:.
 Worm   612 ---------RLLNQDKEKHYTSTFGMGFNGPS-----VTVRRDQVYMDAF-------ETFAPKMQ 655

  Fly  2527 GMLLEIPTPQLLSVISSDETLRQKVNE-----AIEIITFKQKSETSAQS--------SQPKKSPS 2578
            |                     .|||:     .::::.:...:|:....        |:..|:..
 Worm   656 G---------------------DKVNDLKSMVRVKMVNWAGMNESGIDGGGIFREFLSELLKTAF 699

  Fly  2579 VVVVDPVDDDNEPLFYSPGKRGFYT----------PRQGF-ASFERINAFRNIGRLIGLCLLQNE 2632
            .|                 :|||:|          |...| ...:.:..|:.|||:||..:.:.:
 Worm   700 NV-----------------ERGFFTFTESKLLYPNPTAPFLLGVDCLAHFQFIGRMIGKLIYERQ 747

  Fly  2633 LLPL----FLQRHVLKYILGRKIKFHDLAFFDPALYESFRQIIQNAQTKEGEETINRMELCFVID 2693
            |..:    |....:.:....:.:....:..|||.:::..:     |..|.....::.::|.|.:.
 Worm   748 LQEVRFAEFFIAQIFETDKNKDVDLQHMKSFDPIIFKHLK-----ALQKMNNRELDELQLDFSVV 807

  Fly  2694 LMKEEGCGNRELIPGGRDVAVTSSNIFEYVRRYTEYRLIKSQEKALEALKDGVFDVLPDNSMINL 2758
            ........|..|.|.|....||..|:.||||.|..|.|.:.....::|::.|:.:::....|...
 Worm   808 TSDMGLVRNVNLKPNGSKFRVTVENVHEYVRLYVNYHLKQRIASMVDAVRKGISEIISIEWMRMF 872

  Fly  2759 TAEDLRLLLNGVGDINVSTLISYTTFNDESSEGPDKLLKFKKWFWSIVEKMNIMERQDLVYFWTG 2823
            ...:|::::.|..:  |.|......|.:.......:.:.:::.||.:::|::..:::.|:.|.||
 Worm   873 APHELQIMIAGYEE--VFTAKELRKFCELRFAAGTQDINYEEMFWDVIDKLSNDDKKALLKFVTG 935

  Fly  2824 SPALPASEEGF---QPLPSVTIRPADDSHLPTANTCISRLYIPLYSSKSILRSKMLMAIKS 2881
            ....|.  :||   ||...|.:.|:.|..|||:.||::.|.||.||:::.|..|:..||.|
 Worm   936 CSRAPV--DGFKSIQPRMGVLVIPSSDDELPTSATCMNMLRIPKYSNRTKLEEKLRYAINS 994

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hyd	NP_001287262.1	E3_UbLigase_EDD	150..196	CDD:288409
		ZnF_UBR1	1217..1284	CDD:197698
		ASF1_hist_chap	1535..1733	CDD:304562
		PolyA	2498..2561	CDD:197769	10/67 (15%)
		HECTc	2589..2885	CDD:238033	73/311 (23%)
		HECTc	2589..2884	CDD:214523	73/311 (23%)
etc-1	NP_495842.1	HECTc	661..998	CDD:214523	77/360 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900